Glutamine metabolism prognostic index predicts tumour microenvironment characteristics and therapeutic efficacy in ovarian cancer
J Cell Mol Med. 2024 Apr;28(7):e18198. doi: 10.1111/jcmm.18198.ABSTRACTMounting evidence has highlighted the multifunctional characteristics of glutamine metabolism (GM) in cancer initiation, progression and therapeutic regimens. However, the overall role of GM in the tumour microenvironment (TME), clinical stratification and therapeutic efficacy in patients with ovarian cancer (OC) has not been fully elucidated. Here, three distinct GM clusters were identified and exhibited different prognostic values, biological functions and immune infiltration in TME. Subsequently, glutamine metabolism prognostic index (GMPI) was const...
Source: J Cell Mol Med - March 20, 2024 Category: Molecular Biology Authors: Lingling Gao Zheng Wei Feiquan Ying Lin Huang Jingni Zhang Si Sun Zehua Wang Jing Cai Yuan Zhang Source Type: research
Unveiling the role of YARS1 in bladder cancer: A prognostic biomarker and therapeutic target
J Cell Mol Med. 2024 Apr;28(7):1-20. doi: 10.1111/jcmm.18213.ABSTRACTYARS is responsible for catalysing the binding of tyrosine to its cognate tRNA and plays a crucial role in basic biosynthesis. However, its biological functions in bladder cancer remains to be proven. We analysed variations in YARS1 expression and survival in bladder cancer using multiple data sets, including TCGA-BLCA, GSE13507 and bladder cancer-specific tissue microarrays. Furthermore, we explored the biological functions of YARS1 using transcriptome data. Our findings revealed a noteworthy correlation between YARS1 and immune infiltration in bladder c...
Source: J Cell Mol Med - March 20, 2024 Category: Molecular Biology Authors: YaXuan Wang Jinfeng Wang Lu Zhang JiaXing He Bo Ji JianShe Wang BeiChen Ding MingHua Ren Source Type: research
Reduced chemokine C-C motif ligand 1 expression may negatively regulate colorectal cancer progression at liver metastatic sites
J Cell Mol Med. 2024 Apr;28(7):e18193. doi: 10.1111/jcmm.18193.ABSTRACTColorectal cancer (CRC) liver metastasis, albeit a stage-IV disease, is completely curable by surgical resection in selected patients. In addressing the molecular basics of this phenomenon, differentially expressed genes at primary and liver metastatic sites were screened by RNA sequencing with the use of paraffin-embedded surgical specimens. Chemokine C-C motif ligand 1 (CCL1), a chemotactic factor for a ligand of the chemokine C-C motif receptor 8 (CCR8), was isolated as one of the differentially expressed genes. Histological analysis revealed that th...
Source: J Cell Mol Med - March 20, 2024 Category: Molecular Biology Authors: Miku Iwata Ryuma Haraguchi Riko Kitazawa Chihiro Ito Kohei Ogawa Yasutsugu Takada Sohei Kitazawa Source Type: research
Combining bulk and scRNA-seq to explore the molecular mechanisms governing the distinct efferocytosis activities of a macrophage subpopulation in PDAC
In conclusion, the examination of human PDAC tissue samples using immunofluorescence analysis demonstrated the co-localization of CD68 and CD11b within regions exhibiting the presence of keratin (KRT) and alpha-smooth muscle actin (α-SMA). This observation implies a spatial association between macrophages, fibroblasts, and epithelial cells. There is variation in the expression of efferocytosis-associated genes between C0 macrophage TGM2+ and other macrophage cell types. This observation implies that the diversity of macrophage cells might potentially influence the metastatic advancement of PDAC. Moreover, the central tran...
Source: J Cell Mol Med - March 19, 2024 Category: Molecular Biology Authors: Shaoliang Zhu Quan Cheng Mengjie Zou Chunxing Li Yi Tang Longjie Xia Yanming Jiang Zheng Gong Zhenyong Tang Yuntian Tang Honglin Luo Ningfu Peng Xiaojing Wang Xiaofeng Dong Source Type: research
LncRNAs expression profile in a family household cluster of COVID-19 patients
J Cell Mol Med. 2024 Apr;28(7):e18226. doi: 10.1111/jcmm.18226.ABSTRACTMore than 3 years after the start of SARS-CoV-2 pandemic, the molecular mechanisms behind the viral pathogenesis are still not completely understood. Long non-coding RNAs (lncRNAs), well-known players in viral infections, can represent prime candidates for patients' risk stratification. The purpose of the current study was to investigate the lncRNA profile in a family cluster of COVID-19 cases with different disease progression, during the initial wave of the pandemic and to evaluate their potential as biomarkers for COVID-19 evolution. LncRNA expressio...
