Long-term follow-up study of necrotising pancreatitis: interventions, complications and quality of life
Conclusion
Acute necrotising pancreatitis carries a substantial disease burden during long-term follow-up in terms of recurrent disease, the necessity for interventions and development of pancreatic insufficiency, even when treated conservatively during the index admission. Extensive (>50%) pancreatic parenchymal necrosis seems to be an important predictor of interventions and complications during follow-up. (Source: Gut)
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Hollemans, R. A., Timmerhuis, H. C., Besselink, M. G., Bouwense, S. A. W., Bruno, M., van Duijvendijk, P., van Geenen, E.-J., Hadithi, M., Hofker, S., Van-Hooft, J. E., Kager, L. M., Manusama, E. R., Poley, J.-W., Quispel, R., Römkens, T., van der Tags: Gut Pancreas Source Type: research
Oral bacteria accelerate pancreatic cancer development in mice
Conclusion
Taken together, our findings demonstrate a causal role for P. gingivalis in pancreatic cancer development in mice. (Source: Gut)
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Saba, E., Farhat, M., Daoud, A., Khashan, A., Forkush, E., Menahem, N. H., Makkawi, H., Pandi, K., Angabo, S., Kawasaki, H., Plaschkes, I., Parnas, O., Zamir, G., Atlan, K., Elkin, M., Katz, L., Nussbaum, G. Tags: Gut Pancreas Source Type: research
Faecal microbial transfer and complex carbohydrates mediate protection against COPD
Conclusion
The gut microbiome contributes to COPD pathogenesis and can be targeted therapeutically. (Source: Gut)
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Budden, K. F., Shukla, S. D., Bowerman, K. L., Vaughan, A., Gellatly, S. L., Wood, D. L. A., Lachner, N., Idrees, S., Rehman, S. F., Faiz, A., Patel, V. K., Donovan, C., Alemao, C. A., Shen, S., Amorim, N., Majumder, R., Vanka, K. S., Mason, J., Haw, T. J Tags: Editor's choice, Gut Gut microbiota Source Type: research
Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial
Conclusion
A compact standardised EMR training for LNPCPs significantly reduced recurrences in community hospitals. This strongly argues for a national dedicated training programme for endoscopists performing EMR of ≥20 mm LNPCPs. Interestingly, in sensitivity analysis, this benefit was limited for LNPCPs ≥40 mm.
Trial registration number
NTR7477. (Source: Gut)
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Meulen, L. W. T., Bogie, R. M. M., Siersema, P. D., Winkens, B., Vlug, M. S., Wolfhagen, F. H. J., Baven-Pronk, M., van der Voorn, M., Schwartz, M. P., Vogelaar, L., de Vos tot Nederveen Cappel, W. H., Seerden, T. C. J., Hazen, W. L., Schrauwen, R. W. M., Tags: Gut Endoscopy Source Type: research
Unusual cause of abdominal pain
Case presentation An 18-year-old woman presented with a 4-day history of worsening abdominal pain. Physical examination revealed tenderness in the left mid abdomen, without rebound tenderness. Laboratory workups revealed neutrophilia (10 890/µL), elevated C reactive protein (38.59 mg/L) and increased faecal calprotectin (>50 µg/g). Haemoglobin, liver function, renal function and urinalysis results were within normal range. Immunological investigations, including immunoglobulin levels, antineutrophil cytoplasmic antibodies and antinuclear antibodies, were all normal. An abdominal CT scan demonstrated wall thi...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Zhang, J.-Y., Wu, T.-N., Ding, Y., Huang, W.-F. Tags: GUT Snapshot, Gut Editor ' s quiz: GI snapshot Source Type: research
Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barretts oesophagus surveillance: individual-level data analysis
Conclusion
SS-GM is a distinct entity from SS-IM and the malignant potential of GM is lower than IM. It is questionable whether SS-GM warrants inclusion in BO surveillance. (Source: Gut)
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Black, E. L., Ococks, E., Devonshire, G., Ng, A. W. T., ODonovan, M., Malhotra, S., Tripathi, M., Miremadi, A., Freeman, A., Coles, H., Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Fitzgerald, R. C., Fitzgerald, Nutzinger, Tags: Open access, Gut Oesophagus Source Type: research
New AI model for neoplasia detection and characterisation in inflammatory bowel disease
Message Endoscopic neoplasia detection in inflammatory bowel disease (IBD) remains challenging. We developed and validated a novel artificial intelligence (AI) model for lesion detection and characterisation in 478 images from 30 patients with IBD, 10 of whom had a total of 25 neoplastic lesions (including 8 sessile serrated polyps); sensitivity and specificity for lesion detection were 93.5% and 80.6%, respectively. The IBD model was then further validated during a real-time endoscopic assessment of a further 30 consecutive patients with 25 neoplastic lesions found in 11/30 of them and achieved lesion detection rate, lesi...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Abdelrahim, M., Siggens, K., Iwadate, Y., Maeda, N., Htet, H., Bhandari, P. Tags: Gut Endoscopy news Source Type: research
Glucagon-like peptide-1 receptor agonists to treat chronic liver disease: real-world evidence or ambiguity?
