Journal of the Neurological Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nerve compression of the sacral plexuses by an intra-rectal object: A case report
We report the case of a 53-year-old patient who presented to the emergency department after the insertion of a 32cmx9cmx8cm intra-rectal foreign body for sexual purposes, which could not be extracted. The patient complained of severe pain rated 10 on the numeric pain scale and had bilateral lower limb motor deficits. An emergency CT scan was performed (Fig. 1) and the foreign body was extracted through laparotomy and colotomy after the failure of transanal extraction. There were no postoperative complications, and the recovery was uneventful. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 29, 2023 Category: Neurology Authors: Ma ëlig Poitevin, Mohamed Bendimerad, Benoît Vovard, Yolaine Ollivier, Paul Viannay, Julien Barbieux Source Type: research

Effects of preceding antiplatelet agents on severity of ischemic stroke in patients with a history of stroke
Antiplatelet agents are effective for secondary prevention of ischemic stroke and can reduce the severity of first-ever ischemic stroke. However, it is uncertain if prophylactic antiplatelet therapy reduces the severity of recurrent ischemic stroke. The aim of this study was to determine the effect of preceding antiplatelet treatment on the severity of thrombotic stroke (TS) in patients with a prior history of stroke. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 22, 2023 Category: Neurology Authors: Takehiro Yamada, Eijirou Tanaka, Toru Kishitani, Yuta Kojima, Daisuke Nakashima, Takamasa Kitaoji, Satoshi Teramukai, Yoshinari Nagakane Source Type: research

Test-retest reliability and short-term variability of quantitative light reflex pupillometry in a mixed memory clinic cohort
Quantitative light reflex pupillometry (qLRP) may be a promising digital biomarker in neurodegenerative diseases such as Alzheimer's disease (AD), as neuropathological changes have been found in the midbrain structures governing the light reflex. Studies investigating test-retest reliability and short-term, intra-subject variability of qLRP in these patient groups are missing. Our objective was therefore to investigate the test-retest reliability and short-term, intra-subject variability of qLRP in a memory clinic setting, where patients with neurodegenerative disease are frequently evaluated. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 22, 2023 Category: Neurology Authors: Mathias Holsey Gramkow, Frederikke Kragh Clemmensen, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen Source Type: research

Predicting ICU readmission risks in intracerebral hemorrhage patients: Insights from machine learning models using MIMIC databases
Intracerebral hemorrhage (ICH) is a stroke subtype characterized by high mortality and complex post-event complications. Research has extensively covered the acute phase of ICH; however, ICU readmission determinants remain less explored. Utilizing the MIMIC-III and MIMIC-IV databases, this investigation develops machine learning (ML) models to anticipate ICU readmissions in ICH patients. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 21, 2023 Category: Neurology Authors: Jinfeng Miao, Chengchao Zuo, Huan Cao, Zhongya Gu, Yaqi Huang, Yu Song, Furong Wang Source Type: research

Hallmarks of spinal cord pathology in multiple sclerosis
A disparity exists between spinal cord and brain involvement in multiple sclerosis (MS), each independently contributing to disability. Underlying differences between brain and cord are not just anatomical in nature (volume, white/grey matter organization, vascularization), but also in barrier functions (differences in function and composition of the blood-spinal cord barrier compared to blood-brain barrier) and possibly in repair mechanisms. Also, immunological phenotypes seem to influence localization of inflammatory activity. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 20, 2023 Category: Neurology Authors: Daniel Kreiter, Alida A. Postma, Raymond Hupperts, Oliver Gerlach Tags: Review Article Source Type: research

Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage
Spontaneous intracerebral hemorrhage (ICH) is associated with a high case fatality rate in resource-limited settings. The independent predictors of poor outcome after ICH in sub-Saharan Africa remains to be characterized in large epidemiological studies. We aimed to determine factors associated with 30-day fatality among West African patients with ICH. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 20, 2023 Category: Neurology Authors: Morenikeji A. Komolafe, Taofiki Sunmonu, Joshua Akinyemi, Fred S. Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Lukman Owolabi, Godwin O. Osaigbovo, Godwin Ogbole, Hemant K. Tiwari, Carolyn Jenkins, Daniel T. Lackland, Adekunle G. Fakunle, Ezinne Source Type: research

Clinicopathologic characteristics of Nocardia brain abscesses: Necrotic and non-necrotic foci of various stages
Nocardia brain abscesses are rare bacterial infections associated with a high mortality rate, and their preoperative diagnosis can be difficult for various reasons including a nonspecific clinical presentation. While late-stage nocardial brain abscesses may be radiologically characteristic, early-stage lesions are nonspecific and indistinguishable from another inflammatory/infectious process and other mimics. Despite the paucity of previous histopathological descriptions, histopathological examination is critical for the identification of the pathogen, lesion stage(s), and possible coexisting pathology. (Source: Journal of...
Source: Journal of the Neurological Sciences - December 20, 2023 Category: Neurology Authors: Marta Kisiel, Victoria M. Bass, Crystal Fong, Alice K. Graham, Sultan Yahya, Frances-Claire Eichorn, Melissa Lannon, Michelle Kameda-Smith, Kesava K.V. Reddy, Jian-Qiang Lu Source Type: research

