Prebiotic diet changes neural correlates of food decision-making in overweight adults: a randomised controlled within-subject cross-over trial
Conclusions
In this proof-of-concept study, a prebiotic intervention attenuated reward-related brain activation during food decision-making, paralleled by shifts in gut microbiota.
Trial registration number
NCT03829189. (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Medawar, E., Beyer, F., Thieleking, R., Haange, S.-B., Rolle-Kampczyk, U., Reinicke, M., Chakaroun, R., von Bergen, M., Stumvoll, M., Villringer, A., Witte, A. V. Tags: Open access, Editor's choice, Gut Gut microbiota Source Type: research
IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling
Conclusion
IL-20 controls colitis and mucosal healing by interfering with the IFN/STAT2 death signalling pathway in IECs. These results indicate new directions for suppressing gut inflammation by modulating IL-20-controlled STAT2 signals. (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Chiriac, M. T., Hracsko, Z., Günther, C., Gonzalez-Acera, M., Atreya, R., Stolzer, I., Wittner, L., Dressel, A., Schickedanz, L., Gamez-Belmonte, R., Erkert, L., Hundorfean, G., Zundler, S., Rath, T., Vetrano, S., Danese, S., Sturm, G., Trajanoski Tags: Open access, Gut Inflammatory bowel disease Source Type: research
Numerous gastric nodules in a leukaemia patient
Clinical presentation An 81-year-old white man presented with 2 weeks of odynophagia and dysphagia to solids and liquids limiting his oral intake and leading to 5 lb weight loss. He has a history of chronic myelomonocytic leukaemia with recent transition to myelofibrosis, uncontrolled gastro-oesophageal reflux disease (GORD) and chronic obstructive pulmonary disease on home oxygen. He denied fever, chills, nausea, vomiting, early satiety, abdominal pain, melena or haematemesis. The physical examination was unremarkable, and he had no oral thrush. His laboratory tests showed pancytopenia (absolute neutrophils count 62 cells...
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Bahdi, F., Alkassis, S., Lewis, M. S., El-Masry, M., Bejjani, A., Kolb, J. M. Tags: GUT Snapshot, Gut Editor ' s quiz: GI snapshot Source Type: research
Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis
Conclusions
FTO downregulation promoted UC by decreasing CerS6 expression, leading to increased S1P accumulation in IECs and aggravating colitis via m6A-dependent mechanisms. Lower FTO expression in UC patients may enhance their response to vedolizumab treatment. (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Ma, Y., Zhang, X., Xuan, B., Li, D., Yin, N., Ning, L., Zhou, Y.-L., Yan, Y., Tong, T., Zhu, X., Huang, X., Hu, M., Wang, Z., Cui, Z., Li, H., Wang, J., Fang, J.-Y., Liu, R., Chen, H., Hong, J. Tags: Gut Inflammatory bowel disease Source Type: research
Precancerous nature of intestinal metaplasia with increased chance of conversion and accelerated DNA methylation
Conclusions
IM cells were considered to have a precancerous nature potentially with an increased chance of converting into cancer cells, and an accelerated DNA methylation induction due to abnormal NOS2 expression. (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Takeuchi, C., Yamashita, S., Liu, Y.-Y., Takeshima, H., Sasaki, A., Fukuda, M., Hashimoto, T., Naka, T., Ishizu, K., Sekine, S., Yoshikawa, T., Hamada, A., Yamamichi, N., Fujishiro, M., Ushijima, T. Tags: Gut Gastroduodenal Source Type: research
Shorter-acting glucagon-like peptide-1 receptor agonists are associated with increased development of gastro-oesophageal reflux disease and its complications in patients with type 2 diabetes mellitus: a population-level retrospective matched cohort study
Conclusion
Starting shorter-acting GLP-1 RAs is associated with increased risks of GERD and its complications. (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Liu, B. D., Udemba, S. C., Liang, K., Tarabichi, Y., Hill, H., Fass, R., Song, G. Tags: Gut Oesophagus Source Type: research
British Society of Gastroenterology guidelines on sedation in gastrointestinal endoscopy
Over 2.5 million gastrointestinal endoscopic procedures are carried out in the United Kingdom (UK) every year. Procedures are carried out with local anaesthetic r with sedation. Sedation is commonly used for gastrointestinal endoscopy, but the type and amount of sedation administered is influenced by the complexity and nature of the procedure and patient factors. The elective and emergency nature of endoscopy procedures and local resources also have a significant impact on the delivery of sedation. In the UK, the vast majority of sedated procedures are carried out using benzodiazepines, with or without opiates, whereas dee...
