4.5 The How To ’s: The Use and Monitoring of Atypical Antipsychotics in Youth
The goal of this session is to review articles chosen by AACAP ’s Lifelong Learning Committee that share a common focus on the use and monitoring of atypical antipsychotic drugs in children and adolescents. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Jean A. Frazier Source Type: research

4.6 Co-Occurring Medical Issues in Child and Adolescent Psychiatry
The goal of this session is to review articles chosen by AACAP ’s Lifelong Learning Committee highlighting topics important for child and adolescent psychiatrists in the integrated management of patients with co-occurring medical and mental health issues. Important topics include the following: 1) eating disorders; 2) hormonal contraception; 3) sports-related concussion; 4) delirium in pediatric critical care; 5) autoimmune encephalitis; and 6) PANS. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Matthew Dean Willis Source Type: research

Research Institute: Treatment Updates in Pediatric Depression and Suicidality
Depression affects approximately 25% of adolescents. Suicide is the second leading cause of death in adolescents and young adults. This Institute will provide updates from a multidisciplinary team regarding the latest clinical research advancements in the assessment and treatment of child and adolescent depression and suicidality. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Anne L. Glowinski, Michael Bloch Tags: Institute 5 Source Type: research

5.1 Update: Antidepressant Trials for Depression in Children and Adolescents
This presentation will provide a review and update on antidepressant RCTs for depression in children and adolescents. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Karen Dineen Wagner Source Type: research

5.2 Ssris and Suicidality: Cause or Cure?
Significant concerns about the relationship between the use of SSRIs and suicidal risk in adolescents have emerged over the past decade. This presentation will review the extent of the relationship; examine the risks versus the benefits of SSRIs for adolescent depression; discuss the possible explanations for the relationship; and make recommendations for clinical management, public health messaging, and future research. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: David A. Brent Source Type: research

5.3 Ketamine Across the Lifespan: An Emerging Treatment for Depression and Suicidality
Approximately 25% of adolescents experience a major depressive episode. Suicide is the second leading cause of death in individuals aged 15 –24 years. Effective treatments for adolescents include pharmacotherapy with SSRIs and specific psychotherapies. However, these treatments are not effective for many patients, and their therapeutic action is typically delayed when they work. In this session, attendees will do the following: 1) und erstand the evidence base for the use of ketamine, a novel rapid-acting antidepressant, in adult depressive disorders and suicidal ideation; 2) become familiar with initial evidence exa...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Michael Bloch, Jennifer Dwyer Source Type: research

5.4 Computerized Adaptive Screen for Teen Suicide Risk: Development and Three-Month Prediction of Suicide Attempts
Suicide is the second leading cause of death among youth ages 12 to 17 years in the United States. However, many adolescents at high risk for suicide go unrecognized and untreated. Evidence-based screening and recognition strategies are needed. Attendees at this session will be able to do as follows: 1) learn how the computerized adaptive screen for teen suicide risk (CAS-Teen Suicide Risk) was developed in the Emergency Department Screen for Teens at Risk for Suicide (ED-STARS) national study; and 2) understand the sensitivity and specificity of screen questions for the prediction of suicide attempts within 3 months. (Sou...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Cheryl King, Jacqueline Grupp-Phelan, David A. Brent, T. Charles Casper Source Type: research

5.5 Youth Suicide: How Gender, Sexual Orientation, and Gender-Nonconforming Status Shape Risk and Inform Intervention Strategies
Suicide has recently risen to the second leading cause of death in individuals ages 10 –24 years. For every completed suicide, there are an estimated 8–25 attempts, with self-injury even more common. Adolescent females are more likely to engage in suicidal and self-harming behaviors, whereas suicide death is more common among adolescent males. Sexual minority youth endorse higher rates of self-harm, suicidal ideation, and suicide attempts, with gender-diverse youth reporting 2–3 times the rate of suicidal thoughts compared with cis-gender peers. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Elizabeth McCauley, Molly Adrian, Amy Curtis Source Type: research

