Characterization of runs of Homozygosity revealed genomic inbreeding and patterns of selection in indigenous sahiwal cattle
J Appl Genet. 2023 Dec 18. doi: 10.1007/s13353-023-00816-1. Online ahead of print.ABSTRACTRuns of homozygosity (ROH) are contiguous genomic regions, homozygous across all sites which arise in an individual due to the parents transmitting identical haplotypes to their offspring. The genetic improvement program of Sahiwal cattle after decades of selection needs re-assessment of breeding strategy and population phenomena. Hence, the present study was carried out to optimize input parameters in PLINK for ROH estimates, to explore ROH islands and assessment of pedigree and genome-based inbreeding in Sahiwal cattle. The sliding ...
Source: J Appl Genet - December 19, 2023 Category: Genetics & Stem Cells Authors: Satish Kumar Illa Shabahat Mumtaz Sapna Nath Sabyasachi Mukherjee Anupama Mukherjee Source Type: research
The effect of library preparation protocol on the efficiency of heteroplasmy detection in mitochondrial DNA using two massively parallel sequencing Illumina systems
J Appl Genet. 2023 Dec 19. doi: 10.1007/s13353-023-00821-4. Online ahead of print.ABSTRACTMassively parallel sequencing (MPS) technology has become the gold standard in mitochondrial DNA research due to its high sensitivity in detecting mtDNA heteroplasmy, a prognostic marker in various medical applications. Various MPS technologies and platforms used for mtDNA analysis exist. Obtaining reliable and sensitive results requires deep and uniform coverage of the entire mtDNA sequence, which is heavily influenced by the choice of library preparation method and sequencing platform. Here, we present a comparison of the sequencing...
Source: J Appl Genet - December 19, 2023 Category: Genetics & Stem Cells Authors: Daca-Roszak Patrycja Fiedorowicz Joanna Jankowski Maciej Ciesielka Marzanna Teresi ński Grzegorz Lipska-Zietkiewicz Beata Zietkiewicz Ewa Grzybowski Tomasz Skonieczna Katarzyna Source Type: research
Genetic implications of PSMA expression variability in breast cancer subtypes with a focus on triple-negative breast cancer
J Appl Genet. 2023 Dec 12. doi: 10.1007/s13353-023-00814-3. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) is a protein frequently found to be overexpressed in various non-prostate cancer types. Our investigation, based on data from the TCGA databases, revealed a wide range of differential PSMA (encoded by FOLH1 gene) mRNA expressions across several cancer types, with notable findings in triple-negative breast carcinoma. This preclinical study delves into the molecular underpinnings of utilizing PSMA-targeting radiopharmaceuticals within specific breast cancer subtypes. We conducted a transcriptomi...
Source: J Appl Genet - December 12, 2023 Category: Genetics & Stem Cells Authors: Mudassar Shahid Ahmed L Alaofi Mohammed S Alqahtani Rabbani Syed Source Type: research
Genetic implications of PSMA expression variability in breast cancer subtypes with a focus on triple-negative breast cancer
J Appl Genet. 2023 Dec 12. doi: 10.1007/s13353-023-00814-3. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) is a protein frequently found to be overexpressed in various non-prostate cancer types. Our investigation, based on data from the TCGA databases, revealed a wide range of differential PSMA (encoded by FOLH1 gene) mRNA expressions across several cancer types, with notable findings in triple-negative breast carcinoma. This preclinical study delves into the molecular underpinnings of utilizing PSMA-targeting radiopharmaceuticals within specific breast cancer subtypes. We conducted a transcriptomi...
Source: J Appl Genet - December 12, 2023 Category: Genetics & Stem Cells Authors: Mudassar Shahid Ahmed L Alaofi Mohammed S Alqahtani Rabbani Syed Source Type: research
Genetic implications of PSMA expression variability in breast cancer subtypes with a focus on triple-negative breast cancer
J Appl Genet. 2023 Dec 12. doi: 10.1007/s13353-023-00814-3. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) is a protein frequently found to be overexpressed in various non-prostate cancer types. Our investigation, based on data from the TCGA databases, revealed a wide range of differential PSMA (encoded by FOLH1 gene) mRNA expressions across several cancer types, with notable findings in triple-negative breast carcinoma. This preclinical study delves into the molecular underpinnings of utilizing PSMA-targeting radiopharmaceuticals within specific breast cancer subtypes. We conducted a transcriptomi...
Source: J Appl Genet - December 12, 2023 Category: Genetics & Stem Cells Authors: Mudassar Shahid Ahmed L Alaofi Mohammed S Alqahtani Rabbani Syed Source Type: research
Genetic implications of PSMA expression variability in breast cancer subtypes with a focus on triple-negative breast cancer
J Appl Genet. 2023 Dec 12. doi: 10.1007/s13353-023-00814-3. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) is a protein frequently found to be overexpressed in various non-prostate cancer types. Our investigation, based on data from the TCGA databases, revealed a wide range of differential PSMA (encoded by FOLH1 gene) mRNA expressions across several cancer types, with notable findings in triple-negative breast carcinoma. This preclinical study delves into the molecular underpinnings of utilizing PSMA-targeting radiopharmaceuticals within specific breast cancer subtypes. We conducted a transcriptomi...
Source: J Appl Genet - December 12, 2023 Category: Genetics & Stem Cells Authors: Mudassar Shahid Ahmed L Alaofi Mohammed S Alqahtani Rabbani Syed Source Type: research
Genetic implications of PSMA expression variability in breast cancer subtypes with a focus on triple-negative breast cancer
J Appl Genet. 2023 Dec 12. doi: 10.1007/s13353-023-00814-3. Online ahead of print.ABSTRACTProstate-specific membrane antigen (PSMA) is a protein frequently found to be overexpressed in various non-prostate cancer types. Our investigation, based on data from the TCGA databases, revealed a wide range of differential PSMA (encoded by FOLH1 gene) mRNA expressions across several cancer types, with notable findings in triple-negative breast carcinoma. This preclinical study delves into the molecular underpinnings of utilizing PSMA-targeting radiopharmaceuticals within specific breast cancer subtypes. We conducted a transcriptomi...
Source: J Appl Genet - December 12, 2023 Category: Genetics & Stem Cells Authors: Mudassar Shahid Ahmed L Alaofi Mohammed S Alqahtani Rabbani Syed Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations
We present this novel angle that differential expression analysis should be performed separately for different alleles. Our ideas should greatly benefit the cancer community.PMID:38036772 | DOI:10.1007/s13353-023-00813-4 (Source: J Appl Genet)
Source: J Appl Genet - November 30, 2023 Category: Genetics & Stem Cells Authors: Qiuyu Hou Lifeng Shang Xu Chen Qiang Luo Liang Wei Chence Zhang Source Type: research
