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Physical telerehabilitation interventions for gait and balance in multiple sclerosis: A scoping review
Gait and balance impairments affects approximately a quarter of people with multiple sclerosis (pwMS) at onset and increases to almost half by five years. Physical rehabilitation has been recognised as the gold standard method to restore physical function in multiple sclerosis (MS). Emerging evidence in the literature is suggesting that a remote therapy rehabilitation platform (Telerehabilitation) is cost-effective, beneficial, and satisfying for patients and health care practitioners. The overarching aim of this review is to identify and summarise the evidence on the different types of telerehabilitation interventions ava...
Source: Journal of the Neurological Sciences - December 6, 2023 Category: Neurology Authors: Fiona Doherty, Paul Powell, Ciara McBride, Kenneth Monaghan Source Type: research

The WFN Service Page
Permanent Header for the service pages: (See Figs. 1 –16.) (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 5, 2023 Category: Neurology Authors: Wolfgang Grisold, Steven Lewis Tags: Editorial Source Type: research

Retraction notice to “Risk factors for hip fracture among elderly patients with Alzheimer's disease” [Journal of the Neurological Sciences 223 (2004), 107–112]
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 2, 2023 Category: Neurology Authors: Yoshihiro Sato, Tomohiro Kanoko, Kei Satoh, Jun Iwamoto Source Type: research

Predictors of clinically significant anhedonia in refractory epilepsy
This study determined whether specific features of medication refractory epilepsy are predictive of anhedonia. Design: We assessed 267 patients with medication refractory epilepsy for anhedonia, primarily using the clinically validated Snaith-Hamilton Pleasure Scale (SHAPS) scale. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 2, 2023 Category: Neurology Authors: Surapi Wijayendran, Rofael Jabr, Lucy Roberts-West, Dorothea Bindman, Matthew C. Walker, Sallie Baxendale, Umesh Vivekananda Tags: Clinical short communication Source Type: research

Mendelian randomization analysis suggests no causal effect of herpes zoster virus on stroke
Herpes zoster (HZ), also known as shingles, is a viral disease caused by the reactivation of varicella-zoster virus (VZV) in latently infected sensory ganglia. Since the 1970s, various reports have linked VZV-induced vasculopathy and stroke syndrome with HZ attacks. A retrospective cohort study, which is the largest of its kind, has confirmed that HZ is an independent risk factor for myocardial infarction and transient ischemic attack in UK adults over 18  years, up to 24 years after the acute episode. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 1, 2023 Category: Neurology Authors: Kihun Kim, Yun Hak Kim, Hyun-Woo Kim, Eunjeong Son, YunJae Jung, Dai Sik Ko Source Type: research

Troponin T in spinal and bulbar muscular atrophy (SBMA)
Serum biomarkers that might detect clinical progression are currently lacking for Spinal and bulbar muscular atrophy (SBMA), thus limiting the effectiveness of possible future pharmacological trials. Elevation of cardiac troponin T (cTnT) unrelated to myocardial damage in a motor neuron (MN) disease as amyotrophic lateral sclerosis (ALS) was associated to disease severity.We enrolled 47 SBMA patients and 5 Spinal muscular atrophy (SMA) type 3 adult patients as control group; each SBMA patient was evaluated at baseline and at one-year follow-up visit. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 1, 2023 Category: Neurology Authors: Musso Giulia, Blasi Lorenzo, Mion Monica Maria, Fortuna Andrea, Sabbatini Daniele, Zaninotto Martina, Bello Luca, Pegoraro Elena, Basso Daniela, Plebani Mario, Sorar ù Gianni Tags: Clinical short communication Source Type: research

Neuroprotective effects of oral metformin before stroke on cerebral small-vessel disease
This study evaluated whether MET treatment prior to stroke is associated with neurological severity and functional outcome in patients with stroke who were not indicated for endovascular treatment and whether the effects of MET differ for each ischemic stroke subtype. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 29, 2023 Category: Neurology Authors: Natsuki Akiyama, Takayuki Yamashiro, Itaru Ninomiya, Masahiro Uemura, Yorito Hattori, Masafumi Ihara, Osamu Onodera, Masato Kanazawa Source Type: research

Deep and infratentorial cerebral microbleeds are related to wake-up stroke by large-artery atherosclerosis and cardioembolism
Circadian variability of blood pressure (BP) and hypercoagulation in the morning have been proposed as underlying mechanisms of wake-up stroke (WUS). The aim was to determine the impact of cerebral microbleeds (CMBs), showing BP fluctuation and background hypercoagulability, on WUS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 29, 2023 Category: Neurology Authors: Motohiro Okumura, Takeo Sato, Takahiro Ishikawa, Tatsushi Kokubu, Junichiro Takahashi, Tomomichi Kitagawa, Ryoji Nakada, Hiroki Takatsu, Asako Onda, Teppei Komatsu, Kenichi Sakuta, Kenichiro Sakai, Tadashi Umehara, Hidetaka Mitsumura, Masato Matsushima, Y Source Type: research

