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SGLT2i improves kidney senescence by down-regulating the expression of LTBP2 in SAMP8 mice
J Cell Mol Med. 2024 Mar;28(6):e18176. doi: 10.1111/jcmm.18176.ABSTRACTSenescent kidney can lead to the maladaptive repairment and predispose age-related kidney diseases. Here, we explore the renal anti-senescence effect of a known kind of drug, sodium-dependent glucose transporters 2 inhibitor (SGLT2i). After 4 months intragastrically administration with dapagliflozin on senescence-accelerated mouse prone 8 (SAMP8) strain mice, the physiologically effects (lowering urine protein, enhancing glomerular blood perfusion, inhibiting expression of senescence-related biomarkers) and structural changes (improving kidney atrophy, ...
Source: J Cell Mol Med - March 8, 2024 Category: Molecular Biology Authors: Lu Zeng Jie Li Fanfan Gao Yangyang Song Limin Wei Ning Qu Shengnan Chen Xue Zhao Zitong Lei Wenya Cao Lei Chen Hongli Jiang Source Type: research

Identification of key biomarkers for predicting CAD progression in inflammatory bowel disease via machine-learning and bioinformatics strategies
J Cell Mol Med. 2024 Mar;28(6):e18175. doi: 10.1111/jcmm.18175.ABSTRACTThe study aimed to identify the biomarkers for predicting coronary atherosclerotic lesions progression in patients with inflammatory bowel disease (IBD). Related transcriptome datasets were seized from Gene Expression Omnibus database. IBD-related modules were identified via Weighted Gene Co-expression Network Analysis. The 'Limma' was applied to screen differentially expressed genes between stable coronary artery disease (CAD) and acute myocardial infarction (AMI). Subsequently, we employed protein-protein interaction (PPI) network and three machine-le...
Source: J Cell Mol Med - March 7, 2024 Category: Molecular Biology Authors: Xiaoqi Tang Yufei Zhou Zhuolin Chen Chunjiang Liu Zhifeng Wu Yue Zhou Fan Zhang Xuanyuan Lu Liming Tang Source Type: research

Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity
In conclusion, SBSGL had immunomodulatory effects and regulated the malignancy and autophagy of HB by regulating the O-GlcNAcylation of RACK1. These findings suggest that SBSGL holds promise as a potential anticancer drug for HB treatment.PMID:38451046 | DOI:10.1111/jcmm.18223 (Source: J Cell Mol Med)
Source: J Cell Mol Med - March 7, 2024 Category: Molecular Biology Authors: Rui Shen Yang Ge Yunpeng Qin Hang Gao Hongyan Yu Huazhang Wu Hang Song Source Type: research

Overexpression of malic enzyme is involved in breast cancer growth and is correlated with poor prognosis
J Cell Mol Med. 2024 Mar;28(6):e18163. doi: 10.1111/jcmm.18163.ABSTRACTMalic enzyme (ME) genes are key functional metabolic enzymes playing a crucial role in carcinogenesis. However, the detailed effects of ME gene expression on breast cancer progression remain unclear. Here, our results revealed ME1 expression was significantly upregulated in breast cancer, especially in patients with oestrogen receptor/progesterone receptor-negative and human epidermal growth factor receptor 2-positive breast cancer. Furthermore, upregulation of ME1 was significantly associated with more advanced pathological stages (p < 0.001), pT st...
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: Wan-Chung Hu Yi-Fang Yang Ching-Feng Cheng Ya-Ting Tu Hong-Tai Chang Kuo-Wang Tsai Source Type: research

Prebiotics counteract the morphological and functional changes secondary to chronic cisplatin exposition in the proximal colon of mice
In conclusion, the present study shows that daily administration of prebiotics, likely protecting the microbiota, prevents most of the colonic cisplatin-induced alterations.PMID:38445787 | PMC:PMC10915824 | DOI:10.1111/jcmm.18161 (Source: J Cell Mol Med)
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: Cristina Biagioni Chiara Traini Maria Simonetta Faussone-Pellegrini Eglantina Idrizaj Maria Caterina Baccari Maria Giuliana Vannucchi Source Type: research

circ_HMGCS1 modulates hepatocellular carcinoma chemoresistance via miR-338-5p/IL-7 pathway
J Cell Mol Med. 2024 Mar;28(6):e18137. doi: 10.1111/jcmm.18137.ABSTRACTHepatocellular cancer is one of the most serious types of cancer in the world, with high incidence and mortality rates. Most HCC patients with long-term chemotherapy develop chemoresistance, leading to a poor prognosis. However, the underlying mechanism of circRNAs in HCC chemoresistance remains unclear. Our research found that circ_0072391(circ_HMGCS1) expression was significantly upregulated in cisplatin-resistant HCC cells. The silence of circ_HMGCS1 attenuated the cisplatin resistance in HCC. Results showed that circ_HMGCS1 regulated the expression ...
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: Siyu Zhang Jun Ma Tingdong Yu Zhengrui Song Wan Yee Lau Yong Zha Source Type: research

The SGLT family-sodium-glucose transporters with roles beyond glucose and the kidney
J Cell Mol Med. 2024 Mar;28(6):e18152. doi: 10.1111/jcmm.18152.NO ABSTRACTPMID:38445802 | PMC:PMC10915822 | DOI:10.1111/jcmm.18152 (Source: J Cell Mol Med)
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: David Mathew Sean Davidson Derek Yellon Source Type: research

Single-cell transcriptomic analysis in clear cell renal cell carcinoma: Deciphering the role of APP within the tumour microenvironment
This study focuses on the role of amyloid precursor protein (APP) in tumour-associated macrophages (TAMs) within the ccRCC TME, exploring its potential as a prognostic biomarker. Basing TAM-related genes, the prognostic model was important to constructed. Employing advanced single-cell transcriptomic analysis, this research dissects the TME of ccRCC at an unprecedented cellular resolution. By isolating and examining the gene expression profiles of individual cells, particularly focusing on TAMs, the study investigates the expression levels of APP and their association with the clinical outcomes of ccRCC patients. The analy...
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: Bo Guan Ming Li Di Cui Chen Shen Zongyao Hao Xiaowei Li Source Type: research

Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression
J Cell Mol Med. 2024 Mar;28(6):e18164. doi: 10.1111/jcmm.18164.ABSTRACTUbiquitin A-52 residue ribosomal protein fusion product 1 (UBA52) has a role in the occurrence and development of tumours. However, the mechanism by which UBA52 regulates hepatocellular carcinoma (HCC) tumorigenesis and progression remains poorly understood. By using the Cell Counting Kit (CCK-8), colony formation, wound healing and Transwell assays, we assessed the effects of UBA52 knockdown and overexpression on the proliferation and migration of HCC cells in vitro. By establishing subcutaneous and metastatic tumour models in nude mice, we evaluated t...
Source: J Cell Mol Med - March 6, 2024 Category: Molecular Biology Authors: Li Tong Xiaofei Zheng Tianqi Wang Wang Gu Tingting Shen Wenkang Yuan Siyu Wang Songlin Xing Xiaoying Liu Chong Zhang Chao Zhang Source Type: research