9.4 predicting personalized risk of mood recurrences in youths and young adults with bipolar spectrum disorders
With each recurrence, the prognosis of bipolar disorder (BD) worsens, indicating the need to identify the factors associated with increased recurrence risk. The course of BD is heterogeneous, and although risk factors for recurrence for the BD group as a whole have been reported in the literature, identification of risk factors for a specific individual are crucial for developing personalized treatments. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Boris Birmaher Tags: Symposium 9 Source Type: research

Iron deficiency and mental health: an under-recognized association
This Symposium will review current evidence implicating iron deficiency (ID) in brain development and psychopathology. It will also review evidence for iron supplementation to optimize neuropsychiatric functioning. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Chadi A. Calarge, Robert L. Findling Tags: Symposium 10 Source Type: research

10.1 preclinical models that support the association between early-life iron status and subsequent mental health
This presentation aims to assess the mechanisms by which fetal and early neonatal iron deficiency (ID) alters short- and long-term neurodevelopmental function and increases the risk of adverse mental health outcomes. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Michael Georgieff Tags: Symposium 10 Source Type: research

10.2 behavioral, developmental, and neurophysiological consequences of iron deficiency in infancy
This presentation aims to describe the effects of iron deficiency (ID) in human infants on short- and long-term outcomes. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Barbara Felt Tags: Symposium 10 Source Type: research

10.3 iron deficiency and internalizing disorders in adolescents
This study sought to examine the association between body iron status, internalizing symptom severity, and subcortical structure volumes in female adolescents. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Chadi A. Calarge Tags: Symposium 10 Source Type: research

10.4 low-dose oral iron therapy for iron deficiency and associated effects on cognition and mental health
Limited data inform treatment recommendations for children and adolescents affected by iron deficiency. Our objective was to evaluate the efficacy of 2 different oral iron preparations in a population of children commonly affected by iron deficiency anemia (IDA) using a low-dose, once-daily treatment approach. Moreover, we reviewed evidence related to the effect of iron supplementation on cognition and mental health in children. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Jacquelyn M. Powers Tags: Symposium 10 Source Type: research

How telomere biology informs the mental health problems of children
Telomeres and their biology faithfully maintain cellular genetic information. Telomere length is increasingly used as a biomarker of health, indicating whether cells have aged or experienced damage. The response of telomeres may mirror cellular stress responses that impact emotional, cognitive, and behavioral functioning. Efforts have been made to better understand factors contributing to mental health disorders of childhood by examining telomere length differences that occur with exposure to risk factors for child mental health disorders and within clinical populations. (Source: Journal of the American Academy of Child an...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Stacy S. Drury, Hanna E. Stevens Tags: Symposium 11 Source Type: research

11.1 intergenerational transmission of childhood trauma? testing cellular aging in mothers exposed to sexual abuse and their children
Exposure to maltreatment during childhood can lead to increased risk for poor health outcomes in adulthood. Child maltreatment and later poor health may be linked by premature biological aging. We tested whether childhood sexual abuse (CSA) is associated with telomere length (TL) in adult females. We further tested the hypothesis of intergenerational transmission of the effects of CSA by measuring TL in both CSA-exposed and nonexposed mothers and their children. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Laura Etzel, Waylon Hastings, Brooke Mattern, Monica Oxford, Frank W. Putnam, Jennie Noll, Idan Shalev Tags: Symposium 11 Source Type: research

11.2 nonhuman primate leukocyte telomere length increases following early-life stress: potential role of biological compensatory responses
Early life stress (ELS) increases susceptibility to mental health disorders and is associated with alterations in telomere length (TL), a marker of accumulated stress and aging. Primate maternal variable foraging demand (VFD) is a validated ELS model resulting in behavioral signs of anxiety and affective disturbance in offspring. Previous work revealed that VFD is accompanied by changes in corticotropin-releasing factor/hypothalamic-pituitary-adrenal (CRF/HPA) axis functioning, insulin resistance, and elevated plasma glucagon-like peptide 1 (pGLP-1), a neurotrophic gastrointestinal incretin peptide maintaining glucose home...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Kathryn K. Ridout, Shariful Syed, Hung-Te Kao, Barbara Porton, Audrey Tyrka, Jeremy D. Coplan Tags: Symposium 11 Source Type: research

