Journal of the Neurological Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Neurological advocacy: Empowering the next generation of neurologists
In light of last month's publication of the Global Burden of Neurological Disease [1], and in consideration of the 2022 WHO Intersectoral Global Action Plan (IGAP) [2,3], the mandate to act on neurological disorders has never been greater. The World Federation of Neurology has just published twelve recommendations on strengthening neurological advocacy: the way of transitioning from evidence to action [4]. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 11, 2024 Category: Neurology Authors: Arina A. Tamborska, Justin T. Jordan, Benedict D. Michael, Mayowa O. Owolabi Source Type: research

Use of the concussion check protocol for concussion assessment in a female soccer team over two consecutive seasons in New Zealand
Address deficiencies in access to sports sideline medical care by using a Concussion Check Protocol (CCP) for non-medically-trained people. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 10, 2024 Category: Neurology Authors: D. King, P.A. Hume, T.N. Clark, J.V. Wethe Source Type: research

Favorable prognosis in posterior circulation ischemic stroke: Insights from a nationwide stroke databank
This study aimed to comprehensively assess the clinical characteristics and outcomes of PCIS patients compared to those with anterior circulation ischemic stroke (ACIS). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 9, 2024 Category: Neurology Authors: Masaomi Koyanagi, Taketo Hatano, Michikazu Nakai, Takenori Ogura, Kazuo Minematsu, Shotai Kobayashi, Kazunori Toyoda, for the Japan Stroke Data Bank Investigators Source Type: research

Endovascular thrombectomy for large ischemic strokes: An updated living systematic review and meta-analysis of randomized clinical trials
Recent studies indicate endovascular thrombectomy (EVT) as a safe, effective treatment for acute ischemic stroke (AIS) with large ischemic regions. Our study updates an ongoing living systematic review and meta-analysis of randomized controlled trials (RCTs) comparing outcomes of EVT to medical management only. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 8, 2024 Category: Neurology Authors: Rami Z. Morsi, Mohamed Elfil, Hazem S. Ghaith, Mohammad Aladawi, Ahmed Elmashad, Sachin Kothari, Harsh Desai, Sherief Ghozy, Shyam Prabhakaran, Krishna Amuluru, Chirag D. Gandhi, Tareq Kass-Hout, Fawaz Al-Mufti Tags: Review Article Source Type: research

Data-driven subtypes of mixed semantic-logopenic primary progressive aphasia: Linguistic features, biomarker profiles and brain metabolic patterns
In this study, we enrolled 55 patients diagnosed with PPA, comprising 12 semantic variant (svPPA), 23 logopenic variant (lvPPA), and 20 mPPA cases with linguistic characteristics consistent with both svPPA and lvPPA (s/lvPPA). All patients underwent language assessments, evaluation of Alzheimer's disease biomarkers (via cerebrospinal fluid analysis or Amyloid-PET), and 18F-FDG-PET brain scans. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 5, 2024 Category: Neurology Authors: Salvatore Mazzeo, Carmen Morinelli, Cristina Polito, Giulia Giacomucci, Valentina Moschini, Assunta Ingannato, Juri Balestrini, Daniele Frigerio, Filippo Emiliani, Giulia Galdo, Chiara Crucitti, Diletta Piazzesi, Silvia Bagnoli, Sonia Padiglioni, Valentin Source Type: research

Are physical activity levels, cardiorespiratory fitness and peak power associated with Parkinson's disease severity?
The objectives of the, present study were to assess associations between PA, cardiorespiratory fitness (VO2-, max), and muscle peak power and measures of the Movement Disorder Societysponsored, revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS), the Parkinson's disease questionnaire-39 (PDQ-39), and the four PD hallmark motor, symptoms (rigidity, bradykinesia, postural instability, and tremor). (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 5, 2024 Category: Neurology Authors: Frederik Bonde-Jensen, Ulrik Dalgas, Martin Langeskov-Christensen Source Type: research

Stroke risk prediction models: A systematic review and meta-analysis
This study examined the performance and weaknesses of existing stroke risk-score-prediction models (SRSM) and whether performance varied by population and region. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 5, 2024 Category: Neurology Authors: Osahon Jeffery Asowata, Akinkunmi Paul Okekunle, Muideen Olaiya, Joshua Akinyemi, Mayowa Owolabi, Onoja M. Akpa Tags: Review Article Source Type: research

Trends from two decades of orphan designations in paediatric rare neuromuscular diseases
Rare diseases are characterized by substantial unmet need mostly because the majority have limited, or no treatment options and a large number also affect children. Since the inception of EU orphan regulation in 2000 the European Medicines Agency Committee for Orphan Medicinal Products has received several applications for paediatric rare neuromuscular diseases (PERAN) however treatment options remain limited.Here we discuss the results form an observational, retrospective, cross-sectional study to characterize the currently authorised orphan medicinal products (OMP) and orphan designations (OD) given to products for PERAN...
Source: Journal of the Neurological Sciences - April 3, 2024 Category: Neurology Authors: Dinah M. Duarte, Maria Beatriz da Silva Lima, Bruno Sepodes Tags: Review Article Source Type: research

