“Doctor…I’m Pregnant”!
Suddenly she turned, smiled, and said, “Dr Schulman, I’m eight weeks pregnant.” “Mazel tov.” I scurried to review her problem list, medication list, and my last note. I panicked slightly. Sound familiar? Was my patient taking potentially toxic meds during this first trimester? Is my knowledge up-to-date? Can I confidently couns el her, answering her many questions? (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 27, 2022 Category: Allergy & Immunology Authors: Edward S. Schulman Tags: Preface Source Type: research

Immunopathology of Differing Viral Infection in Allergic Asthma Disease
The pathophysiology of asthma development is heterogenous. Although complex interactions between factors are present in any one individual, early life viral infections have been shown to play a major role through induction of epithelial damage as well as various innate and adaptive immune responses. The cytokine profile that results from epithelial damage leads to Th2 skewing of the adaptive immune response. Most asthma exacerbations in children and up to half of adults are related to viral infections that also induce epithelial damage and an acute predominately Th2 inflammatory response, leading to acute symptoms and chro...
Source: Immunology and Allergy Clinics of North America - October 18, 2022 Category: Allergy & Immunology Authors: Jenny Resiliac, Christopher D. Brooks, Mitchell H. Grayson Source Type: research

Air Pollution Effects in Allergies and Asthma
Outdoor air pollution is associated with exacerbations of allergic diseases, including asthma, allergic rhinitis, and other atopic conditions. The increased allergic disease prevalence has been linked to this urbanization, industrialization, and economic growth globally. Air pollutants are well-known to disrupt the epithelium leading to specific diseases in any organ system that has epithelial linings. This review provides an overview of the health effects of air pollution on allergic disorders and specifically addresses how it may impact the epithelial barrier in the upper and lower respiratory tracts to facilitate the he...
Source: Immunology and Allergy Clinics of North America - October 18, 2022 Category: Allergy & Immunology Authors: Anil Nanda, Syed Shahzad Mustafa, Maria Castillo, Jonathan A. Bernstein Source Type: research

Environmental Issues and Allergy
IMMUNOLOGY AND ALLERGYCLINICS OF NORTH AMERICA (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 18, 2022 Category: Allergy & Immunology Authors: Jill A. Poole Source Type: research

Copyright
ELSEVIER (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 18, 2022 Category: Allergy & Immunology Source Type: research

Contributors
JILL A. POOLE, MD (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 18, 2022 Category: Allergy & Immunology Source Type: research

Contents
Jill A. Poole (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 18, 2022 Category: Allergy & Immunology Source Type: research

Forthcoming Issues
Pregnancy and Allergy (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 18, 2022 Category: Allergy & Immunology Source Type: research

Viral Infections and Wheezing in Preschool Children
Wheezing is common in childhood, although only a small percentage of these children develop asthma. The child ’s wheezing phenotype and asthma predictive indices help predict the likelihood of a future asthma diagnosis. Viral infections are common in childhood with most wheezing episodes due to respiratory syncytial virus and rhinovirus. Many treatment options exist for wheezing children including both th ose who wheeze persistently and those who wheeze intermittently due to viral infections. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - September 23, 2022 Category: Allergy & Immunology Authors: Alexa M.A. Doss, Jeffrey R. Stokes Source Type: research

Environmental Exposures Impact Pediatric Asthma Within the School Environment
The school is a microenvironment well-known to host many indoor allergens and pollutants, with a strong association between school allergen exposure and childhood asthma morbidity. Despite advances in therapies, asthma continues to be one of the most common chronic conditions among children, associated with significant morbidity, health care utilization, and productivity loss. Asthma prevalence is also disproportionately high among children in minority communities. This review will focus on environmental exposures associated with asthma morbidity (cockroach, mouse, cat and dog, dust mite, fungus, air pollution). This revie...
Source: Immunology and Allergy Clinics of North America - September 23, 2022 Category: Allergy & Immunology Authors: Caroline L. Mortelliti, Tina M. Banzon, Wanda Phipatanakul, Carolina Zilli Vieira Source Type: research

Eosinophilic Esophagitis
This article discusses the latest data regarding the role of the exposome, microbiome, and environmental allergens on the development and ongoing inflammation of EoE, focusing on the last 10  years of relevant studies. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - September 23, 2022 Category: Allergy & Immunology Authors: Mehr Zahra Shah, Brooke I. Polk Source Type: research

Climate Change Factors and the Aerobiology Effect
There is clear evidence that climate change is occurring as there has been an acceleration of global temperatures since the mid-nineteenth century along with rising atmospheric carbon dioxide levels. It has been proposed that one of the most significant consequences of climate change on human health could be the impact on aeroallergens. Evidence from around globe has pointed to longer and more abundant pollen season associated with global warming. Additional studies have also suggested increased pollen allergenicity due to air pollution. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - September 23, 2022 Category: Allergy & Immunology Authors: Andrew Rorie Source Type: research

Influence of Rural Environmental Factors in Asthma
Conclusion: A complex network of environmental factors exists, which may have detrimental effects on the respiratory health of rural residents. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - September 23, 2022 Category: Allergy & Immunology Authors: Jennilee Luedders, Jill A. Poole Source Type: research

Ozone in the Development of Pediatric Asthma and Atopic Disease
Ozone (O3) is a ubiquitous outdoor air pollutant, which may be derived from various primary pollutants such as nitrates, hydrocarbons, and volatile organ compounds through ultraviolet radiation exposure, and has been shown to negatively impact respiratory health. O3 is the most common noninfectious environmental cause of asthma exacerbations among children and adults. Its effects on pediatric respiratory health could be due to multiple physiologic factors that may contribute to enhanced O3 exposure seen in children compared with adults, including differences in lung surface area per unit of body weight and ventilation rate...
Source: Immunology and Allergy Clinics of North America - September 23, 2022 Category: Allergy & Immunology Authors: Claire E. Atkinson, Matthew J. Kesic, Michelle L. Hernandez Source Type: research

Electronic Cigarettes and Vaping in Allergic and Asthmatic Disease
Electronic nicotine delivery systems (ENDS) were introduced in 2006, offering alternatives to combustible cigarettes. There is significant controversy regarding their sale and regulation, particularly with youth and high-risk patient populations. They were deemed a “major public health concern” by the United States (US) Surgeon General in 2016 . Already associated with health consequences, recently e-cig or vaping product use-associated lung injury (EVALI) has exposed their potential to cause life-threatening complications. This publication aims to educate readers on the the immediate and long-term health consequences ...
Source: Immunology and Allergy Clinics of North America - September 23, 2022 Category: Allergy & Immunology Authors: Marissa Love, Selina Gierer Source Type: research