Blood-based microRNA profiling unveils complex molecular dynamics in breast cancer
CONCLUSION: This study provides significant insights into distinct miRNA expression patterns in normal and malignant breast tissues. The overlapping miRNA profiles in primary and malignant tumors underscore the complexity of genetic regulation in breast cancer. The identification of deregulated miRNAs and affected pathways contributes to our understanding of breast cancer pathogenesis. The validated miRNAs hold potential as diagnostic and prognostic markers, offering avenues for further clinical exploration in breast cancer research.PMID:38478327 | DOI:10.1007/s13353-024-00852-5 (Source: J Appl Genet)
Source: J Appl Genet - March 13, 2024 Category: Genetics & Stem Cells Authors: Mudassar Shahid Rabbani Syed M A Ansari Gowher Shafi James John Source Type: research
Integrative analysis of homologous recombination repair patterns unveils prognostic signatures and immunotherapeutic insights in breast cancer
J Appl Genet. 2024 Mar 13. doi: 10.1007/s13353-024-00848-1. Online ahead of print.ABSTRACTGlobally, breast cancer (BC) is the leading cause of female death and morbidity. Homologous recombination repair (HRR) is critical in BC. However, the prognostic role and immunotherapy response of HRR in BC remains to be clarified. Firstly, we identified HRR types in BC samples from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset (GSE42568) based on 65 HRR genes (HRRGs). A differentially expressed gene (DEG) list for different HRR types was generated. Then, the influences of gene sets composed of these DEGs on...
Source: J Appl Genet - March 13, 2024 Category: Genetics & Stem Cells Authors: Yan-Shuang Li Hong-Chuan Jiang Source Type: research
Blood-based microRNA profiling unveils complex molecular dynamics in breast cancer
CONCLUSION: This study provides significant insights into distinct miRNA expression patterns in normal and malignant breast tissues. The overlapping miRNA profiles in primary and malignant tumors underscore the complexity of genetic regulation in breast cancer. The identification of deregulated miRNAs and affected pathways contributes to our understanding of breast cancer pathogenesis. The validated miRNAs hold potential as diagnostic and prognostic markers, offering avenues for further clinical exploration in breast cancer research.PMID:38478327 | DOI:10.1007/s13353-024-00852-5 (Source: J Appl Genet)
Source: J Appl Genet - March 13, 2024 Category: Genetics & Stem Cells Authors: Mudassar Shahid Rabbani Syed M A Ansari Gowher Shafi James John Source Type: research
Integrative analysis of homologous recombination repair patterns unveils prognostic signatures and immunotherapeutic insights in breast cancer
J Appl Genet. 2024 Mar 13. doi: 10.1007/s13353-024-00848-1. Online ahead of print.ABSTRACTGlobally, breast cancer (BC) is the leading cause of female death and morbidity. Homologous recombination repair (HRR) is critical in BC. However, the prognostic role and immunotherapy response of HRR in BC remains to be clarified. Firstly, we identified HRR types in BC samples from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset (GSE42568) based on 65 HRR genes (HRRGs). A differentially expressed gene (DEG) list for different HRR types was generated. Then, the influences of gene sets composed of these DEGs on...
Source: J Appl Genet - March 13, 2024 Category: Genetics & Stem Cells Authors: Yan-Shuang Li Hong-Chuan Jiang Source Type: research
Blood-based microRNA profiling unveils complex molecular dynamics in breast cancer
CONCLUSION: This study provides significant insights into distinct miRNA expression patterns in normal and malignant breast tissues. The overlapping miRNA profiles in primary and malignant tumors underscore the complexity of genetic regulation in breast cancer. The identification of deregulated miRNAs and affected pathways contributes to our understanding of breast cancer pathogenesis. The validated miRNAs hold potential as diagnostic and prognostic markers, offering avenues for further clinical exploration in breast cancer research.PMID:38478327 | DOI:10.1007/s13353-024-00852-5 (Source: J Appl Genet)
Source: J Appl Genet - March 13, 2024 Category: Genetics & Stem Cells Authors: Mudassar Shahid Rabbani Syed M A Ansari Gowher Shafi James John Source Type: research
Integrative analysis of homologous recombination repair patterns unveils prognostic signatures and immunotherapeutic insights in breast cancer
J Appl Genet. 2024 Mar 13. doi: 10.1007/s13353-024-00848-1. Online ahead of print.ABSTRACTGlobally, breast cancer (BC) is the leading cause of female death and morbidity. Homologous recombination repair (HRR) is critical in BC. However, the prognostic role and immunotherapy response of HRR in BC remains to be clarified. Firstly, we identified HRR types in BC samples from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) dataset (GSE42568) based on 65 HRR genes (HRRGs). A differentially expressed gene (DEG) list for different HRR types was generated. Then, the influences of gene sets composed of these DEGs on...
