Targeted inhibition of colorectal cancer proliferation: The dual-modulatory role of 2,4-DTBP on anti-apoptotic Bcl-2 and Survivin proteins
In this study, we employed both in silico and in vitro methodologies to underpin this interaction at the molecular level. Molecular docking demonstrated a substantial binding affinity of 2,4-DTBP towards Bcl-2 (ΔG = -9.8 kcal/mol) and Survivin (ΔG = -5.6 kcal/mol), suggesting a potential inhibitory effect. Further, molecular dynamic simulations complemented by MM-GBSA calculations confirmed the significant binding of 2,4-DTBP with Bcl-2 (dGbind = -54.85 ± 6.79 kcal/mol) and Survivin (dGbind = -32.36 ± 1.29 kcal/mol). In vitro assays using HCT116 colorectal cancer cells revealed that 2,4-DTBP inhibited proliferation and...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Partha Saha Mangala Hegde Kanak Chakraborty Achinta Singha Nobendu Mukerjee Deepshikha Ghosh Ajaikumar B Kunnumakkara Mohd Shahnawaz Khan Md Irshad Ahmad Arabinda Ghosh Ajoy Kumer Samir Kumar Sil Source Type: research
SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice
J Cell Mol Med. 2024 Mar;28(6):e18176. doi: 10.1111/jcmm.18176.ABSTRACTSenescent kidney can lead to the maladaptive repairment and predispose age-related kidney diseases. Here, we explore the renal anti-senescence effect of a known kind of drug, sodium-dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence-accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence-related biomarkers) and structural changes (improving kidney atrophy, ...
Source: J Cell Mol Med - March 8, 2024 Category: Molecular Biology Authors: Lu Zeng Jie Li Fanfan Gao Yangyang Song Limin Wei Ning Qu Shengnan Chen Xue Zhao Zitong Lei Wenya Cao Lei Chen Hongli Jiang Source Type: research
SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice
J Cell Mol Med. 2024 Mar;28(6):e18176. doi: 10.1111/jcmm.18176.ABSTRACTSenescent kidney can lead to the maladaptive repairment and predispose age-related kidney diseases. Here, we explore the renal anti-senescence effect of a known kind of drug, sodium-dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence-accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence-related biomarkers) and structural changes (improving kidney atrophy, ...
Source: J Cell Mol Med - March 8, 2024 Category: Molecular Biology Authors: Lu Zeng Jie Li Fanfan Gao Yangyang Song Limin Wei Ning Qu Shengnan Chen Xue Zhao Zitong Lei Wenya Cao Lei Chen Hongli Jiang Source Type: research
SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice
J Cell Mol Med. 2024 Mar;28(6):e18176. doi: 10.1111/jcmm.18176.ABSTRACTSenescent kidney can lead to the maladaptive repairment and predispose age-related kidney diseases. Here, we explore the renal anti-senescence effect of a known kind of drug, sodium-dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence-accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence-related biomarkers) and structural changes (improving kidney atrophy, ...
Source: J Cell Mol Med - March 8, 2024 Category: Molecular Biology Authors: Lu Zeng Jie Li Fanfan Gao Yangyang Song Limin Wei Ning Qu Shengnan Chen Xue Zhao Zitong Lei Wenya Cao Lei Chen Hongli Jiang Source Type: research
SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice
J Cell Mol Med. 2024 Mar;28(6):e18176. doi: 10.1111/jcmm.18176.ABSTRACTSenescent kidney can lead to the maladaptive repairment and predispose age-related kidney diseases. Here, we explore the renal anti-senescence effect of a known kind of drug, sodium-dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence-accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence-related biomarkers) and structural changes (improving kidney atrophy, ...
Source: J Cell Mol Med - March 8, 2024 Category: Molecular Biology Authors: Lu Zeng Jie Li Fanfan Gao Yangyang Song Limin Wei Ning Qu Shengnan Chen Xue Zhao Zitong Lei Wenya Cao Lei Chen Hongli Jiang Source Type: research
SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice
J Cell Mol Med. 2024 Mar;28(6):e18176. doi: 10.1111/jcmm.18176.ABSTRACTSenescent kidney can lead to the maladaptive repairment and predispose age-related kidney diseases. Here, we explore the renal anti-senescence effect of a known kind of drug, sodium-dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence-accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence-related biomarkers) and structural changes (improving kidney atrophy, ...
Source: J Cell Mol Med - March 8, 2024 Category: Molecular Biology Authors: Lu Zeng Jie Li Fanfan Gao Yangyang Song Limin Wei Ning Qu Shengnan Chen Xue Zhao Zitong Lei Wenya Cao Lei Chen Hongli Jiang Source Type: research
SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice
J Cell Mol Med. 2024 Mar;28(6):e18176. doi: 10.1111/jcmm.18176.ABSTRACTSenescent kidney can lead to the maladaptive repairment and predispose age-related kidney diseases. Here, we explore the renal anti-senescence effect of a known kind of drug, sodium-dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence-accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence-related biomarkers) and structural changes (improving kidney atrophy, ...
Source: J Cell Mol Med - March 8, 2024 Category: Molecular Biology Authors: Lu Zeng Jie Li Fanfan Gao Yangyang Song Limin Wei Ning Qu Shengnan Chen Xue Zhao Zitong Lei Wenya Cao Lei Chen Hongli Jiang Source Type: research
SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice
J Cell Mol Med. 2024 Mar;28(6):e18176. doi: 10.1111/jcmm.18176.ABSTRACTSenescent kidney can lead to the maladaptive repairment and predispose age-related kidney diseases. Here, we explore the renal anti-senescence effect of a known kind of drug, sodium-dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence-accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence-related biomarkers) and structural changes (improving kidney atrophy, ...
