Exosomal HSPB1, interacting with FUS protein, suppresses hypoxia-induced ferroptosis in pancreatic cancer by stabilizing Nrf2 mRNA and repressing P450
In conclusion, exosomal HSPB1 interacts with the RNA binding protein FUS and decreases FUS-mediated stability of Nrf2 mRNA, thus suppressing hypoxia-induced ferroptosis in pancreatic cancer.PMID:38682349 | PMC:PMC11056849 | DOI:10.1111/jcmm.18209 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Lun Zhang Liuxu Yang Keyuan Du Source Type: research

QiDongNing induces lung cancer cell apoptosis via triggering P53/DRP1-mediated mitochondrial fission
In conclusion, QDN induced apoptosis via triggering p53/DRP1-mediated mitochondrial fission in NSCLC cells.PMID:38682742 | DOI:10.1111/jcmm.18353 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Rongzhen Ding Yichao Wang Ling Xu Shuliu Sang Guanjin Wu Wenxiao Yang Yilu Zhang Chengyan Wang Ao Qi Haiping Xie Yi Liu Aiguo Dai Lijing Jiao Source Type: research

Retraction: Naringenin inhibits migration, invasion, induces apoptosis in human lung cancer cells and arrests tumour progression in  vitro
J Cell Mol Med. 2024 May;28(9):e18325. doi: 10.1111/jcmm.18325.ABSTRACTShi X, Luo X, Chen T, Guo W, Liang C, Tang S, Mo J. Naringenin inhibits migration, invasion, induces apoptosis in human lung cancer cells and arrests tumour progression in vitro. J Cell Mol Med. 2021; 25: 2563-2571. https://doi.org/10.1111/jcmm.16226 The above article, published online on 1 February 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Stefan N. Constantinescu, and the Foundation for Cellular and Molecular Medicine/John Wiley & Sons Ltd. Following publication, con...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Source Type: research

Retraction: Celastrol inhibit the proliferation, invasion and migration of human cervical HeLa cancer cells through down-regulation of MMP-2 and MMP-9
J Cell Mol Med. 2024 May;28(9):e18326. doi: 10.1111/jcmm.18326.ABSTRACTZhang J, Wang R, Cheng L, Xu H. Celastrol inhibit the proliferation, invasion and migration of human cervical HeLa cancer cells through down-regulation of MMP-2 and MMP-9. J Cell Mol Med. 2021;25:5335-5338. doi: 10.1111/jcmm.16488 The above article, published online on 4 May 2021 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Stefan N. Constantinescu, and the Foundation for Cellular and Molecular Medicine/John Wiley & Sons Ltd. Following publication, concerns were raised by thir...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Source Type: research

Melatonin suppresses TLR4-mediated RSV infection in the central nervous cells by inhibiting NLRP3 inflammasome formation and autophagy
J Cell Mol Med. 2024 May;28(9):e18338. doi: 10.1111/jcmm.18338.ABSTRACTRespiratory syncytial virus (RSV) infects neuronal cells in the central nervous system (CNS), resulting in neurological symptoms. In the present study, we intended to explore the mechanism of RSV infection-induced neuroinflammatory injury from the perspective of the immune response and sought to identify effective protective measures against the injury. The findings showed that toll-like receptor 4 (TLR4) was activated after RSV infection in human neuronal SY5Y cells. Furthermore, TLR4 activation induced autophagy and apoptosis in neuronal cells, promot...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Yixuan Huang Chengcheng Jiang Xiaojie Liu Wei Tang Hongya Gui Tao Sun Doudou Xu Maozhang He Maozhen Han Huan Qiu Mingwei Chen Shenghai Huang Source Type: research

Decreased intranuclear cardiac troponin I impairs cardiac autophagy through FOS/ATG5 in ageing hearts
J Cell Mol Med. 2024 May;28(9):e18357. doi: 10.1111/jcmm.18357.ABSTRACTIn our previous study, intranuclear cardiac troponin I (cTnI) may function as a co-factor of Yin Yang 1(YY1). Here, we aimed to explore the role of intranuclear cTnI in ageing hearts. Nuclear translocation of cTnI was demonstrated using Western blot and immunofluorescence. The potential nuclear localization sequences (NLSs) of cTnI were predicted by a web server and then verified in 293T cells by putative NLS-eGFP-GST and NLS-mutant transfection. The ratio of Nuclear cTnI/ Total cTnI (Nu/T) decreased significantly in ageing hearts, accompanied with ATG5...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Rui Min Liu Shan Huang Di Hu Lingjuan Liu Hui Chao Sun Jie Tian Bo Pan Source Type: research

