26.1 anxiety and intolerance of uncertainty in preschool children with asd
Anxiety disorders are highly prevalent conditions in youth with ASD. Most of the research on anxiety, however, has been conducted in children ages 7 years and older. There have not been many studies focused on examining anxiety in preschool-aged children with ASD. This is probably attributed to the intense focus on social communication treatment during early development and the lack of diagnostic measures to evaluate anxiety in this age group. This presentation reports on the prevalence and phenotype of anxiety in preschool-aged children with ASD using a novel measure that carefully differentiates anxiety from core ASD fea...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Roma A. Vasa Source Type: research

26.2 toward better measurement of anxiety in asd
Anxiety is common in youth with ASD. Anxiety symptoms vary from mild to severe in this population. Because of language and cognitive challenges in youth with ASD, measures of anxiety used in the general pediatric population may not be suitable for youth with ASD. This presentation reports on the development, reliability, and validity of a new parent-rated measure of anxiety in youth with ASD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Lawrence Scahill Source Type: research

26.3 cbt for anxiety in children with asd: clinical effects and neuroimaging biomarkers
Anxiety is a common and impairing problem in children with ASD, and over the past 10 years, CBT has emerged as a potentially helpful intervention. However, not all children with ASD show positive response to CBT, and neural mechanisms of CBT remain poorly understood. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Denis Sukhodolsky Source Type: research

26.4 a retrospective chart review of buspirone for the treatment of anxiety in psychiatrically referred youth with high-functioning asd
Anxiety disorders (ADs) are commonly associated with high-functioning ASD (HF-ASD) and often worsen with age. However, pharmacological treatment trials for anxiety in this population are lacking. This presentation will provide a brief overview of the existing pharmacological evidence for treating anxiety in ASD. Additionally, new data on the efficacy of buspirone, a commonly prescribed anxiolytic drug with a favorable tolerability profile, will be presented. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Gagan Joshi Source Type: research

Dimensions of adversity exposure and psychopathology: deprivation and threat
Exposure to childhood adversity is common and strongly associated with risk for psychopathology in childhood, adolescence, and adulthood. The prevailing approach used to examine the consequences of adversity exposure for health is a cumulative risk model. The cumulative risk model highlights the strong links between adversity exposure and health outcomes and has pushed the field toward reducing exposure to adversity and providing intervention to the most vulnerable. However, this approach —where all forms of adversity are counted and summed—implicitly assumes that all forms of adversity function through the sam...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Margaret A. Sheridan, Charles H. Zeanah Tags: Symposium 27 Source Type: research

27.1 neural structure is independently predicted by deprivation and threat in early  childhood
The impact of childhood adversity on risk for psychopathology is commonly examined using a cumulative risk model. In a recently proposed alternative approach, the dimensional model of adversity and psychopathology (DMAP), different dimensions of adversity are hypothesized to impact health and well-being through different neural pathways. We expect deprivation to impact thickness in areas of cortex involved in higher-order cognition such as the prefrontal cortex. In contrast, we expect threat to selectively impact subcortical structures associated with increased reactivity to emotional stimuli. (Source: Journal of the Ameri...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Margaret A. Sheridan, William E. Copeland, Laura S. Machlin, Cheryl R. Stein, Kimberly L.H. Carpenter, Helen L. Egger Source Type: research

27.2 disentangling the roles of threat and deprivation in associations with early childhood psychopathology
The risk for psychopathology increases with the number of adverse childhood experiences. Summing a number of experiences, however, assumes that all adversity equitably confers risk and operates through complementary mechanisms. To disentangle neurobiological pathways between disparate events and mental health, we examined how threat and deprivation —2 common dimensions of adversity—relate to early childhood psychopathology. Threat or the presence of experiences involving harm or threat of harm affects emotional control. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Cheryl R. Stein, Margaret A. Sheridan, William E. Copeland, Laura S. Machlin, Helen L. Egger Source Type: research

