Variants of the CASP9 gene as candidate markers for primary response to anti-TNF therapy in Crohn's disease patients
J Appl Genet. 2023 Sep 2. doi: 10.1007/s13353-023-00783-7. Online ahead of print.ABSTRACTAnti-tumor necrosis factor (TNF) therapy is used to induce and maintain remission in Crohn's disease (CD) patients. However, primary non-responders to initial treatment constitute 20-40% of cases. The causes of this phenomenon are still unknown. We aim to investigate the impact of the caspase 9 (CASP9) gene variants on the variable reactions of CD patients to anti-TNF therapy. The study group included 196 diagnosed and clinically characterized CD Polish patients following anti-TNF therapy. The sequence of the CASP9 gene was analyzed us...
Source: J Appl Genet - September 2, 2023 Category: Genetics & Stem Cells Authors: Liliana Lykowska-Szuber Michal Walczak Kamila Stawczyk-Eder Iwona Krela-Kazmierczak Piotr Eder Oliwia Zakerska-Banaszak Agnieszka Dobrowolska Marzena Skrzypczak-Zielinska Source Type: research
Variants of the CASP9 gene as candidate markers for primary response to anti-TNF therapy in Crohn's disease patients
J Appl Genet. 2023 Sep 2. doi: 10.1007/s13353-023-00783-7. Online ahead of print.ABSTRACTAnti-tumor necrosis factor (TNF) therapy is used to induce and maintain remission in Crohn's disease (CD) patients. However, primary non-responders to initial treatment constitute 20-40% of cases. The causes of this phenomenon are still unknown. We aim to investigate the impact of the caspase 9 (CASP9) gene variants on the variable reactions of CD patients to anti-TNF therapy. The study group included 196 diagnosed and clinically characterized CD Polish patients following anti-TNF therapy. The sequence of the CASP9 gene was analyzed us...
Source: J Appl Genet - September 2, 2023 Category: Genetics & Stem Cells Authors: Liliana Lykowska-Szuber Michal Walczak Kamila Stawczyk-Eder Iwona Krela-Kazmierczak Piotr Eder Oliwia Zakerska-Banaszak Agnieszka Dobrowolska Marzena Skrzypczak-Zielinska Source Type: research
Variants of the CASP9 gene as candidate markers for primary response to anti-TNF therapy in Crohn's disease patients
J Appl Genet. 2023 Sep 2. doi: 10.1007/s13353-023-00783-7. Online ahead of print.ABSTRACTAnti-tumor necrosis factor (TNF) therapy is used to induce and maintain remission in Crohn's disease (CD) patients. However, primary non-responders to initial treatment constitute 20-40% of cases. The causes of this phenomenon are still unknown. We aim to investigate the impact of the caspase 9 (CASP9) gene variants on the variable reactions of CD patients to anti-TNF therapy. The study group included 196 diagnosed and clinically characterized CD Polish patients following anti-TNF therapy. The sequence of the CASP9 gene was analyzed us...
Source: J Appl Genet - September 2, 2023 Category: Genetics & Stem Cells Authors: Liliana Lykowska-Szuber Michal Walczak Kamila Stawczyk-Eder Iwona Krela-Kazmierczak Piotr Eder Oliwia Zakerska-Banaszak Agnieszka Dobrowolska Marzena Skrzypczak-Zielinska Source Type: research
Variants of the CASP9 gene as candidate markers for primary response to anti-TNF therapy in Crohn's disease patients
J Appl Genet. 2023 Sep 2. doi: 10.1007/s13353-023-00783-7. Online ahead of print.ABSTRACTAnti-tumor necrosis factor (TNF) therapy is used to induce and maintain remission in Crohn's disease (CD) patients. However, primary non-responders to initial treatment constitute 20-40% of cases. The causes of this phenomenon are still unknown. We aim to investigate the impact of the caspase 9 (CASP9) gene variants on the variable reactions of CD patients to anti-TNF therapy. The study group included 196 diagnosed and clinically characterized CD Polish patients following anti-TNF therapy. The sequence of the CASP9 gene was analyzed us...
Source: J Appl Genet - September 2, 2023 Category: Genetics & Stem Cells Authors: Liliana Lykowska-Szuber Michal Walczak Kamila Stawczyk-Eder Iwona Krela-Kazmierczak Piotr Eder Oliwia Zakerska-Banaszak Agnieszka Dobrowolska Marzena Skrzypczak-Zielinska Source Type: research
FGFR3 and FGFR4 overexpression in juvenile nasopharyngeal angiofibroma: impact of smoking history and implications for personalized management
This study aims to assess the expression of FGFR3 and FGFR4 genes in patients with and without a history of smoking.A total of 118 participants were recruited, including 83 Juvenile Nasopharyngeal Angiofibroma (JNA) patients and 35 healthy participants, the JNA patients were further stratified as smokers and nonsmokers. Total RNA was extracted from the blood & saliva sample by using TRIzol reagent, and quantified using a Nanodrop, and then subjected to gene expression analysis of FGFR3/4 using RT-PCR. Immunohistochemistry analysis was employed using fresh biopsies of JNA to validate the findings. All experiments were p...
