Evaluating potential developmental toxicity of perfluoroalkyl and polyfluoroalkyl substances in Xenopus laevis embryos and larvae
The objective of these studies was to examine the developmental toxicity of PFAS using the laboratory model amphibian speciesXenopus laevis. We had two primary aims: (1) to understand the developmental toxicity of a structurally diverse set of PFAS compounds in developing embryos and (2) to characterize the potential impacts of perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), and hexafluoropropylene oxide-dimer acid (HFPO-DA a.k.a. GenX), on growth and thyroid hormone-controlled metamorphosis. We employed a combination of static renewal and flow-through exposure desi...
Source: Journal of Applied Toxicology - March 27, 2024 Category: Toxicology Authors: Sigmund J. Degitz,
Philip P. Degoey,
Jonathan T. Haselman,
Jennifer H. Olker,
Emma H. Stacy,
Chad Blanksma,
Scott Meyer,
Kali Z. Mattingly,
Brett Blackwell,
Anne S. Opseth,
Michael W. Hornung Tags: RESEARCH ARTICLE Source Type: research
Asiatic acid and madecassic acid cause cardiotoxicity via inflammation and production of excessive reactive oxygen species in zebrafish
In this study, sample quantification was done using liquid chromatography –tandem mass spectrometry. The cardiotoxicity of Centella total glycosides, asiaticoside, madecassoside, asiatic acid, and madecassic acid was evaluated using zebrafish and cell models. The zebrafish oxidative stress model and myocarditis model were used to explore further the mechanisms through w hich cardiotoxicity is achieved. Asiatic acid and madecassic acid caused zebrafish cardiotoxicity and H9C2 cell death. However, no toxicity effects were observed for asiaticoside and madecassoside in zebrafish, until the solution was saturated. The result...
Source: Journal of Applied Toxicology - March 26, 2024 Category: Toxicology Authors: Qingquan Guo,
Qiuru Li,
Wenyao Liang,
Yudong Zhang,
Chenyang Jiang,
Yihan Zhang,
Jianhua Tan,
Haishan Zhao Tags: RESEARCH ARTICLE Source Type: research
Chronic low ‐dose chromium VI exposure induces oxidative stress and apoptosis with altered expressions of DNA repair genes and promoter hypermethylation in the liver of Swiss albino mice
AbstractThe present investigation dealt with harmful effects of hexavalent chromium (Cr [VI]) on liver of Swiss albino mice. This variant exhibited cytotoxicity, mutagenicity, and carcinogenicity. Our study focused on elucidating the hepatotoxic effects of chronic low-dose exposure to Cr (VI) (2, 5, and 10 ppm) administered via drinking water for 4 and 8 months. The observed elevation in SGPT, ALP, and SGOT and increased oxidative stress markers unequivocally confirmed the severe disruption of liver homeostasis at these low treatment doses. Noteworthy alterations in histoarchitecture, body weight, and water intake provi...
Source: Journal of Applied Toxicology - March 25, 2024 Category: Toxicology Authors: Shehnaz Islam,
Olivia Sarkar,
Sunanda Mukherjee,
Sreejata Kamila,
Arpan Dey Bhowmik,
Ansuman Chattopadhyay Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - March 18, 2024 Category: Toxicology Tags: ISSUE INFORMATION Source Type: research
Genotoxic and neurotoxic potential of intracellular nanoplastics: A review
AbstractPlastic waste comprises polymers of different chemicals that disintegrate into nanoplastic particles (NPLs) of 1 –100-nm size, thereby littering the environment and posing a threat to wildlife and human health. Research on NPL contamination has up to now focused on the ecotoxicology effects of the pollution rather than the health risks. This review aimed to speculate about the possible properties of carcinog enic and neurotoxic NPL as pollutants. Given their low-dimensional size and high surface size ratio, NPLs can easily penetrate biological membranes to cause functional and structural damage in cells. Once ins...
Source: Journal of Applied Toxicology - March 18, 2024 Category: Toxicology Authors: Claudio Casella,
Santiago J. Ballaz Tags: REVIEW ARTICLE Source Type: research
CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan
In conclusion, these insights pave the way for future research, offering promising avenues for therapeutic interventions targeting CYP-14 activity to address age-related diseases and promote healthy aging. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - March 13, 2024 Category: Toxicology Authors: Sharoen Yu Ming Lim,
Yan Pan,
Mustafa Alshagga,
Willone Lim,
Kong Cin,
Salah A. Alshehade,
Mohammed Alshawsh Tags: REVIEW ARTICLE Source Type: research
Saikosaponin d protects pancreatic acinar cells against cerulein ‐induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS‐STING pathway
In conclusion, SSd protected PACs against cerulein-induced pyroptosis by alleviating mitochondrial damage and inhibiting the cGAS-STING pathway, and it could be a therapeutic candidate for acute pancreatitis. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - March 12, 2024 Category: Toxicology Authors: Hui Chen,
Xirong Lu,
Beiqi Xu,
Gang Cheng,
Yuyi Li,
Dan Xie Tags: RESEARCH ARTICLE Source Type: research
Analysis of cantharidin ‐induced kidney injury and the protective mechanism of resveratrol in mice determined by liquid chromatography/mass spectrometry‐based metabonomics
AbstractCantharidin (CTD) is the main active component in the traditional Chinese medicine Mylabris and an effective anti-tumor agent. However, it is relatively toxic and exhibits nephrotoxicity, which limits its clinical use. However, its toxic mechanism is not clear. The toxic effects of CTD exposure on the kidney and the protective effect of resveratrol (RES) were studied in a mouse model, by determination of serum biochemical and renal antioxidant indicators, histopathological and ultrastructural observation, and metabonomics. After CTD exposure, serum uric acid, creatinine, and tissue oxidative stress indicators incre...
Source: Journal of Applied Toxicology - March 7, 2024 Category: Toxicology Authors: Yuanyuan Xiao,
Ruxia Liu,
Xiaoyue Zhang,
Yaofeng Li,
Fang Peng,
Wenchao Tang Tags: RESEARCH ARTICLE Source Type: research