Source: J Cell Mol Med - March 19, 2024 Category: Molecular Biology Authors: Iulia Virginia Iancu Carmen Cristina Diaconu Adriana Plesa Alina Fudulu Adrian Albulescu Ana Iulia Neagu Ioana Madalina Pitica Laura Denisa Dragu Coralia Bleotu Mihaela Chivu-Economescu Lilia Matei Cristina Mambet Saviana Nedeianu Corneliu Petru Popescu C Source Type: research
Combining bulk and scRNA-seq to explore the molecular mechanisms governing the distinct efferocytosis activities of a macrophage subpopulation in PDAC
In conclusion, the examination of human PDAC tissue samples using immunofluorescence analysis demonstrated the co-localization of CD68 and CD11b within regions exhibiting the presence of keratin (KRT) and alpha-smooth muscle actin (α-SMA). This observation implies a spatial association between macrophages, fibroblasts, and epithelial cells. There is variation in the expression of efferocytosis-associated genes between C0 macrophage TGM2+ and other macrophage cell types. This observation implies that the diversity of macrophage cells might potentially influence the metastatic advancement of PDAC. Moreover, the central tran...
Source: J Cell Mol Med - March 19, 2024 Category: Molecular Biology Authors: Shaoliang Zhu Quan Cheng Mengjie Zou Chunxing Li Yi Tang Longjie Xia Yanming Jiang Zheng Gong Zhenyong Tang Yuntian Tang Honglin Luo Ningfu Peng Xiaojing Wang Xiaofeng Dong Source Type: research
LncRNAs expression profile in a family household cluster of COVID-19 patients
J Cell Mol Med. 2024 Apr;28(7):e18226. doi: 10.1111/jcmm.18226.ABSTRACTMore than 3 years after the start of SARS-CoV-2 pandemic, the molecular mechanisms behind the viral pathogenesis are still not completely understood. Long non-coding RNAs (lncRNAs), well-known players in viral infections, can represent prime candidates for patients' risk stratification. The purpose of the current study was to investigate the lncRNA profile in a family cluster of COVID-19 cases with different disease progression, during the initial wave of the pandemic and to evaluate their potential as biomarkers for COVID-19 evolution. LncRNA expressio...
Source: J Cell Mol Med - March 19, 2024 Category: Molecular Biology Authors: Iulia Virginia Iancu Carmen Cristina Diaconu Adriana Plesa Alina Fudulu Adrian Albulescu Ana Iulia Neagu Ioana Madalina Pitica Laura Denisa Dragu Coralia Bleotu Mihaela Chivu-Economescu Lilia Matei Cristina Mambet Saviana Nedeianu Corneliu Petru Popescu C Source Type: research
The relationship of ALPK1, hyaluronic acid and M1 macrophage polarization in the temporomandibular joint synovitis
J Cell Mol Med. 2024 Apr;28(7):e18172. doi: 10.1111/jcmm.18172.ABSTRACTM1 macrophage polarization and synovitis play an important role in the pathogenesis of temporomandibular joint osteoarthritis (TMJOA). Reduced molecular weight of hyaluronic acid (HA) in synovial fluid of patients with TMJOA. In addition, high molecular weight hyaluronic acid (HMW-HA) is often used clinically to treat TMJ inflammation. As a pattern recognition receptor of the cytoplasm, ALPK1 was found to be pro-inflammatory in a variety of diseases. However, the relationship of ALPK1, HA and M1 macrophage polarization in TMJ synovitis remains unclear. ...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Jie Zhao Yaping Feng Xin Liu Huimin Li Huilin Guo Jin Ke Xing Long Source Type: research
Differential genetic mutations and immune cell infiltration in high- and low-risk STAD: Implications for prognosis and immunotherapy efficacy
This study investigates genetic mutations and immune cell dynamics in stomach adenocarcinoma (STAD), focusing on identifying prognostic markers and therapeutic targets. Analysis of TCGA-STAD samples revealed C > A as the most common single nucleotide variant (SNV) in both high and low-risk groups. Key mutated driver genes included TTN, TP53 and MUC16, with frame-shift mutations more prevalent in the low-risk group and missense mutations in the high-risk group. Interaction analysis of hub genes such as C1QA and CD68 showed significant correlations, impacting immune cell infiltration patterns. Using ssGSEA, we found highe...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Yin-Yong Deng Yan Sun Si-Jia Wu Tian-Ying Zhang Jie Yang Kai Liu Source Type: research
Research progress on the roles of dopamine and dopamine receptors in digestive system diseases
