Immune-Related Adverse Drug Reactions and Immunologically Mediated Drug Hypersensitivity

Biologic and other therapies used for the treatment of immune-mediated hypersensitivity conditions, and in people with immune-mediated hypersensitivity, can trigger a wide variety of immune-related adverse drug reactions and immunologically mediated drug hypersensitivities. These range from acute-onset immunoglobulin E –mediated allergies to delayed-onset T-cell–mediated hypersensitivities. Certain therapeutic and diagnostic agents can directly activate mast cells. Biologic agents used to treat immune-mediated hypersensitivity can also globally upregulate or downregulate the immune system leading to pathologic reactions, including cytokine storm and hypogammaglobulinemia.
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Source Type: research