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Clinical narratives as a predictor for prognosticating functional outcomes after intracerebral hemorrhage
This study aimed to investigate whether clinical narratives can improve the performance for predicting functional outcomes after ICH. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 12, 2023 Category: Neurology Authors: Ling-Chien Hung, Ying-Ying Su, Jui-Ming Sun, Wan-Ting Huang, Sheng-Feng Sung Source Type: research

Prevalence of pineal cysts in healthy individuals: Emphasis on size, morphology and pineal recess crowding
The present study aimed to determine prevalence of non-hydrocephalic pineal cysts of different size and morphology in healthy individuals. In a cohort of healthy individuals who as part of research volunteered to undergo magnetic resonance imaging (MRI) of the brain, we performed a systematic search for occurrence of pineal cysts of different sizes, morphology and evidence of crowding of the pineal recess. Degree of crowding in the pineal recess was estimated by the imaging biomarkers anterior-posterior diameter and cyst-tectum-splenium (CTS) ratio at midsagittal MRI. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 11, 2023 Category: Neurology Authors: Bogna Warsza, Pernille Due-T ønnessen, Paulina Due-Tønnessen, Are Pripp, Geir Ringstad, Per K. Eide Source Type: research

The impact of off-hour mechanical thrombectomy therapy on outcomes for acute ischemic stroke: A systematic review and meta-analysis
The impact of off-hours and on-hours mechanical thrombectomy (MT) treatment for acute ischemic stroke (AIS) is not well understood. We conducted a systematic review and met-analysis comparing outcomes between patients undergoing off-hours MT versus on-hours MT. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 11, 2023 Category: Neurology Authors: Sherief Ghozy, Alireza Hasanzadeh, Hassan Kobeissi, Mariam Abdelghaffar, Mahan Shafie, Zahra Beizavi, Amir Hassankhani, Ahmed Y. Azzam, Adam A. Dmytriw, Ramanathan Kadirvel, David F. Kallmes Source Type: research

Plasma p-tau181 as a promising non-invasive biomarker of Alzheimer's disease pathology in subjective cognitive decline and mild cognitive impairment
The aim of this study is to investigate the role of plasma phosphorylated tau (p-tau) 181 as a potential biomarker for Alzheimer's Disease (AD) pathology in the early stages of the disease, as a valuable marker for tauopathy. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 11, 2023 Category: Neurology Authors: Giulia Giacomucci, Salvatore Mazzeo, Chiara Crucitti, Assunta Ingannato, Silvia Bagnoli, Sonia Padiglioni, Giulia Galdo, Filippo Emiliani, Daniele Frigerio, Valentina Moschini, Carmen Morinelli, Sandro Sorbi, Valentina Bessi, Benedetta Nacmias Source Type: research

Effect of edaravone on symptomatic intracranial hemorrhage in patients with acute large vessel occlusion on apixaban for non-valvular atrial fibrillation
Edaravone administration was associated with lower incidence of symptomatic intracranial hemorrhage (sICH) in patients with acute large vessel occlusion (LVO). However, its protective effect on sICH in patients with LVO who receive direct oral anticoagulants for non-valvular atrial fibrillation (NVAF) is uncertain. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 11, 2023 Category: Neurology Authors: Takuya Saito, Fumihiro Sakakibara, Kazutaka Uchida, Shinichi Yoshimura, Nobuyuki Sakai, Hirotoshi Imamura, Hiroshi Yamagami, Takeshi Morimoto Source Type: research

Looking for inconsistency: Combining distraction with spirography for diagnosis of functional tremor
Analysis of spirography has been used to distinguish tremor types and severity, for example with the Bain rating scale [1 –3]. Previous studies in Functional Tremor (FT) have found that computerised analysis of spirography finds increased intraspiral variability in functional tremor [3], but this is not readily available. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 8, 2023 Category: Neurology Authors: Saad Moughal, Andreas Christou, Mark Edwards, Jan Coebergh Source Type: research

In Memoriam: Paula Coutinho (1941 –2022), a pioneer in neurogenetics
Paula Coutinho, MD, PhD, clinical neurologist, professor and researcher, a major figure in neurogenetics and leader in world neurology, passed away, at the age of 80. Maria Paula Mour ão do Amaral Coutinho (Fig. 1) was born at Macieira de Cambra (10 August 1941). She graduated from the School of Medicine (FMUP), University of Porto, with high grades (18/20, 1966). She then made most of her carrier (from intern and resident, to specialist and chief-of service) at Hospital Geral d e Santo António (HGSA, now CHUdSA), Porto, from 1967 to 1998. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 8, 2023 Category: Neurology Authors: Jorge Sequeiros, Jos é Leal Loureiro, José Barros Source Type: research