Source: J Appl Genet - March 13, 2024 Category: Genetics & Stem Cells Authors: Yan-Shuang Li Hong-Chuan Jiang Source Type: research
Blood-based microRNA profiling unveils complex molecular dynamics in breast cancer
CONCLUSION: This study provides significant insights into distinct miRNA expression patterns in normal and malignant breast tissues. The overlapping miRNA profiles in primary and malignant tumors underscore the complexity of genetic regulation in breast cancer. The identification of deregulated miRNAs and affected pathways contributes to our understanding of breast cancer pathogenesis. The validated miRNAs hold potential as diagnostic and prognostic markers, offering avenues for further clinical exploration in breast cancer research.PMID:38478327 | DOI:10.1007/s13353-024-00852-5 (Source: J Appl Genet)
Source: J Appl Genet - March 13, 2024 Category: Genetics & Stem Cells Authors: Mudassar Shahid Rabbani Syed M A Ansari Gowher Shafi James John Source Type: research
Gene-edited cells: novel allogeneic gene/cell therapy for epidermolysis bullosa
This article attempts to summarize the current situation, potential development prospects, and some of the challenges related to the cell therapy approach for EB treatment.PMID:38459407 | DOI:10.1007/s13353-024-00839-2 (Source: J Appl Genet)
Source: J Appl Genet - March 8, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Gila Vahab Alamdari-Palangi Maedeh Rafiee Arezoo Jokar Sajad Ehtiaty Aria Dianatinasab Seyyed Hossein Khatami Mortaza Taheri-Anganeh Ahmad Movahedpour Jafar Fallahi Source Type: research
Gene-edited cells: novel allogeneic gene/cell therapy for epidermolysis bullosa
This article attempts to summarize the current situation, potential development prospects, and some of the challenges related to the cell therapy approach for EB treatment.PMID:38459407 | DOI:10.1007/s13353-024-00839-2 (Source: J Appl Genet)
Source: J Appl Genet - March 8, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Gila Vahab Alamdari-Palangi Maedeh Rafiee Arezoo Jokar Sajad Ehtiaty Aria Dianatinasab Seyyed Hossein Khatami Mortaza Taheri-Anganeh Ahmad Movahedpour Jafar Fallahi Source Type: research
Gene-edited cells: novel allogeneic gene/cell therapy for epidermolysis bullosa
This article attempts to summarize the current situation, potential development prospects, and some of the challenges related to the cell therapy approach for EB treatment.PMID:38459407 | DOI:10.1007/s13353-024-00839-2 (Source: J Appl Genet)
Source: J Appl Genet - March 8, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Gila Vahab Alamdari-Palangi Maedeh Rafiee Arezoo Jokar Sajad Ehtiaty Aria Dianatinasab Seyyed Hossein Khatami Mortaza Taheri-Anganeh Ahmad Movahedpour Jafar Fallahi Source Type: research
Gene-edited cells: novel allogeneic gene/cell therapy for epidermolysis bullosa
This article attempts to summarize the current situation, potential development prospects, and some of the challenges related to the cell therapy approach for EB treatment.PMID:38459407 | DOI:10.1007/s13353-024-00839-2 (Source: J Appl Genet)
Source: J Appl Genet - March 8, 2024 Category: Genetics & Stem Cells Authors: Fatemeh Gila Vahab Alamdari-Palangi Maedeh Rafiee Arezoo Jokar Sajad Ehtiaty Aria Dianatinasab Seyyed Hossein Khatami Mortaza Taheri-Anganeh Ahmad Movahedpour Jafar Fallahi Source Type: research
Identification and validation of a novel nine-gene prognostic signature of stem cell characteristic in hepatocellular carcinoma
J Appl Genet. 2024 Mar 5. doi: 10.1007/s13353-024-00850-7. Online ahead of print.ABSTRACTCurrently, cancer stem cells (CSCs) are regarded as the most promising target for cancer therapy due to their close association with tumor resistance, invasion, and recurrence. Thus, identifying CSCs-related genes and constructing a prognostic risk model associated with CSCs may be crucial for hepatocellular carcinoma (HCC) therapy. Xena Browser was used to download gene expression profiles and clinical data, while MSigDB was used to obtain genes associated with CSCs. Firstly, the non-negative matrix factorization (NMF) algorithm was u...
