Ginkgetin effectively mitigates collagen and AA-induced platelet activation via PLC γ2 but not cyclic nucleotide-dependent pathway in human
In conclusion, GK's profound impact on platelet activation, achieved through inhibiting PLCγ2-PKC cascade, culminates in the suppression of downstream signaling and, ultimately, the inhibition of platelet aggregation. These findings underscore the promising therapeutic potential of GK in the CVDs.PMID:38334198 | PMC:PMC10853947 | DOI:10.1111/jcmm.18139 (Source: J Cell Mol Med)
Source: J Cell Mol Med - February 9, 2024 Category: Molecular Biology Authors: Chih-Wei Hsia Lan-Hsin Shu Ai-Wei Lee Oanh-Thi Tran Chih-Hao Yang Ting-Lin Yen Wei-Chieh Huang Chih-Hsuan Hsia Thanasekaran Jayakumar Kuan-Rau Chiou Joen-Rong Sheu Source Type: research
Anemoside B4 alleviates arthritis pain via suppressing ferroptosis-mediated inflammation
J Cell Mol Med. 2024 Feb;28(4):e18136. doi: 10.1111/jcmm.18136.ABSTRACTChronic pain is the key manifestations of rheumatoid arthritis. Neuroinflammation in the spinal cord drives central sensitization and chronic pain. Ferroptosis has potentially important roles in the occurrence of neuroinflammation and chronic pain. In the current study, mouse model of collagen-induced arthritis was established by intradermal injection of type II collagen in complete Freund's adjuvant (CFA) solution. CFA inducement resulted in swollen paw and ankle, mechanical and spontaneous pain, and impaired motor coordination. The spinal inflammation...
Source: J Cell Mol Med - February 9, 2024 Category: Molecular Biology Authors: Chenlu Guo Yuanfen Yue Bojun Wang Shaohui Chen Dai Li Fangshou Zhen Ling Liu Haili Zhu Min Xie Source Type: research
The novel TERF2::PDGFRB fusion gene enhances tumorigenesis via PDGFRB/STAT5 signalling pathways and sensitivity to TKI in ph-like ALL
J Cell Mol Med. 2024 Feb;28(3):e18114. doi: 10.1111/jcmm.18114.ABSTRACTPatients with Philadelphia chromosome-like acute lymphoblastic leukaemia (Ph-like ALL) often face a grim prognosis, with PDGFRB gene fusions being commonly detected in this subgroup. Our study has unveiled a newfound fusion gene, TERF2::PDGFRB, and we have found that patients carrying this fusion gene exhibit sensitivity to dasatinib. Ba/F3 cells harbouring the TERF2::PDGFRB fusion display IL-3-independent cell proliferation through activation of the p-PDGFRB and p-STAT5 signalling pathways. These cells exhibit reduced apoptosis and demonstrate sensitiv...
Source: J Cell Mol Med - February 7, 2024 Category: Molecular Biology Authors: Guo-Fa Xu Zhao Zeng Zhi-Bo Zhang Xiao-Mei Zhang Man Wang Qing Xiao Jun Li Xiao-Qing Xie Sanxiu He Hui-Hui Fu Yi Liu Zai-Liang Yang Yu Chen Jie Shi Biao Wang Hui-Ying Qiu Qi Zhou Yao Liu Su-Ning Chen Source Type: research
Endoplasmic reticulum stress regulators exhibit different prognostic, therapeutic and immune landscapes in pancreatic adenocarcinoma
J Cell Mol Med. 2024 Feb 1. doi: 10.1111/jcmm.18092. Online ahead of print.ABSTRACTEndoplasmic reticulum stress (ERS) and unfolded protein response are the critical processes of tumour biology. However, the roles of ERS regulatory genes in pancreatic adenocarcinoma (PAAD) remain elusive. A novel ERS-related risk signature was constructed using the Lasso regression analysis. Its prognostic value, immune effect, metabolic influence, mutational feature and therapeutic correlation were comprehensively analysed through multiple bioinformatic approaches. The biofunctions of KDELR3 and YWHAZ in pancreatic cancer (PC) cells were a...
Source: J Cell Mol Med - February 2, 2024 Category: Molecular Biology Authors: Shanshan Liu Kaini He Longbao Yang Fangshi Xu Xiaoguang Cui Li Qu Xueyi Li Bin-Cheng Ren Source Type: research
Unravelling the heterogeneity of oral squamous cell carcinoma by integrative analysis of single-cell and bulk transcriptome data
In this study, we utilized single-cell RNA sequencing (scRNA-seq) analysis to explore distinct subpopulations of tumour cells in OSCC tissues and their interaction with components in TME. We identified four major tumour cell subpopulations (C0, C1, C2 and C3) with unique molecular characteristics and functional features. Pathway enrichment analysis revealed that C0 primarily expressed genes involved in extracellular matrix interactions and C1 showed higher proliferation levels, suggesting that the two cell subpopulations exhibited tumour aggressiveness. Conversely, C2 and C3 displayed features associated with keratinizatio...
Source: J Cell Mol Med - January 27, 2024 Category: Molecular Biology Authors: Jia Li Shengjiao Li Mingyang Shu Weiwei Hu Source Type: research
