Anticoccidial efficacy of Garcinia kola (Heckel H.) against experimental Eimeria tenella infection in chicks
This study evaluated the in vivo anticoccidial activities of the extracts and fractions ofGarcinia kola against experimentalEimeria tenella infection using broiler chickens as experimental subjects. A total of 40 broiler chicks were experimentally infected withE. tenella and assigned randomly into five groups consisting of eight chicks each. Three days post experimental infection groups I and II were administered orally with tween 80 (0.8%) and Amprolium (30 mg/kg) and served as untreated and treated control groups, respectively whereas Groups III, IV, and V were administered orally with crude methanol extract (CME) at d...
Source: Journal of Parasitic Diseases - May 4, 2021 Category: Parasitology Source Type: research
Pre-and post-treatment evaluation of intestinal inflammation in Giardia and Blastocystis infected children: a community-based study
AbstractGiardia intestinalis andBlastocystis hominis cause frequent infections in children in developing countries. However, the role of intestinal inflammation in their pathogenesis is still poorly understood. Faecal calprotectin (FC) level is used as an indicator of intestinal inflammation and neutrophil migration in the intestinal tract. The present study aimed to evaluate intestinal inflammation by measuring FC level among children infected with eitherG. intestinalis orB. hominis before and after treatment. Stool samples were collected from 282 children inhabiting a rural area in Egypt and examined microscopically for ...
Source: Journal of Parasitic Diseases - May 3, 2021 Category: Parasitology Source Type: research
GC –MS screening and antiparasitic action of Putranjiva roxburghii leaves against sensitive and resistant strains of Leishmania donovani
AbstractLooming drug resistance cases of leishmaniasis infection are an undeniably serious danger to worldwide public health, also jeopardize the efficacy of available drugs. Besides this, no successful vaccine is available till date. Since the ancient era, many plants and their parts have been used as medicines against various ailments. Hence, the importance of drug development for new molecules againstLeishmania infection is significant that is a cost-effective and safer drug preferably from the natural herbal resources. We evaluated the GC –MS screening and efficacy ofPutranjiva roxburghii (PR) against the sensitive a...
Source: Journal of Parasitic Diseases - April 26, 2021 Category: Parasitology Source Type: research
Effect of spiramycin versus aminoguanidine and their combined use in experimental toxoplasmosis
In conclusion, the combination of spiramycin and aminoguanidine significantly reduced the parasitic burden, yet, it failed to resolve the pathological sequels in brain tissues ofToxoplasma gondii infected mice. (Source: Journal of Parasitic Diseases)
Source: Journal of Parasitic Diseases - April 26, 2021 Category: Parasitology Source Type: research
A comprehensive and critical overview of schistosomiasis vaccine candidates
AbstractA digenetic platyhelminthSchistosoma is the causative agent of schistosomiasis, one of the neglected tropical diseases that affect humans and animals in numerous countries in the Middle East, sub-Saharan Africa, South America and China. Several control methods were used for prevention of infection or treatment of acute and chronic disease. Mass drug administration led to reduction in heavy-intensity infections and morbidity, but failed to decrease schistosomiasis prevalence and eliminate transmission, indicating the need to develop anti-schistosome vaccine to prevent infection and parasite transmission. This review...
Source: Journal of Parasitic Diseases - April 25, 2021 Category: Parasitology Source Type: research
Unravelling the myth surrounding sterol biosynthesis as plausible target for drug design against leishmaniasis
AbstractThe mortality rate of leishmaniasis is increasing at an alarming rate and is currently second to malaria amongst the other neglected tropical diseases. Unfortunately, many governments and key stakeholders are not investing enough in the development of new therapeutic interventions. The available treatment options targeting different pathways of the parasite have seen inefficiencies, drug resistance, and toxic side effects coupled with longer treatment durations. Numerous studies to understand the biochemistry of leishmaniasis and its pathogenesis have identified druggable targets including ornithine decarboxylase, ...
Source: Journal of Parasitic Diseases - April 24, 2021 Category: Parasitology Source Type: research
Mining the pervasiveness of surra in different animal species of Northeastern states of India: Assam, Mizoram and Tripura
AbstractTrypanosoma evansi is a flagellated, extracellular haemoprotozoan parasite infecting a wide range of mammalian hosts including dromedaries, cattle, equines and dogs cause disease surra. Carrier animals with sub-clinical infection cause significant monetary losses to livestock holders and therefore detection of infection status using molecular diagnostic techniques becomes important in order to control the disease. In the current study cattle, buffalo, goat, pig and dog samples from three northeastern states of India-Assam, Mizoram and Tripura were screened to determine the prevalence of surra. A total of 1702 sampl...
