Anticoccidial efficacy of Garcinia kola (Heckel H.) against experimental Eimeria tenella infection in chicks

This study evaluated the in vivo anticoccidial activities of the extracts and fractions ofGarcinia kola against experimentalEimeria tenella infection using broiler chickens as experimental subjects. A total of 40 broiler chicks were experimentally infected withE. tenella and assigned randomly into five groups consisting of eight chicks each. Three days post experimental infection groups I and II were administered orally with tween 80 (0.8%) and Amprolium (30  mg/kg) and served as untreated and treated control groups, respectively whereas Groups III, IV, and V were administered orally with crude methanol extract (CME) at doses of 200, 400 and 600 mg/kg, respectively, for five consecutive days. Daily weight gains were recorded and faecal oocysts per gra m (OPG) counts were made by the McMaster Egg counting technique. Blood samples from each experimental group were collected on days 0, 3, 6, and 8 for haematological examination. In the acute toxicity studies, the CME ofG. kola did not produce any toxic effect or mortality at doses between 10 and 5000  mg/kg. The CMEG. kola was then considered safe and the LD50 was assumed to be  >  5000 mg/kg. Graded doses of CME ofG. kola considerably (P <  0.05) improved body weight gain and decreased OPG in a dose-depended manner. There was also significant improvement in the Packed Cell Volume (PCV), Red Blood Cell (RBC) and White Blood Cell (WBC) counts upon treatment with the graded doses of CME ofG. kola. Besides,G. kola...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research