Histone modification-linked prognostic model for ovarian cancer reveals LBX2 as a novel growth promoter
This study aimed to investigate the role of histone modification-related genes in predicting the prognosis of OC patients. Transcriptome data from multiple cohorts, including bulk RNA-Seq data and single-cell scRNA-Seq data, were collected. Gene set enrichment analysis was used to identify enriched gene sets in the histone modification pathway. Differentially expressed genes (DEGs) between histone modification-high and histone modification-low groups were identified using Lasso regression. A prognostic model was constructed using five selected prognostic genes from the DEGs in the TCGA-OV cohort. The study found enrichment...
Source: J Cell Mol Med - March 23, 2024 Category: Molecular Biology Authors: Jian Xiong Hongyuan Liang Xiang Sun Kefei Gao Source Type: research

MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease
J Cell Mol Med. 2024 Apr;28(8):e18229. doi: 10.1111/jcmm.18229.ABSTRACTMonoamine oxidase B (MAOB), a neurotransmitter-degrading enzyme, was reported to reveal conflicting roles in various cancers. However, the functional role of MAOB and impacts of its genetic variants on prostate cancer (PCa) is unknown. Herein, we genotyped four loci of MAOB single-nucleotide polymorphisms (SNPs), including rs1799836 (A/G), rs3027452 (G/A), rs6651806 (A/C) and rs6324 (G/A) in 702 PCa Taiwanese patients. We discovered that PCa patients carrying the MAOB rs6324 A-allele exhibited an increased risk of having a high initial prostate-specific...
Source: J Cell Mol Med - March 23, 2024 Category: Molecular Biology Authors: Hsiang-Ching Huang Yi-Hsien Hsieh Chi-Hao Hsiao Chia-Yen Lin Shian-Shiang Wang Kuo-Hao Ho Lun-Ching Chang Huei-Mei Huang Shun-Fa Yang Ming-Hsien Chien Source Type: research

Prognostic and immunotherapeutic potential of regulatory T  cell-associated signature in ovarian cancer
J Cell Mol Med. 2024 Apr;28(8):e18248. doi: 10.1111/jcmm.18248.ABSTRACTTumour-induced immunosuppressive microenvironments facilitate oncogenesis, with regulatory T cells (Tregs) serving as a crucial component. The significance of Treg-associated genes within the context of ovarian cancer (OC) remains elucidated insufficiently. Utilizing single-cell RNA sequencing (scRNA-Seq) for the identification of Treg-specific biomarkers, this investigation employed single-sample gene set enrichment analysis (ssGSEA) for the derivation of a Treg signature score. Weighted gene co-expression network analysis (WGCNA) facilitated the ident...
Source: J Cell Mol Med - March 23, 2024 Category: Molecular Biology Authors: Yinglei Liu Feng Shan Ying Sun Haili Kai Yang Cao Menghui Huang Jinhui Liu Pengpeng Zhang Yanli Zheng Source Type: research

Construction of a prognostic model with CAFs for predicting the prognosis and immunotherapeutic response of lung squamous cell carcinoma
J Cell Mol Med. 2024 Apr;28(8):e18262. doi: 10.1111/jcmm.18262.ABSTRACTLung squamous cell carcinoma (LUSC) is one of the subtypes of lung cancer (LC) that contributes to approximately 25%-30% of its prevalence. Cancer-associated fibroblasts (CAFs) are key cellular components of the TME, and the large number of CAFs in tumour tissues creates a favourable environment for tumour development. However, the function of CAFs in the LUSC is complex and uncertain. First, we processed the scRNA-seq data and classified distinct types of CAFs. We also identified prognostic CAFRGs using univariate Cox analysis and conducted survival an...
Source: J Cell Mol Med - March 23, 2024 Category: Molecular Biology Authors: Xiang Zhang Qingqing Xiao Cong Zhang Qinghua Zhou Tao Xu Source Type: research

Intracerebroventricular BDNF infusion may reduce cerebral ischemia/reperfusion injury by promoting autophagy and suppressing apoptosis
J Cell Mol Med. 2024 Apr;28(8):e18246. doi: 10.1111/jcmm.18246.ABSTRACTHere, it was aimed to investigate the effects of intracerebroventricular (ICV) Brain Derived Neurotrophic Factor (BDNF) infusion for 7 days following cerebral ischemia (CI) on autophagy in neurons in the penumbra. Focal CI was created by the occlusion of the right middle cerebral artery. A total of 60 rats were used and divided into 4 groups as Control, Sham CI, CI and CI + BDNF. During the 7-day reperfusion period, aCSF (vehicle) was infused to Sham CI and CI groups, and BDNF infusion was administered to the CI + BDNF group via an osmotic minipump. By ...
Source: J Cell Mol Med - March 23, 2024 Category: Molecular Biology Authors: Umit Yilmaz Kevser Tanbek Semir Gul Ahmet Koc Mehmet Gul Suleyman Sandal Source Type: research