It's in the game: A review of neurological lesions associated with sports
The practice of sports may lead to neurological injuries. While relatively uncommon (overall incidence of approximately 2.5%), and mostly benign and transient, some conditions may be life-threatening and permanent. Thus, both clinical neurologists and sports physicians should be aware of their existence and relevance. We aimed to review all sports-related neurological injuries and illnesses reported in the literature. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 16, 2023 Category: Neurology Authors: Mariana Pedrosa, B árbara Martins, Rui Araújo Tags: Review Article Source Type: research

Early cortical atrophy is related to depression in patients with neuropathologically confirmed Parkinson's disease
Depression is a common comorbidity in Parkinson's disease (PD) and other synucleinopathies. In non-PD geriatric patients, cortical atrophy has previously been connected to depression. Here, we investigated cortical atrophy and vascular white matter hyperintensities (WMHs) in autopsy-confirmed parkinsonism patients with the focus on clinical depression. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 16, 2023 Category: Neurology Authors: Emmilotta A. Backman, Laura Saari, Riitta Parkkola, Juha Koikkalainen, Maria Gardberg, Valtteri Kaasinen Source Type: research

Editorial Board
(Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 15, 2023 Category: Neurology Source Type: research

Pain is common in early onset Parkinson's disease and pain severity is associated with age and worsening of motor and non-motor symptoms
The consequences of pain in early onset Parkinson's disease (EOPD) remain under appreciated even though pain may exert an increasingly negative impact on patient quality of life as motor and non-motor symptoms worsen.In this prospective study, we investigate the prevalence and severity of pain in 135 Vietnamese patients with EOPD from three medical centers using the King's PD Pain Scale (KPPS), the Mini Mental Status Exam (MMSE), the Unified Parkinson's Disease Rating Scale (UPDRS) and the Non-Motor Symptoms Scale (NMSS). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 15, 2023 Category: Neurology Authors: Hoang Thi Dung, Frank Xing, Nguyen Duc Thuan, Nguyen Dang Ton, Tran Ngoc Tai, Nhu Dinh Son, Nguyen Huu Quang, Nguyen Thanh Hai, Hoang Tien Ung, Than Van Quyen, Daniel Truong Source Type: research

Progressive multifocal leukoencephalopathy analyzed using the Japanese Adverse Drug Event Report database
Progressive multifocal leukoencephalopathy (PML) has been reported as the development of drugs with immunomodulatory properties, such as anticancer, immunosuppressive, and biological agents, has accelerated. To clarify an incidence profile of drug-associated PML in real-world clinical practice, we analyzed reported patients with PML using the Japanese Adverse Drug Event Report (JADER) database. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 14, 2023 Category: Neurology Authors: Shuji Sakurai, Mika Maezawa, Satoshi Nakao, Sakiko Hirofuji, Koumi Miyasaka, Moe Yamashita, Kensuke Matsui, Shohei Nishida, Ryo Kobayashi, Kazuhiro Iguchi, Yuichi Hayashi, Akio Suzuki, Mitsuhiro Nakamura Source Type: research

Enteral tube nutrition for geriatric post-stroke dysphagia evaluation (ENGE) score to evaluate the risk of dysphagia after acute ischemic stroke
Post-stroke dysphagia (PSD) is a common complication after stroke. Early PSD prediction is essential for patient stratification for intensive oral intake rehabilitation. We aimed to develop a PSD prediction score using clinical data obtained at admission. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 14, 2023 Category: Neurology Authors: Hajime Ikenouchi, Kei Nozue, Satoru Yamaguchi, Tatsuo Miyamoto, Kensho Ikeda, Naoki Yamamoto, Kaoru Endo Source Type: research

Patient-reported outcomes based on discontinuation or continuous treatment with natalizumab: New York State Multiple Sclerosis Consortium (NYSMSC) study
Patient-reported outcomes (PRO) are increasingly utilized as part of the routine clinical assessment in people with multiple sclerosis (pwMS). The long-term effect of disease modifying therapies (DMTs) and their discontinuation on PRO measures remains largely unknown. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 13, 2023 Category: Neurology Authors: Dejan Jakimovski, Katelyn S. Kavak, Karen Zakalik, Corey McGraw, Malcolm Gottesman, Patricia K. Coyle, Robert Zivadinov, Bianca Weinstock-Guttman, on behalf of New York State Multiple Sclerosis Consortium (NYSMSC) Source Type: research

Automated CT perfusion analysis reveals medial temporal perfusion abnormalities during transient global amnesia
The underlying pathophysiology of Transient global amnesia (TGA) remains elusive. Reports of perfusion abnormalities in TGA were inconsistent, but semi-automated analysis of perfusion CT (CTP) may improve reliability and precision of perfusion deficit detection. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 13, 2023 Category: Neurology Authors: Netaniel Rein, Naaem Simaan, Ronen R. Leker, Anat Horev, Asaf Honig Tags: Clinical short communication Source Type: research