11.3 early adversity, psychopathology, and telomere erosion in children and adolescents
The objectives of this presentation are to discuss and synthesize research findings evaluating the associations between early adversity, psychopathology, and telomere erosion longitudinally during childhood and adolescence. Findings from 2 longitudinal samples are included: 1) children who experienced severe psychosocial deprivation in Bucharest, Romania; and 2) community children from the United States. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Kathryn Humphreys Tags: Symposium 11 Source Type: research

11.4 sex differences in the effects of prenatal stress on telomere biology in the developing mouse brain
In this study, we examined whether prenatal stress, a risk factor for mental illnesses, affected telomere biology in the developing brain. In particular, we were interested in sex differences in these effects, because of epidemiological studies suggesting greater impacts of prenatal stress on male offspring. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Stephanie Lussier, Allison Momany, Monisa Saravanan, Hanna E. Stevens Tags: Symposium 11 Source Type: research

11.5 the telomere research network
The National Institute on Aging and the National Institute of Environmental Health Sciences launched the Telomere Research Network (TRN) to establish best practices for telomere length measurement in population-based studies and determine the role of telomeres as a marker of early exposures and a predictor of disease. The TRN has worked with telomere experts around the world to address current inconsistencies in the science related to population studies of telomeres. This presentation will outline the current controversies in telomere research related to the measurement of telomere length, inconsistent replications, and me...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Stacy S. Drury Tags: Symposium 11 Source Type: research

Research symposium: developments in irritability: an old phenotype with new frontiers
The goal of this 2020 Research Symposium is to highlight advances in transdiagnostic and diagnosis-specific conceptualizations of irritability and to discuss emerging insights into relevant neural mechanisms. The presenters will highlight the potential for improved treatments for irritability based on current advances in imaging and basic neuroscience and on convergence of these 2 modalities. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Abidemi Adegbola Tags: Symposium 12 Source Type: research

12.1 why bullies attack: insights into the neural circuitry of aggression
Heightened aggression is characteristic of multiple neuropsychiatric disorders and can have a wide variety of negative effects on patients, their families, and the public. Recent studies in humans and animals have implicated brain reward circuits in aggression and suggest that, in subsets of aggressive individuals, repeated domination of subordinate social targets is rewarding. Thus, we define novel circuitry in mice related to aspects of defensive vs proactive aggression, which we hope will shed light on human behaviors such as irritability or reactive aggression. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Scott Russo Tags: Symposium 12 Source Type: research

12.2 irritability: translational opportunities and challenges
Irritability is a common and impairing clinical presentation. Because few data guide its treatment, it is imperative to understand the neural underpinnings of irritability to guide novel treatment development. Such research efforts rely on careful conceptualization, accurate multisource phenotyping, informed neuroimaging approaches, and well-designed clinical trials of new treatments. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Ellen Leibenluft Tags: Symposium 12 Source Type: research

Suicide research in the emergency department: screening, risk assessment, and interventions
Suicidal behavior among youth has increased significantly in the past decade, concurrent with a similar increase in youth presenting to the emergency department (ED) for mental health concerns. However, EDs remain, for the most part, unequipped to screen for, recognize, and address suicide risk in young patients consistently or systematically. Furthermore, ED clinicians (including pediatricians and psychiatrists) typically feel that they lack evidence-based methods to identify youth at imminent (compared to chronic) risk, to stratify risk, or to identify and access immediate interventions to mitigate risk. (Source: Journal...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Ruth Gerson Tags: Symposium 13 Source Type: research

13.1 utilizing the ask suicide-screening questions toolkit for detecting and managing suicide risk in the emergency department
This presentation will describe a brief epidemiology of youth suicide in the medical setting and the importance of utilizing universal screening in the emergency department (ED) to identify young patients at risk for suicide. Lisa Horowitz, PhD, MPH, will describe detecting risk and implementation pathways developed specifically for young medical patients in the ED and how screening contributes to youth suicide prevention initiatives. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Lisa M. Horowitz Tags: Symposium 13 Source Type: research

