Breast cancer, alcohol, and phosphate toxicity
AbstractAlcohol consumption is associated with an increased risk of breast cancer, even at low alcohol intake levels, but public awareness of the breast cancer risk associated with alcohol intake is low. Furthermore, the causative mechanisms underlying alcohol's association with breast cancer are unknown. The present theoretical paper uses a modified grounded theory method to review the research literature and propose that alcohol's association with breast cancer is mediated by phosphate toxicity, the accumulation of excess inorganic phosphate in body tissue. Serum levels of inorganic phosphate are regulated through a netw...
Source: Journal of Applied Toxicology - June 19, 2023 Category: Toxicology Authors: Ronald B. Brown,
Philip Bigelow,
Joel A. Dubin,
Elena Neiterman Tags: REVIEW ARTICLE Source Type: research
Diffractaic acid exhibits thioredoxin reductase 1 inhibition in lung cancer A549 cells
AbstractLung cancer is the leading cause of cancer-related deaths all over the world. Therefore, it has gained importance in the development of new chemotherapeutic strategies to identify anticancer agents with low side effects, reliable, high anticancer potential, and specific to lung cancer cells. Thioredoxin reductase 1 (TrxR1) is an important therapeutic target for lung cancer treatment because of its overexpression in tumor cells. Here, we aimed to examine the anticancer effect of diffractaic acid, a lichen secondary metabolite, in A549 cells by comparing it with the commercial chemotherapeutic drug carboplatin and al...
Source: Journal of Applied Toxicology - June 18, 2023 Category: Toxicology Authors: Şükran Günaydın,
Emine Karaca Sulukoğlu,
Şeyda Nur Kalın,
Ahmet Altay,
Harun Budak Tags: RESEARCH ARTICLE Source Type: research
L ‐carnitine reverses methotrexate‐induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC‐1α/Nrf2/HO‐1 axis
AbstractMethotrexate (MTX) is a chemotherapeutic agent used for treating several types of cancer as well as psoriasis and rheumatoid arthritis, but its use is limited due to its nephrotoxicity. The purpose of this research work was to observe ameliorative effects of L-carnitine (LC) toward renal toxicity caused by MTX and mechanisms responsible for these effects. Thirty-two male Sprague-Dawley rats were divided into four groups (eight rats/group), control group (received saline), MTX group (20 mg/kg/i.p. once), LC group (500 mg/kg/i.p. for 5 days), and MTX + LC group (received a single MTX dose 20 mg/kg/i.p. fo...
Source: Journal of Applied Toxicology - June 14, 2023 Category: Toxicology Authors: Sara M. Radwan,
Mustafa Alqulaly,
Magdy Y. Elsaeed,
Shimaa Z. Elshora,
Asmaa H. Atwa,
Eman F. Wasfey Tags: RESEARCH ARTICLE Source Type: research
Toxicological effects of selenium nanoparticles in laboratory animals: A review
AbstractThis paper provides a comprehensive summary of the main toxicological studies conducted on selenium nanoparticles (NPs) using laboratory animals, up until February 28, 2023. A literature search revealed 17 articles describing experimental studies conducted on warm-blooded animals. Despite some uncertainties, in vivo studies have demonstrated that selenium NPs have an adverse effect on laboratory animals, as evidenced by several indicators of general toxic action. These effects include reductions of body mass, changes in hepatotoxicity indices (increased enzyme activity and accumulation of selenium in the liver), an...
Source: Journal of Applied Toxicology - June 14, 2023 Category: Toxicology Authors: Yuliya V. Ryabova,
Marina P. Sutunkova,
Ilzira A. Minigalieva,
Lada V. Shabardina,
Tommaso Filippini,
Aristides Tsatsakis Tags: REVIEW ARTICLE Source Type: research
Integrative proteomics and metabolomics analysis of non ‐observable acute effect level PM2.5 induced accumulative effects in AC16 cells
In this study, we approached this question by chronic exposure of AC16 to the non-observable acute effect level (NOAEL) PM2.5 5 μg/mL and its positive reference 50 μg/mL, respectively. The doses were respectively defined on the cell viabilities>95% (p = 0.354) and>90% (p = 0.004) when treated acutely (24 h). To mimic the long-term exposure, AC16 was cultured from the 1st to 30th generations and treated with PM2.5 24 h in every three generations. The integration of proteomic and metabolomic analysis was applied, and 212 proteins and 172 metabolites were significantly altered during the experiments. Th...
Source: Journal of Applied Toxicology - June 6, 2023 Category: Toxicology Authors: Bingru Nan,
Xia Sun,
Shijing Yang,
Qingyu Huang,
Heqing Shen Tags: RESEARCH ARTICLE Source Type: research
Toxicological safety assessment of AP ‐Bio®, a standardized extract of Andrographis paniculata in Sprague Dawley rats
The objective of the present study was to assess the safety of AP-Bio ®, a standardizedA. paniculata extract in Sprague Dawley rats by following the Organisation for Economic Cooperation and Development (OECD) test guidelines of acute and 90-day repeated dose sub-chronic toxicity studies. AP-Bio ® did not show any treatment-related clinical signs of toxicity or mortality during the 14-day observation period in animals tested in the single-dose acute oral toxicity study up to a dose of 5000 mg/kg body weight. In the 90-day repeated dose sub-chronic oral toxicity study, no treatment-relate d adverse clinical signs were o...
Source: Journal of Applied Toxicology - June 4, 2023 Category: Toxicology Authors: Sasi Kumar Murugan,
Bharathi Bethapudi,
Amara Nageswara Rao,
Joseph Joshua Allan,
Deepak Mundkinajeddu,
Prashanth D'Souza Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - June 2, 2023 Category: Toxicology Tags: ISSUE INFORMATION Source Type: research
Disruption of neurosteroid synthesis and release by tris(2,3 ‐dibromopropyl)isocyanurate in primary mouse cortical astrocytes in vitro
AbstractNeurosteroidogenesis in astrocytes is crucial for the proper development and functioning of the brain. During this process, key neurohormones such as progesterone (P4), testosterone (T), and estradiol (E2) are produced. Proper production and release of neurosteroids can be affected by substances referred to as endocrine-disrupting compounds (EDCs). Tris-(2,3-dibromopropyl)isocyanurate (TBC) is a representative of novel brominated flame retardants used to stop ignition or reduce fire-related property damage to plastics, polyolefin, polyphenyl alkene, unsaturated polyester, synthetic rubber, and fibers. Interestingly...
Source: Journal of Applied Toxicology - June 1, 2023 Category: Toxicology Authors: Konrad A. Szychowski,
Bartosz Sk óra Tags: RESEARCH ARTICLE Source Type: research
