Integrating ferroptosis-related genes (FRGs) and prognostic models to enhance UCEC outcome prediction and therapeutic insights
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00779-3. Online ahead of print.ABSTRACTFerroptosis is closely associated with uterine corpus endometrial carcinoma (UCEC) development. This project aimed to identify new potential biomarkers to predict the prognosis of UCEC. In this work, UCEC transcriptome data along with clinical information was retrieved from the TCGA database including a total of 382 FRGs. We performed univariate Cox regression analysis to evaluate ferroptosis-related genes (FRGs) for prognostic significance. The genes with prognostic significance were then analyzed using LASSO-Cox to construct a progn...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Weiwei Jin Xiaoping Zhuang Yihe Lin Xiaoying Zhao Source Type: research
Genome-wide identification and characterization of ABC transporter superfamily in the legume Cajanus cajan
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00774-8. Online ahead of print.ABSTRACTPlant ATP-binding cassette (ABC) protein family is the largest multifunctional highly conserved protein superfamily that transports diverse substrates across biological membranes by the hydrolysis of ATP and is also the part of the several other biological processes like cellular detoxification, growth and development, stress biology, and signaling processes. In the agriculturally important legume crop Cajanus cajan, a genome-wide identification and characterization of the ABC gene family was carried out. A total of 159 ABC genes were...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Mridula Sanjana Mall Shreya Shah Shivani Singh Namita Singh Nootan Singh Swati Vaish Divya Gupta Source Type: research
Integrating ferroptosis-related genes (FRGs) and prognostic models to enhance UCEC outcome prediction and therapeutic insights
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00779-3. Online ahead of print.ABSTRACTFerroptosis is closely associated with uterine corpus endometrial carcinoma (UCEC) development. This project aimed to identify new potential biomarkers to predict the prognosis of UCEC. In this work, UCEC transcriptome data along with clinical information was retrieved from the TCGA database including a total of 382 FRGs. We performed univariate Cox regression analysis to evaluate ferroptosis-related genes (FRGs) for prognostic significance. The genes with prognostic significance were then analyzed using LASSO-Cox to construct a progn...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Weiwei Jin Xiaoping Zhuang Yihe Lin Xiaoying Zhao Source Type: research
Genome-wide identification and characterization of ABC transporter superfamily in the legume Cajanus cajan
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00774-8. Online ahead of print.ABSTRACTPlant ATP-binding cassette (ABC) protein family is the largest multifunctional highly conserved protein superfamily that transports diverse substrates across biological membranes by the hydrolysis of ATP and is also the part of the several other biological processes like cellular detoxification, growth and development, stress biology, and signaling processes. In the agriculturally important legume crop Cajanus cajan, a genome-wide identification and characterization of the ABC gene family was carried out. A total of 159 ABC genes were...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Mridula Sanjana Mall Shreya Shah Shivani Singh Namita Singh Nootan Singh Swati Vaish Divya Gupta Source Type: research
Congenital coenzyme Q5-linked pathology: causal genetic association, core phenotype, and molecular mechanism
J Appl Genet. 2023 Aug 21. doi: 10.1007/s13353-023-00773-9. Online ahead of print.ABSTRACTCoenzyme Q5 (COQ5), a C-methyltransferase, modifies coenzyme Q10 (COQ10) during biosynthesis and interacts with polyA-tail regulating zinc-finger protein ZC3H14 in neural development. Here, we present a fifth patient (a third family) worldwide with neurodevelopmental and physiological symptoms including COQ10 deficiency. Our patient harbors one novel c.681+1G>A and one recurrent p.Gly118Ser variant within COQ5. The patient's mRNA profile reveals multiple COQ5 splice-variants. Subsequently, we comprehensively described patient's cli...
Source: J Appl Genet - August 20, 2023 Category: Genetics & Stem Cells Authors: Mateusz Dawidziuk Aleksandra Podwysocka Marta Jurek Ewa Obersztyn Monika Bekiesinska-Figatowska Alicja Goszczanska-Ciuchta Ewelina Bukowska-Olech Agnieszka Magdalena Rygiel Dorothy Lys Guilbride Wojciech Wiszniewski Pawel Gawlinski Source Type: research
Congenital coenzyme Q5-linked pathology: causal genetic association, core phenotype, and molecular mechanism
J Appl Genet. 2023 Aug 21. doi: 10.1007/s13353-023-00773-9. Online ahead of print.ABSTRACTCoenzyme Q5 (COQ5), a C-methyltransferase, modifies coenzyme Q10 (COQ10) during biosynthesis and interacts with polyA-tail regulating zinc-finger protein ZC3H14 in neural development. Here, we present a fifth patient (a third family) worldwide with neurodevelopmental and physiological symptoms including COQ10 deficiency. Our patient harbors one novel c.681+1G>A and one recurrent p.Gly118Ser variant within COQ5. The patient's mRNA profile reveals multiple COQ5 splice-variants. Subsequently, we comprehensively described patient's cli...