Acute onset of adult Alexander disease and the concept of GFAP toxicity
Alexander's disease (AD) is a rare neurodegenerative disorder first described by W. Stewart Alexander in 1949. It comprises central nervous system (CNS) white matter degeneration (leukodystrophy) and the formation of eosinophilic protein aggregates (Rosenthal fibers) in the astrocyte cytoplasm [1,2]. AD is mostly sporadic, caused by de novo heterozygous variants in the GFAP gene encoding the glial fibrillary acidic protein, the major component of astrocytic intermediate filaments and Rosenthal fibers. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 8, 2023 Category: Neurology Authors: Filipe Godinho, Carolina Guerreiro, Jo ão Parente Freixo, Jorge Oliveira, José Lourenço Rosa Source Type: research

Small vessel disease is associated with later onset of major adverse cardiovascular events after acute cervicocerebral artery dissection
Cerebral small vessel disease (CSVD) is common among the elderly and has been associated with an increased risk of major adverse cardiac events (MACE) and increased risk of long-term disability. Little is known whether CSVD affects outcomes after cervicocerebral artery dissection (CAD), which predominantly affects younger patients. Specifically, there is a paucity as to whether CSVD increases the risk of MACE after CAD and whether this risk is different for early versus late events. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 7, 2023 Category: Neurology Authors: Jayachandra Muppa, Muhammed E. Gunduz, Rozaleen Aleyadeh, Shadi Yaghi, Liqi Shu, Nils Henninger Source Type: research

Magnesium deficiency: An overlooked key to the puzzle of posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS)?
Reversible cerebral vasoconstriction syndrome (RCVS) and posterior reversible encephalopathy syndrome (PRES) represent two unique but intertwined clinical entities that present clinicians with diagnostic and therapeutic challenges. In recent years, an element has emerged as a potentially pivotal factor in the etiopathogenesis of these syndromes: magnesium, specifically its deficiency. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 7, 2023 Category: Neurology Authors: Bahadar S. Srichawla, Jared Quast Source Type: research

The impact of SAH finding on CT to the clinical outcome after mechanical thrombectomy for large vessel occlusion
This study aimed to investigate the clinical impact of SAH on computed tomography (CT) after mechanical thrombectomy. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 7, 2023 Category: Neurology Authors: Kentaro Suzuki, Yuji Matsumaru, Masataka Takeuchi, Masafumi Morimoto, Ryuzaburo Kanazawa, Yohei Takayama, Yuki Kamiya, Keigo Shigeta, Seiji Okubo, Mikito Hayakawa, Norihiro Ishii, Yorio Koguchi, Tomoji Takigawa, Masato Inoue, Hiromichi Naito, Takahiro Ota Source Type: research

Quantitative evaluation of the thickened dura mater impacting clinical signs in immune-mediated hypertrophic pachymeningitis
This study evaluated the volume of thickened dura mater lesions and their impact on clinical findings in immune-mediated hypertrophic pachymeningitis (HP). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - September 1, 2023 Category: Neurology Authors: Junji Ikeda, Yasuhiro Shimojima, Akira Yamada, Yoshiki Sekijima Source Type: research

Evidence of altered corticomotor inhibition in older adults with a history of repetitive neurotrauma. A transcranial magnetic stimulation study
This study describes corticomotor changes in retired contact/collision sport athletes and controls, between the ages of 30 and 70  years. Retired athletes (n = 152; 49.1 ± 8.5 years) and controls (n = 72; 47.8 ± 9.5 years) were assessed using single and paired-pulse transcranial magnetic stimulation (TMS) for active motor threshold (aMT), motor evoked potential and cortical silent period duration (expre ssed as MEP:cSP ratio), and short- and long-interval intracortical inhibition (SICI and LICI). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - August 31, 2023 Category: Neurology Authors: Alan J. Pearce, Dawson J. Kidgell, Ashlyn K. Frazer, Billymo Rist, Jamie Tallent Source Type: research

Laboratory evaluation for the differential diagnosis of possible multiple sclerosis in the United States: A physician survey
There is limited evidence and lack of guidelines for diagnostic laboratory evaluation of patients with possible multiple sclerosis (MS). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - August 31, 2023 Category: Neurology Authors: Rafid Mustafa, Eoin P. Flanagan, Dustin J. Duffy, Brian G. Weinshenker, M. Mateo Paz Sold án, Amy Kunchok, Marwa Kaisey, Andrew J. Solomon Source Type: research

Brain radial enhancement pattern in patients with negative glial fibrillary acidic protein-IgG: A cases series study
Brain radial enhancement pattern on magnetic resonance imaging (MRI) has been identified as typical lesions in autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A). However, the authors encountered several patients without GFAP-IgG showing that such specific imaging. In the present study, we reported the clinical pictures of 5 GFAP-IgG-negative patients with GFAP-A specific imaging pattern. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - August 31, 2023 Category: Neurology Authors: Jiajia Yue, Peihao Lin, Chun Lian, Haiyan Yao, Lihong Jiang, Sha Liao, Lufen Xu, Jiayuan Zhang, Jie Tan, Zixuan Chen, Jie Yang, Cong Gao, Li Huang, Xinguang Yang, Youming Long Tags: Clinical short communication Source Type: research