Anti ‐tumor and cardiotoxic effects of microtubule polymerization inhibitors: The mechanisms and management strategies
AbstractMicrotubule polymerization inhibitors (MPIs) have long been used as anticancer agents because they inhibit mitosis. Microtubules are thought to play an important role in the migration of tumor cells and the formation of tumor blood vessels, and new MPIs are being developed. Many clinical trials of novel MPIs have been conducted in humans, while some clinical studies in dogs have also been reported. More attempts to apply MPIs not only in humans but also in the veterinary field are expected to be made in the future. Meanwhile, MPIs have a risk of cardiotoxicity. In this paper, we review findings on the pharmacologic...
Source: Journal of Applied Toxicology - July 27, 2023 Category: Toxicology Authors: Ryota Tochinai,
Yoshiyasu Nagashima,
Shin ‐ichi Sekizawa,
Masayoshi Kuwahara Tags: REVIEW ARTICLE Source Type: research
The role of mitochondrial dysfunction in macrophages on SiO2 ‐induced pulmonary fibrosis: A review
AbstractSeveral epidemiologic and toxicological studies have widely regarded that mitochondrial dysfunction is a popular molecular event in the process of silicosis from different perspectives, but the details have not been systematically summarized yet. Thus, it is necessary to investigate how silica dust leads to pulmonary fibrosis by damaging the mitochondria of macrophages. In this review, we first introduce the molecular mechanisms that silica dust induce mitochondrial morphological and functional abnormalities and then introduce the main molecular mechanisms that silica-damaged mitochondria induce pulmonary fibrosis....
Source: Journal of Applied Toxicology - July 20, 2023 Category: Toxicology Authors: Jia ‐hui Zhao,
Shuang Li,
Shu‐ling Du,
Zhao‐qiang Zhang Tags: REVIEW ARTICLE Source Type: research
Effect of renal tubular damage on non ‐cancer mortality in the general Japanese population living in cadmium non‐polluted areas
This study aimed to clarify the cause-effect relationship between renal tubular damage and non-cancer mortality in the general Japanese population. We conducted a 19-year cohort study including 1110 men and 1,03 women who lived in three cadmium-non-polluted areas in 1993 or 1994. Mortality risk ratios based on urinary β2-microglobulin (β2MG) and N-acetyl-β-glucosaminidase (NAG) concentrations were estimated for specific non-cancer diseases using the Fine and Gray competing risks regression model. In men, continuous urinary NAG (+1 μg/g cre) concentrations were significantly correlated with increased mortali ty caused...
Source: Journal of Applied Toxicology - July 18, 2023 Category: Toxicology Authors: Sayaka Sakuma,
Kazuhiro Nogawa,
Yuuka Watanabe,
Masaru Sakurai,
Muneko Nishijo,
Masao Ishizaki,
Yuko Morikawa,
Teruhiko Kido,
Hideaki Nakagawa,
Yasushi Suwazono Tags: RESEARCH ARTICLE Source Type: research
Effects of polycaprolactone degradation products on the water flea, Daphnia magna: Carbodiimide additives have acute and chronic toxicity
In this study, we investigated the biological toxicity of substances generated during degradation of polycaprolactone (PCL), a common biodegradable plastic, using the indicator organism,Daphnia magna. We examined PCL, oligocaprolactones (OCLs), and monomers resulting from polymer cleavage, as well as carbodiimides, added during polyester synthesis. As a result, PCL, which is insoluble in water, reduced individual survival and total number of offspring at an exposure concentration of 100 mg/L, while no toxicity was observed for water-soluble degradation products, OCLs, and monomers. Furthermore, carbodiimides, which are ...
Source: Journal of Applied Toxicology - July 14, 2023 Category: Toxicology Authors: Megumi Matsumoto,
Haruka Ito,
Ayaka Tateishi,
Yasuaki Kobayashi,
Kotaro Satoh,
Keiji Numata,
Hitoshi Miyakawa Tags: RESEARCH ARTICLE Source Type: research
Methylglyoxal ‐induced neurotoxic effects in primary neuronal‐like cells transdifferentiated from human mesenchymal stem cells: Impact of low concentrations
AbstractIn the last decades, advanced glycation end-products (AGEs) have aroused the interest of the scientific community due to the increasing evidence of their involvement in many pathophysiological processes including various neurological disorders and cognitive decline age related. Methylglyoxal (MG) is one of the reactive dicarbonyl precursors of AGEs, mainly generated as a by-product of glycolysis, whose accumulation induces neurotoxicity. In our study, MG cytotoxicity was evaluated employing a human stem cell-derived model, namely, neuron-like cells (hNLCs) transdifferentiated from mesenchymal stem/stromal cells, wh...