27.3 associations of childhood threat and deprivation on adult psychiatric disorders and functional outcomes
Early adversities are associated with impairment and psychopathology that last into adulthood, but it is still unclear whether different adversities have different outcomes. The Dimensional Model of Adversity and Psychopathology posits deprivation and threat as distinct adversities with distinct paths to psychopathology. This specificity has not been tested in studies following children into adulthood. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: William E. Copeland, Cheryl R. Stein, Laura S. Machlin, Helen L. Egger, Elizabeth Jane Costello, Margaret A. Sheridan Source Type: research

27.4 exploring mechanisms linking exposure to deprivation and threat in early childhood with adolescent psychopathology: longitudinal patterns in a national sample
The dimensional model of adversity and psychopathology (DMAP) posits deprivation and threat as distinct forms of early adversity with different paths to psychopathology. Prior work has not examined the latent structure of DMAP because of small samples and a lack of multiple indicators of deprivation and threat. Here, we examine the latent structure of DMAP in a national sample group. We hypothesized that deprivation and threat would be linked with greater adolescent psychopathology. Further, we expected that the relationship between deprivation, but not threat, and psychopathology would be explained by cognitive abilities....
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Adam Bryant Miller, Laura S. Machlin, Margaret A. Sheridan Source Type: research

Predicting the onset of mood disorders
The goal of this session is to provide data on parental characteristics and preexisting traits, psychopathology, and other risk factors that are related to the onset or early course of bipolar disorder (BD) in the offspring at high risk. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Martin Preisig, Boris Birmaher Tags: Symposium 28 Source Type: research

28.1 the developmental trajectory of bipolar disorder: latest observations from the canadian flourish high-risk study
The goal of this session is to present new data mapping with the emergent course of bipolar disorder (BD) in the high-risk offspring of affected parents subgrouped by parental response to lithium prophylaxis. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Anne Cecilia Duffy, Sarah Goodday, Charles Keown-Stoneman, Paul Grof Source Type: research

28.2 risk factors of bipolar disorders and mdd in a prospective high-risk cohort study
By use of prospective data on the offspring of patients with unipolar and bipolar mood disorders, as well as clinical control subjects, our goals were to identify the risk factors for the onset of bipolar disorder (BD) and MDD, including parental disorders, mental illness antecedents, and personality traits and adverse life events. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Martin Preisig, Dominique Rudaz, Pierre Marquet, Jean-Michel Aubry, Caroline Vandeleur Source Type: research

28.3 person-level prediction of progression along the bipolar trajectory
Bipolar disorder (BD) rarely comes out of the blue; rather, it is generally preceded by subthreshold mood symptoms that may portend a full-threshold bipolar I disorder/bipolar II disorder (BD-I/II), particularly in youth at familial risk. Over the past several years, we and others have used longitudinal data from familial and/or clinical high-risk groups to assess predictors of progression along the trajectory to BD-I/II. These analyses are a crucial first step but do not answer the most pertinent clinical question: What is the probability that a given individual will develop BD? Recently, we have built risk calculators (R...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Danella Hafeman, John Merranko, Benjamin I. Goldstein, Dara J. Sakolsky, Rasim Somer Diler, David Axelson, Heather Meg Hower, Boris Birmaher, Coby Group, Bios Group Source Type: research

Sleep mechanisms in typical development and pediatric affective disorders
Sleep has been implicated as a crucial factor in neurodevelopment and is associated with neuroplasticity and synaptic homeostasis. Sleep dysfunction likely plays a causal role in risk for, and maintenance of, affective disorders and other psychopathology in youth. However, the impacts of sleep and sleep dysfunction on neurodevelopment and affective processes in youth remain poorly understood. This Symposium will: 1) highlight new findings examining sleep and neurodevelopment in healthy youth; and 2) highlight mechanisms of sleep dysfunction as a potential contributor to pediatric affective disorders. (Source: Journal of th...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Ryan Herringa, Neal Ryan Tags: Symposium 29 Source Type: research