Source: J Cell Mol Med - March 8, 2024 Category: Molecular Biology Authors: Lu Zeng Jie Li Fanfan Gao Yangyang Song Limin Wei Ning Qu Shengnan Chen Xue Zhao Zitong Lei Wenya Cao Lei Chen Hongli Jiang Source Type: research
SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice
J Cell Mol Med. 2024 Mar;28(6):e18176. doi: 10.1111/jcmm.18176.ABSTRACTSenescent kidney can lead to the maladaptive repairment and predispose age-related kidney diseases. Here, we explore the renal anti-senescence effect of a known kind of drug, sodium-dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence-accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence-related biomarkers) and structural changes (improving kidney atrophy, ...
Source: J Cell Mol Med - March 8, 2024 Category: Molecular Biology Authors: Lu Zeng Jie Li Fanfan Gao Yangyang Song Limin Wei Ning Qu Shengnan Chen Xue Zhao Zitong Lei Wenya Cao Lei Chen Hongli Jiang Source Type: research
Identification of key biomarkers for predicting CAD progression in inflammatory bowel disease via machine-learning and bioinformatics strategies
J Cell Mol Med. 2024 Mar;28(6):e18175. doi: 10.1111/jcmm.18175.ABSTRACTThe study aimed to identify the biomarkers for predicting coronary atherosclerotic lesions progression in patients with inflammatory bowel disease (IBD). Related transcriptome datasets were seized from Gene Expression Omnibus database. IBD-related modules were identified via Weighted Gene Co-expression Network Analysis. The 'Limma' was applied to screen differentially expressed genes between stable coronary artery disease (CAD) and acute myocardial infarction (AMI). Subsequently, we employed protein-protein interaction (PPI) network and three machine-le...
Source: J Cell Mol Med - March 7, 2024 Category: Molecular Biology Authors: Xiaoqi Tang Yufei Zhou Zhuolin Chen Chunjiang Liu Zhifeng Wu Yue Zhou Fan Zhang Xuanyuan Lu Liming Tang Source Type: research
Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity
In conclusion, SBSGL had immunomodulatory effects and regulated the malignancy and autophagy of HB by regulating the O-GlcNAcylation of RACK1. These findings suggest that SBSGL holds promise as a potential anticancer drug for HB treatment.PMID:38451046 | DOI:10.1111/jcmm.18223 (Source: J Cell Mol Med)
Source: J Cell Mol Med - March 7, 2024 Category: Molecular Biology Authors: Rui Shen Yang Ge Yunpeng Qin Hang Gao Hongyan Yu Huazhang Wu Hang Song Source Type: research
Overexpression of malic enzyme is involved in breast cancer growth and is correlated with poor prognosis
J Cell Mol Med. 2024 Mar;28(6):e18163. doi: 10.1111/jcmm.18163.ABSTRACTMalic enzyme (ME) genes are key functional metabolic enzymes playing a crucial role in carcinogenesis. However, the detailed effects of ME gene expression on breast cancer progression remain unclear. Here, our results revealed ME1 expression was significantly upregulated in breast cancer, especially in patients with oestrogen receptor/progesterone receptor-negative and human epidermal growth factor receptor 2-positive breast cancer. Furthermore, upregulation of ME1 was significantly associated with more advanced pathological stages (p < 0.001), pT st...
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: Wan-Chung Hu Yi-Fang Yang Ching-Feng Cheng Ya-Ting Tu Hong-Tai Chang Kuo-Wang Tsai Source Type: research
Prebiotics counteract the morphological and functional changes secondary to chronic cisplatin exposition in the proximal colon of mice
In conclusion, the present study shows that daily administration of prebiotics, likely protecting the microbiota, prevents most of the colonic cisplatin-induced alterations.PMID:38445787 | PMC:PMC10915824 | DOI:10.1111/jcmm.18161 (Source: J Cell Mol Med)
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: Cristina Biagioni Chiara Traini Maria Simonetta Faussone-Pellegrini Eglantina Idrizaj Maria Caterina Baccari Maria Giuliana Vannucchi Source Type: research
circ_HMGCS1 modulates hepatocellular carcinoma chemoresistance via miR-338-5p/IL-7 pathway
J Cell Mol Med. 2024 Mar;28(6):e18137. doi: 10.1111/jcmm.18137.ABSTRACTHepatocellular cancer is one of the most serious types of cancer in the world, with high incidence and mortality rates. Most HCC patients with long-term chemotherapy develop chemoresistance, leading to a poor prognosis. However, the underlying mechanism of circRNAs in HCC chemoresistance remains unclear. Our research found that circ_0072391(circ_HMGCS1) expression was significantly upregulated in cisplatin-resistant HCC cells. The silence of circ_HMGCS1 attenuated the cisplatin resistance in HCC. Results showed that circ_HMGCS1 regulated the expression ...
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: Siyu Zhang Jun Ma Tingdong Yu Zhengrui Song Wan Yee Lau Yong Zha Source Type: research
The SGLT family-sodium-glucose transporters with roles beyond glucose and the kidney
J Cell Mol Med. 2024 Mar;28(6):e18152. doi: 10.1111/jcmm.18152.NO ABSTRACTPMID:38445802 | PMC:PMC10915822 | DOI:10.1111/jcmm.18152 (Source: J Cell Mol Med)
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: David Mathew Sean Davidson Derek Yellon Source Type: research
