Decamethylcyclopentasiloxane affects estradiol production in female rats but not H295R cells
AbstractSex hormones, such as androgens and estrogens, are predominantly produced in the gonads (ovaries and testes) and adrenal cortex. Endocrine-disrupting chemicals (EDCs) are substances that mimic, block, or interfere with hormones in the endocrine systems of humans and organisms. EDCs mainly act via nuclear receptors and steroidogenesis-related enzymes. In the OECD conceptual framework for testing and assessment of EDCs, several well-known assays are used to identify the potential disruption of nuclear receptors both in vivo and in vitro, whereas the H295R steroidogenesis assay is the only assay that detects the disru...
Source: Journal of Applied Toxicology - August 8, 2023 Category: Toxicology Authors: Masahiro Ogawa,
Junya Kitamoto,
Takeo Takeda,
Masami Hori,
Kisako Shikano,
Amami Yamanaka ‐Tanaka,
Tomoki Tanaka,
Tomoya Kawaguchi,
Megumi Terada,
Taku Tanaka Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - August 7, 2023 Category: Toxicology Tags: ISSUE INFORMATION Source Type: research
Impact of microsampling on toxicological evaluation in rodent safety studies
This report aims to promote the application of microsampling to nonclinical studies, as it is beneficial for improving animal welfare and can contribute to the 3Rs. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - August 7, 2023 Category: Toxicology Authors: Kazuaki Takahashi,
Norimichi Hattori,
Hideaki Yokoyama,
Fumihiro Jinno,
Hirohiko Ohtsuka,
Keiko Nakai,
Asuka Takumi,
Yusuke Shibui,
Koki Yamaguchi,
Taishi Shimazaki,
Yoichi Tanaka,
Kosuke Saito,
Akio Kobayashi,
Yoshiro Saito Tags: REVIEW ARTICLE Source Type: research
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua)
In conclusion, the genome-wid e transcriptomic study suggests that the UPR pathway is a sensitive common target of halogenated organic environmental pollutants in fish. (Source: Journal of Applied Toxicology)
Source: Journal of Applied Toxicology - August 2, 2023 Category: Toxicology Authors: P ål A. Olsvik,
Sonnich Meier,
Xiaokang Zhang,
Anders Goksøyr,
Odd Andre Karlsen,
Fekadu Yadetie Tags: RESEARCH ARTICLE Source Type: research
Biological mechanism of ZnO nanomaterials
AbstractModern nanotechnology has made zinc oxide nanomaterials (ZnO NMts) multifunctional, stable, and low cost, enabling them to be widely used in commercial and biomedical fields. With its wide application, the risk of human direct contact and their release into the environment also increases. This review aims to summarize the toxicity studies of ZnO NMts in vivo, including neurotoxicity, inhalation toxicity, and reproductive toxicity. The antibacterial and antiviral mechanisms of ZnO NMts in vitro and the toxicity to eukaryotic cells were summarized. The summary found that it was mainly related to reactive oxygen speci...
Source: Journal of Applied Toxicology - August 2, 2023 Category: Toxicology Authors: Yuanyuan Li,
Jingjing Li,
Mei Li,
Jiwen Sun,
Xiaofen Shang,
Yonghua Ma Tags: REVIEW ARTICLE Source Type: research
An evaluation of the genotoxicity and 90 ‐day repeated‐dose toxicity of a CBD‐rich hemp oil
AbstractCurrently, there is much interest in the sales and study of consumableCannabis sativa L. products that contain relatively high levels of cannabidiol (CBD) and low levels of Δ-9-tetrahydrocannabinol. While there are published safety evaluations for extracts containing low concentrations of CBD, toxicological assessments for those with higher concentrations are still scant in the public domain. In this paper, genotoxicity tests and a 90-day repeated-dose toxicity study of an ethanolic extract ofC. sativa containing ~85% CBD were performed following relevant OECD guidelines. No increased gene mutations were observed ...
Source: Journal of Applied Toxicology - July 29, 2023 Category: Toxicology Authors: Amy Clewell,
R óbert Glávits,
John R. Endres,
Timothy S. Murbach,
Péter Tamás Báldi,
Tibor Renkecz,
Gábor Hirka,
Adél Vértesi,
Erzsébet Béres,
Ilona Pasics Szakonyiné Tags: RESEARCH ARTICLE Source Type: research
Gene expression analyses reveal potential mechanism of inorganic arsenic ‐induced apoptosis in zebrafish
AbstractOur previous study showed that sodium arsenite (200 mg/L) affected the nervous system and induced motor neuron development via the Sonic hedgehog pathway in zebrafish larvae. To gain more insight into the effects of arsenite on other signaling pathways, including apoptosis, we have performed quantitative polymerase chain reaction array-based gene expression analyses. The 96-well array plates contained primers for 84 genes representing 10 signaling pathways that regulate several biological functions, including apoptosis. We exposed eggs at 5 h postfertilization until the 72 h postfertilization larval stage to ...
Source: Journal of Applied Toxicology - July 28, 2023 Category: Toxicology Authors: Camila S. Silva,
Tetyana Kudlyk,
Volodymyr P. Tryndyak,
Nathan C. Twaddle,
Bonnie Robinson,
Qiang Gu,
Frederick A. Beland,
Suzanne C. Fitzpatrick,
Jyotshna Kanungo Tags: RESEARCH ARTICLE Source Type: research
