Identification of potential biomarkers for melanoma cancer (black tumor) using bioinformatics strategy: a study based on GEO and SRA datasets
J Appl Genet. 2023 Oct 24. doi: 10.1007/s13353-023-00794-4. Online ahead of print.ABSTRACTMelanoma, a highly invasive type of skin cancer that penetrates the entire dermis layer, is associated with increased mortality rates. Excessive exposure of the skin to sunlight, specifically ultraviolet radiation, is the underlying cause of this malignant condition. The appearance of unique skin moles represents a visible clue, referred to as the "ugly duckling" sign, indicating the presence of melanoma and its association with cellular DNA damage. This research aims to explore potential biomarkers derived from microarray data, emplo...
Source: J Appl Genet - October 24, 2023 Category: Genetics & Stem Cells Authors: Tahani Ahmad ALMatrafi Zuhair M Mohammedsaleh Mamdoh S Moawadh Zaid Bassfar Mohammed M Jalal Fatima Ahmed Badahdah Youssef S Alghamdi Hassan Hussain Almasoudi Mohammed Ageeli Hakami Abdulkarim S Binshaya Hailah M Almohaimeed Mona H Soliman Source Type: research
The forerunners and successful partnerships behind the BioNTech mRNA vaccine
J Appl Genet. 2023 Oct 20. doi: 10.1007/s13353-023-00793-5. Online ahead of print.ABSTRACTThe discovery of nucleic acids stands as a paramount achievement in the history of scientific endeavors. By applying transformative advancements in the fields of chemistry and physics to biological systems, researchers unveiled the enigmatic nature of life. Notably, messenger RNA (mRNA) emerged as a crucial player in this profound revelation, serving as a transient intermediary for genetic information transfer between genes and proteins. Groundbreaking investigations carried out from 1944 to 1961 led to the initial identification of t...
Source: J Appl Genet - October 20, 2023 Category: Genetics & Stem Cells Authors: Ilkin Ayg ün Jan Barciszewski Source Type: research
The forerunners and successful partnerships behind the BioNTech mRNA vaccine
J Appl Genet. 2023 Oct 20. doi: 10.1007/s13353-023-00793-5. Online ahead of print.ABSTRACTThe discovery of nucleic acids stands as a paramount achievement in the history of scientific endeavors. By applying transformative advancements in the fields of chemistry and physics to biological systems, researchers unveiled the enigmatic nature of life. Notably, messenger RNA (mRNA) emerged as a crucial player in this profound revelation, serving as a transient intermediary for genetic information transfer between genes and proteins. Groundbreaking investigations carried out from 1944 to 1961 led to the initial identification of t...
Source: J Appl Genet - October 20, 2023 Category: Genetics & Stem Cells Authors: Ilkin Ayg ün Jan Barciszewski Source Type: research
The forerunners and successful partnerships behind the BioNTech mRNA vaccine
J Appl Genet. 2023 Oct 20. doi: 10.1007/s13353-023-00793-5. Online ahead of print.ABSTRACTThe discovery of nucleic acids stands as a paramount achievement in the history of scientific endeavors. By applying transformative advancements in the fields of chemistry and physics to biological systems, researchers unveiled the enigmatic nature of life. Notably, messenger RNA (mRNA) emerged as a crucial player in this profound revelation, serving as a transient intermediary for genetic information transfer between genes and proteins. Groundbreaking investigations carried out from 1944 to 1961 led to the initial identification of t...
Source: J Appl Genet - October 20, 2023 Category: Genetics & Stem Cells Authors: Ilkin Ayg ün Jan Barciszewski Source Type: research
The forerunners and successful partnerships behind the BioNTech mRNA vaccine
J Appl Genet. 2023 Oct 20. doi: 10.1007/s13353-023-00793-5. Online ahead of print.ABSTRACTThe discovery of nucleic acids stands as a paramount achievement in the history of scientific endeavors. By applying transformative advancements in the fields of chemistry and physics to biological systems, researchers unveiled the enigmatic nature of life. Notably, messenger RNA (mRNA) emerged as a crucial player in this profound revelation, serving as a transient intermediary for genetic information transfer between genes and proteins. Groundbreaking investigations carried out from 1944 to 1961 led to the initial identification of t...
Source: J Appl Genet - October 20, 2023 Category: Genetics & Stem Cells Authors: Ilkin Ayg ün Jan Barciszewski Source Type: research
The forerunners and successful partnerships behind the BioNTech mRNA vaccine
J Appl Genet. 2023 Oct 20. doi: 10.1007/s13353-023-00793-5. Online ahead of print.ABSTRACTThe discovery of nucleic acids stands as a paramount achievement in the history of scientific endeavors. By applying transformative advancements in the fields of chemistry and physics to biological systems, researchers unveiled the enigmatic nature of life. Notably, messenger RNA (mRNA) emerged as a crucial player in this profound revelation, serving as a transient intermediary for genetic information transfer between genes and proteins. Groundbreaking investigations carried out from 1944 to 1961 led to the initial identification of t...
