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Contents
Susan Nedorost (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - July 3, 2021 Category: Allergy & Immunology Source Type: research

Forthcoming Issues
Pediatric Immunology and Allergy (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - July 3, 2021 Category: Allergy & Immunology Source Type: research

Advances in the Translational Science of Dermatitis
The cycle of converting mechanistic insight into therapeutic interventions is called translational science. It has been relatively sluggish in atopic dermatitis (AD), but finally pathomechanisms have been identified and therapeutic targets selected and refined. From inflammatory mediators, skin barrier enhancement, itch relief, and alteration of the microbiota, several therapies have been proposed and are actively being studied for AD, suggesting an end to the drought of innovation. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - June 4, 2021 Category: Allergy & Immunology Authors: Sara Bilimoria, Kyle Tegtmeyer, Peter Lio Source Type: research

Environmental Causes of Dermatitis
Environmental, or exogenous, dermatitis is comprised of irritant and allergic contact dermatitis, which account for 80% and 20% of cases of contact dermatitis, respectively. Contact dermatitis is extremely common, and failure to diagnose this entity may result in overlooking a potentially curable driver of disease. In this review, we describe how clinical features, such as morphology or history, can assist in distinguishing exogenous from endogenous causes of dermatitis, and allergic from irritant contact dermatitis. Additionally, we provide an overview of common contact allergens and how dermatitis distribution can sugges...
Source: Immunology and Allergy Clinics of North America - June 4, 2021 Category: Allergy & Immunology Authors: Jannett Nguyen, Jennifer K. Chen Source Type: research

Laboratory Techniques for Identifying Causes of Allergic Dermatitis
This article reviews the laboratory ’s role in identifying causes of chemical-induced allergic dermatitis. Several topics will be discussed. Allergen hazard identification refers to testing of chemicals for their sensitization potential. Animal-based, in silico, in chemico, and in vitro tests have been developed to identify the sk in sensitization hazard of potential chemical allergens, but only a few of these are accepted by regulatory agencies. Laboratory investigations have also evaluated the stability of several commercially available allergic contact dermatitis patch tests. Such studies are considered product test...
Source: Immunology and Allergy Clinics of North America - June 4, 2021 Category: Allergy & Immunology Authors: Itai Chipinda, Stacey E. Anderson, Paul D. Siegel Source Type: research

Pediatric Allergic Contact Dermatitis
This article examines methods of patch testing and up-to-date data on pediatric ACD. The top allergens are reviewed, and avoidance strategies are discussed. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - June 4, 2021 Category: Allergy & Immunology Authors: Christen Brown, JiaDe Yu Source Type: research

Epidemics of Dermatitis
Allergic contact dermatitis (ACD) remains a globally prevalent disease for both children and adults. The silent ACD epidemic continues to be fueled by the introduction of novel allergens in industrial and household products and the continued presence of known allergens. In 1997, Allan Dillarstone noted a sinusoidal pattern to epidemics when allergenic preservatives were replaced by alternative chemicals within the market, which then similarly increased in allergenicity. A call for public health vigilance and prevention initiatives is needed to intervene in the ACD epidemic. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - June 4, 2021 Category: Allergy & Immunology Authors: Mohsen Baghchechi, Alina Goldenberg, Sharon E. Jacob Source Type: research

Occupational Dermatitis and Urticaria
Occupational contact dermatitis is the most common occupational skin disease (OSD), and most of them are irritant in nature. There is less information available about contact urticaria than contact dermatitis. There are several strategies to prevent OSD, although workplace studies suggest there are gaps in their use in the workplace. Because early detection leads to improved outcomes, screening for dermatitis in industries such as health care would be useful. Both diagnosis and management involve 2 components: the actual disease diagnosis and medical treatment and the work-relatedness and management of the workplace to red...
Source: Immunology and Allergy Clinics of North America - June 4, 2021 Category: Allergy & Immunology Authors: Dorothy Linn Holness Source Type: research

