A comparative urinary proteomic and metabolomic analysis between renal aa amyloidosis and membranous nephropathy with clinicopathologic correlations
This study is the first comprehensive urinary omics analysis focusing on renal AA Amyloidosis to the best of our knowledge. Based on physiologic roles and clinicopathologic correlations of the molecules; UMOD, AMBP and myo-inositol were related with tubulointerstitial damage, whereas RNase1 and urate were believed to be increased with systemic inflammation and endothelial damage in AA amyloidosis.PMID:38154551 | DOI:10.1016/j.jprot.2023.105064 (Source: Journal of Proteomics)
Source: Journal of Proteomics - December 28, 2023 Category: Biochemistry Authors: Deniz Aral Ozbek Sila Cankurtaran Koc Nazli Ezgi Ozkan Ku çuk Sevilay Erdogan Kablan Idil Yet Meral Uner Nurhan Ozlu Emirhan Nemutlu Incilay Lay Arzu Saglam Ayhan Tolga Yildirim Mustafa Arici Seref Rahmi Yilmaz Yunus Erdem Bulent Altun Source Type: research
The impact of dietary Laminaria digitata and alginate lyase supplementation on the weaned piglet liver: A comprehensive proteomics and metabolomics approach
This study's aim was to investigate the impact of incorporating 10% dietary Laminaria digitata, supplemented with alginate lyase, on the hepatic proteome and metabolome of weaned piglets. These diets introduced minor variations to the metabolome and caused significant shifts in the proteome. Dietary seaweed provided a rich source of n-3 PUFAs that could signal hepatic fatty acid oxidation (FABP, ACADSB and ALDH1B1). This may have affected the oxidative stability of the tissue, requiring an elevated abundance of GST for regulation. The presence of reactive oxygen species likely inflicted protein damage, triggering increased...
Source: Journal of Proteomics - December 27, 2023 Category: Biochemistry Authors: David M Ribeiro Celine C Leclercqc Sophie A B Charton M ónica M Costa Daniela F P Carvalho Kjell Sergeant Emmanuelle Cocco Jenny Renaut Jo ão P B Freire Jos é A M Prates Andr é M de Almeida Source Type: research
A comprehensive proteomic profiling of urinary exosomes and the identification of early non-invasive biomarker in patients with coronary artery disease
J Proteomics. 2023 Dec 25:105059. doi: 10.1016/j.jprot.2023.105059. Online ahead of print.ABSTRACTUrinary small extracellular vesicles or exosomes (uEVs) source could be an emerging trove of biomarkers in coronary artery disease (CAD). It is a chronic inflammatory disease having a long asymptomatic phase of fatty-fibrous development in arteries leading to angina, myocardial infarction, and death. Our study was aimed at identifying differential protein expression profiling of uEVs in CAD. We collected urine samples of CAD patients (n = 41) age 18-65 years and gender matched healthy controls (n = 41). We isolated uEVs using ...
Source: Journal of Proteomics - December 27, 2023 Category: Biochemistry Authors: Pratibha Sharma Ambuj Roy Rajinder K Dhamija Sudha Bhushan Kamal Baswal Rajkumar Kulandaisamy Satyavir Yadav Saroj Kumar Krishna Kishore Inampudi Source Type: research
The impact of dietary Laminaria digitata and alginate lyase supplementation on the weaned piglet liver: A comprehensive proteomics and metabolomics approach
This study's aim was to investigate the impact of incorporating 10% dietary Laminaria digitata, supplemented with alginate lyase, on the hepatic proteome and metabolome of weaned piglets. These diets introduced minor variations to the metabolome and caused significant shifts in the proteome. Dietary seaweed provided a rich source of n-3 PUFAs that could signal hepatic fatty acid oxidation (FABP, ACADSB and ALDH1B1). This may have affected the oxidative stability of the tissue, requiring an elevated abundance of GST for regulation. The presence of reactive oxygen species likely inflicted protein damage, triggering increased...
Source: Journal of Proteomics - December 27, 2023 Category: Biochemistry Authors: David M Ribeiro Celine C Leclercqc Sophie A B Charton M ónica M Costa Daniela F P Carvalho Kjell Sergeant Emmanuelle Cocco Jenny Renaut Jo ão P B Freire Jos é A M Prates Andr é M de Almeida Source Type: research
A comprehensive proteomic profiling of urinary exosomes and the identification of early non-invasive biomarker in patients with coronary artery disease
J Proteomics. 2023 Dec 25:105059. doi: 10.1016/j.jprot.2023.105059. Online ahead of print.ABSTRACTUrinary small extracellular vesicles or exosomes (uEVs) source could be an emerging trove of biomarkers in coronary artery disease (CAD). It is a chronic inflammatory disease having a long asymptomatic phase of fatty-fibrous development in arteries leading to angina, myocardial infarction, and death. Our study was aimed at identifying differential protein expression profiling of uEVs in CAD. We collected urine samples of CAD patients (n = 41) age 18-65 years and gender matched healthy controls (n = 41). We isolated uEVs using ...
Source: Journal of Proteomics - December 27, 2023 Category: Biochemistry Authors: Pratibha Sharma Ambuj Roy Rajinder K Dhamija Sudha Bhushan Kamal Baswal Rajkumar Kulandaisamy Satyavir Yadav Saroj Kumar Krishna Kishore Inampudi Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
Proteomic profiling of membrane vesicles from Mycobacterium avium subsp. paratuberculosis: Navigating towards an insilico design of a multi-epitope vaccine targeting membrane vesicle proteins
J Proteomics. 2023 Dec 7;292:105058. doi: 10.1016/j.jprot.2023.105058. Online ahead of print.ABSTRACTBacteria typically produce membrane vesicles (MVs) at varying levels depending on the surrounding environments. Gram-negative bacterial outer membrane vesicles (OMVs) have been extensively studied for over 30 years, but MVs from Gram-positive bacteria only recently have been a focus of research. In the present study, we isolated MVs from Mycobacterium avium subsp. paratuberculosis (MAP) and analyzed their protein composition using LC-MS/MS. A total of 316 overlapping proteins from two independent preparations were identifie...
Source: Journal of Proteomics - December 8, 2023 Category: Biochemistry Authors: Jen-Jie Lee Mohd Abdullah Jinjing Liu Isabel Azevedo Carvalho Abelardo Silva Junior Maria Aparecida Scatamburlo Moreira Hussni Mohammed Matthew P DeLisa Sean P McDonough Yung-Fu Chang Source Type: research