Source: J Appl Genet - October 20, 2023 Category: Genetics & Stem Cells Authors: Ilkin Ayg ün Jan Barciszewski Source Type: research
The mitogenomes characterization of two Peltigera species (Peltigera elisabethae and Peltigera polydactylon) and comparative mitogenomic analyses of six Peltigera
J Appl Genet. 2023 Oct 11. doi: 10.1007/s13353-023-00791-7. Online ahead of print.ABSTRACTIn the present study, the mitochondrial genomes of Peltigera elisabethae and P. polydactylon were sequenced and assembled. The two mitogenomes were composed of circular DNA molecules, with sizes of 64,034 bp and 59,208 bp, respectively. Comparative analysis showed that the genome size, GC content, GC skew, and AT skew varied between the two mitochondrial genomes. In codon analysis, phenylalanine (Phe), isoleucine (Ile), and leucine (Leu) were most frequently used in six Peltigera genomes. Evolutionary analysis showed that all 14 prote...
Source: J Appl Genet - October 11, 2023 Category: Genetics & Stem Cells Authors: Reyim Mamut Gulmira Anwar Lidan Wang Jinjin Fang Source Type: research
The mitogenomes characterization of two Peltigera species (Peltigera elisabethae and Peltigera polydactylon) and comparative mitogenomic analyses of six Peltigera
J Appl Genet. 2023 Oct 11. doi: 10.1007/s13353-023-00791-7. Online ahead of print.ABSTRACTIn the present study, the mitochondrial genomes of Peltigera elisabethae and P. polydactylon were sequenced and assembled. The two mitogenomes were composed of circular DNA molecules, with sizes of 64,034 bp and 59,208 bp, respectively. Comparative analysis showed that the genome size, GC content, GC skew, and AT skew varied between the two mitochondrial genomes. In codon analysis, phenylalanine (Phe), isoleucine (Ile), and leucine (Leu) were most frequently used in six Peltigera genomes. Evolutionary analysis showed that all 14 prote...
Source: J Appl Genet - October 11, 2023 Category: Genetics & Stem Cells Authors: Reyim Mamut Gulmira Anwar Lidan Wang Jinjin Fang Source Type: research
The mitogenomes characterization of two Peltigera species (Peltigera elisabethae and Peltigera polydactylon) and comparative mitogenomic analyses of six Peltigera
J Appl Genet. 2023 Oct 11. doi: 10.1007/s13353-023-00791-7. Online ahead of print.ABSTRACTIn the present study, the mitochondrial genomes of Peltigera elisabethae and P. polydactylon were sequenced and assembled. The two mitogenomes were composed of circular DNA molecules, with sizes of 64,034 bp and 59,208 bp, respectively. Comparative analysis showed that the genome size, GC content, GC skew, and AT skew varied between the two mitochondrial genomes. In codon analysis, phenylalanine (Phe), isoleucine (Ile), and leucine (Leu) were most frequently used in six Peltigera genomes. Evolutionary analysis showed that all 14 prote...
Source: J Appl Genet - October 11, 2023 Category: Genetics & Stem Cells Authors: Reyim Mamut Gulmira Anwar Lidan Wang Jinjin Fang Source Type: research
The mitogenomes characterization of two Peltigera species (Peltigera elisabethae and Peltigera polydactylon) and comparative mitogenomic analyses of six Peltigera
J Appl Genet. 2023 Oct 11. doi: 10.1007/s13353-023-00791-7. Online ahead of print.ABSTRACTIn the present study, the mitochondrial genomes of Peltigera elisabethae and P. polydactylon were sequenced and assembled. The two mitogenomes were composed of circular DNA molecules, with sizes of 64,034 bp and 59,208 bp, respectively. Comparative analysis showed that the genome size, GC content, GC skew, and AT skew varied between the two mitochondrial genomes. In codon analysis, phenylalanine (Phe), isoleucine (Ile), and leucine (Leu) were most frequently used in six Peltigera genomes. Evolutionary analysis showed that all 14 prote...