Source: J Appl Genet - August 20, 2023 Category: Genetics & Stem Cells Authors: Mateusz Dawidziuk Aleksandra Podwysocka Marta Jurek Ewa Obersztyn Monika Bekiesinska-Figatowska Alicja Goszczanska-Ciuchta Ewelina Bukowska-Olech Agnieszka Magdalena Rygiel Dorothy Lys Guilbride Wojciech Wiszniewski Pawel Gawlinski Source Type: research
Congenital coenzyme Q5-linked pathology: causal genetic association, core phenotype, and molecular mechanism
J Appl Genet. 2023 Aug 21. doi: 10.1007/s13353-023-00773-9. Online ahead of print.ABSTRACTCoenzyme Q5 (COQ5), a C-methyltransferase, modifies coenzyme Q10 (COQ10) during biosynthesis and interacts with polyA-tail regulating zinc-finger protein ZC3H14 in neural development. Here, we present a fifth patient (a third family) worldwide with neurodevelopmental and physiological symptoms including COQ10 deficiency. Our patient harbors one novel c.681+1G>A and one recurrent p.Gly118Ser variant within COQ5. The patient's mRNA profile reveals multiple COQ5 splice-variants. Subsequently, we comprehensively described patient's cli...
Source: J Appl Genet - August 20, 2023 Category: Genetics & Stem Cells Authors: Mateusz Dawidziuk Aleksandra Podwysocka Marta Jurek Ewa Obersztyn Monika Bekiesinska-Figatowska Alicja Goszczanska-Ciuchta Ewelina Bukowska-Olech Agnieszka Magdalena Rygiel Dorothy Lys Guilbride Wojciech Wiszniewski Pawel Gawlinski Source Type: research
Congenital coenzyme Q5-linked pathology: causal genetic association, core phenotype, and molecular mechanism
J Appl Genet. 2023 Aug 21. doi: 10.1007/s13353-023-00773-9. Online ahead of print.ABSTRACTCoenzyme Q5 (COQ5), a C-methyltransferase, modifies coenzyme Q10 (COQ10) during biosynthesis and interacts with polyA-tail regulating zinc-finger protein ZC3H14 in neural development. Here, we present a fifth patient (a third family) worldwide with neurodevelopmental and physiological symptoms including COQ10 deficiency. Our patient harbors one novel c.681+1G>A and one recurrent p.Gly118Ser variant within COQ5. The patient's mRNA profile reveals multiple COQ5 splice-variants. Subsequently, we comprehensively described patient's cli...
Source: J Appl Genet - August 20, 2023 Category: Genetics & Stem Cells Authors: Mateusz Dawidziuk Aleksandra Podwysocka Marta Jurek Ewa Obersztyn Monika Bekiesinska-Figatowska Alicja Goszczanska-Ciuchta Ewelina Bukowska-Olech Agnieszka Magdalena Rygiel Dorothy Lys Guilbride Wojciech Wiszniewski Pawel Gawlinski Source Type: research
Development of a prognostic model for personalized prediction of colon adenocarcinoma (COAD) patient outcomes using methylation-driven genes
In conclusion, we identified the methylation driver gene of COAD and constructed a prognostic model and nomogram to personalized predict the prognosis of patients, which opened a new prospect for accurate diagnosis and treatment in clinical practice.PMID:37589877 | DOI:10.1007/s13353-023-00778-4 (Source: J Appl Genet)
Source: J Appl Genet - August 17, 2023 Category: Genetics & Stem Cells Authors: Di Chen Bo Zhang Kui Kang LiKun Li Yuan Liao Sheng Qing YaNan Di Source Type: research
Development of a prognostic model for personalized prediction of colon adenocarcinoma (COAD) patient outcomes using methylation-driven genes
In conclusion, we identified the methylation driver gene of COAD and constructed a prognostic model and nomogram to personalized predict the prognosis of patients, which opened a new prospect for accurate diagnosis and treatment in clinical practice.PMID:37589877 | DOI:10.1007/s13353-023-00778-4 (Source: J Appl Genet)
Source: J Appl Genet - August 17, 2023 Category: Genetics & Stem Cells Authors: Di Chen Bo Zhang Kui Kang LiKun Li Yuan Liao Sheng Qing YaNan Di Source Type: research
Development of a prognostic model for personalized prediction of colon adenocarcinoma (COAD) patient outcomes using methylation-driven genes