Innovative Interventions in Child and Adolescent Psychiatry: Extending Our Reach
The participant will be able to do the following: 1) discuss how the PAX-Good Behavior Game, a preventive intervention, works in elementary schools and how the strategy can be scaled up for more general benefit; 2) extend general mental health interventions directly through the use of internet technology [applications (Apps) or online computerized treatment] and telemedicine; 3) implement a relatively brief psychological intervention to enhance treatment of depression that does not require the specialized training of CBT and interpersonal psychotherapy; 4) describe interventions for the more seriously impairing internalizi...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Gabrielle A. Carlson Tags: Institute 6 Source Type: research

6.1 Brief Psychosocial Intervention for Teens With Major Depression
In the United Kingdom, there is an increasing demand for child and adolescent mental health services. The UK National Institute for Health and Care Excellence (NICE) recommends specialized psychological therapy as first-line treatment for depression; however, this is an expensive and relatively scarce resource. There is an urgent need to increase access to cost-effective psychological treatments. In this presentation, attendees will be able to do the following: 1) learn about the key components of a manualized brief psychosocial intervention (BPI) for adolescents with depressive disorder; 2) be informed about the delivery ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Bernadka W. Dubicka Source Type: research

6.2 Therapy Apps: What They Can and Can ’t Do
By the end of this session, the attendee will understand the following: 1) the spectrum of behavioral intervention technologies available in child and adolescent mental health; 2) the rationale and evidence for these interventions; and 3) how these might be implemented into the practice of child psychiatry, including strengths and limitations. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Sally N. Merry Source Type: research

6.3 Talk the Talk: Intensive Behavioral Treatment for Children With Selective Mutism
In this session, we describe the following: 1) the evaluation process highlighting novel approaches, such as use of video samples and observation of the parent-child interaction for children with selective mutism (SM); and 2) a way that clinicians can transport components of intensive treatment to their practice. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Rachel Busman, Harold S. Koplewicz Source Type: research

6.4 Ketamine: An Emerging Treatment for Adolescent Depression
MDD is a significant pediatric health problem, with a point prevalence of up to 8% and a lifetime prevalence approaching 25% by the end of adolescence. Suicide is the second leading cause of death in youths age 15 –24 years. Although we currently have several effective pharmacological and psychological treatments for depression, treatments that work better and faster are urgently needed. We plan to review the evidence base for ketamine as an emerging treatment for depression and discuss our experience using ketamine in adolescent populations. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Michael Bloch, Jennifer Dwyer Source Type: research

6.5 The Good Behavior Game: How It Works and What It Does for Psychiatric Disorders
Pediatric psychiatric disorders are increasing every 2 years. Can a fun, well-tested classroom game invented in 1969 reduce these disorders? The answer is “yes.” In this session, participants will learn the following: 1) how the game works; 2) the breadth of longitudinal outcomes; and 3) how to scale up the game. The game is played during regular school instruction. Teachers divide children into 2 to 5 teams per classroom, balancing teams with hig h-achieving, shy, and disruptive students. The teams work to increase PAX (“peace, productivity, health, and happiness”). (Source: Journal of the American...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Alan A. Axelson Source Type: research

6.6 Telemental Health: Facilitating Innovative Mental Health Interventions
Attendees will learn the following: 1) the expanding uses of telemental health (TMH) to increase access to and capacity for the delivery of evidence-based mental health interventions; 2) models of care that are most amenable to TMH delivery; 3) the practical steps of establishing a TMH clinic; and 4) whether TMH is right for their practice. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: David E. Roth Source Type: research

Developmental Considerations in Substance Use Disorders: From Pregnancy to Puberty and Beyond
The implementation of developmentally informed clinical interventions for individuals and families struggling with substance use disorders (SUDs) is essential in child and adolescent psychiatric practice. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Iliyan Ivanov, Kevin M. Gray Tags: Institute 7 Source Type: research