Immunogenicity and safety of vaccines in multiple sclerosis: A systematic review and meta-analysis
Seroconversion rate of vaccines varies and requires further elucidation in patients with multiple sclerosis (MS) under treatment with disease-modifying therapies (DMTs). We aimed to investigate this in a systematic review and meta-analysis. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 20, 2023 Category: Neurology Authors: Theodoros Marantos, Evdoxia Kyriazopoulou, Vasileios Lekakis, Konstantinos I. Voumvourakis, Sotirios Tsiodras Tags: Review Article Source Type: research

Cilostazol addition to aspirin may worsen the short-term outcome in patients with large artery disease: ADS subanalysis
Our previous acute dual study (ADS) reported that dual antiplatelet therapy (DAPT) using cilostazol and aspirin did not reduce the rate of neurological deterioration in non-cardioembolic stroke patients. In this post-hoc analysis, we investigated whether the impact of dual antiplatelet therapy (DAPT) may depend on neurological severity, as represented by large artery disease. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 20, 2023 Category: Neurology Authors: Junya Aoki, Kazumi Kimura, on behalf of the ADS Investigators Source Type: research

Reported head trauma and odds of acute ischemic stroke or transient ischemic attack: A population-based study (NEDICES)
This study aims to reexamine the relationship between head trauma and the risk of ischemic stroke/transient ischemic attack (TIA) in an older population using data from the Neurological Disorders in Central Spain (NEDICES) study, a population-based study that includes rigorous clinical examinations for patients with suspected neurological diseases. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 20, 2023 Category: Neurology Authors: Ritwik Ghosh, F élix Bermejo-Pareja, Souvik Dubey, Julián Benito-León Source Type: research

Non-lesional white matter changes depicted by q-space diffusional MRI correlate with clinical disabilities in multiple sclerosis
We previously developed an optimized q-space diffusional MRI technique (normalized leptokurtic diffusion [NLD] map) to delineate the demyelinated lesions of multiple sclerosis (MS) patients. Herein, we evaluated the utility of NLD maps to discern the white matter abnormalities in normal-appearing white matter (NAWM) and the abnormalities' possible associations with physical and cognitive disabilities in MS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 19, 2023 Category: Neurology Authors: Haruhiko Motegi, Kenji Kufukihara, Satoshi Kitagawa, Koji Sekiguchi, Junichi Hata, Hirokazu Fujiwara, Masahiro Jinzaki, Hideyuki Okano, Masaya Nakamura, Yasuyuki Iguchi, Jin Nakahara Source Type: research

The role of intravenous thrombolysis before mechanical Thrombectomy: A subgroup analysis of the RESILIENT trial
Randomized trials have recently evaluated the non-inferiority of direct thrombectomy versus intravenous thrombolysis (IVT) followed by endovascular therapy in anterior circulation large vessel occlusion (LVO) stroke in patients eligible for IVT within 4.5  h from stroke onset with controversial results. We aimed to assess the effect of IVT on the clinical outcome of mechanical thrombectomy (MT) in the RESILIENT trial. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 19, 2023 Category: Neurology Authors: Gisele Sampaio Silva, Maramelia Miranda Alves, Felipe Chaves Duarte Barros, Michel Eli Frudit, Octavio Marques Pontes-Neto, Francisco Jose Montalverne, Let ícia Rebello, Leonardo Augusto Carbonera, Daniel Abud, Fabrício Lima, Ana Claudia de Souza, David Source Type: research

GABA storage and release from direct pathway neurons account for the enhanced short-duration response of L-dopa in Parkinson's disease
Levo-dihydroxyphenylalanine (L-dopa) is the most effective drug for treating motor symptoms of Parkinson's disease (PD). It provides both rapid and long-term therapeutic effects to alleviate PD symptoms. The former is known as the short-duration response (SDR), while the latter is known as the long-duration response (LDR). The SDR begins rapidly and lasts several hours before declining. Meanwhile, the LDR, which is achieved by chronic and repetitive L-dopa administration, lasts for several weeks [1]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 18, 2023 Category: Neurology Authors: Haruo Nishijima, Masahiko Tomiyama Source Type: research

Prognostic value of Beta 2-Microglobulinin in cerebrospinal fluid in primary central nervous system lymphoma.
Dear editor, prognosis stratification of primary central nervous system lymphoma (PCNSL) is essential for patient management. Beta2-microglobulin ( β2MG) is a polypeptide chain constituting the light chain of the major histocompatibility complex (MHC), β2MG is ubiquitously expressed in nucleated cells, and high expression of β2MG was observed in stromal cells included in tumor microenvironment. In onco-hematology, β2MG blood level is associ ated with patient prognosis and residual disease in systemic lymphoma, and myeloma [1,2]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 18, 2023 Category: Neurology Authors: Alexandre Bertucci, C éline Boucard, Vincent Harlay, Romain Appay, Gregorio Petrirena, Maryline Barrié, Olivier Chinot, Emeline Tabouret Source Type: research

Aggregation of E121K mutant D-amino acid oxidase and ubiquitination-mediated autophagy mechanisms leading to amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a terminal adult-onset neuromuscular disorder. Our group has been studying this illness and previously reported novel mutations and rare mutations in a study using next-generation sequencing of DNA samples from Indian ALS patients. In this paper, we focus on the E121K mutation in the DAO gene to understand how it leads to ALS. Our experiments in SH-SY5Y cells indicate that the E121K mutation results in the accumulation of mutant protein aggregates, a change in cell morphology, and the death of neuronal cells. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 17, 2023 Category: Neurology Authors: Upma Dave, Priyam Narain, Dibyakanti Mishra, James Gomes Source Type: research