Immunology and Allergy Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Immune-Related Adverse Drug Reactions and Immunologically Mediated Drug Hypersensitivity
Biologic and other therapies used for the treatment of immune-mediated hypersensitivity conditions, and in people with immune-mediated hypersensitivity, can trigger a wide variety of immune-related adverse drug reactions and immunologically mediated drug hypersensitivities. These range from acute-onset immunoglobulin E –mediated allergies to delayed-onset T-cell–mediated hypersensitivities. Certain therapeutic and diagnostic agents can directly activate mast cells. Biologic agents used to treat immune-mediated hypersensitivity can also globally upregulate or downregulate the immune system leading to pathologic reaction...
Source: Immunology and Allergy Clinics of North America - September 8, 2020 Category: Allergy & Immunology Authors: Eric Macy Source Type: research

Current and Potential Biologic Drugs for the Treatment of Chronic Urticaria
This article reviews biologic treatments that are currently applied for the treatment of severe chronic urticaria. Monoclonal anti –immunoglobulin E (omalizumab) is effective and safe in many patients, but accessibility and cost constitute barriers to its wider use. Questions on the optimal duration of the treatment and possible symptom recurrences after discontinuing the drug are still raised. A discussion is presented about several other biologics currently under investigation with potential to be incorporated in the near future in patients with severe chronic urticaria. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - September 8, 2020 Category: Allergy & Immunology Authors: Mario S ánchez-Borges, Sandra González Díaz, Jose Antonio Ortega-Martell, Maria Isabel Rojo, Ignacio J. Ansotegui Source Type: research

Vaccines in Patients with Primary Immune Deficiency
Evaluation of antibodies produced after immunization is central to immune deficiency diagnosis. This includes assessment of responses to routine immunizations as well as to vaccines administered specifically for diagnosis. Here, we present the basic concepts of the humoral immune response and their relevance for vaccine composition and diagnosis of immune deficiency. Current vaccines are discussed, including nonviable protein and glycoprotein vaccines, pure polysaccharide vaccines, polysaccharide –protein conjugate vaccines, and live agent vaccines. Diagnostic and therapeutic applications of vaccine antibody measurement ...
Source: Immunology and Allergy Clinics of North America - July 10, 2020 Category: Allergy & Immunology Authors: Francisco A. Bonilla Source Type: research

Asplenia and Hyposplenism
The number of disorders associated with congenital or acquired asplenia and functional hyposplenism has increased substantially over the past couple decades. Previously, screening for asplenia and hyposplenism was a barrier to identifying patients at risk. Recent methods for measuring splenic function have emerged as accurate and reliable. Identifying patients prevents overwhelming postsplenectomy infection or invasive pneumococcal disease. Approaches to protect patients with asplenia or hyposplenism include patient education of risks and signs/symptoms of infection, vaccination, and antibiotic prophylaxis. Physicians have...
Source: Immunology and Allergy Clinics of North America - July 10, 2020 Category: Allergy & Immunology Authors: Jacqueline D. Squire, Mandel Sher Source Type: research

Precision Therapy for the Treatment of Primary Immunodysregulatory Diseases
This article reviews targeted precision-based therapy for treatment of cytotoxic T-lymphocyte antigen haploinsufficiency, lipopolysaccharide-responsive beige-like anchor deficiency, activated PI3K defic iency syndrome, signal transducer and activator of transcription– 1 and -3 – gain-of-function disorders, and disorders of inflammasome activation. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - July 10, 2020 Category: Allergy & Immunology Authors: Deepak Chellapandian, Maria Chitty-Lopez, Jennifer W. Leiding Source Type: research