YTHDF1 promotes gallbladder cancer progression via post-transcriptional regulation of the m6A/UHRF1 axis
J Cell Mol Med. 2024 May;28(9):e18328. doi: 10.1111/jcmm.18328.ABSTRACTGallbladder cancer is a rare but fatal malignancy. However, the mechanisms underlying gallbladder carcinogenesis and its progression are poorly understood. The function of m6A modification and its regulators was still unclear for gallbladder cancer. The current study seeks to investigate the function of YTH m6A RNA-binding protein 1 (YTHDF1) in gallbladder cancer. Transcriptomic analysis and immunochemical staining of YTHDF1 in gallbladder cancer tissues revealed its upregulation compared to paracancerous tissues. Moreover, YTHDF1 promotes the prolifera...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Jiemin Chen Xuesong Bai Wenqin Zhang Zhiyu Yan Yongru Liu Shengnan Zhou Xi Wu Xiaodong He Aiming Yang Source Type: research

CRKL but not CRKII contributes to hemin-induced erythroid differentiation of CML
J Cell Mol Med. 2024 May;28(9):e18308. doi: 10.1111/jcmm.18308.ABSTRACTDestruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR-429-CT10 regulation of kinase-like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR-429-CRKL axis in leukaemic cell differentiation are still unknown. The current work aimed to uncover the effect of miR-429-CRKL axis on erythropoiesis. In the present study, CRKL upregulation was negatively correlated with miR-429 downregulation in both chronic myeloid leukaemia (CML) patient an...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Chunmei Guo Xinxin Lv Qiuling Zhang Lina Yi Yingying Ren Zhaopeng Li Jinsong Yan Shanliang Zheng Ming-Zhong Sun Shuqing Liu Source Type: research

PBAC: A pathway-based attention convolution neural network for predicting clinical drug treatment responses
J Cell Mol Med. 2024 May;28(9):e18298. doi: 10.1111/jcmm.18298.ABSTRACTPrecise and personalized drug application is crucial in the clinical treatment of complex diseases. Although neural networks offer a new approach to improving drug strategies, their internal structure is difficult to interpret. Here, we propose PBAC (Pathway-Based Attention Convolution neural network), which integrates a deep learning framework and attention mechanism to address the complex biological pathway information, thereby provide a biology function-based robust drug responsiveness prediction model. PBAC has four layers: gene-pathway layer, atten...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Dexun Deng Xiaoqiang Xu Ting Cui Mingcong Xu Kunpeng Luo Han Zhang Qiuyu Wang Chao Song Chao Li Guohua Li Desi Shang Source Type: research

Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research

The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research

Irisin attenuates ventilator-induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK
J Cell Mol Med. 2024 May;28(9):e18259. doi: 10.1111/jcmm.18259.ABSTRACTMechanical ventilation (MV) is an essential life-saving technique, but prolonged MV can cause significant diaphragmatic dysfunction due to atrophy and decreased contractility of the diaphragm fibres, called ventilator-induced diaphragmatic dysfunction (VIDD). It is not clear about the mechanism of occurrence and prevention measures of VIDD. Irisin is a newly discovered muscle factor that regulates energy metabolism. Studies have shown that irisin can exhibit protective effects by downregulating endoplasmic reticulum (ER) stress in a variety of diseases;...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Jumei Zhang Rui Tu Fasheng Guan Jianguo Feng Jing Jia Jun Zhou Xiaobin Wang Li Liu Source Type: research

Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells
In this study, we found that adoptive transfer of MDSCs to doxorubicin-induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high-dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin-induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α-SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis-related cy...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Xiaowen Gu Lianmei Zhang Min Sun Ying Zhou Jinling Ji YunFang Xu Jianguo You Zhikui Deng Source Type: research

The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research

Irisin attenuates ventilator-induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK
J Cell Mol Med. 2024 May;28(9):e18259. doi: 10.1111/jcmm.18259.ABSTRACTMechanical ventilation (MV) is an essential life-saving technique, but prolonged MV can cause significant diaphragmatic dysfunction due to atrophy and decreased contractility of the diaphragm fibres, called ventilator-induced diaphragmatic dysfunction (VIDD). It is not clear about the mechanism of occurrence and prevention measures of VIDD. Irisin is a newly discovered muscle factor that regulates energy metabolism. Studies have shown that irisin can exhibit protective effects by downregulating endoplasmic reticulum (ER) stress in a variety of diseases;...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Jumei Zhang Rui Tu Fasheng Guan Jianguo Feng Jing Jia Jun Zhou Xiaobin Wang Li Liu Source Type: research