Source: J Appl Genet - March 5, 2024 Category: Genetics & Stem Cells Authors: Yahang An Weifeng Liu Yanhui Yang Zhijie Chu Junjun Sun Source Type: research
Transcriptome profiling and metabolic pathway analysis towards reliable biomarker discovery in early-stage lung cancer
J Appl Genet. 2024 Mar 5. doi: 10.1007/s13353-024-00847-2. Online ahead of print.ABSTRACTEarlier diagnosis of lung cancer is crucial for reducing mortality and morbidity in high-risk patients. Liquid biopsy is a critical technique for detecting the cancer earlier and tracking the treatment outcomes. However, noninvasive biomarkers are desperately needed due to the lack of therapeutic sensitivity and early-stage diagnosis. Therefore, we have utilized transcriptomic profiling of early-stage lung cancer patients to discover promising biomarkers and their associated metabolic functions. Initially, PCA highlights the diversity ...
Source: J Appl Genet - March 5, 2024 Category: Genetics & Stem Cells Authors: Muthu Kumar Thirunavukkarasu Priyanka Ramesh Ramanathan Karuppasamy Shanthi Veerappapillai Source Type: research
Identification and validation of a novel nine-gene prognostic signature of stem cell characteristic in hepatocellular carcinoma
J Appl Genet. 2024 Mar 5. doi: 10.1007/s13353-024-00850-7. Online ahead of print.ABSTRACTCurrently, cancer stem cells (CSCs) are regarded as the most promising target for cancer therapy due to their close association with tumor resistance, invasion, and recurrence. Thus, identifying CSCs-related genes and constructing a prognostic risk model associated with CSCs may be crucial for hepatocellular carcinoma (HCC) therapy. Xena Browser was used to download gene expression profiles and clinical data, while MSigDB was used to obtain genes associated with CSCs. Firstly, the non-negative matrix factorization (NMF) algorithm was u...
Source: J Appl Genet - March 5, 2024 Category: Genetics & Stem Cells Authors: Yahang An Weifeng Liu Yanhui Yang Zhijie Chu Junjun Sun Source Type: research
Transcriptome profiling and metabolic pathway analysis towards reliable biomarker discovery in early-stage lung cancer
J Appl Genet. 2024 Mar 5. doi: 10.1007/s13353-024-00847-2. Online ahead of print.ABSTRACTEarlier diagnosis of lung cancer is crucial for reducing mortality and morbidity in high-risk patients. Liquid biopsy is a critical technique for detecting the cancer earlier and tracking the treatment outcomes. However, noninvasive biomarkers are desperately needed due to the lack of therapeutic sensitivity and early-stage diagnosis. Therefore, we have utilized transcriptomic profiling of early-stage lung cancer patients to discover promising biomarkers and their associated metabolic functions. Initially, PCA highlights the diversity ...
Source: J Appl Genet - March 5, 2024 Category: Genetics & Stem Cells Authors: Muthu Kumar Thirunavukkarasu Priyanka Ramesh Ramanathan Karuppasamy Shanthi Veerappapillai Source Type: research