New perspectives in late-onset multiple acyl-CoA dehydrogenase deficiency: Clinical and genetic findings
In the realm of neuromuscular disorders, late-onset myopathies, particularly those manifesting in the seventh or eighth decade of life, have often presented a diagnostic and therapeutic challenge [1]. In this group of diseases, late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is included. It is a less severe, yet clinically significant form of MADD. Unlike its neonatal counterparts, late-onset MADD presents in childhood, adolescence, or even adulthood, and is characterized by a more variable and often milder symptomatology [2]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 28, 2023 Category: Neurology Authors: Sara Missaglia Source Type: research

Effect of acute levodopa challenge test on cerebral blood flow in Parkinson's disease with the supine-to-standing transcranial Doppler test
Levodopa, a common drug that improves symptoms of Parkinson's disease (PD), can induce a reduction in blood pressure (BP); however, the effect of levodopa on cerebral blood flow (CBF) remains unclear. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 28, 2023 Category: Neurology Authors: Jingrong Zeng, Haixia Song, Peng Liu, Xiaofan Xue, Shanshan Mei, Baolei Xu, Yingqi Xing, Dian Qu, Erhe Xu Source Type: research

MR myelin imaging in multiple sclerosis: A scoping review
The inability of disease-modifying therapies to stop the progression of multiple sclerosis (MS), has led to the development of a new therapeutic strategy focussing on myelin repair. While conventional MRI lacks sensitivity for quantifying myelin damage, advanced MRI techniques are proving effective. The development of targeted therapeutics requires histological validation of myelin imaging results, alongside the crucial task of establishing correlations between myelin imaging results and clinical assessments, so that the effectiveness of therapeutic interventions can be evaluated. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 26, 2023 Category: Neurology Authors: Ibrahim Khormi, Oun Al-iedani, Abdulaziz Alshehri, Saadallah Ramadan, Jeannette Lechner-Scott Tags: Review Article Source Type: research

Botulinum toxin treatment in parkinsonism
This article is a narrative review of the therapeutic use of BoNT in tremors, dystonia, sialorrhea, bladder and other autonomic symptoms, levodopa-induced dyskinesia and other problems occuring in the setting of parkinsonism. Though FDA approval is lacking for some of these indications, expert experiences have shown that BoNT is often beneficial in this group of patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 26, 2023 Category: Neurology Authors: Charenya Anandan, Joseph Jankovic Tags: Review Article Source Type: research

Riboflavin-responsive lipid-storage myopathy in elderly patients
We describe three elderly patients with riboflavin-responsive lipid-storage myopathy. All three patients (aged 67 –71 years on first examination) had subacute onset of neck extensors and proximal limb weakness progressing to inability to rise from a sitting position or to walk. Muscle biopsies showed vacuoles with lipid content, mainly in type 1 fibers. Genetic analysis failed to identify any pathogenic var iant in one patient, identified a heterozygous variant of uncertain significance c.812 A > G; p.Tyr271Cys in the ETFDH gene in the second patient, and revealed a heterozygote likely pathogenic variant c.1286-2...
Source: Journal of the Neurological Sciences - November 23, 2023 Category: Neurology Authors: Menachem Sadeh, Amir Dory, Dorit Lev, Keren Yosovich, Ron Dabby Tags: Clinical short communication Source Type: research

Predicting amyloid-PET status in a memory clinic: The role of the novel antero-posterior index and visual rating scales
This study aims to assess the accuracy of a novel visual rating assessment, the antero-posterior index (API) scale, in predicting amyloid-PET status. Furthermore, the study seeks to determine the optimal cohort-based cutoffs for the medial temporal atrophy (MTA) and parietal atrophy (PA) scales and to integrate the main visual rating scores into a predictive model. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - November 21, 2023 Category: Neurology Authors: Alessandro Zilioli, Francesco Misirocchi, Beatrice Pancaldi, Carlotta Mutti, Chiara Ganazzoli, Nicola Morelli, Francesca Ferrari Pellegrini, Giovanni Messa, Maura Scarlattei, Rosaleena Mohanty, Livia Ruffini, Eric Westman, Marco Spallazzi Source Type: research

Pathology of human organic mercury poisoning: Lessons from an autopsy case
We had an opportunity to perform a general autopsy of a case with chronic organic mercury toxicosis in 2017. He had been engaged in synthesizing a variety of organic mercury compounds throughout the four years from 1966 and developed chronic organic mercury poisoning in 1969. Almost forty years on, he still remained to complain of persistent paresthesia at finger tips and tongue, and of narrowed visual field. Neurological examinations clarified a rise of two-point discrimination thresholds, a systemic increase of touch thresholds, constriction of the visual field caused by general visual depression, and sensorineural heari...
Source: Journal of the Neurological Sciences - November 20, 2023 Category: Neurology Authors: Shigeo Ekino, Kazuaki Sato, Masako Kurashige, Eiichi Morii, Hideaki Uozumi, Mari Susa Source Type: research