A systematic review on deep learning-based automated cancer diagnosis models
J Cell Mol Med. 2024 Mar;28(6):e18144. doi: 10.1111/jcmm.18144.ABSTRACTDeep learning is gaining importance due to its wide range of applications. Many researchers have utilized deep learning (DL) models for the automated diagnosis of cancer patients. This paper provides a systematic review of DL models for automated diagnosis of cancer patients. Initially, various DL models for cancer diagnosis are presented. Five major categories of cancers such as breast, lung, liver, brain and cervical cancer are considered. As these categories of cancers have a very high percentage of occurrences with high mortality rate. The comparati...
Source: J Cell Mol Med - March 1, 2024 Category: Molecular Biology Authors: Ritu Tandon Shweta Agrawal Narendra Pal Singh Rathore Abhinava K Mishra Sanjiv Kumar Jain Source Type: research
CDDO regulates central and peripheral sensitization to attenuate post-herpetic neuralgia by targeting TRPV1/PKC- δ/p-Akt signals
This study aimed to explore whether CDDO could generate analgesic action in a PHN-rats' model. The behavioural test was determined by calibrated forceps testing. The number of apoptotic neurons and degree of glial cell reaction were assessed by immunofluorescence assay. Activation of PKC-δ and the phosphorylation of Akt were measured by western blots. CDDO improved PHN by decreasing TRPV1-positive nociceptive neurons, the apoptotic neurons, and reversed glial cell reaction in adult rats. It also suppressed the enhanced PKC-δ and p-Akt signalling in the sciatic nerve, dorsal root ganglia (DRG) and spinal dorsal horn. Our ...
Source: J Cell Mol Med - March 1, 2024 Category: Molecular Biology Authors: Chun-Ching Lu Chia-Yang Lin Ying-Yi Lu Hung-Pei Tsai Chih-Lung Lin Chieh-Hsin Wu Source Type: research
Rhizoma Paridis saponins attenuate Gram-negative bacteria-induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways
In this study, we aimed to evaluate the antiacne effects and the underlying mechanisms of PPH and a PPH-enriched Rhizoma Paridis extract (RPE) in treating the Gram-negative bacteria-induced acne. PPH and RPE treatments significantly suppressed the mRNA and protein expressions of interleukin (IL)-1β and IL-6 in lipopolysaccharide (LPS)-induced RAW 264.7 and HaCaT cells, along with the intracellular reactive oxygen species (ROS) generation. Furthermore, PPH and RPE inhibited the nuclear translocation of nuclear factor kappa-B (NF-κB) P65 in LPS-induced RAW 264.7 cells. Based on molecular docking, PPH could bind to kelch-li...
Source: J Cell Mol Med - March 1, 2024 Category: Molecular Biology Authors: Yang Yang Chaofan Wang Juan Wang Lingli Yang Zheng Lv Quan An Yiming Wang Xue Shao Fei Wang Tong Huo Jiali Liu Haoshu Luo Qianghua Quan Source Type: research
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma
J Cell Mol Med. 2024 Mar;28(6):e18129. doi: 10.1111/jcmm.18129.ABSTRACTATP citrate lyase (ACLY), as a key enzyme in lipid metabolism, plays an important role in energy metabolism and lipid biosynthesis of a variety of tumours. Many studies have shown that ACLY is highly expressed in various tumours, and its pharmacological or gene inhibition significantly inhibits tumour growth and progression. However, the roles of ACLY in oesophageal squamous cell carcinoma (ESCC) remain unclear. Here, our data showed that ACLY inhibitor significantly attenuated cell proliferation, migration, invasion and lipid synthesis in different ESC...
Source: J Cell Mol Med - March 1, 2024 Category: Molecular Biology Authors: Xueying Zhang Yue Xu Shenglei Li Yue Qin Guangzhao Zhu Qing Zhang Yanting Zhang Fangxia Guan Tianli Fan Hongtao Liu Source Type: research
A systematic review on deep learning-based automated cancer diagnosis models
J Cell Mol Med. 2024 Mar;28(6):e18144. doi: 10.1111/jcmm.18144.ABSTRACTDeep learning is gaining importance due to its wide range of applications. Many researchers have utilized deep learning (DL) models for the automated diagnosis of cancer patients. This paper provides a systematic review of DL models for automated diagnosis of cancer patients. Initially, various DL models for cancer diagnosis are presented. Five major categories of cancers such as breast, lung, liver, brain and cervical cancer are considered. As these categories of cancers have a very high percentage of occurrences with high mortality rate. The comparati...
