Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an in silico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 6:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identified in...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an in silico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 6:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identified in...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an in silico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 6:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identified in...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
MAPK signaling pathway orchestrates and fine-tunes the pathogenicity of Colletotrichum falcatum
J Proteomics. 2023 Dec 1;292:105056. doi: 10.1016/j.jprot.2023.105056. Online ahead of print.ABSTRACTColletotrichum falcatum is the causal organism of red rot, the most devastating disease of sugarcane. Mitogen-activated protein kinase (MAPK) signaling pathway plays pivotal role in coordinating the process of pathogenesis. We identified eighteen proteins implicated in MAPK signaling pathway in C. falcatum, through nanoLCMS/MS based proteomics approach. Twelve of these proteins were the part of core MAPK signaling pathway, whereas remaining proteins were indirectly implicated in MAPK signaling. Majority of these proteins ha...
Source: Journal of Proteomics - December 3, 2023 Category: Biochemistry Authors: Ranjit Singh Gujjar Rajeev Kumar Sanjay Kumar Goswami Sangeeta Srivastava Sanjeev Kumar Source Type: research
The erythromycin polyketide compound TMC-154 stimulates ROS generation to exert antibacterial effects against Streptococcus pyogenes
This study provides potential options for the treatment of S. pyogenes infections in the future.PMID:38043864 | DOI:10.1016/j.jprot.2023.105057 (Source: Journal of Proteomics)
Source: Journal of Proteomics - December 3, 2023 Category: Biochemistry Authors: Yuan-Feng Yan Ying Liu Hangeri Liang Le Cai Xiao-Yan Yang Tian-Peng Yin Source Type: research
MAPK signaling pathway orchestrates and fine-tunes the pathogenicity of Colletotrichum falcatum
J Proteomics. 2023 Dec 1;292:105056. doi: 10.1016/j.jprot.2023.105056. Online ahead of print.ABSTRACTColletotrichum falcatum is the causal organism of red rot, the most devastating disease of sugarcane. Mitogen-activated protein kinase (MAPK) signaling pathway plays pivotal role in coordinating the process of pathogenesis. We identified eighteen proteins implicated in MAPK signaling pathway in C. falcatum, through nanoLCMS/MS based proteomics approach. Twelve of these proteins were the part of core MAPK signaling pathway, whereas remaining proteins were indirectly implicated in MAPK signaling. Majority of these proteins ha...
Source: Journal of Proteomics - December 3, 2023 Category: Biochemistry Authors: Ranjit Singh Gujjar Rajeev Kumar Sanjay Kumar Goswami Sangeeta Srivastava Sanjeev Kumar Source Type: research
The erythromycin polyketide compound TMC-154 stimulates ROS generation to exert antibacterial effects against Streptococcus pyogenes
This study provides potential options for the treatment of S. pyogenes infections in the future.PMID:38043864 | DOI:10.1016/j.jprot.2023.105057 (Source: Journal of Proteomics)
Source: Journal of Proteomics - December 3, 2023 Category: Biochemistry Authors: Yuan-Feng Yan Ying Liu Hangeri Liang Le Cai Xiao-Yan Yang Tian-Peng Yin Source Type: research
MAPK signaling pathway orchestrates and fine-tunes the pathogenicity of Colletotrichum falcatum
J Proteomics. 2023 Dec 1:105056. doi: 10.1016/j.jprot.2023.105056. Online ahead of print.ABSTRACTColletotrichum falcatum is the causal organism of red rot, the most devastating disease of sugarcane. Mitogen-activated protein kinase (MAPK) signaling pathway plays pivotal role in coordinating the process of pathogenesis. We identified eighteen proteins implicated in MAPK signaling pathway in C. falcatum, through nanoLCMS/MS based proteomics approach. Twelve of these proteins were the part of core MAPK signaling pathway, whereas remaining proteins were indirectly implicated in MAPK signaling. Majority of these proteins had en...
Source: Journal of Proteomics - December 3, 2023 Category: Biochemistry Authors: Ranjit Singh Gujjar Rajeev Kumar Sanjay Kumar Goswami Sangeeta Srivastava Sanjeev Kumar Source Type: research