29.1 a sleep eeg marker to assess brain myelin development in children
Poor sleep in children has been linked to negative cognitive and emotional consequences later in life. However, the physiological underpinnings of these epidemiological observations remain understudied. Based on the overarching hypothesis that sleep contributes to neurodevelopmental processes, we tested whether more mature (ie, more “frontalized”) slow-wave activity topography relates longitudinally to increased myelin content in children over time. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Salome Kurth Source Type: research

29.2 experimentally imposed circadian misalignment alters the neural response to monetary rewards in healthy adolescents
Sleep and circadian timing shifts later during adolescence, conflicting with early school start times and resulting in circadian misalignment. Although circadian misalignment has been linked to mood disturbance and substance abuse, as well as altered reward function, a paucity of experimental studies precluded determination of causality. In the present study, we tested for the first time whether experimentally imposed circadian misalignment alters the neural response to monetary reward. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Brant P. Hasler Source Type: research

29.3 prospective association between sleep health and suicidality in ultra-high-risk adolescents and college students
Suicide is the second leading cause of death among young people ages 14 –24 years, and rates of suicide in this age group are increasing. The majority of suicide risk factors are distal (ie, long-standing, static) and thus informative regarding who is at risk but not when. As such, our ability to reliably predict near-term suicide risk among vulnerable populations rem ains grossly inadequate. Studies consistently demonstrate a link between subjective sleep disturbances and the continuum of suicidality. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Peter Franzen Source Type: research

29.4 sleep and emotion processing in pediatric ptsd
Sleep disturbance and emotion processing abnormalities are core features of pediatric PTSD (pPTSD), and a wealth of evidence indicates that sleep is crucial for optimal daytime emotional function. Furthermore, sleep not only plays a crucial role in consolidating the content of emotional experience but also in reducing its affective potency. Despite these relationships, the contributions of sleep to emotion processing in pPTSD have received little attention. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Stephanie Jones Source Type: research

Children and screens: new research reveals how digital media affects mental health
This program presents new findings on the effects of screen media on parameters of well-being and development of youth. A sizable body of research documents that screen engagement habits often significantly affect susceptibility to and recovery from mental illness. However, youth media habits are shifting rapidly as are their risks and benefits, so new data are especially valuable for practitioners. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Paul Weigle, Pamela Hurst-Della Pietra Tags: Symposium 30 Source Type: research

30.1 digital media and sleep health among adolescents: does sleep mediate the association between screen time and depressive symptoms?
Given the pervasive use of screen-based media and the high prevalence of insufficient sleep among adolescents, we will review the evidence linking both and we will present new findings. Numerous studies find an adverse association between screen-based media use and sleep, primarily via delayed bedtimes and reduced total sleep duration. Underlying mechanisms include: 1) time displacement (ie, time spent on screens replaces time spent sleeping and other activities); 2) psychological stimulation from the media content; and 3) effects of light emitted from devices on circadian timing, sleep physiology, and alertness. (Source: ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Lauren E. Hale Source Type: research

30.2 screen media activity and impact on mental health and suicidality: results from the adolescent brain cognitive development (abcd) cohort
This presentation is designed to determine the impact of screen media activity (SMA) on health, recreational activities, and suicide in the Adolescent Brain Cognitive Development (ABCD) study. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Kara Bagot Source Type: research

30.3 digital media use and mental health among adolescents: evidence from four large data sets
The aim of this presentation is to understand associations between time spent on digital media and psychological well-being among adolescents. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Jean Twenge Source Type: research

30.4 improving measurement and assessment of digital media use: results from an international scoping review
The goal of this session is to describe ongoing efforts to develop a suite of state-of-the-art clinical and research tools that redress challenges with reliability, validity, and clinical utility in measuring parameters of digital media engagement in children and adolescents. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Dillon Browne Source Type: research

