Nonclinical safety assessment of an mRNA Covid ‐19 vaccine candidate following repeated administrations and biodistribution
AbstractMessenger RNA (mRNA) vaccines have demonstrated efficacy against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in humans. mRNA technology holds tremendous potential for rapid control and prevention of emergencies due to its flexibility with respect to production, application, and design for an efficacious and safe use in humans. We assessed the toxicity and biodistribution of MRT5500, an mRNA vaccine encoding for the full-length of the SARS-CoV-2 spike protein and delivered by lipid nanoparticles (LNPs) containing a novel ionizable lipid, Lipid-1 in preclinical animal models. In the repeated dose tox...
Source: Journal of Applied Toxicology - September 19, 2023 Category: Toxicology Authors: Karine Broudic,
S ébastien Laurent,
Vladimir Perkov,
Charlene Simon,
Marie Garinot,
Nathalie Truchot,
Julie Latour,
Paul Désert Tags: RESEARCH ARTICLE Source Type: research
Narcissin induces developmental toxicity and cardiotoxicity in zebrafish embryos via Nrf2/HO ‐1 and calcium signaling pathways
In conclusion, here we provide the first evidence that demonstrates narcissin-induced developmental toxicity and cardiotoxicity in zebrafish via Nrf2/HO-1 and calcium signaling pathways for the first time. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - September 18, 2023 Category: Toxicology Authors: Shuo Gao,
Chaoyi Zhou,
Linhua Hou,
Kuo Xu,
Yun Zhang,
Xue Wang,
Jianheng Li,
Kechun Liu,
Qing Xia Tags: RESEARCH ARTICLE Source Type: research
Nonclinical safety assessment of an mRNA Covid ‐19 vaccine candidate following repeated administrations and biodistribution
AbstractMessenger RNA (mRNA) vaccines have demonstrated efficacy against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in humans. mRNA technology holds tremendous potential for rapid control and prevention of emergencies due to its flexibility with respect to production, application, and design for an efficacious and safe use in humans. We assessed the toxicity and biodistribution of MRT5500, an mRNA vaccine encoding for the full-length of the SARS-CoV-2 spike protein and delivered by lipid nanoparticles (LNPs) containing a novel ionizable lipid, Lipid-1 in preclinical animal models. In the repeated dose tox...
Source: Journal of Applied Toxicology - September 18, 2023 Category: Toxicology Authors: Karine Broudic,
S ébastien Laurent,
Vladimir Perkov,
Charlene Simon,
Marie Garinot,
Nathalie Truchot,
Julie Latour,
Paul Désert Tags: RESEARCH ARTICLE Source Type: research
Narcissin induces developmental toxicity and cardiotoxicity in zebrafish embryos via Nrf2/HO ‐1 and calcium signaling pathways
In conclusion, here we provide the first evidence that demonstrates narcissin-induced developmental toxicity and cardiotoxicity in zebrafish via Nrf2/HO-1 and calcium signaling pathways for the first time. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - September 18, 2023 Category: Toxicology Authors: Shuo Gao,
Chaoyi Zhou,
Linhua Hou,
Kuo Xu,
Yun Zhang,
Xue Wang,
Jianheng Li,
Kechun Liu,
Qing Xia Tags: RESEARCH ARTICLE Source Type: research
Developmental and reproductive toxicity hazard characterization of 2 ‐amino‐2‐methyl‐1‐propanol (AMP)
Abstract2-Amino-2-methyl-1-propanol (AMP ™) is a widely used pH stabilizer in personal care products (PCPs); thus, the safety implications of dermal AMP exposure remain of interest. We have previously reported that exposure to AMP in PCPs when used as intended is not anticipated to result in an increased risk of hepatotoxicity (primarily steatosis and altered phospholipid homeostasis). The current study focuses on AMP in PCP's potential for developmental and reproductive toxicity (DART) in humans, based on data from animal studies. Animal studies suggest that exposure to AMP can result in post-implantation loss. However,...
Source: Journal of Applied Toxicology - September 17, 2023 Category: Toxicology Authors: Lindsey Garnick,
Christopher Bates,
Andrey Massarsky,
Pamela Spencer,
Priyanka Sura,
Andrew D. Monnot,
Andrew Maier Tags: REVIEW ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - September 15, 2023 Category: Toxicology Tags: ISSUE INFORMATION Source Type: research
Application of a skin and liver Chip2 microphysiological model to investigate the route ‐dependent toxicokinetics and toxicodynamics of consumer‐relevant doses of genistein
In conclusion, the skin–liver Chip2 provides route-specific information on metabolic fate and toxicodynamics that may be relevant to safety assessment. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - September 13, 2023 Category: Toxicology Authors: Thi ‐Phuong Tao,
Katrin Brandmair,
Silke Gerlach,
Julia Przibilla,
Andreas Schepky,
Uwe Marx,
Nicola J. Hewitt,
Ilka Maschmeyer,
Jochen Kühnl Tags: RESEARCH ARTICLE Source Type: research
Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first ‐pass skin metabolism of the hair dye, 4‐amino‐2‐hydroxytoluene
In conclusion, epidermal and FT skin models u sed in the Chip2 can mimic the first-pass skin metabolism of AHT. This highlights the flexibility of the Chip2 to incorporate different skin models according to the purpose. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - September 13, 2023 Category: Toxicology Authors: Katrin Brandmair,
Thi ‐Phuong Tao,
Silke Gerlach,
Julia Przibilla,
Andreas Schepky,
Uwe Marx,
Nicola J. Hewitt,
Jochen Kühnl,
Ilka Maschmeyer Tags: RESEARCH ARTICLE Source Type: research
Frontier of toxicology studies in zebrafish model
This report may provide a frontier focus benefit to researchers engaging in a zebrafish model for environment, medicine, food, and other fields. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - September 12, 2023 Category: Toxicology Authors: Xinting Shao,
Dandan Xiao,
Zhaoyi Yang,
Lulu Jiang,
Yong Li,
Ye Wang,
Yuling Ding Tags: REVIEW ARTICLE Source Type: research
Snake venom toxins: Potential anticancer therapeutics
AbstractSnake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment of these diseases. In this regard, Captopril used in the treatment of cardiovascular diseases was the first animal venom toxin-based drug approved by the US Food and Drug Administration and the European Medicines Agency. Cancers cause morbidity and mortality worldwide. Due to...
Source: Journal of Applied Toxicology - September 12, 2023 Category: Toxicology Authors: Benedict C. Offor,
Lizelle A. Piater Tags: REVIEW ARTICLE Source Type: research
