Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research

The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research

Irisin attenuates ventilator-induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK
J Cell Mol Med. 2024 May;28(9):e18259. doi: 10.1111/jcmm.18259.ABSTRACTMechanical ventilation (MV) is an essential life-saving technique, but prolonged MV can cause significant diaphragmatic dysfunction due to atrophy and decreased contractility of the diaphragm fibres, called ventilator-induced diaphragmatic dysfunction (VIDD). It is not clear about the mechanism of occurrence and prevention measures of VIDD. Irisin is a newly discovered muscle factor that regulates energy metabolism. Studies have shown that irisin can exhibit protective effects by downregulating endoplasmic reticulum (ER) stress in a variety of diseases;...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Jumei Zhang Rui Tu Fasheng Guan Jianguo Feng Jing Jia Jun Zhou Xiaobin Wang Li Liu Source Type: research

Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research

The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research

Irisin attenuates ventilator-induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK
J Cell Mol Med. 2024 May;28(9):e18259. doi: 10.1111/jcmm.18259.ABSTRACTMechanical ventilation (MV) is an essential life-saving technique, but prolonged MV can cause significant diaphragmatic dysfunction due to atrophy and decreased contractility of the diaphragm fibres, called ventilator-induced diaphragmatic dysfunction (VIDD). It is not clear about the mechanism of occurrence and prevention measures of VIDD. Irisin is a newly discovered muscle factor that regulates energy metabolism. Studies have shown that irisin can exhibit protective effects by downregulating endoplasmic reticulum (ER) stress in a variety of diseases;...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Jumei Zhang Rui Tu Fasheng Guan Jianguo Feng Jing Jia Jun Zhou Xiaobin Wang Li Liu Source Type: research

Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research

The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research

Irisin attenuates ventilator-induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK
J Cell Mol Med. 2024 May;28(9):e18259. doi: 10.1111/jcmm.18259.ABSTRACTMechanical ventilation (MV) is an essential life-saving technique, but prolonged MV can cause significant diaphragmatic dysfunction due to atrophy and decreased contractility of the diaphragm fibres, called ventilator-induced diaphragmatic dysfunction (VIDD). It is not clear about the mechanism of occurrence and prevention measures of VIDD. Irisin is a newly discovered muscle factor that regulates energy metabolism. Studies have shown that irisin can exhibit protective effects by downregulating endoplasmic reticulum (ER) stress in a variety of diseases;...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Jumei Zhang Rui Tu Fasheng Guan Jianguo Feng Jing Jia Jun Zhou Xiaobin Wang Li Liu Source Type: research

Anti-inflammatory effect of Trichospira verticillata via suppression of the NLRP3 inflammasome in neutrophilic asthma
This study demonstrates that TVE modulates the binding of NLPR3 to NEK7, thereby reporting novel insights into the mechanism by which TVE inhibits NLRP3 inflammasome. These findings suggest TVE as a potential therapeutic of NLRP3 inflammasome-mediated diseases, particularly NA.PMID:38668995 | PMC:PMC11048967 | DOI:10.1111/jcmm.18356 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 26, 2024 Category: Molecular Biology Authors: Hyeyun Yang Gunwoo Park Sojung Lee Sumin Lee YeJi Kim Nelson A Zamora Dong-Keun Yi Soo-Yong Kim Chun Whan Choi Sangho Choi Yong Hwan Park Source Type: research

Cartilage stem/progenitor cells-derived exosomes facilitate knee cartilage repair in a subacute osteoarthritis rat model
In this study, we prepared exosomes (EXOs) from cartilage stem/progenitor cells (CSPCs) and found that treatment with EXOs increased the viability, migration, and proliferation of cultured primary chondrocytes. In a subacute OA rat model, the application of EXOs facilitated cartilage regeneration as evidenced by histological staining. Exosomal protein analysis together with bioinformatics suggested that cyclin-dependent kinase 9 (CDK9) is a key factor for chondrocyte growth and migration. Functional studies confirmed this prediction, that is, inhibiting CDK9 reduced the beneficial effects induced by EXOs in primary chondro...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Authors: Jing Chen Xiaohui Ni Jian Yang Hongwei Yang Xiaoyu Liu Minhao Chen Cheng Sun Youhua Wang Source Type: research

Detecting early-warning biomarkers associated with heart-exosome genetic-signature for acute myocardial infarction: A source-tracking study of exosome
J Cell Mol Med. 2024 Apr;28(8):e18334. doi: 10.1111/jcmm.18334.ABSTRACTThe genetic information of plasma total-exosomes originating from tissues have already proven useful to assess the severity of coronary artery diseases (CAD). However, plasma total-exosomes include multiple sub-populations secreted by various tissues. Only analysing the genetic information of plasma total-exosomes is perturbed by exosomes derived from other organs except the heart. We aim to detect early-warning biomarkers associated with heart-exosome genetic-signatures for acute myocardial infarction (AMI) by a source-tracking analysis of plasma exoso...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Authors: Xiaojun Jin Weifeng Xu Qiaoping Wu Chen Huang Yongfei Song Jiangfang Lian Source Type: research

Retraction: Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18312. doi: 10.1111/jcmm.18312.ABSTRACTZhi-Dong Lv, Zhao-Chuan Yang, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Hui-Li Qu, Fu-Nian Li, Bin Kong, Jiao Sun, Jiao-Jiao Zhao, Hai-Bo Wang, Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 1640-1650. https://doi.org/10.1111/jcmm.12856 The above article, published online on 29 March 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-i...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Source Type: research

Anti-inflammatory and immunoregulatory effects of colistin sulphate on human PBMCs
J Cell Mol Med. 2024 Apr;28(8):e18322. doi: 10.1111/jcmm.18322.ABSTRACTIn previous studies, CST has been identified as having an immunostimulatory effect on Caenorhabditis elegans and macrophage of rats. Here, we further investigated its immunomodulatory effects on human peripheral blood mononuclear cells (PBMCs). LPS-stimulated PBMCs inflammatory model was established. Flow cytometry was applied to measure phagocytosis of PBMCs. Cytokine mRNA and protein expression levels of LPS-stimulated PBMCs with or without CST were measured by qRT-PCR and ELISA. The transcriptomic profile of CST-treated PBMCs was investigated by RNA-...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Authors: Huiling Chen Tianli Yang Yiran Xu Beibei Liang Xianyong Liu Yun Cai Source Type: research

KIAA0040 enhances glioma growth by controlling the JAK2/STAT3 signalling pathway
In this study, KIAA0040 expression levels were evaluated using qRT-PCR, WB and IHC, and functional assays were conducted to assess its impact on glioma progression, along with animal experiments. Moreover, WB was used to examine the impact of KIAA0040 on the JAK2/STAT3 signalling pathway. Our study found that KIAA0040 was increased in glioma and linked to tumour grade and poor clinical outcomes, serving as an independent prognostic factor. Functional assays showed that KIAA0040 enhances glioma growth, migration and invasion by activating the JAK2/STAT3 pathway. Of course, KIAA0040 enhances glioma growth by preventing tumou...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Authors: Jie He Kaming Xue Fei Fan Lin Li Xinyu Rao Wei Liu Chuansheng Nie Source Type: research