Interpreting the multiple facets of pediatric bipolar spectrum disorders: clinical and biological models
In this Symposium, the speakers will discuss the psychopathological, neurophysiological, and neurobiological characteristics underlying the diverse facets of bipolar disorder in children and adolescents to define different models of illness onset, clinical presentation, and illness progression that can help understand this clinical entity. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Kirti Saxena, Gabriele Sani, Rasim Somer Diler Tags: Symposium 31 Source Type: research

31.1 typical and atypical onset of bipolar disorder in childhood and adolescence
In the last decade, the growing evidence supporting the hypothesis of bipolar disorder (BD) as a progressive neurobiological illness prompted research to identify early symptoms to provide treatments that might attenuate the illness course. As a consequence, the attention on populations of children and adolescents has increased sharply in the recent years. However, to date, the concept of pediatric bipolar disorder (PBD) still raises important and etiological questions. In particular, the evidence of the existence of different subtypes of illnesses raises doubts on the unitary construct of this disorder and undermines the ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Gabriele Sani Source Type: research

31.2 update on borderline personality features in youth with bipolar disorders and  bipolar offspring
Differentiating the bipolar disorders (BDs) from borderline personality disorder (BPD) can be challenging diagnostically, because certain symptoms and traits, such as depression, aggression, and interpersonal relationships, are common to both conditions. The fact that all individuals diagnosed with BD do not meet BPD criteria suggests that both unique and related facets of the 2 conditions exist. Identifying related and unrelated items between BD and BPD should improve diagnostic accuracy. In addition, assessing for BPD features in youths at high risk for bipolar disorder can be clinically relevant. (Source: Journal of the...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Kirti Saxena Source Type: research

31.3 specific learning disability in math is associated with risk for pediatric bipolar disorder
Children and adolescents who are offspring of parents with bipolar disorder (BD) present an increased risk for mental disorders compared with the general population. Indicators of risk and protection in these youth are scarcely studied. Mathematics learning problems are overexpressed in children and adolescents with BD, and we hypothesize that those youth who are the offspring of parents with BD will also present higher rates of mathematics learning problems than typically developing youth. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Cristian Zeni Source Type: research

31.4 developmental trajectories of resting state networks in youth with bipolar disorder
Previous studies suggest that youth with bipolar disorder (BD) have abnormal resting-state networks and/or connectivity between networks. In addition, there is some indication that the age-related development of intrinsic network connectivity is impaired in BD. However, neurodevelopment of network connectivity has not been explored fully. The current study examined abnormalities in the development of intrinsic connectivity networks in youth with BD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Amy Garrett Source Type: research

31.5 neurophysiological correlates of predictors of illness severity in pediatric bipolar disorder
The coexisting presence of borderline features, substance abuse, suicidality, and episode polarity and exposure to childhood trauma in children and adolescents with bipolar disorder (BD) has been associated with greater illness burden and greater impairment in social and affective life. MRI techniques emphasized that these characteristics are associated with alterations in the cortical and subcortical structures of the brain. However, the temporal dynamics of these neurobiological dysfunctions still are not possible to evaluate with MRI techniques. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Alessio Simonetti Source Type: research

Promoting well-being in children facing  adversity: what can us military children teach us?
This presentation will inform attendees about the effects of a range of adversities faced by military families and foster strategies to promote well-being in affected children. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Stephen J. Cozza, Patricia Lester Tags: Symposium 32 Source Type: research

32.1 the deployment cycle and young military families
The goals of this session are to characterize the functioning of active duty families with young children in the predeployment phase of the deployment cycle and to present initial findings from an ongoing randomized, controlled trial examining the efficacy of Strong Families Strong Forces, a reflective parenting program designed to reduce parenting stress and adverse child outcomes among military families experiencing deployment separation. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Ellen DeVoe, Abby Blankenship, Vanessa Jacoby Source Type: research