Source: J Appl Genet - October 11, 2023 Category: Genetics & Stem Cells Authors: Reyim Mamut Gulmira Anwar Lidan Wang Jinjin Fang Source Type: research
The mitogenomes characterization of two Peltigera species (Peltigera elisabethae and Peltigera polydactylon) and comparative mitogenomic analyses of six Peltigera
J Appl Genet. 2023 Oct 11. doi: 10.1007/s13353-023-00791-7. Online ahead of print.ABSTRACTIn the present study, the mitochondrial genomes of Peltigera elisabethae and P. polydactylon were sequenced and assembled. The two mitogenomes were composed of circular DNA molecules, with sizes of 64,034 bp and 59,208 bp, respectively. Comparative analysis showed that the genome size, GC content, GC skew, and AT skew varied between the two mitochondrial genomes. In codon analysis, phenylalanine (Phe), isoleucine (Ile), and leucine (Leu) were most frequently used in six Peltigera genomes. Evolutionary analysis showed that all 14 prote...
Source: J Appl Genet - October 11, 2023 Category: Genetics & Stem Cells Authors: Reyim Mamut Gulmira Anwar Lidan Wang Jinjin Fang Source Type: research
The mitogenomes characterization of two Peltigera species (Peltigera elisabethae and Peltigera polydactylon) and comparative mitogenomic analyses of six Peltigera
J Appl Genet. 2023 Oct 11. doi: 10.1007/s13353-023-00791-7. Online ahead of print.ABSTRACTIn the present study, the mitochondrial genomes of Peltigera elisabethae and P. polydactylon were sequenced and assembled. The two mitogenomes were composed of circular DNA molecules, with sizes of 64,034 bp and 59,208 bp, respectively. Comparative analysis showed that the genome size, GC content, GC skew, and AT skew varied between the two mitochondrial genomes. In codon analysis, phenylalanine (Phe), isoleucine (Ile), and leucine (Leu) were most frequently used in six Peltigera genomes. Evolutionary analysis showed that all 14 prote...
Source: J Appl Genet - October 11, 2023 Category: Genetics & Stem Cells Authors: Reyim Mamut Gulmira Anwar Lidan Wang Jinjin Fang Source Type: research
The mitogenomes characterization of two Peltigera species (Peltigera elisabethae and Peltigera polydactylon) and comparative mitogenomic analyses of six Peltigera
J Appl Genet. 2023 Oct 11. doi: 10.1007/s13353-023-00791-7. Online ahead of print.ABSTRACTIn the present study, the mitochondrial genomes of Peltigera elisabethae and P. polydactylon were sequenced and assembled. The two mitogenomes were composed of circular DNA molecules, with sizes of 64,034 bp and 59,208 bp, respectively. Comparative analysis showed that the genome size, GC content, GC skew, and AT skew varied between the two mitochondrial genomes. In codon analysis, phenylalanine (Phe), isoleucine (Ile), and leucine (Leu) were most frequently used in six Peltigera genomes. Evolutionary analysis showed that all 14 prote...
Source: J Appl Genet - October 11, 2023 Category: Genetics & Stem Cells Authors: Reyim Mamut Gulmira Anwar Lidan Wang Jinjin Fang Source Type: research
Genetic variants of MTHFR gene in relation to folic acid levels and bone mineral density in Polish patients with inflammatory bowel disease
J Appl Genet. 2023 Oct 11. doi: 10.1007/s13353-023-00792-6. Online ahead of print.ABSTRACTLower bone mineral density (BMD) constitutes a common issue in inflammatory bowel disease (IBD). Studies often explore the association between BMD and folic acid level. The presented study aimed to evaluate the impact of MTHFR gene polymorphism and folic acid levels on BMD in patients with IBDs: Crohn's disease (CD) and ulcerative colitis (UC). The study group comprised IBD patients and a healthy control group. BMD, T-score, and Z-score of the lumbar spine (L1-L4) and femoral neck (FN) were assessed using dual-energy X-ray absorptiome...
Source: J Appl Genet - October 10, 2023 Category: Genetics & Stem Cells Authors: Alicja E Ratajczak-Paw łowska Szymon Hryhorowicz Aleksandra Szymczak-Tomczak Ewa Wysocka Micha ł Michalak Marta Kaczmarek-Ry ś Emilia Lis-Tana ś Lena Bielawska Andrzej P ławski Ryszard S łomski Agnieszka Dobrowolska Iwona Krela-Ka źmierczak Source Type: research
Comprehensive bioinformatics analysis reveals the oncogenic role of FoxM1 and its impact on prognosis, immune microenvironment, and drug sensitivity in osteosarcoma
In conclusion, FoxM1 emerges as a central player in the pathogenesis of osteosarcoma, impacting gene expression, immune responses, and therapeutic outcomes. This comprehensive analysis deepens our understanding of FoxM1's role in osteosarcoma and offers potential avenues for improved diagnosis and treatment.PMID:37782449 | DOI:10.1007/s13353-023-00785-5 (Source: J Appl Genet)
Source: J Appl Genet - October 2, 2023 Category: Genetics & Stem Cells Authors: Shaoyan Shi Qian Wang Xiaolong Du Source Type: research