7.1 Epidemiology of Substance Use Disorders Among Youth and Parents
Child and adolescent psychiatrists need to be aware of the prevalence of substance use and substance use disorders (SUDs) in adolescence, young adulthood, and pregnancy, and among parents to identify SUDs in the children and families they treat. Child and adolescent psychiatrists also need to understand the prevalence of engagement in SUD treatment across the lifespan. Child and adolescent psychiatrists need to understand demographic differences in substance use/SUD and engagement in SUD treatment. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Amy Yule Source Type: research

7.2 High Times for Cannabis: Epigenetic Imprint and Its Legacy on Brain and Behavior
The reduced perception regarding risks associated with marijuana (Cannabis sativa), as well as the growing industry evolving around recreational and medical cannabis, has led to increased use of the drug, and is now used to a greater extent than cigarettes by adolescents. In this presentation, I will provide an overview of our findings regarding the vulnerabilities of the developing brain to cannabis exposure during particularly sensitive windows of development and its epigenetic legacy later in life. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Henrietta Szutorisz Source Type: research

7.3 Neurobiology of Substance Use Disorder Risk and Initial Exposure to Drugs
As more has been learned about the neurobiology of substance use disorders (SUDs) in adults, investigations in children at risk before exposure to abusable substances remain limited. As evidence points out that early experimentation with drugs may be linked to higher rates of later SUD, the mechanisms by which early drug exposure may influence the development of SUD still remain poorly understood. Furthermore, new evidence suggests that deficits in reward processing in the brain may represent putative predispositions for SUD development in youth. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Iliyan Ivanov Source Type: research

7.4 Substance Use in Pregnancy and Its Impact on Child Development
Substance use during pregnancy has a significant negative impact on maternal, fetal, newborn and child health. Although few randomized controlled trials for the treatment of perinatal substance use disorder (SUD) exist, it is important to know what treatments are available for pregnant women and how to counsel women about the risks of substance use, as well as the risks and potential benefits of available treatment options. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Constance Guille Source Type: research

7.5 Psychotherapies for Substance Use Disorders in Youth
Evidenced-based psychotherapies are foundational in the treatment of any substance use disorder (SUD). Despite research demonstrating effectiveness, adoption of evidenced-based psychotherapies is hardly uniform. Many medical providers are underinformed and undertrained in the use of these interventions. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Joseph S. Lee Source Type: research

7.6 The Impact of Parents and Family in the Prevention and Treatment of Adolescent Substance Use Disorders: Developmental and Transgenerational Perspectives
Despite a strong evidence base, family-based interventions for adolescent substance use disorders (SUDs) can be underappreciated in clinical practice and underemphasized in training. Treatment focused solely on individual interventions for an adolescent struggling with substance use represents a missed opportunity for more impactful and lasting improvement in symptoms of SUD. Both genetic and environmental factors contribute to the perpetuation of SUDs in a multigenerational pattern. Developmentally informed, family-based intervention at any stage in an individual and family ’s life cycle can represent not only treat...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Peter Jackson Source Type: research

7.7 Pharmacotherapies for Youth Substance Use Disorder: Rationale, Evidence-Base, and Practical Strategies
Substance use disorders (SUDs) are prevalent and impairing across the lifespan. Psychosocial interventions remain the cornerstone of SUD treatment, but long-term abstinence outcomes are limited. Amid advances in characterizing the neurobiology of SUD, a number of pharmacotherapies have been developed and several currently have US FDA approval in adults. Application of these medications to adolescents with SUD has been less well-studied, but a number of recent randomized controlled trials may provide guidance for clinicians treating adolescents with SUD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Kevin M. Gray Source Type: research

Coordinated Specialty Care for First-Episode Psychosis
The goal of this Symposium is to review the implementation, outcomes, and clinical correlates of coordinated specialty care programs for treating the first episode of psychosis. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Jon M. McClellan Tags: Symposium 1 Source Type: research