13.2 suicide research in the emergency department: extant literature and future directions
Suicide is the second most common cause of death in adolescents and young adults. According to National Safety Goal 15.01.01, all individuals evaluated for behavioral conditions should be screened for suicide using a validated tool. Unfortunately, emergency department (ED) settings are often not adequately equipped to screen for suicidality and major psychopathology in children and adolescents. The goal of this presentation is to review suicide screening methods in the ED setting and present a novel ED screening approach based on computerized adaptive tests that are starting to be implemented in a large metropolitan ED. (S...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Argelinda Baroni Tags: Symposium 13 Source Type: research

13.3 suicide prevention in the emergency department: a parent decision aid to support lethal means counseling
Emergency department (ED) visits offer a window of opportunity to deliver suicide prevention care. Lethal means counseling to reduce access to potentially lethal suicide attempt methods is an evidence-based strategy included in the United States National Strategy for Suicide Prevention (Objective 6.1). However, data indicate that lethal means counseling is often not a routine part of suicide prevention care. In this presentation, Joan R. Asarnow, PhD, will: 1) describe the development of the Lock to Protect decision aid for supporting parents/caregivers in reducing access to firearms and other dangerous suicide attempt met...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Joan R. Asarnow Tags: Symposium 13 Source Type: research

13.4 novel strategies for suicide risk assessment in the emergency department
A challenge when assessing suicide risk is the predominant reliance on patient self-report. Brief behavioral measures such as the Suicide Implicit Association Test (IAT) and adapted Suicide Stroop Task offer performance-based data points that may further inform clinical decision making. The current study tests the predictive validity of these novel performance-based assessments among a sample of suicidal adolescents presenting to a psychiatric emergency department (ED). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Christine Cha, Olivia Pollak Tags: Symposium 13 Source Type: research

Infections, immune function, and psychopathology in youth
The contribution of infections and immune function to childhood psychopathology has been investigated and debated for many years. Recently, a number of large-scale analyses using the Scandinavian Health Registries have shown increased associations between infections and childhood mental health conditions, such as anorexia nervosa, OCD, and tic disorders. Advances in the technology of metabolomics and immune system profiling have also shed new light on the potential immune system alterations that underlie these associations. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Kyle Allen Williams, Daniel A. Geller Tags: Symposium 14 Source Type: research

14.1 immune markers and immunogenetics in pans
PANS is characterized by sudden-onset OCD and additional neuropsychiatric symptoms. Imaging studies point to inflammation in the basal ganglia as a potential driver of the mental health symptoms. Patients with PANS also develop other comorbid inflammatory disorders. Like other autoimmune diseases, during PANS disease flares, patients have high levels of the C4 split product, which is consistent with activation of this pathway. Because there is emerging evidence for copy number variations in the C4 gene, which presents with symptoms that affect the brain, we wanted to know whether patients with PANS have vulnerability for d...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Jennifer Frankovich Tags: Symposium 14 Source Type: research

14.2 multimodal neuroimaging in children with pandas and healthy controls
This study examines neurophysiological changes related to neuroinflammation in children with PANDAS compared to healthy controls (HCs) and in relation to OCD severity. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Sarah L. O'Dor Tags: Symposium 14 Source Type: research

14.3 proteomic profiling identifies markers of inflammation in anorexia nervosa in support of immuno-metabolic dysfunction
Studies on inflammatory markers in anorexia nervosa to date have focused on a small set of key inflammation markers, yielding contradictory results. We explored differences between low-weight eating disorders (LWED; anorexia nervosa and atypical anorexia) and healthy controls (HCs) across 92 inflammation markers in plasma. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Lauren Breithaupt Tags: Symposium 14 Source Type: research

14.4 tapping into the neuroimmune pathophysiology of pans
PANS is characterized by an abrupt onset of OCD and/or eating restriction and other severe neuropsychiatric symptoms, often following a cycle of flare remission. Although PANS etiology is unknown, clinical evidence implicates the immune system and postinfectious neuroinflammatory mechanisms. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Nora Or-Geva Tags: Symposium 14 Source Type: research

Ghost busters in the nursery: cost-effective solutions to the effects of early environmental trauma
Accumulating evidence suggests that strengthening the infant-parent relationship can reduce the effect of environmental stressors and influence health outcomes. However, current infant mental health (IMH) interventions tend to be costly and to lack robust empirical support. The need for innovative cost-effective prevention is critical. This session  presents 4 IMH interventions and evidence to support their effectiveness. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Alexandra Harrison Tags: Symposium 15 Source Type: research

