Lowering the pH leads to the disaggregation of NiO and ZnO nanoparticles and modifies the mutagenic response
AbstractIn a changing environmental scenario, acid rain can have a significant impact on aquatic ecosystems. Acidification is known to produce corrosion in metals, hence increasing their harmful effects on the environment, organisms and human health. The prevalent use of metallic nanoparticles (NPs) in everyday products raises concerns regarding exposure and nanotoxicity even in these acidified conditions. We thus report on the cytotoxic and genotoxic potential of nickel oxide (NiO-NP) and zinc oxide (ZnO-NP) NPs when suspended in aqueous media in light of pH variations (7.5 and 5). A modified microsuspension method of the...
Source: Journal of Applied Toxicology - October 13, 2023 Category: Toxicology Authors: Ismael Kr üger Pescke,
Lívia de Oliveira Rozino,
Karoline Zenato,
Tatiane Cardozo,
Wladimir Hernandez Flores,
Vera Maria Ferrão Vargas Tags: RESEARCH ARTICLE Source Type: research
Species differences in small intestinal exposure ‐related epithelial vacuolation in rats and dogs treated with a heteroaryldihydropyrimidine molecule
In conclusion, HAP-1-induced intestinal epithelial vacuolation was related to lipid metabolism dysregulation in both species and ER-related injuries in rats only. The species differences were likely related to the difference in intestinal exposure to HAP-1 and its reactive metabolite. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - October 10, 2023 Category: Toxicology Authors: Jieyu Dai,
Tao Chen,
Ryan Meng,
Ferran Jardi,
Stephanie Kourula,
Ly Pham,
Sandra De Jonghe,
Ann De Smedt,
Anna ‐Lena Frisk,
Jianxun Xie Tags: RESEARCH ARTICLE Source Type: research
Inhibition of voltage ‐dependent K+ channels in rabbit coronary arterial smooth muscle cells by the atypical antipsychotic agent sertindole
In this study, native VSMCs from rabbit coronary arteries were used to investigate the inhibitory effect of sertindole, an atypical antipsychotic agent, on Kv channels. Sertindole induced dose-dependent inhibition of Kv channels, with an IC50 of 3.13 ± 0.72 μM. Although sertindole did not cause a change in the steady-state activation curve, it did lead to a negative shift in the steady-state inactivation curve. The application of 1- or 2-Hz train pulses failed to alter the sertindole-induced inhibition of Kv channels, suggesting use-ind ependent effects of the drug. The inhibitory response to sertindole was signif...
Source: Journal of Applied Toxicology - October 9, 2023 Category: Toxicology Authors: Wenwen Zhuang,
Seo ‐Yeong Mun,
Minju Park,
Junsu Jeong,
Hye Ryung Kim,
Sunghun Na,
Se Jin Lee,
Hongzoo Park,
Won Sun Park Tags: RESEARCH ARTICLE Source Type: research
The repeated administration of rhIL ‐12 for 14 weeks in rhesus monkeys: A toxicity assessment
In this study, we conducted a comprehensive evaluation of the toxicity and safety of repeated rhIL-12 (recombinant human interleukin-12) administration in rhesus monkeys by assessing its effects on the immune system, organ function, and vital signs. Rhesus monkeys were subcutaneously injected with 0.5, 2.5, and 12.5 μg/kg of rhIL-12 for up to for 14 consecutive weeks. The low dose exhibited no signs of toxicity, whereas animals receiving higher doses displayed symptoms such as loose stools, reduced activity, anemia, and elevated liver function indicators (AST and TBIL). Following three administrations of 12. 5 μg/kg, ...
Source: Journal of Applied Toxicology - September 29, 2023 Category: Toxicology Authors: Huiqin Ding,
Huan Qin,
Jiangang Wang,
Yansheng Dong,
Quanjun Wang,
Yantao Han Tags: RESEARCH ARTICLE Source Type: research
Dual effects of endogenous formaldehyde on the organism and drugs for its removal
This study offers fresh perspectives for managing illnesses associated with endogenous FA exposure. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - September 28, 2023 Category: Toxicology Authors: Jiaxin Chen,
Wenhui Chen,
Jinjia Zhang,
Huanhuan Zhao,
Ji Cui,
Junzi Wu,
Anhua Shi Tags: REVIEW ARTICLE Source Type: research
In vivo evaluation of the neurogenotoxic effects of exposure to validamycin A in neuroblasts of Drosophila melanogaster larval brain
In this study, we performed a neurotoxic evaluation of validamycin A inD. melanogaster larvae. Several endpoints were evaluated, including toxicity, intracellular oxidative stress (reactive oxygen species), intestinal damage, larval behavior (crawling behavior, light/dark sensitivity assay, and temperature sensitivity assay), locomotor (climbing) behavior, and neurogenotoxic effects (impaired DNA via Comet assay, enhanced by Endo III and formamidopyrimidine DNA glycosylase [FPG]). The results showed that exposure to validamycin A, especially at higher doses (1 and 2.5 mM), induced DNA impairment in neuroblasts as obser...
Source: Journal of Applied Toxicology - September 22, 2023 Category: Toxicology Authors: Fatma Turna Demir,
E şref Demir Tags: RESEARCH ARTICLE Source Type: research
Nonclinical safety assessment of an mRNA Covid ‐19 vaccine candidate following repeated administrations and biodistribution
AbstractMessenger RNA (mRNA) vaccines have demonstrated efficacy against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in humans. mRNA technology holds tremendous potential for rapid control and prevention of emergencies due to its flexibility with respect to production, application, and design for an efficacious and safe use in humans. We assessed the toxicity and biodistribution of MRT5500, an mRNA vaccine encoding for the full-length of the SARS-CoV-2 spike protein and delivered by lipid nanoparticles (LNPs) containing a novel ionizable lipid, Lipid-1 in preclinical animal models. In the repeated dose tox...
Source: Journal of Applied Toxicology - September 19, 2023 Category: Toxicology Authors: Karine Broudic,
S ébastien Laurent,
Vladimir Perkov,
Charlene Simon,
Marie Garinot,
Nathalie Truchot,
Julie Latour,
Paul Désert Tags: RESEARCH ARTICLE Source Type: research
Narcissin induces developmental toxicity and cardiotoxicity in zebrafish embryos via Nrf2/HO ‐1 and calcium signaling pathways
In conclusion, here we provide the first evidence that demonstrates narcissin-induced developmental toxicity and cardiotoxicity in zebrafish via Nrf2/HO-1 and calcium signaling pathways for the first time. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - September 18, 2023 Category: Toxicology Authors: Shuo Gao,
Chaoyi Zhou,
Linhua Hou,
Kuo Xu,
Yun Zhang,
Xue Wang,
Jianheng Li,
Kechun Liu,
Qing Xia Tags: RESEARCH ARTICLE Source Type: research
