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Urinary β2-microglobulin and disease activity in patients with tubulointerstitial nephritis and uveitis syndrome
ConclusionsU β2M correlate with uveitis activity and trend down over the course of TINU. Uβ2M may serve as a useful tool in determining where patients are in their systemic disease course. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - December 29, 2018 Category: Opthalmology Source Type: research

Syphilitic uveitis misdiagnosed as viral retinitis —a misleading history
ConclusionSyphilitic uveitis does not occur in primary disease and is common in secondary and early latent phase of syphilis. History given by the patient is often contributory however at times can be misleading. A high clinical suspicion and thorough investigation is necessary for the correct diagnosis and timely intervention in preventing loss of vision. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - December 4, 2018 Category: Opthalmology Source Type: research

Laser flare photometry: a cost-effective method for early detection of endophthalmitis after intravitreal injection of anti-VEGF agents
ConclusionLaser flare photometry is a cost-effective method of screening for early stage post-injection endophthalmitis. Values>  50 ph/ms 72-h post-injection should prompt immediate evaluation by an ophthalmologist. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - December 4, 2018 Category: Opthalmology Source Type: research

Clinical presentations, management outcomes, and diagnostic dilemma in Kocuria endophthalmitis
ConclusionsKocuria is a relatively rare cause of endophthalmitis often misdiagnosed asStaphylococcal endophthalmitis. Clinical presentation can be variable but favorable antibiotic susceptibility and appropriate timely management can result in acceptable visual and anatomic outcomes. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - November 20, 2018 Category: Opthalmology Source Type: research

Atypical white dot syndrome with choriocapillaris ischemia in a patient with latent tuberculosis
ConclusionAtypical WDS associated with choriocapillaris hypoperfusion may show features of multiple evanescent white dot syndrome and acute posterior multifocal placoid pigment epitheliopathy melting together. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - November 3, 2018 Category: Opthalmology Source Type: research

Comparative in vitro effectiveness of a novel contact lens multipurpose solution on Acanthamoeba castellanii
ConclusionsResults suggest that the inclusion of a novel ingredient combination within the MPS under development clearly is required and is ideal for rapid and effective killing ofAcanthamoeba species in the context of contact lens disinfection systems. The representative commercially available MPS used in this testing provided minimal effectiveness against the protozoa regardless of contact time. In addition, comparative results with the bacterial agent in the control study show distinct differences in the speed to disinfection with the novel MPS. Future MPS development should consider inclusion of novel chemical entities...
Source: Journal of Ophthalmic Inflammation and Infection - October 24, 2018 Category: Opthalmology Source Type: research

Acute multifocal retinitis: a retrospective review of 35 cases
ConclusionRickettsial disease was the most common cause of acute multifocal retinitis. Other identified causes included cat-scratch disease and syphilis, and a very small subset of patients was diagnosed with idiopathic multifocal retinitis. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - October 17, 2018 Category: Opthalmology Source Type: research

Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study
ConclusionsTears contain similar cytokine profiles to aqueous humor in children with CAU and may be a clinically useful source of disease biomarkers. Tears from children with JIA-U also contain cytokines associated with inflammatory arthritis; furthermore, differential expression of other tear proteins as well may provide clues to intrinsic differences between JIA-U and I-CAU, despite their similar clinical phenotypes. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - October 16, 2018 Category: Opthalmology Source Type: research

Swept-source OCT in patients with multiple evanescent white dot syndrome
ConclusionsSS-OCT imaging allows a better visualization of the choriocapillaris, and its normal appearance in MEWDS may suggest that the outer retina and photoreceptors represent the primary site of inflammation. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - October 13, 2018 Category: Opthalmology Source Type: research

Endogenous endophthalmitis: a 9-year retrospective study at a tertiary referral hospital in Malaysia
ConclusionsThe visual prognosis of endogenous endophthalmitis is often poor, leading to blindness. As expected, gram-negative organisms specificallyKlebsiella pneumonia were the most common organisms isolated. Urinary tract infection was the main source of infection. Poor presenting visual acuity was significantly associated with grave visual outcomes. A high index of suspicion, early diagnosis, and treatment are crucial to salvage useful vision. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - October 11, 2018 Category: Opthalmology Source Type: research

Filamentous gram-negative bacteria masquerading as actinomycetes in infectious endophthalmitis: a review of three cases
ConclusionsGram-negative bacilli can develop abnormal morphology due to stress or sub-inhibitory antibiotic exposure, and it is important for ocular microbiologists and pathologists to be aware of this phenomenon to avoid misinterpretation that may lead to inappropriate treatment. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - October 11, 2018 Category: Opthalmology Source Type: research

An update on inflammatory choroidal neovascularization: epidemiology, multimodal imaging, and management
AbstractInflammatory choroidal neovascular membranes are challenging to diagnose and manage. A number of uveitic entities may be complicated by the development of choroidal neovascularization leading to a decrease in central visual acuity. In conditions such as punctate inner choroidopathy, development of choroidal neovascularization is extremely common and must be suspected in all cases. On the other hand, in patients with conditions such as serpiginous choroiditis, and multifocal choroiditis, it may be difficult to differentiate between inflammatory choroiditis lesions and choroidal neovascularization. Multimodal imaging...
Source: Journal of Ophthalmic Inflammation and Infection - September 12, 2018 Category: Opthalmology Source Type: research

Rituximab and bilateral HSV epithelial keratitis in a patient with mucous membrane pemphigoid
ConclusionsAlthough rituximab is a promising biologic agent for the treatment of autoimmune diseases, it bears the risk of reactivation of viral infections, including the onset of herpes simplex virus keratitis. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - August 23, 2018 Category: Opthalmology Source Type: research