2.1 recent national trends in youth suicide and suicidal behavior
Jeff Bridge, PhD, will provide context for the session by reviewing recent trends and disparities in suicide among children and adolescents in the United States. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Jeff Bridge Tags: Symposium 2 Source Type: research

2.2 changing face of suicidal behaviors and suicide for girls: the social media connection
The objectives of this presentation are to discuss: 1) how social media (SM) may contribute to increasing numbers of preadolescent and early adolescent girls; 2) the results of qualitative interviews with teenagers about the impact of SM use on mood and suicidal thoughts and behaviors; and 3) early results from a pilot feasibility study that collected subjective and objective SM data from teenagers who recently attempted suicide. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Jamie Zelazny Tags: Symposium 2 Source Type: research

2.3 early vulnerability among minority youth with and without a parental history of suicidal behavior
This presentation aims to discuss early vulnerability factors of suicidal behavior in Black/minority youth with (PH+) and without (PH-) a parental history of suicidal behavior. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Arielle H. Sheftall Tags: Symposium 2 Source Type: research

2.4 report from the congressional black caucus taskforce for black youth suicide and mental health
The Congressional Black Caucus convened an emergency task force focused on Black youth suicide and mental health. This presentation will present the findings from this task force ’s workgroup report focusing on research, policy, and practice. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Rhonda C. Boyd Tags: Symposium 2 Source Type: research

Integrating mind, brain, and body in the research and treatment of pediatric mood disorders
The presentations in this Symposium address mood disorders in youth from a combination of dimensional, diagnosis-driven, and familial-genetic perspectives. Each presentation spans at least one of the bridges between mind, brain, and body, such that collectively the Symposium is intended to provide attendees with clinically relevant, integrative perspectives on mood disorders in youth. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Benjamin I. Goldstein, Kathryn R. Cullen Tags: Symposium 3 Source Type: research

3.1 adolescents ’ motivated behavior predicts anhedonia and is associated with inflammation via neural response to reward
Inflammation is related to affective disorders, potentially through influence on neural reward circuitry, reward-motivated behavior, and the symptom of anhedonia, or difficulty with enjoyment of or motivation to obtain pleasant experiences. This pathway could contribute to the development of affective psychopathology in adolescence, a vulnerable period of ongoing development in reward systems. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Erika E. Forbes Tags: Symposium 3 Source Type: research

3.2 sex differences in cerebral blood flow among adolescents with bipolar disorder
We examined sex differences in CBF among adolescents with BD vs healthy controls (HC), and we hypothesized a significant interaction effect on CBF. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Rachel Mitchell, Anahit Grigorian, Andrew Robertson, Nicholas Luciw, Arron Metcalfe, Henk J. Mutsaerts, Lisa Fiksenbaum, Brad MacIntosh, Benjamin I. Goldstein Tags: Symposium 3 Source Type: research

3.3 neural mechanisms of a mindfulness-based intervention for youth at risk for bipolar disorder
In youth at familial risk for bipolar disorder (BD), mood lability is an important precursor to BD onset. Previous work in adults indicates that mindfulness-based interventions (MBI) may improve emotion regulation, in part by increasing resting-state functional connectivity (rsFC) between the posterior cingulate cortex (PCC) and executive control network (ECN). In this pilot study, we assessed whether an MBI could increase PCC-ECN rsFC and decrease mood lability in at-risk early adolescents. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Danella Hafeman, Noelle Ostroff, Jamie Feldman, Mary Phillips, J. David Creswell, Boris Birmaher, Tina R. Goldstein Tags: Symposium 3 Source Type: research

3.4 clinical and neuroimaging correlates of cardiorespiratory fitness in adolescents with bipolar disorder
Cardiovascular disease (CVD) is more prevalent, and occurs prematurely, in individuals with bipolar disorder (BD) vs the general population. Cardiorespiratory/aerobic fitness (CRF) is the most important modifiable CVD risk factor and is also associated with brain structure and function. No prior study has examined this topic in adolescents with BD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Benjamin I. Goldstein, Najla Popel, Kody Kennedy, Lisa Fiksenbaum, Rachel Mitchell, Brad MacIntosh Tags: Symposium 3 Source Type: research

