Pitavastatin induces caspase ‐mediated apoptotic death through oxidative stress and DNA damage in combined with cisplatin in human cervical cancer cell line
This study was aimed to elucidate the effect of PITA alone and in combination with cisplatin on cervical cancer cells (HeLa) in vitro. Cytotoxicity of PITA (5 –200 μM) was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red uptake (NRU) assays for 24, 48, and 72 h. Cell apoptosis and cell cycle analyses were performed in flow cytometry (0.1–100 μM). The evaluation of genotoxic effects and oxidative D NA damage of PITA (2–200 μM) were performed with standard comet assay, formamidopyrimidine glycosylase (fpg)-modified comet assay, and reactive oxygen species (ROS) ...
Source: Journal of Applied Toxicology - December 6, 2023 Category: Toxicology Authors: Aysun Ökçesiz Hacıseyitoğlu,
Tuğbagül Çal Doğan,
Sevtap Aydın Dilsiz,
Hande Canpınar,
Ayşe Eken,
Ülkü Ündeğer Bucurgat Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - December 5, 2023 Category: Toxicology Tags: ISSUE INFORMATION Source Type: research
Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum ‐induced neurotoxicity in an in vitro Alzheimer's disease model
AbstractAlzheimer's disease (AD) is a progressive neurological disorder that affects various cognitive functions, behavior, and personality. AD is thought to be caused by a combination of genetic and environmental factors, including exposure to aluminum (Al). Virgin coconut oil (VCO) may have potential as a natural neuroprotectant against AD. Aim of this study was to determine neuroprotective effects of VCO on Al-induced neurotoxicity in an in vitro AD model. SH-SY5Y cells were initially cultured in normal growth medium and then differentiated by reducing fetal bovine serum content and adding retinoic acid (RA). Later, bra...
Source: Journal of Applied Toxicology - November 22, 2023 Category: Toxicology Authors: G öksun Demirel,
Sonia Sanajou,
Anil Yirün,
Deniz Arca Çakir,
Aysel Berkkan,
Terken Baydar,
Pinar Erkekoğlu Tags: RESEARCH ARTICLE Source Type: research
Biological effects of molybdenum(IV) sulfide nanoparticles and microparticles in the rat after repeated intratracheal administration
In this study, molybdenum(IV) sulfide (MoS2) nanoparticles (97 ± 32 nm) and microparticles (1.92 ± 0.64 μm) stabilized with poly (vinylpolypyrrolidone) (PVP) were administered intratracheally to male and female rats (dose of 1.5 or 5 mg/kg bw), every 14 days for 90 days (seven administrations in total). Blood parameters were assessed during and at the end of the study (hematology, biochemistry including glucose, albumins, uric acid, urea, high density lipoprotein HDL, total cholesterol, triglycerides, aspartate transaminase, and alanine transaminase ALT). Bronchoalveolar lavage fluid (BALF) analyses in...
Source: Journal of Applied Toxicology - November 16, 2023 Category: Toxicology Authors: Z. Soba ńska,
K. Sitarek,
J. Gromadzińska,
R. Świercz,
M. Szparaga,
K. Domeradzka‐Gajda,
K. Kowalczyk,
L. Zapór,
W. Wąsowicz,
J. Grobelny,
K. Ranoszek‐Soliwoda,
E. Tomaszewska,
G. Celichowski,
J. Roszak,
M. Stępnik Tags: RESEARCH ARTICLE Source Type: research
Allocholic acid protects against α‐naphthylisothiocyanate‐induced cholestasis in mice by ameliorating disordered bile acid homeostasis
In conclusion, ACA demonstrated its potential to ameliorate ANIT-induced liver damage by inhibiting BA synthesis and promoting both BA efflux and renal elimination pathways, thus, restoring BA homeostasis. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - November 16, 2023 Category: Toxicology Authors: Xue Han,
Chuyi Lin,
Huijie Liu,
Shan Li,
Bei Hu,
Lei Zhang Tags: RESEARCH ARTICLE Source Type: research
Using particle dimensionality ‐based modeling to estimate lung carcinogenicity of 3D printer emissions
The objective of the study was to demonstrate a methodology for modeling lung cancer risk related to specific exposure levels as derived from an experimental study of 3D printer emissions for various types of filaments (ABS, PLA, and PETG).The emissions of 15 filaments were assessed at varying extrusion temperatures for a total of 23 conditions in a Class 1,000 cleanroom following procedures described by ANSI/CAN/UL 2904. Three approaches were utilized for cancer risk estimation: (a) calculation based on PM2.5 and PM10 concentrations, (b) a proximity assessment based on the pulmonary deposition fraction, and (c) modeling b...
Source: Journal of Applied Toxicology - November 12, 2023 Category: Toxicology Authors: Andrey A. Korchevskiy,
W. Cary Hill,
Matthew Hull,
Arseniy Korchevskiy Tags: RESEARCH ARTICLE Source Type: research
The involvement of calcium in the toxic effect of 4 ‐methylethcathinone on SH‐SY5Y cells
This study provides a molecular basis for the toxicity mechanism and therapeutic intervention of psychoactive substances. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - November 11, 2023 Category: Toxicology Authors: Wei Zhang,
Fangqi Cao,
Ming Li,
Zhiwen Xu,
Jing Sun,
Zhiwei Huang,
Ping Shi Tags: RESEARCH ARTICLE Source Type: research