Contact Urticaria
This article discusses contact urticaria syndrome definition, history, epidemiology, occupational relevance, mechanisms, clinical manifestations, diagnostic tools, agents responsible, and how to prevent and treat the patients affected. Contact urticaria syndrome is often misdiagnosed because it is not well known or recognized by physicians. Commonly the patient recognizes the cause of the clinical symptom, but the cause can be exceptional or new. Triggers include proteins, chemical compounds, agricultural chemicals, metals, plants, foods, and other substances. The objective of this article is to help dermatologists, toxico...
Source: Immunology and Allergy Clinics of North America - June 4, 2021 Category: Allergy & Immunology Authors: Ana M. Gimenez-Arnau, Howard Maibach Source Type: research

Protein Causes of Urticaria and Dermatitis
Protein contact dermatitis is a cutaneous hypersensitivity reaction after chronic, recurrent exposure or chronic irritation to animal or plant protein. Although the pathophysiological mechanisms underlying protein contact dermatitis are not well characterized, protein contact dermatitis is thought to be caused by combined type I/IV-mediated, type-1 mediated, or a Langerhans cell immunoglobulin E –mediated delayed hypersensitivity reaction. This chapter reviews the epidemiology, pathogenesis, clinical features, common protein allergens, diagnostic process, treatment options, and prognosis of protein contact dermatitis. (S...
Source: Immunology and Allergy Clinics of North America - June 4, 2021 Category: Allergy & Immunology Authors: Alyssa Gwen Ashbaugh, Mary Kathryn Abel, Jenny E. Murase Source Type: research

Innate Immune Regulation of Dermatitis
This article highlights the diverse ways by which type 2 immune cells regulate diseases beyond AD. The discovery of human Mas-related G protein –coupled receptor X2 on mast cells has revealed novel T cell–independent and immunoglobulin E–independent mechanisms of allergic contact dermatitis–associated and urticarial itch, respectively. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - June 4, 2021 Category: Allergy & Immunology Authors: Damien Abreu, Brian S. Kim Source Type: research

Food Allergies
This article provides an overview of cutting-edge research into food allergy and immune tolerance mechanisms utilizing mouse models, human studies, and systems biology approaches. This research is being translated and implemented in the clinical setting to improve diagnosis and reduce food allergy ’s public health burden. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 14, 2021 Category: Allergy & Immunology Authors: James Walter Krempski, Christopher Warren, Xiaorui Han, Wenming Zhang, Ziyuan He, St éphanie Lejeune, Kari Nadeau Source Type: research

Dietary Management of Food Allergy
Worldwide food allergy prevalence is increasing, especially in children. Food allergy management strategies include appropriate avoidance measures and identifying suitable alternatives for a nutritionally sound diet. Individualized dietary intervention begins teaching label reading, which differs among countries or regions. Dietary intervention must result in a nutritionally sound plan including alternatives to support optimal growth and development. Inappropriate or incomplete dietary advice may increase the risk of adverse reactions, growth faltering, and nutrient deficiencies. Evidence indicates input from a registered ...
Source: Immunology and Allergy Clinics of North America - April 14, 2021 Category: Allergy & Immunology Authors: Raquel Durban, Marion Groetch, Rosan Meyer, Sherry Coleman Collins, Wendy Elverson, Alyssa Friebert, Jamie Kabourek, Stephanie M. Marchand, Vicki McWilliam, Merryn Netting, Isabel Skypala, Taryn Van Brennan, Emillia Vassilopoulou, Berber Vlieg –Boerstra Source Type: research

Food Allergy
This article examines the tools for diagnosis and management and therapy options available to physicians providing care for patients with FA. The article touches on pressing needs of clinicians and highlights the rapid and important movements in national and international support and advances that will have a positive impact on the field of FA. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 14, 2021 Category: Allergy & Immunology Authors: Sami L. Bahna, Amal H. Assa ’ad Source Type: research

Food Allergy
Immunol Allergy Clin N Am (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - April 14, 2021 Category: Allergy & Immunology Authors: Amal H. Assa ’ad Source Type: research