Novel early intervention in autism spectrum disorder: basic principles and new research
Autism spectrum disorder (ASD) is characterized by social communication deficits and restricted repetitive behaviors. Early intervention is critical for optimal outcomes in ASD. However, parents need guidance in selecting which treatments to try and providers, including child and adolescent psychiatrists, need to be familiar with available interventions. There is growing consensus that treatments that integrate both behavioral learning principles and developmental theory hold particular promise for young children with ASD. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Antonio Hardan, Grace W. Gengoux, Jeremy Veenstra-VanderWeele Tags: Symposium 4 Source Type: research

4.1 pivotal response treatment: application to new populations and service-delivery models
This presentation will introduce pivotal response treatment (PRT), a naturalistic developmental behavioral intervention for autism spectrum disorder (ASD). A review of recent randomized controlled trials will take place, followed by new data from 2 studies applying PRT to broader populations and novel service-delivery models. Our aim is to highlight new data particularly relevant to the practice of child and adolescent psychiatry. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Grace W. Gengoux, Ambreen Shahabuddin, Jessica Schwartzman, Rachel Schuck, Kristen Strong, Christina Ardel, Antonio Hardan Tags: Symposium 4 Source Type: research

4.2 outcomes and factors underlying intervention response for children with autism spectrum disorder receiving the early start denver model
The presentation will address recent research on the Early Start Denver Model (ESDM), a naturalistic developmental behavioral intervention designed to address social, cognitive, and adaptive deficits in young children with autism spectrum disorder (ASD). We will present novel data focused on group-level outcomes as well as child- and context-related factors associated with optimal vs suboptimal intervention response. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Giacomo Vivanti, Cheryl Dissanayake, Cathy Bent, Sally J. Rogers Tags: Symposium 4 Source Type: research

4.3 initial efficacy of a short-term parent-mediated intervention for core social communication skills: baby jasper
This presentation examines social communication outcomes of a randomized trial of Baby JASPER, a downward extension of an evidence-based parent-mediated intervention. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Amanda Gulsrud, Kyle Sterrett, Connie Kasari Tags: Symposium 4 Source Type: research

4.4 a randomized controlled trial of a developmental reciprocity treatment program in young children with autism spectrum disorder
Developmental approaches have been used in autism spectrum disorder (ASD) treatment for decades, and empirical support is growing. These procedures focus on child-led interactions and embedding teaching within affectively rich social interactions. As the ASD field increasingly incorporates these techniques into behavioral early-intervention programming, there remains a need for controlled trials to objectively evaluate the efficacy of these popular and promising treatment procedures. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Antonio Hardan, Maria Estefania Millan, Gina Baldi, Jennifer Phillips, Rebecca Goodman, Grace W. Gengoux Tags: Symposium 4 Source Type: research

Made to measure: perspectives on promoting outcome quality to enhance care for adolescent depression
These presentations will describe the variability of outcomes and the quality of outcome measurement instruments currently used to measure adolescent MDD as well as discuss the importance of the need for enhanced measurement-based care in pediatric mental health disorders. The clinical implications stemming from the current research being conducted in measurement-based care will be reviewed and discussed in an interactive fashion. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Peter Szatmari, Oscar Gary Bukstein Tags: Symposium 5 Source Type: research

5.1 what to measure? the need for a core outcome set in adolescent mdd trials
The wide heterogeneity in what, how, and when outcomes are measured in adolescent MDD trials limits the evaluation of treatment efficacy, because individual trial results cannot be pooled together and conclusions around the most effective treatment cannot be made. A Core Outcome Set (COS), as defined by the COMET (Core Outcome Measures in Effectiveness Trials) Initiative, is an agreed standardized set of outcomes that should be measured and reported as a minimum in all clinical trials and audits in a specific area of health or health care. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Suneeta Monga Tags: Symposium 5 Source Type: research