1.1 Washington State New Journeys Program for Young Adults Experiencing First-Episode Psychosis: Implementation and Outcomes
The goals of this session are to implement and evaluate treatment outcomes of Washington State ’s New Journeys program, a coordinated specialty care early intervention program for treating first-episode psychosis. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Maria Monroe-DeVita Source Type: research

1.2 Racial Differences in First-Episode Psychosis Treatment Outcomes: Data From the National RA1SE Early Treatment Program (ETP) Study
This study examined racial differences in treatment outcomes among participants enrolled in a large multisite, randomized controlled trial evaluating a coordinated specialty care model for first-episode psychosis called NAVIGATE. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Oladunni Oluwoye Source Type: research

1.3 The Impact of Tobacco, Alcohol, and Cannabis Use on Treatment Outcomes Among Patients Experiencing First-Episode Psychosis: Data From the National RA1SE Early Treatment Program (ETP) Study
The goal of this session is to examine the effect of recent tobacco, alcohol, and cannabis use on treatment outcomes among participants experiencing first-episode psychosis (FEP); these participants were enrolled in a large multisite clinical trial called Recovery After an Initial Schizophrenia Episode —Early Treatment Program (RAISE-ETP). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Michael McDonell Source Type: research

1.4 Implementing the Navigate Model for First-Episode Psychosis
The goals of this presentation are as follows: 1) to review the treatment components of the NAVIGATE model for treating first-episode psychosis; and 2) to describe the development and implementation of a first-episode psychosis clinic. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Krystal Ozanick Source Type: research

Maturation of Complex Cognition and the Risk for Psychopathology in Transition-Age Youth
This Symposium will focus on neurodevelopmental maturation occurring in transition-age youth (TAY), implications for mental health, and efforts to use cognitive subtypes in TAY with psychopathology to drive clinical/treatment innovation. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Stephanie Hope Ameis, Jeremy Veenstra-VanderWeele Tags: Symposium 2 Source Type: research

2.1 Neurobiological Underpinnings of Cognitive Development
Why are some people more proficient in cognitive skills than others? Insights into the biological bases of these differences came from post mortem and imaging studies that revealed positive associations between morphometry and intelligence in focal brain regions. However, most of the previous studies have considered each brain region in statistical isolation from the rest of the brain, although emerging evidence suggests that anatomical changes occur in a coordinated fashion across distributed brain regions during development. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Budhachandra Khundrakpam Source Type: research

2.2 Adolescent Development of Brain Systems Supporting Cognition and Motivation
Our presentation will characterize changes in brain systems underlying the transition through adolescence underlying cognitive control and motivational systems. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Beatriz Luna Source Type: research

2.3 Stratifying at Risk Youth With Psychosis Spectrum Symptoms
Major mental illnesses, including psychosis (schizophrenia, bipolar I disorder, psychotic depression), tend to onset in the late teenage years to mid-20s and are often functionally disabling with a high risk of suicide. Most research focuses on fully diagnosed adults, but an alternative strategy is to study a wider range of psychosis spectrum symptoms (PSS) in youth. The Philadelphia Neurodevelopmental Cohort (PNC) is a large population sample group (aged 8 –21 years) with multimodal neuroimaging, genetic, cognitive, and behavioral data. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Aristotle Voineskos Source Type: research

2.4 Brain-Behavior Profiles in Transition-Age Youth With ASD and Executive Function Deficits
Cognitive impairment is highly variable in ASD, challenging treatment innovation efforts for this target. Within the context of a pilot clinical trial of repetitive transcranial magnetic stimulation (rTMS) for executive function deficits in ASD, we performed functional neuroimaging using an N-back spatial working memory (SWM) task known to activate frontoparietal and deactivate default mode networks (DMNs). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Stephanie Hope Ameis Source Type: research