Successful treatment of cranial dystonia using a Zolpidem+Melatonin combination: A video case-series
Cranial dystonias (CrD) are challenging to treat. Oral pharmacotherapy is often sub-optimal, while delicate anatomy and limited availability of skilled botulinum toxin injectors makes this approach risky, and often difficult to access; neurosurgical options e.g. deep brain stimulation, are high-risk in the elderly populations most affected.We observed significant improvement in CrD in 2 patients prescribed Zolpidem/Melatonin combination treatment for insomnia, and therefore trialled this treatment in a further 4 patients with CrD. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 2, 2024 Category: Neurology Authors: Narendrakumar H. Barad, Eoin Mulroy Tags: Clinical short communication Source Type: research

Neuronal intranuclear inclusion disease in New Zealand: A novel discovery
We report the first four genetically confirmed cases of neuronal intranuclear inclusion di sease in New Zealand, all having Polynesian ancestry (three New Zealand Māori and one Cook Island Māori). Phenotypically, they resemble cases reported from recent large East Asian cohorts. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 2, 2024 Category: Neurology Authors: Tony Zhang, Andrew Chancellor, Bernard Liem, Clinton Turner, David Hutchinson, Edward Wong, Emma Glamuzina, Jae Beom Hong, James Cleland, Nicholas Child, Richard H. Roxburgh, Shilpan Patel, Yi-Chung Lee, Yi-Chu Liao, Neil E. Anderson Tags: Clinical short communication Source Type: research

Pathogenesis and management of low-pressure hydrocephalus: A narrative review
Patients diagnosed with low-pressure hydrocephalus typically present with enlarged ventricles and unusually low intracranial pressure, often measuring below 5 cmH2O or even below atmospheric pressure. This atypical presentation often leads to low recognition and diagnostic rates. The development of low-pressure hydrocephalus is believed to be associated with a decrease in the viscoelasticity of brain tissue or separation between the ventricular and subarachnoid spaces. Risk factors for low-pressure hydrocephalus include subarachnoid hemorrhage, aqueduct stenosis, prior cranial radiotherapy ， ventricular shunting, and cer...
Source: Journal of the Neurological Sciences - April 1, 2024 Category: Neurology Authors: Shanshan Duan, Jin Hu Tags: Review Article Source Type: research

Sex differences in treatment effect in neuroprotectant trials for acute ischemic stroke: A systematic review
Pre-clinical data suggest sex differences in mechanisms of cerebral ischemic injury. This might result in differential outcomes of putative neuroprotectants by sex, though little systematic data is available to assess this. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 1, 2024 Category: Neurology Authors: Sahily Reyes-Esteves, Donna K. George, Brett Cucchiara Tags: Clinical short communication Source Type: research

Psilocybin pulse regimen reduces cluster headache attack frequency in the blinded extension phase of a randomized controlled trial
In a recent randomized, double-blind, placebo-controlled study, we observed a nonsignificant reduction of attack frequency in cluster headache after pulse administration of psilocybin (10  mg/70 kg, 3 doses, 5 days apart each). We carried out a blinded extension phase to consider the safety and efficacy of repeating the pulse regimen. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 1, 2024 Category: Neurology Authors: Emmanuelle A.D. Schindler, R. Andrew Sewell, Christopher H. Gottschalk, L. Taylor Flynn, Yutong Zhu, Brian P. Pittman, Nicholas V. Cozzi, Deepak C. D'Souza Source Type: research

Diagnostic value of lower extremity ultrasonographic nerve enlargement for differentiating demyelinating Charcot-Marie-Tooth disease from chronic inflammatory demyelinating polyneuropathy
We previously reported that nerve enlargement assessment by nerve ultrasonography of the intermediate upper limb is applicable for distinguishing demyelinating Charcot-Marie-Tooth disease (CMT) from chronic inflammatory demyelinating polyneuropathy (CIDP). However, differences in the severity and distribution patterns of lower extremity nerve enlargement have not been established for either disease. Therefore, we examined the utility of lower extremity nerve ultrasonography for differentiating between CMT and CIDP. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 1, 2024 Category: Neurology Authors: Hiroyuki Naito, Takamichi Sugimoto, Akemi Hironaka, Masahiro Nakamori, Yu Yamazaki, Kazuhide Ochi, Hirofumi Maruyama Source Type: research

Hypothalamic involvement in multiple system atrophy: A structural MRI study
To investigate hypothalamic atrophy and its clinical correlates in multiple system atrophy (MSA) in-vivo. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - April 1, 2024 Category: Neurology Authors: Jacopo Pasquini, Michael Firbank, Laura Best, Victoria Foster, Debra Galley, Vincenzo Silani, Roberto Ceravolo, George Petrides, David J. Brooks, Kirstie N. Anderson, Nicola Pavese Source Type: research