5.2 from research to practice: are our measurement tools fit for purpose?
The objectives of this study were to identify which OMIs are commonly used in clinical research studies of MDD in adolescents and to evaluate their appropriateness for use in this population. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Nancy Butcher Tags: Symposium 5 Source Type: research

5.3 a global standard set of outcomes for routine use with children and young people with anxiety, depression, ocd, or ptsd
The global burden from depression and anxiety in childhood and adolescence is high. There is a pressing need for early and effective intervention, but treatments performing well in trials do not always deliver the expected results in practice. Valid and meaningful outcome data are central to understanding and improving the effectiveness of routine care. However, the absence of a global standard for measuring outcomes is currently limiting data quality, consistency, and availability. The International Consortium for Health Outcomes Measurement (ICHOM) convened a working group of 27 clinical, research, and lived-experience e...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Karolin Krause Tags: Symposium 5 Source Type: research

5.4 tailoring treatment over time: a clinical trial using measurement-based care within an integrated care pathway
Dr. David Sackett's concept of evidence-based care involves the synthesis among: 1) research evidence; 2) clinician expertise; 3) the context in which care is taking place; and 4) patient values. Integrated care pathways (ICPs) are treatment algorithms intended to bring this conceptualization to life. Our team developed an ICP for the management of adolescent depression with a psychotherapy stream and a medication stream. The ICP emphasizes the use of measurement-based care, where youth participants complete the Mood and Feelings Questionnaire every 4 weeks to guide collaborative treatment decisions. (Source: Journal of th...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Darren Courtney Tags: Symposium 5 Source Type: research

The benefits and potential harms of technology: an international perspective
There has been an exponential rise in the use of technology by children and young people (CYP). Novel developments for the use of technology in mental health are rapidly emerging, presenting challenges for implementation. This Symposium discusses the evidence for benefits and potential harms and challenges of technology use. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Bernadka Dubicka, Paul Mitrani Tags: Symposium 6 Source Type: research

6.1 artificial intelligence chatbot for depression in youth: development, usage, and outcomes
Artificial intelligence –based chatbots could be a scalable resource for treating mental health problems in youth. There is limited information about how chatbots are developed and used and about their effects in treating depression. Study 1: This presentation will describe how users engage with a chatbot designed to add ress depression. Study 2: This presentation will present preliminary data on a randomized controlled study for depression in youth. Study 3: This presentation will provide recommendations on how booster sessions for a depression study in adolescents could be developed through chatbots. (Source: Journ...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Eduardo L. Bunge Tags: Symposium 6 Source Type: research

6.2 the benefits and potential harms of technology: a uk perspective
Much anxiety exists around the potential harms of screen use in children and young people. In the United Kingdom, this has generated significant media and government interest. As a response, the Royal College of Psychiatrists published a report in January 2020 on the benefits and potential harms of technology, to much national and international interest. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Bernadka Dubicka Tags: Symposium 6 Source Type: research

6.3 beyond apps: integrating technology in practice
This presentation aims to: 1) provide a brief overview of the evidence supporting the use of technology to support therapy; 2) outline the strengths and challenges of this approach; and 3) present an example of a digital ecosystem to address the challenges. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Sally N. Merry Tags: Symposium 6 Source Type: research

6.4 better together: working with industry to understand online risks
This presentation aims to: 1) describe how a collaboration with a social media platform increased understanding of an online behavior; 2) examine the validity of the concept of “digital self-harm"; and 3) outline how support is possible in-platform. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Richard D. Graham Tags: Symposium 6 Source Type: research

Integrating recent research findings into the care of children and adolescents with anxiety disorders
This presentation aims to apply recent findings from the Child/Adolescent Anxiety Multimodal Study (CAMS) and Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS) to individualize psychotherapeutic and psychopharmacologic treatments for youth with anxiety disorders and to enhance long-term outcomes. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Jeffrey Robert Strawn, James T. McCracken Tags: Symposium 7 Source Type: research

7.1 enhancing clinical decision making to improve outcomes for anxious youth
The objective of this presentation is to review factors impacting treatment response for anxiety and to demonstrate how they can be used to inform clinical decision making that leads to more robust therapeutic outcomes. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: John Piacentini Tags: Symposium 7 Source Type: research