32.2 child neglect types in us army communities and associated risk factors
The goal of this session is to characterize the types of child neglect and their associated risk factors within the US Army community to inform effective prevention, policy, and strategy. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Stephen J. Cozza, Joscelyn Fisher, Christin Ogle, Jing Zhou Source Type: research

32.3 the impact of parental injury and illness on military children ’s mental health and psychiatric medication use
Parental illness and injury have been linked to children ’s mental health issues. We sought to quantify the effect of parental injury on the care for specific mental health diagnoses and psychotropic medications. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Elizabeth Hisle-Gorman, Apryl Susi, Gregory Gorman Source Type: research

Social (pragmatic) communication deficits in pediatric psychiatry populations: clarifying issues for clinical practice
The goals of this presentation are as follows: 1) to describe social pragmatic communication (SPC) throughout childhood and when impaired in the development of other mental health disorders; 2) to present the issues in differentiating SPC disorder (SPCD) from ASD; and 3) to help clinicians become familiar with SPC deficits in youth engaged in aggressive behavior. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Theodore Petti, Molly Losh Tags: Symposium 33 Source Type: research

33.1 comorbidity of language and literacy disorders in children with psychiatric impairments: what psychiatrists need to know
The goals of this session are as follows: 1) to describe research by detailing the connection between language and social/pragmatic language development and the ensuing risk of social emotional disturbances and associated mental illness in young children from toddlerhood through adolescence; and 2) to provide guidance to clinicians on when to refer for further assessment. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Tatyana Elleseff Source Type: research

33.2 adolescent self-report of deficits in language and social communication
The goals of this presentation are to summarize the range of psychometrically valid instruments for assessing social/pragmatic communication deficits (SPCD) and to share self-report survey data of adolescents receiving mental health services on their perceived competence in receptive and expressive language and social/pragmatic communication. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Theodore Petti, Anu Upadhyay, Yuli Fradkin Source Type: research

33.3 overlap of pragmatic language impairments in asd and related neurodevelopmental disorders
The goal of this session is to understand the overlap of pragmatic language impairments in ASD and related neurodevelopmental disorders, including neural and molecular genetic correlates. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Molly Losh Source Type: research

33.4 emotional regulation in children with asd with and without concurrent language impairment
The goal of this session is to describe the role of language ability in emotional regulation by children ascertained for ASD and language disorder (ASD+LD). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Yuli Fradkin, Judy Flax, Christine Gwin, Linda Brzustowicz Source Type: research

Animal models for child psychiatry
Animal model systems are valuable tools for advancing our understanding of child and adolescent mental health disorders and improving the lives of the children and adolescents affected. This session provides a forum for novel animal model work relevant to child and adolescent psychiatry to be presented to a wide range of audience members, from those who care for children and families full time to those performing neurobiological research themselves and all others in between. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Paul E.A. Glaser, Hanna E. Stevens, Angela M. Reiersen, Sunil Q. Mehta Tags: Symposium 34 Source Type: research

34.1 genetic mutations and environmental factors that promote adverse neurodevelopmental outcomes in preclinical models
Developmental exposure to environmental neurotoxicants, such as polychlorinated biphenyls (PCBs), is implicated in the pathogenesis of neurodevelopmental disorders (NDDs). Mechanistic studies have shown that PCBs alter calcium-dependent signaling pathways linked to activity-dependent dendritic growth. Mutations in calcium signaling molecules are associated with increased NDD risk, so we are using mouse models to test the hypothesis that heritable mutations that alter the fidelity of calcium signals influence neurodevelopmental outcomes after developmental PCB exposure. (Source: Journal of the American Academy of Child and ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Kimberly P. Keil, Sunjay Sethi, Machelle D. Wilson, Jill L. Silverman, Isaac N. Pessah, Pamela J. Lein Source Type: research

34.2 dopamine d4 receptors in animal models of neurodevelopmental disorders
Previous research suggests that the exon 3 variable number of tandem repeat (VNTR) polymorphism of the human dopamine D4 receptor gene (DRD4) contributes to ADHD and other psychiatric phenotypes. Animal studies may show how differences in D4 expression and function lead to these phenotypes and whether environmental factors influence behavioral outcomes. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Angela M. Reiersen, Steven K. Harmon, Karen L. O'Malley Source Type: research

