Antioxidant dihydrolipolic acid protects against in vitro aluminum ‐induced toxicity
AbstractDihydrolipoic acid (DHLA) is a natural antioxidant known for its ability to counteract metal toxicity and oxidative stress. It has shown the potential to safeguard cells from harmful environmental substances. It may hold therapeutic benefits in treating neurodegenerative disorders by defending against oxidative damage and chronic inflammation. Thus, this study aimed to explore the potential neuroprotective effects of DHLA against aluminum (Al)-induced toxicity using an Alzheimer's disease (AD) model in vitro. The study focused on two important pathways: GSK-3 β and the Wnt signaling pathways. The SH-SY5Y cell line...
Source: Journal of Applied Toxicology - July 6, 2023 Category: Toxicology Authors: Sonia Sanajou,
Anil Yir ün,
Göksun Demirel,
Deniz Arca Çakir,
Gönül Şahin,
Pinar Erkekoğlu,
Terken Baydar Tags: RESEARCH ARTICLE Source Type: research
Influences of lysine ‐specific demethylase 1 inhibitors on NO synthase–Kruppel‐like factor pathways in human endothelial cells in vitro and zebrafish (Danio rerio) larvae in vivo
In this study, we compared the influences of ORY-1001 (an LSD1 inhibitor being advanced into clinical trials) and 199 (a novel LSD1 inhibitor recently developed by us) to human umbilical vein endothelial cells (HUVECs) in vitro and further verified the bioeffects of ORY-1001 to zebrafish (Danio rerio) larvae in vivo. The results showed that up to 10 μM ORY-1001 or 199 did not significantly affect the cellular viability of HUVECs but substantially reduced the release of inflammatory interleukin-8 (IL-8) and IL-6. The signaling molecule in vasculatures, NO, was also increased in HUVECs. As the mechanism, the protein level...
Source: Journal of Applied Toxicology - July 6, 2023 Category: Toxicology Authors: Jialin Yuan,
Ruiman Que,
Weichao Zhao,
Fengmei Song,
Yi Cao,
Bin Yu Tags: RESEARCH ARTICLE Source Type: research
Evaluation of immunotoxicity of sodium metavanadate following drinking water exposure in female B6C3F1/N mice in a 28 ‐day study
The objective of this study was to assess the potential immunotoxicity of NaVO3. Female B6C3F1/N mice were exposed to 0 –500 ppm NaVO3 in drinking water for 28 days and evaluated for effects on immune cell populations and innate, cellular-mediated, and humoral-mediated immunity. There was a decreasing trend in body weight (BW) and BW gain in NaVO3 exposed mice, with a decrease (p ≤ 0.05) in BW gain at ≥250 ppm, relative to control. Conversely, increasing trends in spleen weights and an increase (p ≤ 0.05) in the spleen:BW ratio at ≥250 ppm NaVO3 were observed. NaVO3 exposure altered antibody prod...
Source: Journal of Applied Toxicology - July 5, 2023 Category: Toxicology Authors: Rachel Frawley,
Victor J. Johnson,
Gary R. Burleson,
Keith R. Shockley,
Mark F. Cesta,
Greg Travlos,
Michelle Cora,
Georgia Roberts,
Dori Germolec Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - July 3, 2023 Category: Toxicology Tags: ISSUE INFORMATION Source Type: research
Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis
AbstractEmodin has been demonstrated to possess multiple pharmacological activities. However, emodin has also been reported to induce nephrotoxicity at high doses and with long-term use, and the underlying mechanism has not been fully disclosed. The current study aimed to investigate the roles of oxidative stress and ferroptosis in emodin-induced kidney toxicity. Mice were intraperitoneally treated with emodin, and NRK-52E cells were exposed to emodin in the presence or absence of treatment with Jagged1, SC79, or t-BHQ. Emodin significantly upregulated the levels of blood urea nitrogen, serum creatinine, malondialdehyde, a...