7.2 pharmacotherapy in the child/adolescent anxiety multimodal study and beyond
This presentation aims to summarize recent findings from the Child/Adolescent Anxiety Multimodal Study (CAMS), RCTs, and meta-analyses of SSRIs and SNRIs in pediatric anxiety disorders. It also aims to review data that will allow clinicians to tailor pharmacotherapy for anxious youth. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Jeffrey Robert Strawn Tags: Symposium 7 Source Type: research

7.3 long-term outcomes in pediatric anxiety disorders
Anxious youth contend with substantial distress and impairment and are at heightened risk for a host of negative outcomes in adulthood including depression, substance use, educational underachievement, and poor physical health. This presentation seeks to provide data related to the long-term outcomes of anxious youth who receive evidence-based treatments. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Tara Peris Tags: Symposium 7 Source Type: research

7.4 look to the future: models of integrated care/collaborative care
Integrating mental health care into pediatric primary care offers the opportunity to improve mental health outcomes by early identification and early intervention. This presentation will focus on strategies to disseminate findings from the Child/Adolescent Anxiety Multimodal Study (CAMS) and the Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS) into pediatric primary care. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: John T. Walkup Tags: Symposium 7 Source Type: research

Youth self-harm and suicide: causes and prediction
Suicide is the second leading cause of death for adolescents, with an increasing prevalence. Knowing which at-risk youth will go on to a suicide attempt and how this process occurs is critical for directing and developing treatment. To that end, we present an update from cutting-edge predictive and mechanistic research on youth self-injury and suicide. This Symposium will present emerging, unpublished findings using computation models and cognitive neuroscience methods to advance our understanding of risk and mechanisms. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Daniel P. Dickstein, Joel Stoddard Tags: Symposium 8 Source Type: research

8.1 dysregulation and suicide risk: combining levels of analysis for predicting risk
This presentation aims to determine whether the addition of measures of cognitive control and physiological response to stress are associated with suicidal thoughts and behaviors in children and adolescents. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Robert R. Althoff Tags: Symposium 8 Source Type: research

8.2 brain connectivity in adolescent girls with and without a history of nonsuicidal self-injury
Nonsuicidal self-injury (NSSI) is a serious clinical problem that is highly prevalent in adolescents and represents an important risk factor for future suicide attempts. This longitudinal study is examining how neural circuitry relates to NSSI and other risk factors across early adolescence to midadolescence. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Kathryn R. Cullen Tags: Symposium 8 Source Type: research

8.3 aberrant reward function and structure is associated with suicidal ideation and behavior in youth with depression and obesity
Youth with depression and obesity report varying degrees of suicidal ideation (SI) and nonsuicidal self-injury (NSSI). Anticipatory reward dysfunction in the orbitofrontal cortex (OFC) is a key biobehavioral mechanism underlying the emergence of depression symptoms, but the association with the emergence of SI and NSSI is unknown. To better understand the neural mechanisms associated with SI and NSSI behaviors, we examined their relationship with reward structure and function in youth with depression and obesity. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Manpreet K. Singh, Akua Nimarko, Ananya Nrusimha, Aaron Gorelik, Nicholas Rodriguez, Kayla Carta, Yvonne Lu, Jaskanwaljeet Kaur, Kelsey Hagan, Adina Fischer Tags: Symposium 8 Source Type: research

8.4 advancing what is known about brain/behavior mechanisms underlying nonsuicidal self-injury and youth suicide
Despite our best clinical care, suicide has risen to become the second leading cause of death in 10- to 34-year-old individuals in the United States. Relatedly, nonsuicidal self-injury (NSSI) —defined as deliberate self-harm without intent to die—is also increasingly common, affecting upwards of 18% of children and adolescents. This presentation seeks to address both problems by discussing shared vs unique brain/behavior mechanisms in jargon-free language useful to child and adolesce nt psychiatrists. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Daniel P. Dickstein, Heather A. MacPherson, Kerri L. Kim, Gilbert Anna, Lena DeYoung, Gracie Jenkins, Barthelemy Christine Tags: Symposium 8 Source Type: research