Mental Health Crisis in Youth With ASD
This Symposium ’s goal is to provide guidance to the child and adolescent psychiatrist in private practice in assisting families who are struggling to manage their child with ASD and in crisis. Evidence shows that almost 70% of youth with ASD have one form of mental illness, 56% of individuals with ASD have a hi story of aggression toward their caregivers, 30% are found to engage in self-injurious behaviors, and 49% have a history of elopement. Individuals with ASD are also 28 times more likely to report suicidal ideation. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Roma A. Vasa, Matthew Siegel Tags: Symposium 3 Source Type: research

3.1 Prevalence and Characteristics of Mental Health Crisis in Youth With ASD
Individuals with ASD have high rates of dangerous behaviors, including elopement, aggression, and self-injury. These behaviors can result in danger to self and others. Such crises can result in devastating outcomes, such as loss of school placement and significant caregiver strain. Despite this enormous toll, little to nothing is known about mental health crises among youth with ASD. The goal of this study is to fill this gap by examining the prevalence, characteristics, and correlates of mental health crises among youth with ASD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Luke Kalb Source Type: research

3.2 Suicide Risk in Youth With ASD: Feasibility of Screening in the Medical Setting
Suicide is an international public health crisis and the second leading cause of death for youth aged 10 to 24 years. Recent studies suggest that youth with ASD are at increased risk. There has been significant progress in the development and validation of suicide risk tools for typically developing youth in medical settings; however, there are no suicide risk screening instruments validated specifically for the ASD population. Before screening programs can be implemented for people with ASD, it is critical to assess the feasibility of screening in this population. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Lisa M. Horowitz, Rachel Greenbaum, Elizabeth Lanzillo, Audrey Thurm Source Type: research

3.3 Making the Emergency Department Work for Youth With ASD: A Clinical Research Review
Youth with ASD access emergency services at higher rates than peers without ASD, yet emergency department (ED) staff members typically have limited experience and expertise in the emergency evaluation and crisis management of children and adolescents with ASD. As a result, youth with ASD and their families often have negative experiences of emergency care, including high rates of restraint and sedative medication. This presentation will focus on the evaluation and behavioral management of patients with ASD in ED settings. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Alla Alexander, Ruth Gerson Source Type: research

3.4 Managing Mental Health Crisis in ASD: Current Challenges
The objectives of this study are as follows: 1) to present data on how child and adolescent psychiatrists manage mental health crises in youth with ASD in their outpatient practice; and 2) to discuss current strategies for preventing and m anaging mental health crises in this population. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Roma A. Vasa Source Type: research

Talking Tics: Research Updates on the Genetics, Phenomenology, and Treatment of Tourette ’s Disorder
This Symposium presents research updates on the genetics, phenomenology, and treatment of youth with Tourette ’s disorder (TD). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Joseph McGuire, John T. Walkup Tags: Symposium 4 Source Type: research

4.1 New Genetic Findings in Tourette ’s and Tic Disorders
This presentation will provide an overview of the latest research findings and methodologies in genetic investigations of Tourette ’s disorder (TD) and tic disorders. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Thomas V. Fernandez Source Type: research

4.2 Piloting Actigraphy for the Assessment of Sleep Functioning in Youth With Persistent Tic Disorders
Tourette ’s disorder (TD) and tic disorders are frequently associated with sleep problems (ie, difficulties with sleep initiation, maintenance, and quality) at a rate of approximately 65%. Polysomnography has revealed objective sleep impairment in TDs, with delayed sleep onset, increased nighttime awakenin gs and movements after sleep onset, and lower sleep efficiency commonly reported. Actigraphy is increasingly used as an alternative to polysomnography for sleep measurement. The present study is the first to pilot actigraphy as a tool for sleep measurement in tic disorders. (Source: Journal of the American Academy ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Emily J. Ricketts, Michelle Rozenman, Dana McMakin, Hannah B. Goldberg, Christopher Colwell, John Piacentini Source Type: research