Source: J Cell Mol Med - March 1, 2024 Category: Molecular Biology Authors: Ritu Tandon Shweta Agrawal Narendra Pal Singh Rathore Abhinava K Mishra Sanjiv Kumar Jain Source Type: research
CDDO regulates central and peripheral sensitization to attenuate post-herpetic neuralgia by targeting TRPV1/PKC- δ/p-Akt signals
This study aimed to explore whether CDDO could generate analgesic action in a PHN-rats' model. The behavioural test was determined by calibrated forceps testing. The number of apoptotic neurons and degree of glial cell reaction were assessed by immunofluorescence assay. Activation of PKC-δ and the phosphorylation of Akt were measured by western blots. CDDO improved PHN by decreasing TRPV1-positive nociceptive neurons, the apoptotic neurons, and reversed glial cell reaction in adult rats. It also suppressed the enhanced PKC-δ and p-Akt signalling in the sciatic nerve, dorsal root ganglia (DRG) and spinal dorsal horn. Our ...
Source: J Cell Mol Med - March 1, 2024 Category: Molecular Biology Authors: Chun-Ching Lu Chia-Yang Lin Ying-Yi Lu Hung-Pei Tsai Chih-Lung Lin Chieh-Hsin Wu Source Type: research
Rhizoma Paridis saponins attenuate Gram-negative bacteria-induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways
In this study, we aimed to evaluate the antiacne effects and the underlying mechanisms of PPH and a PPH-enriched Rhizoma Paridis extract (RPE) in treating the Gram-negative bacteria-induced acne. PPH and RPE treatments significantly suppressed the mRNA and protein expressions of interleukin (IL)-1β and IL-6 in lipopolysaccharide (LPS)-induced RAW 264.7 and HaCaT cells, along with the intracellular reactive oxygen species (ROS) generation. Furthermore, PPH and RPE inhibited the nuclear translocation of nuclear factor kappa-B (NF-κB) P65 in LPS-induced RAW 264.7 cells. Based on molecular docking, PPH could bind to kelch-li...
Source: J Cell Mol Med - March 1, 2024 Category: Molecular Biology Authors: Yang Yang Chaofan Wang Juan Wang Lingli Yang Zheng Lv Quan An Yiming Wang Xue Shao Fei Wang Tong Huo Jiali Liu Haoshu Luo Qianghua Quan Source Type: research
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma
J Cell Mol Med. 2024 Mar;28(6):e18129. doi: 10.1111/jcmm.18129.ABSTRACTATP citrate lyase (ACLY), as a key enzyme in lipid metabolism, plays an important role in energy metabolism and lipid biosynthesis of a variety of tumours. Many studies have shown that ACLY is highly expressed in various tumours, and its pharmacological or gene inhibition significantly inhibits tumour growth and progression. However, the roles of ACLY in oesophageal squamous cell carcinoma (ESCC) remain unclear. Here, our data showed that ACLY inhibitor significantly attenuated cell proliferation, migration, invasion and lipid synthesis in different ESC...
Source: J Cell Mol Med - March 1, 2024 Category: Molecular Biology Authors: Xueying Zhang Yue Xu Shenglei Li Yue Qin Guangzhao Zhu Qing Zhang Yanting Zhang Fangxia Guan Tianli Fan Hongtao Liu Source Type: research
IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer
This report highlights a potential new approach to enhancing the chemotherapeutic potential of NSCLC-treating cisplatin.PMID:38396325 | PMC:PMC10891307 | DOI:10.1111/jcmm.18185 (Source: J Cell Mol Med)
Source: J Cell Mol Med - February 24, 2024 Category: Molecular Biology Authors: Jieheng Wu Qiaoling Zhang Jiangwei Wu Zeyang Yang Xinlei Liu Chunju Lou Xuanyin Wang Jiangying Peng Jinyuan Zhang Zhenling Shang Jing Xiao Nianxue Wang Ruya Zhang Jinyao Zhou Yun Wang Zuquan Hu Rui Zhang Jian Zhang Zhu Zeng Source Type: research
Retraction: miR-365 secreted from M2 Macrophage-derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT axis
J Cell Mol Med. 2024 Feb;28(4):e18188. doi: 10.1111/jcmm.18188.ABSTRACTXin Li, Hao Xu, Jianfeng Yi, Chunlu Dong, Hui Zhang, Zhengfeng Wang, Long Miao, Wence Zhou. miR-365 secreted from M2 Macrophage-derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT axis. J Cell Mol Med. 2021; 25: 4671-4683. https://doi.org/10.1111/jcmm.16405. The above article, published online on 03 April 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Stefan Constantinescu, The Foundation for Cellular and Mo...