34.3 effects of third-trimester equivalent ethanol exposure on neurodevelopmental gene expression
Third-trimester alcohol exposure has profound effects on neurodevelopmental gene expression, especially in brain regions that develop in late gestation such as the prefrontal cortex (PFC). Ethanol (EtOH) induces poly(ADP-ribose) polymerase (PARP) enzymatic activity in cell and animal models, which reportedly participates in 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) removal. We hypothesized that EtOH increases PARP activity, inducing its DNA demethylation activity, leading to increased expression of genes involved in neuronal development and cellular differentiation. (Source: Journal of the American Academy ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: David P. Gavin, Gian Paolo Vallerini, Shumila Kazmi, Marina Guizzetti, Maheen Kazmi Source Type: research

Dmdd and borderline personality disorder: in search of the missing link
Youths with DMDD are at high risk for developing depressive disorders as adults. A key question is whether DMDD can be considered as an expression of depressive disorder in prepubertal children and, therefore, be treated as such. Besides, DMDD shares many clinical features with borderline personality disorder (BPD), such as intense feelings of anger and difficulty managing negative emotions. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Xavier Benarous, Brian Greenfield Tags: Symposium 35 Source Type: research

35.1 dmdd, depression, hopelessness, suicidality, and borderline traits in clinical sample of adolescents: convergence analyses and consensus panel
The aim of this research is to continue the validation of the Breton, Labelle, and Bergeron DMDD scale (2011) by analyzing the convergence links between this disorder and other mental health issues such as depression, hopelessness, suicidality, and borderline traits, and to examine which of the CBT strategies for depression disorder (DD) or DBT for borderline personality disorder (BPD) would be most useful for treating this disorder. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: R éal Labelle Source Type: research

35.2 are youths with dmdd different from youths with other depressive disorders? a retrospective chart review
In the current report, we aimed to describe the sociodemographic and clinical features of youths with DMDD, in comparison with 2 other depressive mood disorders. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Xavier Benarous Source Type: research

35.3 sleep abnormalities in disruptive mood dysregulation disorder: an actigraphy study
The goal of this session is to explore the clinical characteristics and motor activity profile during sleep periods of children and adolescents presenting with DMDD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Jean-Marc Guile Source Type: research

35.4 borderline personality features and history of prior suicide attempts define a severity gradient in adolescent suicide attempters: evidence from a large cross-sectional study of adolescent inpatients
This study presents a comprehensive assessment of adolescent inpatient suicide attempters, allowing testing clinical interactions between BPD features and number of prior suicide attempts. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Aveline Aouidad Source Type: research

Effective interventions for problematic sexual behaviors in youth
More than 30 percent of sexual offenses against children are committed by other youth. Evidence-based treatments (EBTs) for youth with problematic sexual behaviors (PSBs) are available; however, few child and adolescent psychiatrists are aware of them. This Symposium describes 3 forms of EBTs for youth with PSBs and the community implementation of one of them. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Judith A. Cohen, Anthony P. Mannarino Tags: Symposium 36 Source Type: research

36.1 problematic sexual behavior cbt: model, research, and outcomes
This study provides long-term 10-year outcomes of children in an RCT of problematic sexual behavior-CBT and dynamic play therapy. The study included a comparison group of children with nonsexual behavior problems. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Jimmy Widdifield Source Type: research

36.2 community implementation of problematic sexual behavior cbt
Approximately 30 percent of child sexual abuse incidents is committed by youth. Broad implementation of evidence-based early intervention to address problematic sexual behavior of youth has a high potential for impact, given this high prevalence and studies demonstrating low recidivism with appropriate treatment. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2019 Category: Psychiatry Authors: Jane Silovsky Source Type: research