Immunology and Allergy Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Contents
Panida Sriaroon, Dennis K. Ledford and Richard F. Lockey (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - November 23, 2021 Category: Allergy & Immunology Source Type: research

Forthcoming Issues
Drug Hypersensitivity (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - November 23, 2021 Category: Allergy & Immunology Source Type: research

Pediatric Inner-City Asthma
Inner-city children with asthma are known to have high disease mortality and morbidity. Frequently, asthma in this high-risk population is difficult to control and more severe in nature. Several factors, including socioeconomic hardship, ability to access to health care, adherence to medication, exposure to certain allergens, pollution, crowd environment, stress, and infections, play an important role in the pathophysiology of inner-city asthma. Comprehensive control of home allergens and exposure to tobacco smoke, the use of immune based therapies, and school-based asthma programs have shown promising results in asthma co...
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Divya Seth, Shweta Saini, Pavadee Poowuttikul Source Type: research

Innate Immunity
The innate immune response system forms an important line of defense by deploying a limited number of receptors specific for conserved microbial components. This deployment generates a rapid inflammatory response, while activating the adaptive immune system. Improvements in our understanding of the innate immune system have allowed us to explore various therapeutic strategies via modulation of the immune response. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Bani Preet Kaur, Elizabeth Secord Source Type: research

Humoral Immune Deficiencies of Childhood
This article reviews, in a case-based discussion, the most common of the humoral immune deficiencies; their presentations, diagnoses, treatments; and, when known, the genetic defects. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Marwa El-Bohy, Pavadee Poowuttikul, Elizabeth Secord Source Type: research

New Insights and Treatments in Atopic Dermatitis
Atopic dermatitis is a complex, chronic inflammatory skin disorder with significant morbidity. It is often a frustrating condition for both children and parents due to chronic and relapsing course. There is now an increasing understanding of the disease pathogenesis resulting in discovery of much wanted newer therapeutics and targeted therapies after a long time. Whether these interventions will result in sustained benefits or long term cure remains to be seen. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Shweta Saini, Milind Pansare Source Type: research

Biologic Agents and Secondary Immune Deficiency
Biologics are protein-based pharmaceuticals derived from living organisms or their proteins. We discuss the mechanism of action for currently approved biologics and a give summary of the studies on immune suppression from biologics. Most of these studies have been conducted with rheumatology patients, and many in adults. Their relevance for children is explored and existing gaps in data for children are highlighted. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Heather Axelrod, Matthew Adams Source Type: research

Newborn Screening for Severe Combined Immunodeficiency
The T-cell receptor excision circle (TREC) assay is an effective screening tool for severe combined immunodeficiency (SCID). The TREC assay was designed to detect typical SCID and leaky SCID, but any condition causing low na ïve T-cell counts will also be detected. Newborn screening for SCID using the TREC assay has proven itself to be highly sensitive and cost-efficient. This review covers the history of SCID newborn screening, elaborates on the SCID subtypes and TREC assay limitations, and discusses diagnostic and ma nagement considerations for infants with a positive screen. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Mohammed Taki, Tayaba Miah, Elizabeth Secord Source Type: research

Pediatric Drug Allergies
Adverse drug reactions are frequently reported in pediatric patients. In this review article, the authors discuss pediatric drug allergies with emphasis on the most common culprits, beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. The authors also discuss reactions to non-beta-lactam antibiotics and chemotherapeutics. Skin testing has not yet been validated for many drugs, although notable exceptions include penicillin and carboplatin. The gold standard for diagnosis in most cases remains drug challenge, and the need for penicillin skin testing prior to oral provocation challenge has been questioned in re...
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Shazia Lutfeali, David A. Khan Source Type: research

Anaphylaxis in Children and Adolescents
Anaphylaxis is an acute, potentially life-threatening systemic hypersensitivity reaction. Classically, anaphylaxis is an immunoglobulin (Ig) E –mediated reaction; however, IgG or immune complex complement-related immunologic reactions that lead to degranulation of mast cells can also cause anaphylaxis. Food allergy is the most common cause of anaphylaxis, followed by drugs. Patients with anaphylaxis commonly present with symptoms involvi ng skin or mucous membranes, followed by respiratory and gastrointestinal symptoms. Epinephrine is the drug of choice for treating anaphylaxis. Patients and caregivers should be educated...
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Pavadee Poowuttikul, Divya Seth Source Type: research

Allergic Rhinitis in Children and Adolescents
Allergic rhinitis is a common disorder that regularly occurs in children and adolescents. The disease is associated with other allergic diseases, such as asthma, and it carries a heavy burden, with effects on sleep, school performance, and quality of life. Classic symptoms include sneezing, rhinorrhea, nasal obstruction, and nasal itching. When the eyes are involved, the term allergic rhinoconjunctivitis is used. Triggers may include airborne pollens, molds, dust mites, and animals. Skin or blood allergy testing can be a useful diagnostic modality that may guide therapy. Immunotherapy can prevent the development of further...
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Charles Frank Schuler IV, Jenny Maribel Montejo Source Type: research

Eosinophilic Esophagitis
Eosinophilic esophagitis is a recently defined condition that has dramatically increased in prevalence in the last several decades. It may occur at any age, but the clinical presentation in young children is often more vague than the classic solid food dysphagia and food impacting that are the major presenting symptoms of eosinophilic esophagitis in adults and adolescents. Successful therapies exist, including medications and dietary modifications, but disease typically recurs when the intervention is discontinued. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Heather K. Lehman, Weyman Lam Source Type: research

Diagnosis and Management of Food Allergy
Food allergy is an immune-mediated disease and must be differentiated from other adverse effects related to food that are non –immune mediated. Symptoms of immunoglobulin (Ig) E–mediated allergy can range from mild to severe, and life-threatening anaphylaxis may occur. Current recommended strategies for diagnosis include the use of skin prick tests, allergen-specific serum IgE, and/or oral food challenges. Management e ntails allergen avoidance and appropriate treatment of allergic reactions should accidental ingestions occur. Treatment approaches under investigation include immunotherapy as well as biologics and novel...
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Roxanne Carbonell Oriel, Julie Wang Source Type: research

New Treatments for Asthma
Asthma is a complex, heterogeneous chronic airway disease with high prevalence of uncontrolled disease. New therapies, including biologics, are now available to treat T2 high asthma. Treatment of T2 low asthma remains a challenge. Asthma guidelines need be to updated to incorporate new therapeutics. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Jenny Huang, Milind Pansare Source Type: research

Pediatric Immunology and Allergy
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - October 1, 2021 Category: Allergy & Immunology Authors: Elizabeth Secord Source Type: research