15.1 outcome study of infant mental health training for health workers
This study focuses on what we see as the critical gap in knowledge of the health workers and consequently in the services and attention provided to the infant-caregiver relationship. The current study will assess the effectiveness of an intervention on the capacity of nurses to support the infant-parent relationship in Kasganj, India, through the Infant Mental Health Mini Course “Protect, Nurture, and Enjoy” (PNE). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Abishek Bala, Rashmi Singh Tags: Symposium 15 Source Type: research

15.2 maternal trauma and offspring behavioral problems: findings from a cohort study in peru
Trauma tends to run across generations, with devastating consequences at individual, family, and population levels. Available evidence, largely from developed countries, suggests that maternal exposure to interpersonal trauma negatively impacts child behavioral development. We sought to evaluate the extent to which maternal exposures to intimate partner violence (IPV) are associated with behavioral problems among children in Peru. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Elizabeth J. Levey Tags: Symposium 15 Source Type: research

15.3 perinatal mental health, critical omission from psychiatry training: a suggested training module
A significant knowledge gap exists in psychiatry training about the mental health of pregnant and early postpartum (perinatal) women. However, the consequences of maternal mental illness on the developing infant can be devastating; the infant nervous system is developing most rapidly in the first 1,000 days of life, when postpartum depression (PPD) typically occurs. The reason for this gap may be the failure to link teaching about neurobiology to clinical problems, such that few trainees consider underlying neurobiological changes when clinically assessing perinatal patients. (Source: Journal of the American Academy of Chi...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Elizabeth Fenstermacher Tags: Symposium 15 Source Type: research

15.4 three steps toward creating effective interventions in infant mental health
More than 200 million children under the age of 5 years in developing countries fail to reach their developmental potential. At least 20% of women in low-income countries suffer from perinatal depression. Women from low socioeconomic groups are more prone to depression due to gender-based risks like domestic violence, son preference, and role restriction around housework and infant care. These stresses in the environment can impact the brain of the developing child. This session will present 3 steps toward creating effective interventions in infant mental health (IMH). (Source: Journal of the American Academy of Child and ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Muhammad Zeshan, Henry Marquez-Castro Tags: Symposium 15 Source Type: research

Window of opportunity: reducing youth substance use and addressing mental needs at time of first justice contact
Over 2 million youth are arrested annually, and 31 million are under juvenile court jurisdiction. Most past research on juvenile justice, substance misuse, and mental health symptoms has focused on detained youth, but less is known about the nearly 80% of justice-involved youth diverted to the community. This Symposium presents data on substance use and mental health symptom trajectories starting from the diverted youth ’s first ever juvenile court contact to inform the development and implementation of early behavioral health screening, prevention, and treatment interventions. (Source: Journal of the American Academ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Marina Tolou-Shams, Eraka Bath Tags: Symposium 16 Source Type: research

16.1 cannabis use among minority sexual orientation and gender identity, court-involved adolescents
The current study examined the effects of family functioning and perceived peer cannabis use on cannabis use among minority and nonminority sexual orientation and gender identity (SOGI) first-time court-involved adolescents. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Matthew Hirschtritt, Johanna B. Folk, Brandon Marshall, Yu Li, Marina Tolou-Shams Tags: Symposium 16 Source Type: research

16.2 cannabis use early-onset and initiation among first-time justice involved youth
Justice-involved youth use cannabis at higher rates than their same-aged peers, placing them at risk for adverse behavioral health problems and continued legal involvement. The current study aimed to understand individual-level predictors (eg, mental health symptoms, other substance use, externalizing behaviors, impulsivity, self-concept, self-esteem) of early-onset cannabis use ( (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Johanna B. Folk, Marina Tolou-Shams, Brandon Marshall, Emily Dauria, Kathleen Kemp, Daphne Koinis-Mitchell, Larry Brown Tags: Symposium 16 Source Type: research

16.3 the role of adhd in youth substance misuse and delinquent behavior among court-involved adolescents: the importance of promotive and protective mechanisms
Adolescents with ADHD are at high risk for delinquency, substance misuse, and justice involvement. Growing evidence indicates that substance use risk increases as a function of ADHD symptom severity. However, there is substantial variability among youth, and little is known about promotive and protective factors. The current study examined: 1) the role of ADHD in predicting patterns of youth substance use and delinquency during the 2 years following first court contact; and 2) how individual (eg, self-esteem, emotional self-control), family (eg, parent relationships, parental monitoring), and social (eg, school engagement,...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Melissa R. Dvorsky, Johanna B. Folk, Marina Tolou-Shams Tags: Symposium 16 Source Type: research