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Sidhu, R., Turnbull, D., Haboubi, H., Leeds, J. S., Healey, C., Hebbar, S., Collins, P., Jones, W., Peerally, M. F., Brogden, S., Neilson, L. J., Nayar, M., Gath, J., Foulkes, G., Trudgill, N. J., Penman, I. Tags: Open access, Gut Guideline Source Type: research
Extent of normal polyp resection margin: a possible quality measure for polyp resection
We examined the extent of a normal mucosal tissue margin surrounding 1–10 mm neoplastic polyps following cold snare resection as a possible surrogate marker for quality of resection. Following a standard polyp preparation protocol, we found a complete resection rate (R0) based on clear margin of the polyp specimen of 84.8%. Among all R0 polyps, a 2 mm margin was only achieved for 27.7%. The extent of a healthy margin varied by expertise of endoscopist and... (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Taghiakbari, M., Anderson, J. C., von Renteln, D., Hirschmann, S., Jobse, B., Pohl, H. Tags: Gut Endoscopy news Source Type: research
Female advantage in neoadjuvant pancreatic cancer therapy: is it down to macrophages?
Pancreatic cancer still carries the worst survival rate among all solid tumours, mostly due to the absence of early symptoms and a lack of satisfying treatment options, leading to an appalling 5-year survival rate of less than 12%. The only potentially curative treatment option is surgical resection followed by adjuvant chemotherapy. Since pancreatic cancer is usually diagnosed at advanced stage, treatment with curative intent can be provided to only 15–20% of patients. However, even after surgical resection, most patients develop local or systemic recurrence. During recent years, neoadjuvant chemotherapeutic regimen...
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Michl, P., Roth, L. Tags: Gut Commentary Source Type: research
Microbiome is the key to preventing anastomotic leak in colorectal surgery
Surgery is the definitive treatment for colorectal cancer and anastomotic leak (AL) remains its most feared complication. Advances in enhanced recovery, surgical technique and intraoperative imaging have had a relatively modest impact in reducing the incidence of this life-threatening event.1 A major reason for this has been that the molecular mechanisms of anastomotic wound healing are incompletely understood. The study by Hajjar et al provides further evidence that the microbiome represents a critical missing piece in this puzzle because it modulates the innate immune response to anastomotic wound healing.2 The more intr...
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Kinross, J. M. Tags: Gut Commentary Source Type: research
GORD and GLP-1 receptor agonists: an emerging concern for gastroenterologists
The global rise in the prevalence of obesity has reached epidemic proportions, with the associated comorbidities straining healthcare budgets and adversely affecting the quality and duration of patients’ lives. Any therapy that could bend the curve on this crisis would be welcome. The pharmaceutical class of glucacon-like peptide-1 receptor agonists (GLP-1 RAs) has the potential to be a game changer. These agents, initially developed for glycaemic control, were found to cause significant weight loss in patients with type 2 diabetes. This observation led to trials in patients with obesity but without diabetes, and the...
Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Massey, B. T. Tags: Gut Commentary Source Type: research
Correction: O11 Utilising peer support workers in hepatitis C screening in emergency departments: a pilot study
Lagnado A, Caulder A, Gitahi J, et al. O11 Utilising peer support workers in hepatitis C screening in emergency departments: a pilot study. Gut 2023;72:A8-A9.
The first author should read AJ Archer . Oral presentation by Jeesha George for BLNA.
doi: 10.1136/gutjnl-2023-BSG.11.corr1 (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Tags: Gut Correction Source Type: research
Correction: P97 A patient information bundle outlining dietary advice in liver disease specific to the cost of living crisis improves patient care: 'Looking after Your Liver for Less
Lagnado A, Taylor O, Hayes B, et al. P97 A patient information bundle outlining dietary advice in liver disease specific to the cost of living crisis improves patient care: ‘Looking after Your Liver for Less’. Gut 2023;72:A76-A77.
The first author should read Dr Lagnado. Dr AJ Archer should be the second to last author.
doi: 10.1136/gutjnl-2023-BSG.112.corr1 (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Tags: Gut Correction Source Type: research
Correction: P23 Opportunistic cirrhosis case finding in alcohol dependent inpatients through alcohol specialist nurse assessment and transient elastography: early detection in a high-risk group
Lagnado A, Thorpe M, Roy S, et al. P23 Opportunistic cirrhosis case finding in alcohol dependent inpatients through alcohol specialist nurse assessment and transient elastography: early detection in a high-risk group. Gut 2023;72:A27. doi: 10.1136/gutjnl-2023-BASL-39
The first author should read AJ Archer 1,2. Dr Lagnado was not involved with this abstract. (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Tags: Gut Correction Source Type: research
Correction: O4 Acceptability and feasibility of a multimodal early detection pilot study for liver disease in high risk groups: "Alright My Liver?"
Lagnado A, Tilden S, May T, et al. O4 Acceptability and feasibility of a multimodal early detection pilot study for liver disease in high risk groups: "Alright My Liver?" Gut 2023;72:A3-A4. doi: 10.1136/gutjnl-2023-BSG.4.corr1
The first author should read AJ Archer 1,2. Dr Langnado was not involved with this abstract. (Source: Gut)
Source: Gut - January 5, 2024 Category: Gastroenterology Tags: Gut Correction Source Type: research
