Involvement of peroxisome proliferator ‐activated receptor gamma (PPARγ) and autophagic pathways in the mechanism of action of the tris(2,3‐dibromopropyl) isocyanurate (TDBP‐TAZTO or TBC) flame retardant in the lung adenocarcinoma (A549) cells in vitro
AbstractTris(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO or TBC) belongs to the class of novel brominated flame retardants. TBC is relatively easily released from products both during production and use; hence, it has been detected in various environmental samples. It has also been reported that TBC causes toxic effects in different cell types and now its mechanism of action is connected with oxidative stress. However, the molecular mechanism of the TBC action is mostly unknown. The aim of this study was to determine the involvement of the PPAR γ receptor and certain autophagic proteins (mTOR and p62) in the mechanism of ...
Source: Journal of Applied Toxicology - March 31, 2023 Category: Toxicology Authors: Konrad A. Szychowski,
Bartosz Sk óra Tags: RESEARCH ARTICLE Source Type: research
Responses for the concerns raised for “alendronate reduces the cognitive and neurological disturbances induced by combined doses of d‐galactose and aluminum chloride in mice” (https://doi.org/10.1002/jat.4160) in Journal of Applied Toxicology
(Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - March 31, 2023 Category: Toxicology Authors: Saima Zameer,
Salman Hussain,
Divya Vohora,
Abul Kalam Najmi,
Javed Ali,
Mohd Akhtar Tags: CORRIGENDUM Source Type: research
Evaluation of the effects of Herpes simplex glycoprotein B on complement system and cytokines in in vitro models of Alzheimer's disease
AbstractAlzheimer's disease (AD) is a neurodegenerative disorder that causes memory loss and dementia, and is characterized by a decline in cognitive functions. Brain infections, especially induced byHerpes simplex virus type-1 (HSV-1), are suggested to play a key role in the pathogenesis of AD. Within the scope of this study, two different AD models [Tau model and amyloid beta (A β)] were created in the SH-SY5Y cell line and HSV glycoprotein B (gB) was applied to the cell line and on the generated AD models. Study groups (n = 3) were designed as: 1. control; 2. HSV-gB group; 3. retinoic acid (RA) and brain derived neurot...
Source: Journal of Applied Toxicology - March 31, 2023 Category: Toxicology Authors: Anil Yir ün,
Deniz Arca Çakır,
Sonia Sanajou,
Selinay Başak Erdemli Köse,
Aylin Balcı Özyurt,
Dilara Zeybek,
Özlem Bozdemir,
Terken Baydar,
Pinar Erkekoglu Tags: RESEARCH ARTICLE Source Type: research
Molluscicidal activity of plant alkaloids
AbstractSome snail species pose a serious threat for human health, economy and the environment due to their widespread distribution and the transmission of dangerous parasites causing, among others, schistosomiasis and fascioliasis. Scientists from around the world have been studying the effects of plant extracts on snails for many years in order to find an alternative to molluscicides of synthetic origin. The main purpose of this study was to collect the results obtained so far on the effect of plant alkaloids on snails in the context of their molluscicidal properties. This work presents the results of publications on the...
Source: Journal of Applied Toxicology - March 29, 2023 Category: Toxicology Authors: Sebastian Wszelaki,
Pawe ł Podobiński,
Kacper Środoń Tags: REVIEW ARTICLE Source Type: research