Source: J Appl Genet - September 1, 2023 Category: Genetics & Stem Cells Authors: Fatmah Ahmed Safhi Tahani Mohamed Ibrahim Al-Hazani Areej Saud Jalal Manal Abdullah Alduwish Dalal S Alshaya Nawaf Abdulrahman Almufareh Dalia Mostafa Domiaty Eman Alshehri Salha M Al-Shamrani Tahani Saeed Abboosh Mashael Alhumaidi Alotaibi Maha Abdulla A Source Type: research
FGFR3 and FGFR4 overexpression in juvenile nasopharyngeal angiofibroma: impact of smoking history and implications for personalized management
This study aims to assess the expression of FGFR3 and FGFR4 genes in patients with and without a history of smoking.A total of 118 participants were recruited, including 83 Juvenile Nasopharyngeal Angiofibroma (JNA) patients and 35 healthy participants, the JNA patients were further stratified as smokers and nonsmokers. Total RNA was extracted from the blood & saliva sample by using TRIzol reagent, and quantified using a Nanodrop, and then subjected to gene expression analysis of FGFR3/4 using RT-PCR. Immunohistochemistry analysis was employed using fresh biopsies of JNA to validate the findings. All experiments were p...
Source: J Appl Genet - September 1, 2023 Category: Genetics & Stem Cells Authors: Fatmah Ahmed Safhi Tahani Mohamed Ibrahim Al-Hazani Areej Saud Jalal Manal Abdullah Alduwish Dalal S Alshaya Nawaf Abdulrahman Almufareh Dalia Mostafa Domiaty Eman Alshehri Salha M Al-Shamrani Tahani Saeed Abboosh Mashael Alhumaidi Alotaibi Maha Abdulla A Source Type: research
FGFR3 and FGFR4 overexpression in juvenile nasopharyngeal angiofibroma: impact of smoking history and implications for personalized management
This study aims to assess the expression of FGFR3 and FGFR4 genes in patients with and without a history of smoking.A total of 118 participants were recruited, including 83 Juvenile Nasopharyngeal Angiofibroma (JNA) patients and 35 healthy participants, the JNA patients were further stratified as smokers and nonsmokers. Total RNA was extracted from the blood & saliva sample by using TRIzol reagent, and quantified using a Nanodrop, and then subjected to gene expression analysis of FGFR3/4 using RT-PCR. Immunohistochemistry analysis was employed using fresh biopsies of JNA to validate the findings. All experiments were p...
Source: J Appl Genet - September 1, 2023 Category: Genetics & Stem Cells Authors: Fatmah Ahmed Safhi Tahani Mohamed Ibrahim Al-Hazani Areej Saud Jalal Manal Abdullah Alduwish Dalal S Alshaya Nawaf Abdulrahman Almufareh Dalia Mostafa Domiaty Eman Alshehri Salha M Al-Shamrani Tahani Saeed Abboosh Mashael Alhumaidi Alotaibi Maha Abdulla A Source Type: research
Integrative multiomics and weighted network approach reveals the prognostic role of RPS7 in lung squamous cell carcinoma pathogenesis
J Appl Genet. 2023 Sep 1. doi: 10.1007/s13353-023-00782-8. Online ahead of print.ABSTRACTLung cancer is one of the most commonly occurring malignant cancers with the highest rate of mortality globally. Difference between lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) and their treatment strategies according to genetic markers may be helpful in reducing the cancer progression and increasing the overall survival (OS) in patients. LUSC is known for comparatively less typical onco-drivers, target therapy resistance, marked genomic complexity, and a reasonably higher mutation rate. The mRNA-seq data and clin...