16.4 mental health and substance use predictors of recidivism among first-time justice involved youth
Most recidivism research focuses on serious violent offending youth and finds that dual diagnosis (mental health and substance use disorder) is strongly predictive of youth recidivism. We sought to understand how mental health symptoms and substance misuse are associated with recidivism among first-time justice-involved youth (diverted from detention, ie, less severe offenses) to identify ways to prevent future justice system involvement. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Marina Tolou-Shams, Johanna B. Folk, Evan Holloway, Kathleen Kemp, Brandon Marshall Tags: Symposium 16 Source Type: research

Psychosocial predictors of self-harm, stalking perpetration, and dating violence among justice-impacted youth
The objective of this Symposium is to evaluate current findings on psychological and social measures as predictors of a range of violent behaviors in justice-involved youth. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Marina Tolou-Shams, Larry Brown Tags: Symposium 17 Source Type: research

17.1 nonsuicidal self injury among first-time offending, court-involved, nonincarcerated, latinx youth
This study seeks to examine key psychosocial correlates of NSSI severity among first-time offending (FTO) court-involved nonincarcerated (CINI) Latinx youth. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Jocelyn I. Meza Tags: Symposium 17 Source Type: research

17.2 substance use and dating violence among first-time offending, court-involved, nonincarcerated latinx youth
Dating violence is a public health concern affecting a disproportionate percentage of Latinx youth in both community- and justice-involved samples. Understanding clinical correlates can elucidate key predictors of dating violence in youth. The current study will examine the relationship between dating violence and recent substance use (marijuana and alcohol, number of days used past 4 months) with a justice-involved, Latinx sample at first contact with the justice system. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: David Hoskins Tags: Symposium 17 Source Type: research

17.3 the neighborhood environment and adolescent dating violence among first-time offending, justice-involved youth
This study, driven by Social Disorganization Theory, examines whether neighborhood factors (cohesion and disadvantage) are associated with ADV among a cohort of court-involved nonincarcerated (CINI) youth. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Emily Dauria Tags: Symposium 17 Source Type: research

17.4 stalking perpetration among justice-involved youth: the role of personality traits and emotion dysregulation
This study examined stalking among court-involved, nonincarcerated (CINI) adolescents, including: the prevalence of stalking perpetration and victimization; individual characteristics of perpetrators; and overlap of stalking perpetration with bullying, interpersonal violence with a romantic partner (IPV), and social networking abuse (SNA). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Evan Holloway Tags: Symposium 17 Source Type: research

The gut microbiota in autism spectrum disorder: from bench to bedside
This Symposium will review current evidence implicating the microbiota-gut-brain axis in the pathophysiology and treatment of autism spectrum disorder (ASD). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Chadi A. Calarge, James T. McCracken Tags: Symposium 18 Source Type: research

18.1 examining the role of the gut microbiota in mental health
The objective of this presentation is to review evidence in support of the microbiota-gut-brain axis, along with the mechanisms that mediate this association. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Chadi A. Calarge Tags: Symposium 18 Source Type: research

18.2 mechanisms underlying microbial-mediated changes in social behavior in mouse models for autism spectrum disorder
A precision microbial-based therapy, Lactobacillus reuteri, was previously shown to reverse social deficits in maternal high-fat-diet offspring, an environmental mouse model for autism spectrum disorder (ASD). However, whether the effect of L. reuteri on social behavior is generalizable to other ASD mouse models and its mechanism(s) of action remain unknown. Here, we investigated whether L. reuteri is able to rescue the social deficits in ASD mouse models associated with different underlying etiologies. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Martina Sgritta Tags: Symposium 18 Source Type: research