Source: Journal of Applied Toxicology - July 2, 2023 Category: Toxicology Authors: Miao Xing,
Xiaoyu Ma,
Xi Wang,
Haoze Wang,
Minjuan Xie,
Ziwen Zhang,
Jie Zhou Tags: RESEARCH ARTICLE Source Type: research
The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes
AbstractMicroplastics (MPs) and nanoplastics (NPs) are extensively distributed in the environment. However, a comprehensive review and in-depth discussion on the effects of MPs and NPs to reproductive capacity and transgenerational toxicity on mammals, especially on humans, is lacked. It is suggested that microplastics and nanoplastics could accumulate in mammalian reproductive organs and exert toxic effects on the reproductive system for both sexes. For males, the damage of microplastics consists of abnormal testicular and sperm structure, decreased sperm vitality, and endocrine disruption, which were caused by oxidative ...
Source: Journal of Applied Toxicology - June 30, 2023 Category: Toxicology Authors: Yuchong He,
Ruocheng Yin Tags: REVIEW ARTICLE Source Type: research
Ultimate fate, transformation, and toxicological consequences of herbicide pretilachlor to biotic components and associated environment: An overview
AbstractHerbicides are applied for effective weed management in order to increase the crop yield. In recent decades, the overuse of these chemicals has posed adverse effects on different biotic components of the environment. Pretilachlor has been widely used during last few decades for weed management in paddy crop. Its excessive use may prove fatal for environment, various organisms, and nontarget plants. Thus, it is pertinent to know the extent to which herbicide residues remain in environment. The potential mobility and the release rate of herbicide in the soil are important factors governing ecotoxicological impact and...
Source: Journal of Applied Toxicology - June 24, 2023 Category: Toxicology Authors: Vidhi Dhanda,
Ravi Kumar,
Neelam Yadav,
Sarita Sangwan,
Anil Duhan Tags: REVIEW ARTICLE Source Type: research
A novel strategy for the study on molecular mechanism of prostate injury induced by 4,4 ′‐sulfonyldiphenol based on network toxicology analysis
AbstractThe study aimed to investigate the underlying molecular mechanisms of prostate injury induced by 4,4 ′-sulfonyldiphenol (BPS) exposure and propose a novel research strategy to systematically explore the molecular mechanisms of toxicant-induced adverse health effects. By utilizing the ChEMBL, STITCH, and GeneCards databases, a total of 208 potential targets associated with BPS exposure and prostat e injury were identified. Through screening the potential target network in the STRING database and Cytoscape software, we determined 21 core targets including AKT1, EGFR, and MAPK3. Gene ontology (GO) and Kyoto Encyclop...
Source: Journal of Applied Toxicology - June 21, 2023 Category: Toxicology Authors: Shujun Huang Tags: HYPOTHESIS Source Type: research
Evaluation of multigenerational effects of 2 ‐ethylhexyl 4‐hydroxybenzoate in Japanese medaka
AbstractThe Japanese medaka (Oryzias latipes) extended one-generation reproduction test (MEOGRT) (Test Guideline 890.2200) is a Tier 2 test within the Endocrine Disruptor Screening Program of the US Environmental Protection Agency (US EPA). A modified MEOGRT was used to evaluate multigenerational effects of 2-ethylhexyl 4-hydroxybenzoate (2-EHHB) under flow-through conditions starting with adults (parent generation, F0) through a 3-week reproductive phase of the second generation (F2). Fish were exposed to one of five 2-EHHB test concentrations or a dechlorinated tap water control. Fecundity was affected at the lowest expo...
Source: Journal of Applied Toxicology - June 21, 2023 Category: Toxicology Authors: Sharlene Matten,
Dawn Fallacara,
Alaa Kamel,
Scott G. Lynn,
Douglas J. Fort,
Jeffrey C. Wolf,
Tom Leak,
Haley Holst,
Ronnie Joe Bever,
Amy Thomas,
Vincent J. Brown Tags: RESEARCH ARTICLE Source Type: research