Source: Journal of Applied Toxicology - July 11, 2023 Category: Toxicology Authors: Teresa Coccini,
Azzurra Schicchi,
Carlo Alessandro Locatelli,
Francesca Caloni,
Sara Negri,
Elena Grignani,
Uliana De Simone Tags: RESEARCH ARTICLE Source Type: research
Neurodevelopmental toxicity of bisphenol AF in zebrafish larvae and the protective effects of curcumin
In this study, the effects of BPAF on neurotoxicity of zebrafish embryos/larvae and whether CUR could reverse effects induced by BPAF were investigated. The results showed that BPAF treatment induced deficits in locomotor behavior, altered the larval brain development, caused aberrant expression of neurogenesis related genes (elavl3,zn5,α-tubulin,syn2a, andgap43), decreased acetylcholinesterase (AChE) activity, and induced oxidative stress, cell apoptosis, and neuroinflammation in zebrafish larvae. CUR addition could block the adverse effects of BPAF on nervous development by attenuated oxidative stress and cell apoptosis...
Source: Journal of Applied Toxicology - July 10, 2023 Category: Toxicology Authors: Qian Yang,
Jianmei Liu,
Jie Ding,
Jining Liu Tags: RESEARCH ARTICLE Source Type: research
Antioxidant dihydrolipolic acid protects against in vitro aluminum ‐induced toxicity
AbstractDihydrolipoic acid (DHLA) is a natural antioxidant known for its ability to counteract metal toxicity and oxidative stress. It has shown the potential to safeguard cells from harmful environmental substances. It may hold therapeutic benefits in treating neurodegenerative disorders by defending against oxidative damage and chronic inflammation. Thus, this study aimed to explore the potential neuroprotective effects of DHLA against aluminum (Al)-induced toxicity using an Alzheimer's disease (AD) model in vitro. The study focused on two important pathways: GSK-3 β and the Wnt signaling pathways. The SH-SY5Y cell line...
Source: Journal of Applied Toxicology - July 7, 2023 Category: Toxicology Authors: Sonia Sanajou,
Anil Yir ün,
Göksun Demirel,
Deniz Arca Çakir,
Gönül Şahin,
Ülfet Pinar Erkekoğlu,
Terken Baydar Tags: RESEARCH ARTICLE Source Type: research
Influences of lysine ‐specific demethylase 1 inhibitors on NO synthase–Kruppel‐like factor pathways in human endothelial cells in vitro and zebrafish (Danio rerio) larvae in vivo
In this study, we compared the influences of ORY-1001 (an LSD1 inhibitor being advanced into clinical trials) and 199 (a novel LSD1 inhibitor recently developed by us) to human umbilical vein endothelial cells (HUVECs) in vitro and further verified the bioeffects of ORY-1001 to zebrafish (Danio rerio) larvae in vivo. The results showed that up to 10 μM ORY-1001 or 199 did not significantly affect the cellular viability of HUVECs but substantially reduced the release of inflammatory interleukin-8 (IL-8) and IL-6. The signaling molecule in vasculatures, NO, was also increased in HUVECs. As the mechanism, the protein level...
Source: Journal of Applied Toxicology - July 6, 2023 Category: Toxicology Authors: Jialin Yuan,
Ruiman Que,
Weichao Zhao,
Fengmei Song,
Yi Cao,
Bin Yu Tags: RESEARCH ARTICLE Source Type: research
Antioxidant dihydrolipolic acid protects against in vitro aluminum ‐induced toxicity
AbstractDihydrolipoic acid (DHLA) is a natural antioxidant known for its ability to counteract metal toxicity and oxidative stress. It has shown the potential to safeguard cells from harmful environmental substances. It may hold therapeutic benefits in treating neurodegenerative disorders by defending against oxidative damage and chronic inflammation. Thus, this study aimed to explore the potential neuroprotective effects of DHLA against aluminum (Al)-induced toxicity using an Alzheimer's disease (AD) model in vitro. The study focused on two important pathways: GSK-3 β and the Wnt signaling pathways. The SH-SY5Y cell line...
Source: Journal of Applied Toxicology - July 6, 2023 Category: Toxicology Authors: Sonia Sanajou,
Anil Yir ün,
Göksun Demirel,
Deniz Arca Çakir,
Gönül Şahin,
Pinar Erkekoğlu,
Terken Baydar Tags: RESEARCH ARTICLE Source Type: research