Source: Journal of Parasitic Diseases - April 23, 2021 Category: Parasitology Source Type: research
Morphological and pathological appraisal of Huffmanela sp. (Nematoda: Trichosomoididae) infecting orange-spotted grouper ( Epinephelus coioides , Hamilton, 1822) at Jubail Province, Saudi Arabia: a case report
In conclusion; this case report confirmed the occurrence ofHuffmanela spp. infection in the muscles ofEpinephelus coioides by using light and scanning electron microscopy. Further molecular assessment is recommended. (Source: Journal of Parasitic Diseases)
Source: Journal of Parasitic Diseases - April 22, 2021 Category: Parasitology Source Type: research
Distribution and prevalence of gastrointestinal tract nematodes of sheep at highland and midland areas, Ethiopia
This study was conducted with the objectives of estimating the prevalence of gastrointestinal nematodes infection, and the associated risk factors. The overall prevalence of gastrointestinal nematodes infection was 83% (n = 568). The prevalence of gastrointestinal nematodes infection at Debre-Zeit and Debre-Birhan were 84% and 82.3%, respectively. It was significantly higher in poor body condition and soft faecal consistency (P < 0.05) sheep. The overall mean eggs per gram of faeces was 635.2 (95% CI 590.6–679.9). The mean egg per gram was significantly influenced by site of the study, body condition score a...
Source: Journal of Parasitic Diseases - April 22, 2021 Category: Parasitology Source Type: research
Significant decline of malaria incidence in a low socioeconomic area in the southeast of Iran: 10 years field assessment during malaria elimination programme
AbstractAlthough malaria burden and its active foci have sharply declined after the implementation of elimination programme since 2010, it is still considered as a major public health problem in southeast Iran. This descriptive-analytical study aimed to determine 10-years of malaria epidemiological trends in Bashagard County. Data were collected from 7 selected malarious region of the county based on active and passive surveillance of clinical cases. For diagnosis of malaria, the examination of microscopic slides and rapid diagnostic test, were used. In total, 237 malaria cases were found from 2009 to 2018.Plasmodium vivax...
Source: Journal of Parasitic Diseases - April 22, 2021 Category: Parasitology Source Type: research
Parasite-derived microRNAs as a diagnostic biomarker: potential roles, characteristics, and limitations
AbstractMicroRNAs (miRNAs), a subclass of small regulatory RNAs that present from ancient unicellular protozoans to parasitic helminths and parasitic arthropods. MiRNAs' mode of action has attracted wide attention as a result of their unique functional importance. MiRNAs play a role in diverse physiological and pathological processes ranging from organ development, immune function to apoptosis and cancer at the post-transcription gene expression. Thus, miRNAs are known to be targets for clinical treatment and therapy. The discovery of the high stability of circulating miRNA in various types of host body fluids, such as who...
Source: Journal of Parasitic Diseases - April 22, 2021 Category: Parasitology Source Type: research
Detection of Neoascarophis mariae (Nematoda: Cystidicolidae) parasitic in Parupeneus forsskali and Mulloidichthys flavolineatus (Perciformes: Mullidae) from the Red Sea in Egypt
AbstractThe nematode parasiteNeoascarophis mariae was collected from the intestine ofParupeneus forsskali andMulloidichthys flavolineatus from the Red Sea in Egypt and was described using both light and scanning electron microscopy. It is mainly characterized by the presence of four submedian labia surrounded the oral aperture in the outer side, two sublabia and two pseudolabia in the inner side, rounded cephalic end, and short vestibule in both sexes. The females vulva is located near the posterior end of the body, their oval uterine eggs have a smooth surface devoid of filaments. Males have bifurcated deirids, a large le...
Source: Journal of Parasitic Diseases - April 19, 2021 Category: Parasitology Source Type: research
In vitro effect of artemether-loaded nanostructured lipid carrier (NLC) on Leishmania infantum
Conclusion: The NLC-ART can be a good candidate for the treatment of visceral leishmaniasis. (Source: Journal of Parasitic Diseases)
Source: Journal of Parasitic Diseases - April 16, 2021 Category: Parasitology Source Type: research
Histopathologic and histomorphometric evaluation of Dipetalonema evansi infection in camel testicular tissue
This study was carried out on testicular samples of camels infected withD. evansi referred from slaughterhouse. In each of the control and contaminated groups, 5 samples were examined. In this study, in addition to the qualitative description of parasite histopathologic lesions, the spermatogenesis process was evaluated quantitatively including spermatogenesis process, diameter of the seminiferous tubules and Johnsen ranking and compared with the control group. Histopathological examination of infected testis withD. evansi showed lumen obstruction of testicular blood vessels by parasites, hypertrophy of blood vessels, dege...
Source: Journal of Parasitic Diseases - April 16, 2021 Category: Parasitology Source Type: research
Seroprevalence of Neospora caninum and Toxoplasma gondii IgG and IgM antibodies among buffaloes and cattle from Menoufia Province, Egypt
In conclusion, seroprevalence of neosporosis was more than toxoplasmosis in cattle and buffaloes in Menoufia Province, Egypt. (Source: Journal of Parasitic Diseases)
Source: Journal of Parasitic Diseases - April 15, 2021 Category: Parasitology Source Type: research