4.3 Advances in the Pharmacological Treatments of Tic Disorders
The objectives of this presentation are to review the current evidence base for commonly used pharmacological forms of treatment for tic disorders and to discuss additional pharmacological agents that are additionally being studied to treat tic disorders. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Michael Bloch Source Type: research

4.4 Optimizing Therapeutic Outcomes for Youth With Tourette ’s Disorder
Tourette ’s disorder (TD) is a mental health condition characterized by significant distress, impairment, and a poor quality of life. Presently, AACAP practice parameters recommend behavior therapy for youth with mild-to-moderate tic symptom severity and behavior therapy combined with pharmacotherapy for m ore severe tics. Despite its therapeutic benefit, behavior therapy yields a limited response for many youth with TD and/or youth who have limited access because of clinician availability. Thus, there remains a need to improve and enhance treatment outcomes for behavior therapy. (Source: Journal of the American Acad...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Joseph McGuire, Nathaniel Ginder, James T. McCracken, John Piacentini Source Type: research

From Bench to Bedside: Molecular and Genetic Mechanisms in Neurodevelopmental Disorders
The goal of this research is to advance our understanding of the biology of neurodevelopmental disorders using molecular and genetics approaches as a path toward discovering novel pharmacological treatments. We will highlight how progress at the bench advances our understanding of the biology of these disorders and paves the way for rational drug discovery with the aim of shaping future applications at the bedside. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Ellen J. Hoffman, Devanand Manoli, Matthew State Tags: Symposium 5 Source Type: research

5.1 Gene Discovery in Neuropsychiatric Disorders
The goal of this presentation will be to introduce the audience to methods of genetic discovery in childhood neuropsychiatric disorders. Recent studies in ASD, OCD, and Tourette ’s disorder (TD) will be reviewed, highlighting successful and unsuccessful strategies for gene discovery. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Thomas V. Fernandez Source Type: research

5.2 Leveraging Genomics and Genome-Editing Technologies to Illuminate Neurodevelopmental Processes
This symposium will review state-of-the-art methods for generating genetic mouse models of neurodevelopmental disorders and present methods of analyzing gene expression in these models using next-generation sequencing technologies. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Rebecca Muhle Source Type: research

5.3 Epigenetic Mechanisms of Gene Repression in ASD
POGZ (Pogo transposable element derived with ZNF domain) and KMT5B are 2 proteins with recurrent mutations in ASD. We study the function of these chromatin regulators during neuronal development to gain insight into the underlying mechanisms of ASD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Eirene Markenscoff-Papadimitriou Source Type: research

5.4 Accounting for Behavioral Variability Due to Fmr1 Knockout in Rats
Wide variation in the presentation of most neuropsychiatric conditions results from the following: 1) genetic heterogeneity; 2) experience-dependent changes in brain function; and 3) the natural variation in the output of the circuits underlying complex behaviors. Even just understanding the relationship between behavior and genotypic differences remains a complex endeavor. Such endogenous variation may outweigh the phenotypes that result from genetic lesions, resulting in a significant overlap in the distribution of behavioral phenotypes in populations with genetic differences. (Source: Journal of the American Academy of ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: David Kastner Source Type: research

5.5 Getting Bench Players Into the Clinic Game: Early Swings at Translation in Neurodevelopmental Disorders
This presentation describes initial treatment studies based upon developmental neurobiology findings in cellular and animal models of neurodevelopmental disorders. It highlights both the advantages of mechanistic hypotheses and challenges of targeting symptoms across development. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Jeremy Veenstra-VanderWeele Source Type: research

Research Symposium: Opioids From the Receptor to the Clinic
The goal of the 2018 Research Symposium is to highlight relevant clinical and translational developments in the study of adolescent opioid use disorders and opioid receptor neurobiology. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2018 Category: Psychiatry Authors: Leslie Hulvershorn Tags: Symposium 6 Source Type: research