Genetic implications of PSMA expression variability in breast cancer subtypes with a focus on triple-negative breast cancer
J Appl Genet. 2023 Dec 12. doi: 10.1007/s13353-023-00814-3. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) is a protein frequently found to be overexpressed in various non-prostate cancer types. Our investigation, based on data from the TCGA databases, revealed a wide range of differential PSMA (encoded by FOLH1 gene) mRNA expressions across several cancer types, with notable findings in triple-negative breast carcinoma. This preclinical study delves into the molecular underpinnings of utilizing PSMA-targeting radiopharmaceuticals within specific breast cancer subtypes. We conducted a transcriptomi...
Source: J Appl Genet - December 12, 2023 Category: Genetics & Stem Cells Authors: Mudassar Shahid Ahmed L Alaofi Mohammed S Alqahtani Rabbani Syed Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Enumeration of olive derived lignan, pinoresinol for activity against recent Omicron variant spike protein for structure-based drug design, DFT, molecular dynamics simulations, and MMGBSA studies
This study focuses on virtual screening, docking, and molecular dynamic analysis; we aimed to identify therapeutic candidates for the SARS-CoV-2 variant Omicron based on their ability to inhibit non-structural proteins. We investigate the prediction of the properties of a substantial database of drug molecules obtained from the OliveNet™ database. Compounds that did not exhibit adequate gastrointestinal absorption and failed the Lipinski test are not considered for further research. The filtered compounds were coupled with our primary target, SARS-CoV-2 Omicron spike protein. We focused on SARS-CoV-2 Omicron spike protei...
Source: J Appl Genet - November 29, 2023 Category: Genetics & Stem Cells Authors: Samia S Alkhalil Shoruq E Alosaimi Manal E Alosaimi Zuhair M Mohammedsaleh Waleed Al Abdulmonem Abdullah Saleh Alkhamiss Ruqaih S Alghsham Abdullah S M Aljohani Abdullah F Shater Fayez M Saleh Hailah M Almohaimeed Mona H Soliman Source Type: research
In vitro evaluation of biofilm phenotypic and genotypic characteristics among clinical isolates of Pseudomonas aeruginosa in Hamadan, West of Iran
This study was performed to determine the antibiotic resistance pattern, biofilm formation, and frequency of biofilm-related genes in P. aeruginosa strains. In total, 123 P. aeruginosa isolates were collected from different clinical sources. Antimicrobial susceptibility testing (AST) was performed to detect multidrug-resistant P. aeruginosa (MDRPA) isolates. To evaluate the biofilm-forming isolates, the microtiter plate (MTP) method was carried out. Also, the prevalence of biofilm genotype patterns, including pslA, pslD, pelA, pelF, and algD genes, was detected by polymerases chain reaction (PCR). According to our findings...
Source: J Appl Genet - November 28, 2023 Category: Genetics & Stem Cells Authors: Jaber Hemmati Mohsen Nazari Amjad Ahmadi Maral Bayati Mahsa Jalili Mohammad Taheri Younes Mohammadi Babak Asghari Source Type: research
In vitro evaluation of biofilm phenotypic and genotypic characteristics among clinical isolates of Pseudomonas aeruginosa in Hamadan, West of Iran
This study was performed to determine the antibiotic resistance pattern, biofilm formation, and frequency of biofilm-related genes in P. aeruginosa strains. In total, 123 P. aeruginosa isolates were collected from different clinical sources. Antimicrobial susceptibility testing (AST) was performed to detect multidrug-resistant P. aeruginosa (MDRPA) isolates. To evaluate the biofilm-forming isolates, the microtiter plate (MTP) method was carried out. Also, the prevalence of biofilm genotype patterns, including pslA, pslD, pelA, pelF, and algD genes, was detected by polymerases chain reaction (PCR). According to our findings...
Source: J Appl Genet - November 28, 2023 Category: Genetics & Stem Cells Authors: Jaber Hemmati Mohsen Nazari Amjad Ahmadi Maral Bayati Mahsa Jalili Mohammad Taheri Younes Mohammadi Babak Asghari Source Type: research
High expression of ACKR1 predicts a good prognosis and suppresses sarcoma cell progression via regulating the tumor immune microenvironment
In conclusion, low expression of ACKR1 presented as an independent prognostic biomarker in sarcoma. Overexpression of ACKR1 can significantly suppress cell progression ability in sarcoma by regulating the immune microenvironment.PMID:38006471 | DOI:10.1007/s13353-023-00805-4 (Source: J Appl Genet)
Source: J Appl Genet - November 25, 2023 Category: Genetics & Stem Cells Authors: Jinluan Lin Fude Liang Lifeng Zheng Jinyuan Zeng Jianhua Lin Source Type: research