J Cell Mol Med. 2024 Apr;28(7):e18154. doi: 10.1111/jcmm.18154.ABSTRACTDopamine (DA) is a neurotransmitter synthesized in the human body that acts on multiple organs throughout the body, reaching them through the blood circulation. Neurotransmitters are special molecules that act as messengers by binding to receptors at chemical synapses between neurons. As ligands, they mainly bind to corresponding receptors on central or peripheral tissue cells. Signalling through chemical synapses is involved in regulating the activities of various body systems. Lack of DA or a decrease in DA levels in the brain can lead to serious dise...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Xianmin Lu Qi Liu Ya Deng Jiangbo Wu Xingyi Mu Xiaoxu Yang Ting Zhang Chen Luo Zhuo Li Siqi Tang Yanxia Hu Qian Du Jingyu Xu Rui Xie Source Type: research
Bilirubin ameliorates osteoarthritis via activating Nrf2/HO-1 pathway and suppressing NF- κB signalling
J Cell Mol Med. 2024 Apr;28(7):e18173. doi: 10.1111/jcmm.18173.ABSTRACTOsteoarthritis (OA) is a chronic degenerative joint disease that affects worldwide. Oxidative stress plays a critical role in the chronic inflammation and OA progression. Scavenging overproduced reactive oxygen species (ROS) could be rational strategy for OA treatment. Bilirubin (BR) is a potent endogenous antioxidant that can scavenge various ROS and also exhibit anti-inflammatory effects. However, whether BR could exert protection on chondrocytes for OA treatment has not yet been elucidated. Here, chondrocytes were exposed to hydrogen peroxide with or...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Xinyu Zhao Baiqun Duan Jianing Wu Lihui Huang Sheng Dai Jie Ding Meng Sun Xinlu Lin Yiling Jiang Tuyue Sun Ruijie Lu Huirong Huang Guangyong Lin Ruijie Chen Qing Yao Longfa Kou Source Type: research
Avocado-derived extracellular vesicles loaded with ginkgetin and berberine prevent inflammation and macrophage foam cell formation
J Cell Mol Med. 2024 Apr;28(7):e18177. doi: 10.1111/jcmm.18177.ABSTRACTAtherosclerosis, a chronic inflammatory disease of aorta, remains the major cause of morbidity and mortality among cardiovascular disease patients. Macrophage foam cell formation and inflammation are critically involved in early stages of atherosclerosis, hence chemopreventive targeting of foam cell formation by nutraceuticals may be a promising approach to curbing the progression of atherosclerosis. However, many nutraceuticals including berberine and ginkgetin have low stability, tissue/cell penetration and bioavailability resulting in inadequate chem...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Shweta Sharma Manisha Mahanty Suneha G Rahaman Pritha Mukherjee Bidisha Dutta Mohammad Imran Khan Karunakaran Reddy Sankaran Xiaoming He Lakshmyya Kesavalu Wei Li Shaik O Rahaman Source Type: research
Microglia orchestrate synaptic and neuronal stripping: Implication in neuropsychiatric lupus
J Cell Mol Med. 2024 Apr;28(7):e18190. doi: 10.1111/jcmm.18190.ABSTRACTSystemic lupus erythematosus (SLE), a multifactorial autoimmune disease, can affect the brain and cause neuropsychiatric dysfunction, also named neuropsychiatric lupus (NPSLE). Microglial activation is observed in NPSLE patients. However, the mechanisms regulating microglia-mediated neurotoxicity in NPSLE remain elusive. Here, we showed that M1-like proinflammatory cytokine levels were increased in the cerebrospinal fluid (CSF) of SLE patients, especially those with neuropsychiatric symptoms. We also demonstrated that MRL/lpr lupus mice developed anxiet...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Yishan Zhou Liang Chen Xiulan Zheng Qijun Fang Yunzhi Qian Tianshu Xu Jun Liang Huajun Zhang Xiaojuan Han Lingyun Sun Source Type: research
CPA4 as a biomarker promotes the proliferation, migration and metastasis of clear cell renal cell carcinoma cells
J Cell Mol Med. 2024 Apr;28(7):e18165. doi: 10.1111/jcmm.18165.ABSTRACTClear cell renal cell carcinoma (ccRCC) is a commonly occurring and highly aggressive urological malignancy characterized by a significant mortality rate. Current therapeutic options for advanced ccRCC are limited, necessitating the discovery of novel biomarkers and therapeutic targets. Carboxypeptidase A4 (CPA4) is a zinc-containing metallocarboxypeptidase with implications in various cancer types, but its role in ccRCC remains unexplored. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were utilized in order to investigate t...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Kongjia Wang Yixin Ding Yunbo Liu Mingyu Ma Ji Wang Zengshun Kou Shuo Liu Bo Jiang Sichuan Hou Source Type: research
Correction to Aureusidin derivative CNQX inhibits chronic colitis inflammation and mucosal barrier damage by targeting myeloid differentiation 2 protein
J Cell Mol Med. 2024 Apr;28(7):e18117. doi: 10.1111/jcmm.18117.NO ABSTRACTPMID:38494846 | PMC:PMC10945072 | DOI:10.1111/jcmm.18117 (Source: J Cell Mol Med)
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Source Type: research