18.3 identifying factors that alter the gut microbiome and affect associated behavioral and gastrointestinal symptoms in autism spectrum disorder
This presentation will focus on the identification of clinical factors that are important considerations when evaluating microbiome and metabolome data in autism spectrum disorder (ASD). Using the extensive data obtained from a large, well-controlled pediatric cohort (including children with and without ASD, with and without gastrointestinal [GI] issues, and unaffected siblings), the effects of dietary preferences, medication regimens, behavioral characteristics, and therapeutic options will be discussed. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Ruth Ann Luna Tags: Symposium 18 Source Type: research

18.4 microbiota transplant therapy for children with autism spectrum and gastrointestinal disorders
The objective of this presentation is to determine the safety and efficacy of microbiota transplant therapy (MTT) for children with autism spectrum disorder (ASD) who have gastrointestinal (GI) problems (constipation and/or diarrhea). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: James Adams Tags: Symposium 18 Source Type: research

Epigenetics and inflammation in childhood psychiatric disorders: evidence from animal models
This session focuses on animal models that have been used to study the role of epigenetic and inflammatory mechanisms in neurodevelopment and behavior. Animal model systems are valuable tools for advancing our understanding of child and adolescent mental health disorders and improving the lives of the children and adolescents affected. Similar to the organizers ’ symposia from past years, this session provides a forum for novel animal model work relevant for child and adolescent psychiatry to be presented to a wide range of audience members, from those who care for children and families full time, to those performing...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Angela M. Reiersen, Sunil Q. Mehta Tags: Symposium 19 Source Type: research

19.1 neuroimmune, epigenetic, and metabolic interactions during symptom progression in a mouse model of rett syndrome
Mutations in the X-linked gene MECP2 cause Rett syndrome (RTT), a neurodevelopmental disorder in females. Because of the complex MeCP2 mutant/wild-type mosaicism observed in MeCP2 mutant female mice, the majority of RTT preclinical studies are performed only on MeCP2 null male mice lacking MeCP2 in all cells. But RTT patients are heterozygous females that exhibit delayed and progressive symptom onset beginning in late infancy, including neurologic as well as metabolic, immune, respiratory, and gastrointestinal phenotypes. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Janine M. LaSalle, Dag H. Yasui, Kari E. Neier, Sharifi Osman, Annie Vogel Ciernia, Rebecca Palmer, Tiana E. Grant, Sophia M. Hakam Tags: Symposium 19 Source Type: research

19.2 animal models and the role of epigenetics in adhd
The biological mechanisms of ADHD have traditionally focused on the role of different gene variants of dopamine and other neurotransmitter-regulating proteins. In utero drug exposure, poverty, and early adverse life events have also been associated with increased risk for ADHD. This presentation will focus on animal models that have shed light on possible epigenetic mechanisms that connect neurobiological mechanisms and the risk for ADHD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Paul E.A. Glaser Tags: Symposium 19 Source Type: research

19.3 developmental exposure to near-roadway pollution produces behavioral and histological phenotypes relevant to neurodevelopmental disorders
Epidemiological studies consistently implicate traffic-related air pollution (TRAP) and/or proximity to heavily trafficked roads as risk factors for developmental delays and neurodevelopmental disorders (NDDs); however, there are limited preclinical data demonstrating a causal relationship. To test the effects of TRAP, pregnant rat dams were transported to a vivarium adjacent to a major freeway tunnel system in Northern California where they were exposed to TRAP drawn directly from the tunnel or filtered air (FA). (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Jill L. Silverman, Elizabeth L. Berg, Kelley T. Patten, Anthony E. Valenzuela, Christopher Wallis, Janine M. LaSalle, Annie Vogel Ciernia, Keith J. Bein, Anthony S. Wexler, Pamela J. Lein Tags: Symposium 19 Source Type: research

19.4 the effect of maternal inflammation on striatal development and autism spectrum disorder –relevant phenotypes
Neuropsychiatric disorders of childhood have disruptions of striatal-dependent learning. Embryonic development of the striatum underpins all subsequent striatal function. There are gaps in knowledge about factors that disrupt striatal development and the mechanisms by which striatal developmental changes may affect learning. The striatum is often enlarged in individuals with autism spectrum disorder (ASD); we have pilot data suggesting that prenatal maternal stress causes overproduction of striatal neurons. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Hanna E. Stevens, S. Banu Gumusoglu, Jonathan Dowell, Benjamin Elser, Edenia Menezes, Jessica DeWitt, Olivia Lewis Tags: Symposium 19 Source Type: research