Neurological manifestations of syphilis-HIV coinfection in South Africa
We describe the clinical presentation and outcome of neurosyphilis in patients with and without HIV coinfection diagnosed at a tertiary facility, Groote Schuur Hospital (GSH), in South Africa. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 13, 2023 Category: Neurology Authors: E.F. Shorer, C.Z. Zauchenberger, S. Govender, G.E. Shorer, A.A. Geragotellis, C.M. Centner, S. Marais Source Type: research

An overview of clinical machine learning applications in neurology
Machine learning techniques for clinical applications are evolving, and the potential impact this will have on clinical neurology is important to recognize. By providing a broad overview on this growing paradigm of clinical tools, this article aims to help healthcare professionals in neurology prepare to navigate both the opportunities and challenges brought on through continued advancements in machine learning. This narrative review first elaborates on how machine learning models are organized and implemented. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 13, 2023 Category: Neurology Authors: Colin M. Smith, Allison L. Weathers, Steven L. Lewis Tags: Review Article Source Type: research

Response to letter: “Switching from calcitonin gene-related peptide monoclonal antibody monthly to fremanezumab quarterly based on the patient's preferred dosing schedule” by Suzuki et al.
We read with great interest the letter titled “Switching from calcitonin gene-related peptide monoclonal antibody monthly to fremanezumab quarterly based on the patient's preferred dosing schedule” by Suzuki et al. and appreciated the aspects that they emphasized. We agree that real-world data about the effect on migraine of switching betwe en anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) based on the dosing schedule should be investigated further and we would like to respond to their letter by providing detailed information on monthly migraine day (MMD) response rates, accompanying sympto...
Source: Journal of the Neurological Sciences - November 13, 2023 Category: Neurology Authors: Keiko Ihara, Seiya Ohtani, Narumi Watanabe, Nobuyuki Takahashi, Satoko Hori, Jin Nakahara, Tsubasa Takizawa Source Type: research

Switching from calcitonin gene-related peptide monoclonal antibody monthly to fremanezumab quarterly based on the patient's preferred dosing schedule
We have read with great interest the paper by Ihara et al. [1] entitled “Switching between anti-calcitonin gene-related peptide monoclonal antibodies: A comparison of monthly and quarterly dosing”. The authors retrospectively reviewed the clinical data of 15 patients with migraine who initially responded well to monthly galcanezumab but later switched to quarterly f remanezumab (n = 13) to reduce the number of hospital visits for monthly galcanezumab dosing or to monthly fremanezumab (n = 2) to avoid side effects related to galcanezumab. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 13, 2023 Category: Neurology Authors: Shiho Suzuki, Keisuke Suzuki, Tomohiko Shiina, Saro Kobayashi, Mukuto Shioda, Koichi Hirata Source Type: research

Understanding cost effectiveness in neurology
The USA spends more in healthcare per capita than any other country in the world, but ranks last among high-income industrialized nations in major markers of healthcare effectiveness such as life expectancy, maternal mortality, neonatal mortality, and infant mortality. Unlike other high-income industrialized nations, the USA does not have a national agency that systematically evaluates the cost-effectiveness of health care interventions and negotiates their price accordingly. This manuscript aims to introduce the rationale, terminology, advantages, and limitations of cost-effectiveness analysis. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 13, 2023 Category: Neurology Authors: Iv án Sánchez Fernández Tags: Review Article Source Type: research

Perampanel as only add-on epilepsy treatment in elderly: A subgroup analysis of real-world data from retrospective, multicenter, observational study
This study aimed to assess the effectiveness and tolerability of perampanel (PER) used as only add-on to a background anti-seizure medication (ASM) in the elderly in a real-world setting. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 13, 2023 Category: Neurology Authors: Angelo Pascarella, Sara Gasparini, Lucia Manzo, Oreste Marsico, Claudia Torino, Domenico Abelardo, Vittoria Cianci, Alfonso Iudice, Francesca Bisulli, Paolo Bonanni, Emanuele Caggia, Alfredo D'Aniello, Carlo Di Bonaventura, Jacopo C. DiFrancesco, Elisabet Source Type: research

Parkinson Disease: A painful realization
A confession is in order: We have not been paying enough attention at how pain in Parkinson Disease (PD) contributes to disease-related reduction in quality of life. In fact, it is only in recent years that we have been gathering enough information to measure, classify and treat the many nonmotor symptoms present in patients with parkinsonian disorders. There are likely many reasons for this lag. But we must agree that upon assuming the primary role of caring for patients with Movement Disorders, we do so with the understanding that they have motor and non-motor symptoms that require our unbiased attention. (Source: Journa...
Source: Journal of the Neurological Sciences - November 9, 2023 Category: Neurology Authors: Diego Torres-Russotto Source Type: research