Predictors of course and outcomes in youths and young adults with bipolar spectrum disorders
This Symposium will provide an overview of updated findings from the Course and Outcome of Bipolar Youth (COBY) and Predicting Adult Outcomes of Bipolar Youth (PROBY) studies, which have followed the same cohort longitudinally. Data will be presented regarding psychosocial functioning, energy, medication effects, and individualized risk prediction. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Heather Meg Hower, Eric Youngstrom Tags: Symposium 9 Source Type: research

9.1 predictors of longitudinal psychosocial functioning in youth with bipolar disorder transitioning to adults
In a sample of participants diagnosed with bipolar disorder (BD) in youth, we aim to: 1) examine longitudinal psychosocial functioning; 2) determine whether psychosocial impairment remains in those who remitted from mood disorders during later periods of follow-up; and 3) examine predictors of psychosocial impairment despite symptomatic remission. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Heather Meg Hower Tags: Symposium 9 Source Type: research

9.2 correlates, course, and outcomes of increased energy in youth with bipolar disorder
The conceptualization of bipolar disorder (BD) has recently changed such that, in the DSM-5, diagnosing BD now requires the presence of increased energy as a gate A criterion for hypo/mania. This change has resulted in some conflicting reactions in the field. The current study assesses whether there are differences between youth with DSM-IV BD who endorsed increased energy, and those who did not, during their baseline worst lifetime mood episode. The longitudinal trajectories of increased energy as a symptom, mental health symptomatology, and clinical outcomes, are also analyzed. (Source: Journal of the American Academy of...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Elisabeth Frazier Tags: Symposium 9 Source Type: research

9.3 lithium vs other mood stabilizers in youth with bipolar disorder: clinical findings and potential mechanisms
There is strong evidence in adults with bipolar disorder (BD) that lithium (LI) reduces mood recurrence, decreases suicide deaths, and reduces hospitalization rates; however, evidence in youth is limited. We use data from the Course and Outcome of Bipolar Youth (COBY) study to assess whether LI vs other mood-stabilizing medication (OMS) is associated with improved outcomes, including mood symptoms and suicidality. Here, we discuss these recently published clinical findings, as well as potential mechanisms for these effects. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Danella Hafeman Tags: Symposium 9 Source Type: research

9.4 predicting personalized risk of mood recurrences in youths and young adults with bipolar spectrum disorders
With each recurrence, the prognosis of bipolar disorder (BD) worsens, indicating the need to identify the factors associated with increased recurrence risk. The course of BD is heterogeneous, and although risk factors for recurrence for the BD group as a whole have been reported in the literature, identification of risk factors for a specific individual are crucial for developing personalized treatments. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Boris Birmaher Tags: Symposium 9 Source Type: research

Iron deficiency and mental health: an under-recognized association
This Symposium will review current evidence implicating iron deficiency (ID) in brain development and psychopathology. It will also review evidence for iron supplementation to optimize neuropsychiatric functioning. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Chadi A. Calarge, Robert L. Findling Tags: Symposium 10 Source Type: research

10.1 preclinical models that support the association between early-life iron status and subsequent mental health
This presentation aims to assess the mechanisms by which fetal and early neonatal iron deficiency (ID) alters short- and long-term neurodevelopmental function and increases the risk of adverse mental health outcomes. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Michael Georgieff Tags: Symposium 10 Source Type: research

10.2 behavioral, developmental, and neurophysiological consequences of iron deficiency in infancy
This presentation aims to describe the effects of iron deficiency (ID) in human infants on short- and long-term outcomes. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Barbara Felt Tags: Symposium 10 Source Type: research

10.3 iron deficiency and internalizing disorders in adolescents
This study sought to examine the association between body iron status, internalizing symptom severity, and subcortical structure volumes in female adolescents. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Chadi A. Calarge Tags: Symposium 10 Source Type: research