Source: J Cell Mol Med - February 24, 2024 Category: Molecular Biology Source Type: research
Calotropis procera extract inhibits prostate cancer through regulation of autophagy
J Cell Mol Med. 2024 Feb 23. doi: 10.1111/jcmm.18050. Online ahead of print.ABSTRACTCurrent treatment options available for prostate cancer (PCa) patients have many adverse side effects and hence, new alternative therapies need to be explored. Anticancer potential of various phytochemicals derived from Calotropis procera has been studied in many cancers but no study has investigated the effect of leaf extract of C. procera on PCa cells. Hence, we investigated the effect of C. procera leaf extract (CPE) on cellular properties of androgen-independent PC-3 and androgen-sensitive 22Rv1 cells. A hydroalcoholic extract of C. pro...
Source: J Cell Mol Med - February 24, 2024 Category: Molecular Biology Authors: Palak Singh Bodhana Dhole Jaganmoy Choudhury Anannya Tuli Deepak Pandey Thirumurthy Velpandian Surabhi Gupta Pradeep Kumar Chaturvedi Source Type: research
IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer
This report highlights a potential new approach to enhancing the chemotherapeutic potential of NSCLC-treating cisplatin.PMID:38396325 | PMC:PMC10891307 | DOI:10.1111/jcmm.18185 (Source: J Cell Mol Med)
Source: J Cell Mol Med - February 24, 2024 Category: Molecular Biology Authors: Jieheng Wu Qiaoling Zhang Jiangwei Wu Zeyang Yang Xinlei Liu Chunju Lou Xuanyin Wang Jiangying Peng Jinyuan Zhang Zhenling Shang Jing Xiao Nianxue Wang Ruya Zhang Jinyao Zhou Yun Wang Zuquan Hu Rui Zhang Jian Zhang Zhu Zeng Source Type: research
Retraction: miR-365 secreted from M2 Macrophage-derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT axis
J Cell Mol Med. 2024 Feb;28(4):e18188. doi: 10.1111/jcmm.18188.ABSTRACTXin Li, Hao Xu, Jianfeng Yi, Chunlu Dong, Hui Zhang, Zhengfeng Wang, Long Miao, Wence Zhou. miR-365 secreted from M2 Macrophage-derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT axis. J Cell Mol Med. 2021; 25: 4671-4683. https://doi.org/10.1111/jcmm.16405. The above article, published online on 03 April 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Stefan Constantinescu, The Foundation for Cellular and Mo...
Source: J Cell Mol Med - February 24, 2024 Category: Molecular Biology Source Type: research
Calotropis procera extract inhibits prostate cancer through regulation of autophagy
J Cell Mol Med. 2024 Feb 23. doi: 10.1111/jcmm.18050. Online ahead of print.ABSTRACTCurrent treatment options available for prostate cancer (PCa) patients have many adverse side effects and hence, new alternative therapies need to be explored. Anticancer potential of various phytochemicals derived from Calotropis procera has been studied in many cancers but no study has investigated the effect of leaf extract of C. procera on PCa cells. Hence, we investigated the effect of C. procera leaf extract (CPE) on cellular properties of androgen-independent PC-3 and androgen-sensitive 22Rv1 cells. A hydroalcoholic extract of C. pro...
Source: J Cell Mol Med - February 24, 2024 Category: Molecular Biology Authors: Palak Singh Bodhana Dhole Jaganmoy Choudhury Anannya Tuli Deepak Pandey Thirumurthy Velpandian Surabhi Gupta Pradeep Kumar Chaturvedi Source Type: research
IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer
This report highlights a potential new approach to enhancing the chemotherapeutic potential of NSCLC-treating cisplatin.PMID:38396325 | PMC:PMC10891307 | DOI:10.1111/jcmm.18185 (Source: J Cell Mol Med)
Source: J Cell Mol Med - February 24, 2024 Category: Molecular Biology Authors: Jieheng Wu Qiaoling Zhang Jiangwei Wu Zeyang Yang Xinlei Liu Chunju Lou Xuanyin Wang Jiangying Peng Jinyuan Zhang Zhenling Shang Jing Xiao Nianxue Wang Ruya Zhang Jinyao Zhou Yun Wang Zuquan Hu Rui Zhang Jian Zhang Zhu Zeng Source Type: research
