Immunology and Allergy Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Role of Smoking in Asthma and Chronic Obstructive Pulmonary Disease Overlap
Exposure to cigarette smoke has a key role in the development, adverse health outcomes, and impaired response to some therapies among individuals with features of asthma and chronic obstructive pulmonary disease overlap (ACO). To aid the identification of clinical subtypes, the description of ever smokers with features of asthma and COPD should include data on smoking status, cumulative smoking history, and the phenotype of asthma and smoking-related chronic airway disease. Pathogenic mechanisms in smoking-related ACO involve poorly understood, complex interactions between smoking-induced and asthma-induced airway inflamma...
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: Neil C. Thomson Source Type: research

The Physiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap
Asthma and chronic obstructive pulmonary disease (COPD) are both characterized by airway obstruction and share similar clinical manifestations. However, they differ in many respects related to underlying cause, mechanism of airway obstruction, pattern and progression of symptoms, and response to therapy. It remains unclear whether there is a unique physiologic phenotype that characterizes asthma-COPD overlap (ACO). This review describes the common and distinct physiologic tests that help define asthma and COPD and potentially how they may contribute to understanding the underlying physiology of ACO. (Source: Immunology and...
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: David A. Kaminsky, Charles G. Irvin Source Type: research

Asthma-Chronic Obstructive Pulmonary Disease Overlap
Asthma and chronic obstructive pulmonary disease (COPD) are 2 distinct diseases with different clinical presentations. Chronic inflammation and airway obstruction are key features of asthma and COPD. Increased morbidity and mortality rates seem to be an important characteristic associated with asthma-COPD overlap (ACO).Atopy is an important clinical characteristic of patients categorized as ACO. Herein, the authors review the recent advancements in basic research, clinical assessment, and defining characteristics of ACO and the role for allergy as well as highlight future potential for disease-specific therapeutics for thi...
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: Kasey M. Shao, Jonathan A. Bernstein Source Type: research

Imaging in Asthma-Chronic Obstructive Pulmonary Disease Overlap
The purpose of this article is to review the imaging features in patients defined by researchers as having asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO), highlight the existing imaging studies investigating patients with ACO when compared with those with asthma and COPD alone, and, finally, discuss some remaining gaps in the understanding of ACO that imaging may help resolve. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: Sarah Svenningsen, Miranda Kirby Source Type: research

Clinical Assessment and Utility of Biomarkers in Asthma-Chronic Obstructive Pulmonary Disease Overlap
This article reviews the recent advances in clinical assessment of and the utility of biomarkers in ACO, as well as highlights a treatable trait approach to identify and manage these chronic airway diseases. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: Kewu Huang, Kian Fan Chung Source Type: research

Novel Therapeutic Strategies in Asthma-Chronic Obstructive Pulmonary Disease Overlap
The term asthma-chronic obstructive pulmonary disease (COPD) overlap applies where there are features of asthma and COPD. Agents targeting eosinophilic inflammation have transformed asthma management and indicate promise across airways disease, whereas agents targeting neutrophilic inflammation have demonstrated limited efficacy. Successful treatment of airway dysbiosis, mucous hypersecretion, or airway remodeling may occur with better understanding of the impact of current agents on specific clinical end points or through novel approaches. Biomarkers indicating specific disease mechanisms are key to select appropriate pop...
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: Sarah Diver, Chris E. Brightling, Neil J. Greening Source Type: research

Unmet Needs and the Future of Asthma-Chronic Pulmonary Obstructive Disease Overlap
If there is a need to consider the possible overlapping of features of asthma and chronic obstructive pulmonary disease (COPD) in the same patient as a clinical condition that deserves specific attention, an acceptable definition for it must be found. The identification of specific biomarkers using multi-omics platforms, may help in differentiating ACO from asthma and COPD and in choosing the right treatment. It is likely that an approach based on treatable traits and additional knowledge about the mechanisms underlying these treatable traits will be the solution to the problem. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: Mario Cazzola, Paola Rogliani, Maria Gabriella Matera Source Type: research

Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap
Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a condition in which a person has clinical and biological features of both asthma and COPD. The pathophysiology behind the development of ACO is complex, with various inflammatory cells, cytokines, environmental factors, and architectural changes within the airways, all affecting a patient ’s clinical manifestation. A better understanding of the pathophysiologic mechanisms resulting in the development of ACO will help us to better identify potential drug targets and improve symptom burden and overall quality of life for patients living with ACO. (Source...
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: Andi Hudler, Fernando Holguin, Sunita Sharma Source Type: research

Phenotypes of Asthma –Chronic Obstructive Pulmonary Disease Overlap
Asthma and chronic obstructive pulmonary disease are considered unique diseases with distinct characteristics. Asthma –chronic obstructive pulmonary disease overlap is a disorder in which the clinical characteristics of asthma and chronic obstructive pulmonary disease coexist. Asthma–chronic obstructive pulmonary disease overlap is a heterogenous condition; patients can have varied clinical presentations. There are significant gender variations among different phenotypes overlap. Age of symptom onset is another important consideration. Severity of symptoms, spirometry findings, smoking history, and type of airway infla...
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: Muhammad Adrish, Mahesh P. Anand, Nicola A. Hanania Source Type: research

Asthma –Chronic Obstructive Pulmonary Disease: An Update
Asthma and chronic obstructive pulmonary disease (COPD) are common airway diseases that often have overlapping clinical presentation, which may cause a major challenge for the health care providers. This overlap, although recognized for many years, has been called Asthma COPD Overlap (ACO). There is no consensus on the exact definition of ACO, although several epidemiologic studies suggest that its presence is associated with worse clinical outcomes than asthma or COPD. In the following series, our invited authors detail the various features associated with ACO, focusing on current knowledge and outlining future needs. (So...
Source: Immunology and Allergy Clinics of North America - June 30, 2022 Category: Allergy & Immunology Authors: Nicola A. Hanania, Louis-Philippe Boulet Tags: Preface Source Type: research

Drug Hypersensitivity
IMMUNOLOGY AND ALLERGYCLINICS OF NORTH AMERICA (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 23, 2022 Category: Allergy & Immunology Authors: Elizabeth J. Phillips Source Type: research

Copyright
ELSEVIER (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 23, 2022 Category: Allergy & Immunology Source Type: research

Contributors
ELIZABETH J. PHILLIPS, MD, FIDSA, FAAAAI (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 23, 2022 Category: Allergy & Immunology Source Type: research

Contents
Elizabeth J. Phillips (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 23, 2022 Category: Allergy & Immunology Source Type: research

Forthcoming Issues
Asthma and COPD Overlap: An Update (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 23, 2022 Category: Allergy & Immunology Source Type: research