10.4 low-dose oral iron therapy for iron deficiency and associated effects on cognition and mental health
Limited data inform treatment recommendations for children and adolescents affected by iron deficiency. Our objective was to evaluate the efficacy of 2 different oral iron preparations in a population of children commonly affected by iron deficiency anemia (IDA) using a low-dose, once-daily treatment approach. Moreover, we reviewed evidence related to the effect of iron supplementation on cognition and mental health in children. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Jacquelyn M. Powers Tags: Symposium 10 Source Type: research

How telomere biology informs the mental health problems of children
Telomeres and their biology faithfully maintain cellular genetic information. Telomere length is increasingly used as a biomarker of health, indicating whether cells have aged or experienced damage. The response of telomeres may mirror cellular stress responses that impact emotional, cognitive, and behavioral functioning. Efforts have been made to better understand factors contributing to mental health disorders of childhood by examining telomere length differences that occur with exposure to risk factors for child mental health disorders and within clinical populations. (Source: Journal of the American Academy of Child an...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Stacy S. Drury, Hanna E. Stevens Tags: Symposium 11 Source Type: research

11.1 intergenerational transmission of childhood trauma? testing cellular aging in mothers exposed to sexual abuse and their children
Exposure to maltreatment during childhood can lead to increased risk for poor health outcomes in adulthood. Child maltreatment and later poor health may be linked by premature biological aging. We tested whether childhood sexual abuse (CSA) is associated with telomere length (TL) in adult females. We further tested the hypothesis of intergenerational transmission of the effects of CSA by measuring TL in both CSA-exposed and nonexposed mothers and their children. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Laura Etzel, Waylon Hastings, Brooke Mattern, Monica Oxford, Frank W. Putnam, Jennie Noll, Idan Shalev Tags: Symposium 11 Source Type: research

11.2 nonhuman primate leukocyte telomere length increases following early-life stress: potential role of biological compensatory responses
Early life stress (ELS) increases susceptibility to mental health disorders and is associated with alterations in telomere length (TL), a marker of accumulated stress and aging. Primate maternal variable foraging demand (VFD) is a validated ELS model resulting in behavioral signs of anxiety and affective disturbance in offspring. Previous work revealed that VFD is accompanied by changes in corticotropin-releasing factor/hypothalamic-pituitary-adrenal (CRF/HPA) axis functioning, insulin resistance, and elevated plasma glucagon-like peptide 1 (pGLP-1), a neurotrophic gastrointestinal incretin peptide maintaining glucose home...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Kathryn K. Ridout, Shariful Syed, Hung-Te Kao, Barbara Porton, Audrey Tyrka, Jeremy D. Coplan Tags: Symposium 11 Source Type: research

11.3 early adversity, psychopathology, and telomere erosion in children and adolescents
The objectives of this presentation are to discuss and synthesize research findings evaluating the associations between early adversity, psychopathology, and telomere erosion longitudinally during childhood and adolescence. Findings from 2 longitudinal samples are included: 1) children who experienced severe psychosocial deprivation in Bucharest, Romania; and 2) community children from the United States. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Kathryn Humphreys Tags: Symposium 11 Source Type: research

11.4 sex differences in the effects of prenatal stress on telomere biology in the developing mouse brain
In this study, we examined whether prenatal stress, a risk factor for mental illnesses, affected telomere biology in the developing brain. In particular, we were interested in sex differences in these effects, because of epidemiological studies suggesting greater impacts of prenatal stress on male offspring. (Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Stephanie Lussier, Allison Momany, Monisa Saravanan, Hanna E. Stevens Tags: Symposium 11 Source Type: research

11.5 the telomere research network
The National Institute on Aging and the National Institute of Environmental Health Sciences launched the Telomere Research Network (TRN) to establish best practices for telomere length measurement in population-based studies and determine the role of telomeres as a marker of early exposures and a predictor of disease. The TRN has worked with telomere experts around the world to address current inconsistencies in the science related to population studies of telomeres. This presentation will outline the current controversies in telomere research related to the measurement of telomere length, inconsistent replications, and me...
Source: Journal of the American Academy of Child and Adolescent Psychiatry - October 1, 2020 Category: Psychiatry Authors: Stacy S. Drury Tags: Symposium 11 Source Type: research