In conclusion, we identified the methylation driver gene of COAD and constructed a prognostic model and nomogram to personalized predict the prognosis of patients, which opened a new prospect for accurate diagnosis and treatment in clinical practice.PMID:37589877 | DOI:10.1007/s13353-023-00778-4 (Source: J Appl Genet)
Source: J Appl Genet - August 17, 2023 Category: Genetics & Stem Cells Authors: Di Chen Bo Zhang Kui Kang LiKun Li Yuan Liao Sheng Qing YaNan Di Source Type: research
Development of a prognostic model for personalized prediction of colon adenocarcinoma (COAD) patient outcomes using methylation-driven genes
In conclusion, we identified the methylation driver gene of COAD and constructed a prognostic model and nomogram to personalized predict the prognosis of patients, which opened a new prospect for accurate diagnosis and treatment in clinical practice.PMID:37589877 | DOI:10.1007/s13353-023-00778-4 (Source: J Appl Genet)
Source: J Appl Genet - August 17, 2023 Category: Genetics & Stem Cells Authors: Di Chen Bo Zhang Kui Kang LiKun Li Yuan Liao Sheng Qing YaNan Di Source Type: research
Relationship between antibiotic resistance with class 1 integron and SmeDEF efflux pump encoding genes in clinical isolates of Stenotrophomonas maltophilia
J Appl Genet. 2023 Aug 14. doi: 10.1007/s13353-023-00776-6. Online ahead of print.ABSTRACTStenotrophomonas maltophilia is an emerging multidrug-resistant organism with an increasing frequency of hospital-acquired infections predominantly in developing countries. The purpose of this study was to determine the antibiotic resistance and frequency of the smeD, class 1 integron, and sul1 genes in clinical isolates of S. maltophilia in two Iranian provinces. From January 2020 to September 2021, 38 clinical isolates of S. maltophilia were collected from patients in hospitals in Tabriz and Sanandaj provinces of Iran. S. maltophili...
Source: J Appl Genet - August 13, 2023 Category: Genetics & Stem Cells Authors: Soheila Bafandeh Zamanpour Rasoul Yousefi Mashouf Himen Salimizand Mohsen Nazari Mohammad Yousef Alikhani Safar Farajnia Source Type: research
Relationship between antibiotic resistance with class 1 integron and SmeDEF efflux pump encoding genes in clinical isolates of Stenotrophomonas maltophilia
J Appl Genet. 2023 Aug 14. doi: 10.1007/s13353-023-00776-6. Online ahead of print.ABSTRACTStenotrophomonas maltophilia is an emerging multidrug-resistant organism with an increasing frequency of hospital-acquired infections predominantly in developing countries. The purpose of this study was to determine the antibiotic resistance and frequency of the smeD, class 1 integron, and sul1 genes in clinical isolates of S. maltophilia in two Iranian provinces. From January 2020 to September 2021, 38 clinical isolates of S. maltophilia were collected from patients in hospitals in Tabriz and Sanandaj provinces of Iran. S. maltophili...
Source: J Appl Genet - August 13, 2023 Category: Genetics & Stem Cells Authors: Soheila Bafandeh Zamanpour Rasoul Yousefi Mashouf Himen Salimizand Mohsen Nazari Mohammad Yousef Alikhani Safar Farajnia Source Type: research
Relationship between antibiotic resistance with class 1 integron and SmeDEF efflux pump encoding genes in clinical isolates of Stenotrophomonas maltophilia
J Appl Genet. 2023 Aug 14. doi: 10.1007/s13353-023-00776-6. Online ahead of print.ABSTRACTStenotrophomonas maltophilia is an emerging multidrug-resistant organism with an increasing frequency of hospital-acquired infections predominantly in developing countries. The purpose of this study was to determine the antibiotic resistance and frequency of the smeD, class 1 integron, and sul1 genes in clinical isolates of S. maltophilia in two Iranian provinces. From January 2020 to September 2021, 38 clinical isolates of S. maltophilia were collected from patients in hospitals in Tabriz and Sanandaj provinces of Iran. S. maltophili...
Source: J Appl Genet - August 13, 2023 Category: Genetics & Stem Cells Authors: Soheila Bafandeh Zamanpour Rasoul Yousefi Mashouf Himen Salimizand Mohsen Nazari Mohammad Yousef Alikhani Safar Farajnia Source Type: research