Source: J Appl Genet - August 31, 2023 Category: Genetics & Stem Cells Authors: Prithvi Singh Archana Sharma Bhupender Kumar Anuradha Sinha Mansoor Ali Syed Ravins Dohare Source Type: research
Genome-wide identification and characterization of ABC transporter superfamily in the legume Cajanus cajan
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00774-8. Online ahead of print.ABSTRACTPlant ATP-binding cassette (ABC) protein family is the largest multifunctional highly conserved protein superfamily that transports diverse substrates across biological membranes by the hydrolysis of ATP and is also the part of the several other biological processes like cellular detoxification, growth and development, stress biology, and signaling processes. In the agriculturally important legume crop Cajanus cajan, a genome-wide identification and characterization of the ABC gene family was carried out. A total of 159 ABC genes were...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Mridula Sanjana Mall Shreya Shah Shivani Singh Namita Singh Nootan Singh Swati Vaish Divya Gupta Source Type: research
Integrating ferroptosis-related genes (FRGs) and prognostic models to enhance UCEC outcome prediction and therapeutic insights
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00779-3. Online ahead of print.ABSTRACTFerroptosis is closely associated with uterine corpus endometrial carcinoma (UCEC) development. This project aimed to identify new potential biomarkers to predict the prognosis of UCEC. In this work, UCEC transcriptome data along with clinical information was retrieved from the TCGA database including a total of 382 FRGs. We performed univariate Cox regression analysis to evaluate ferroptosis-related genes (FRGs) for prognostic significance. The genes with prognostic significance were then analyzed using LASSO-Cox to construct a progn...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Weiwei Jin Xiaoping Zhuang Yihe Lin Xiaoying Zhao Source Type: research
Genome-wide identification and characterization of ABC transporter superfamily in the legume Cajanus cajan
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00774-8. Online ahead of print.ABSTRACTPlant ATP-binding cassette (ABC) protein family is the largest multifunctional highly conserved protein superfamily that transports diverse substrates across biological membranes by the hydrolysis of ATP and is also the part of the several other biological processes like cellular detoxification, growth and development, stress biology, and signaling processes. In the agriculturally important legume crop Cajanus cajan, a genome-wide identification and characterization of the ABC gene family was carried out. A total of 159 ABC genes were...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Mridula Sanjana Mall Shreya Shah Shivani Singh Namita Singh Nootan Singh Swati Vaish Divya Gupta Source Type: research
Integrating ferroptosis-related genes (FRGs) and prognostic models to enhance UCEC outcome prediction and therapeutic insights
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00779-3. Online ahead of print.ABSTRACTFerroptosis is closely associated with uterine corpus endometrial carcinoma (UCEC) development. This project aimed to identify new potential biomarkers to predict the prognosis of UCEC. In this work, UCEC transcriptome data along with clinical information was retrieved from the TCGA database including a total of 382 FRGs. We performed univariate Cox regression analysis to evaluate ferroptosis-related genes (FRGs) for prognostic significance. The genes with prognostic significance were then analyzed using LASSO-Cox to construct a progn...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Weiwei Jin Xiaoping Zhuang Yihe Lin Xiaoying Zhao Source Type: research
Genome-wide identification and characterization of ABC transporter superfamily in the legume Cajanus cajan
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00774-8. Online ahead of print.ABSTRACTPlant ATP-binding cassette (ABC) protein family is the largest multifunctional highly conserved protein superfamily that transports diverse substrates across biological membranes by the hydrolysis of ATP and is also the part of the several other biological processes like cellular detoxification, growth and development, stress biology, and signaling processes. In the agriculturally important legume crop Cajanus cajan, a genome-wide identification and characterization of the ABC gene family was carried out. A total of 159 ABC genes were...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Mridula Sanjana Mall Shreya Shah Shivani Singh Namita Singh Nootan Singh Swati Vaish Divya Gupta Source Type: research
Integrating ferroptosis-related genes (FRGs) and prognostic models to enhance UCEC outcome prediction and therapeutic insights
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00779-3. Online ahead of print.ABSTRACTFerroptosis is closely associated with uterine corpus endometrial carcinoma (UCEC) development. This project aimed to identify new potential biomarkers to predict the prognosis of UCEC. In this work, UCEC transcriptome data along with clinical information was retrieved from the TCGA database including a total of 382 FRGs. We performed univariate Cox regression analysis to evaluate ferroptosis-related genes (FRGs) for prognostic significance. The genes with prognostic significance were then analyzed using LASSO-Cox to construct a progn...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Weiwei Jin Xiaoping Zhuang Yihe Lin Xiaoying Zhao Source Type: research
Genome-wide identification and characterization of ABC transporter superfamily in the legume Cajanus cajan
J Appl Genet. 2023 Aug 25. doi: 10.1007/s13353-023-00774-8. Online ahead of print.ABSTRACTPlant ATP-binding cassette (ABC) protein family is the largest multifunctional highly conserved protein superfamily that transports diverse substrates across biological membranes by the hydrolysis of ATP and is also the part of the several other biological processes like cellular detoxification, growth and development, stress biology, and signaling processes. In the agriculturally important legume crop Cajanus cajan, a genome-wide identification and characterization of the ABC gene family was carried out. A total of 159 ABC genes were...
Source: J Appl Genet - August 25, 2023 Category: Genetics & Stem Cells Authors: Mridula Sanjana Mall Shreya Shah Shivani Singh Namita Singh Nootan Singh Swati Vaish Divya Gupta Source Type: research
