Development and validation of a novel scoring system for acute ischemic stroke
This study aimed to assess the clinical application of the Artery Occlusion Image Score (AOIS), a new metric based on computed tomographic angiography (CTA) that reflects the severity of occlusive changes in t... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 14, 2024 Category: Research Authors: Rui Xu, Shixin Peng, Yulong Qiu, Ji Zhu, Xiaodong Zhang and Li Jiang Tags: Research Source Type: research
Recent advances of m6A methylation in skeletal system disease
Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 position of adenosine in RNA, is a r... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 14, 2024 Category: Research Authors: Jianhui Liang, Qian Yi, Yang Liu, Jiachen Li, Zecheng Yang, Wei Sun and Weichao Sun Tags: Review Source Type: research
Tubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin β1
Tumor cells of diffuse-type gastric cancer (DGC) are discohesive and infiltrate into the stroma as single cells or small subgroups, so the stroma significantly impacts DGC progression. Cancer-associated fibrob... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 14, 2024 Category: Research Authors: Dagyeong Lee, In-Hye Ham, Hye Jeong Oh, Dong Min Lee, Jung Hwan Yoon, Sang-Yong Son, Tae-Min Kim, Jae-Young Kim, Sang-Uk Han and Hoon Hur Tags: Research Source Type: research
ROS-mediated up-regulation of SAE1 by Helicobacter pylori promotes human gastric tumor genesis and progression
Helicobacter pylori (H. pylori) is a major risk factor of gastric cancer (GC). The SUMO-activating enzyme SAE1(SUMO-activating enzyme subunit 1), which is indispensable for protein SUMOylation, involves in human ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 13, 2024 Category: Research Authors: Liu Shi, Jianfang Shangguan, Ying Lu, Jianfang Rong, Qinyu Yang, Yihan Yang, Chuan Xie and Xu Shu Tags: Research Source Type: research
Very low-calorie ketogenic diet (VLCKD) in the management of hidradenitis suppurativa (Acne Inversa): an effective and safe tool for improvement of the clinical severity of disease. Results of a pilot study
Hidradenitis suppurativa (HS), an inflammatory-based dermatological condition often associated with obesity, poses significant challenges in management. The very low-calorie ketogenic diet (VLCKD) has shown ef... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 13, 2024 Category: Research Authors: Ludovica Verde, Sara Cacciapuoti, Giuseppina Caiazzo, Matteo Megna, Fabrizio Martora, Annarita Cavaliere, Maria Mattera, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri and Luigi Barrea Tags: Research Source Type: research
Comparison of standard mismatch repair deficiency and microsatellite instability tests in a large cancer series
The tumor-agnostic indication of immune checkpoint inhibitors to treat cancers with mismatch repair deficiency (dMMR)/microsatellite instability (MSI) increased the demand for such tests beyond Lynch syndrome.... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 13, 2024 Category: Research Authors: Maja L. N ádorvári, István Kenessey, András Kiss, Tamás Barbai, Janina Kulka, Erzsébet Rásó and József Tímár Tags: Research Source Type: research
From the identification of actionable molecular targets to the generation of faithful neuroblastoma patient-derived preclinical models
Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Although the overall survival of patients with NB has improved in the last years, more than 50% of hi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 13, 2024 Category: Research Authors: Mario Capasso, Chiara Brignole, Vito A. Lasorsa, Veronica Bensa, Sueva Cantalupo, Enrico Sebastiani, Alessandro Quattrone, Eleonora Ciampi, Marianna Avitabile, Angela R. Sementa, Katia Mazzocco, Barbara Cafferata, Gabriele Gaggero, Valerio G. Vellone, Mic Tags: Research Source Type: research
High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures
Excessive energy intake in modern society has led to an epidemic surge in metabolic diseases, such as obesity and type 2 diabetes, posing profound threats to women ’s reproductive health. However, the precise i... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 12, 2024 Category: Research Authors: Congcong Liu, Yunde Dou, Mengge Zhang, Shan Han, Shourui Hu, Yuxuan Li, Zhiheng Yu, Yue Liu, Xiaofan Liang, Zi-Jiang Chen, Han Zhao and Yuqing Zhang Tags: Research Source Type: research
The application of time-to-event analysis in machine learning prognostic models
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 12, 2024 Category: Research Authors: Zi-He Peng, Zhi-Xin Huang, Juan-Hua Tian, Tie Chong and Zhao-Lun Li Tags: Letter to the Editor Source Type: research
Emerging evidence linking stress and glucocorticoid signaling with cancer phenotypes
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 12, 2024 Category: Research Authors: Anthony S. Zannas Tags: Letter to the Editor Source Type: research
COSMIC-based mutation database enhances identification efficiency of HLA-I immunopeptidome
Neoantigens have emerged as a promising area of focus in tumor immunotherapy, with several established strategies aiming to enhance their identification. Human leukocyte antigen class I molecules (HLA-I), whic... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 10, 2024 Category: Research Authors: Fanghzou Wang, Zhenpeng Zhang, Mingsong Mao, Yudai Yang, Ping Xu and Shichun Lu Tags: Research Source Type: research
Enhanced molecular release from elderly bone samples using collagenase I: insights into fatty acid metabolism alterations
Bone is a metabolically active tissue containing different cell types acting as endocrine targets and effectors. Further, bone is a dynamic depot for calcium, phosphorous and other essential minerals. The tiss... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 9, 2024 Category: Research Authors: Amir Mohammad Malvandi, Esra Halilaj, Martina Faraldi, Laura Mangiavini, Simone Cristoni, Valerio Leoni and Giovanni Lombardi Tags: Research Source Type: research
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients
Overweight is known to be an important risk factor for colorectal cancer (CRC), and the differences in intestinal flora among CRC patients with different BMI status have not been clearly defined. The purpose o... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 9, 2024 Category: Research Authors: Yongqi Huang, Xiaoliang Huang, Zhen Wang, Fuhai He, Zigui Huang, Chuanbin Chen, Binzhe Tang, Mingjian Qin, Yongzhi Wu, Chenyan Long, Weizhong Tang, Xianwei Mo and Jungang Liu Tags: Research Source Type: research
Ensemble methods of rank-based trees for single sample classification with gene expression profiles
Building Single Sample Predictors (SSPs) from gene expression profiles presents challenges, notably due to the lack of calibration across diverse gene expression measurement technologies. However, recent resea... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 7, 2024 Category: Research Authors: Min Lu, Ruijie Yin and X. Steven Chen Tags: Methodology Source Type: research
Cancer testis antigen burden (CTAB): a novel biomarker of tumor-associated antigens in lung cancer
Cancer-testis antigens (CTAs) are tumor antigens that are normally expressed in the testes but are aberrantly expressed in several cancers. CTA overexpression drives the metastasis and progression of lung canc... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 7, 2024 Category: Research Authors: R. J. Seager, Maria-Fernanda Senosain, Erik Van Roey, Shuang Gao, Paul DePietro, Mary K. Nesline, Durga Prasad Dash, Shengle Zhang, Heidi Ko, Stephanie B. Hastings, Kyle C. Strickland, Rebecca A. Previs, Taylor J. Jensen, Marcia Eisenberg, Brian J. Cavene Tags: Research Source Type: research