Chronic liver diseases are prevalent, particularly among patients with type 2 diabetes, who have a higher incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) and are subject to other liver diseases.1 With no pharmacotherapy for these liver conditions, recent attention was given to glucagon-like peptide-1 receptor agonists (GLP1a) for their effectiveness in treating type 2 diabetes and obesity and in reducing liver enzyme levels and liver fat levels.2 A 72-week, phase II, placebo-controlled randomised trial in patients with non-alcoholic steatohepatitis (NASH) and liver fibrosis found that the GLP1...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Suissa, S., Hernaez, R. Tags: Gut Commentary Source Type: research
Ferritin--a promising biomarker in MASLD
Human ferritins are expressed in essentially all cells of the human body. From an evolutionary perspective, human ferritins are part of a diverse ferritin-like superfamily—the ‘rubrerythins’, that include plant ferritins and bacterioferritins, where they cover a wide range of biological functions.1 Although best known as a 24-meric intracellular iron storage protein, ferritin is also present in the human circulation, where its biological functions are still being unravelled. Recent studies have shown that ferritin can be actively secreted from cells in extracellular vesicles (EVs). These ferritin-laden EV...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Zoller, H., Tilg, H. Tags: Gut Commentary Source Type: research
Is acute necrotising pancreatitis a chronic disease?
Acute pancreatitis (AP) is a common disease with an annual incidence of 34 (23–49) per 100 000 population.1 Patients with acute interstitial pancreatitis have a shorter self-limiting disease course while acute necrotising pancreatitis (ANP) is a much more severe disease with major local and systemic complications mandating prolonged hospitalisation.2 Among the local complications, acute necrotic fluid collections and walled-off necrosis require interventions preferably minimally invasively such as percutaneous and per-oral endoscopic drainage, and necrosectomy.3 Although the majority of patients survive the illness b...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Gunjan, D., Mahapatra, S. J., Garg, P. K. Tags: Gut Commentary Source Type: research
CD39 deletion in TCR-engineered T cells enhances antitumour immunity
Tumour-reactive T cells infiltrating solid tumours are often rendered exhausted, a cell differentiation state characterised by upregulation of inhibitory receptors and reduced effector function. The process of T-cell exhaustion permits cancer progression and interferes with immunotherapy response. Efforts to overcome T-cell exhaustion, such as immune checkpoint blockade (ICB), can lead to remarkable clinical responses in some patients with cancer. However, only a minority of patients respond to ICB, responses often lack durability, and undesirable immune-related toxicities are prevalent. Thus, elucidating additional factor...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Tsai, A. K., Stromnes, I. M. Tags: Gut Commentary Source Type: research
Refining definitions of Barretts oesophagus to improve clinical resource utilisation
Oesophageal adenocarcinoma (OAC) is a devastating disease with an average 5-year survival of around 15%.1 Moreover, rates of OAC have increased substantially in recent decades, adding greatly to the clinical and economic burden of this disease.2 OAC arises out of a metaplastic precursor in which the normal squamous lining of the oesophagus is replaced with columnar, mucin-secreting cells. This is termed Barrett’s oesophagus (BO) and is thought to form as a protective mechanism in response to gastro-oesophageal reflux disease (GORD). The cells that make up this oesophageal metaplasia can take several forms, roughly be...
Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Stachler, M. D., Ain, Q. U. Tags: Gut Commentary Source Type: research
Correction: Identification of c-FLIPL and c-FLIPS as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells
Haag C, Stadel D, Zhou S, et al. Identification of c-FLIPL and c-FLIPS as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells. Gut 2011;60:225-237. doi: 10.1136/gut.2009.202325
Figure 9a illustrates the downregulation of c-FLIP by Cisplatin. The authors observed that while five Western Blot lanes depict the effect of increasing Cisplatin concentrations on c-FLIP protein, six lanes are presented for the loading control beta-Actin. Thus, the 6th lane of the loading control beta-Actin has unintentionally been included in Figure 9a.
The authors sincerely apologise for this unintentional error.
do...
Source: Gut - April 5, 2024 Category: Gastroenterology Tags: Gut Correction Source Type: research
Robust SARS-CoV-2 antibody and T cell immunity following three COVID-19 vaccine doses in inflammatory bowel disease patients receiving anti-TNF or alternative treatments
We read Kennedy et al1’s findings with interest, and report in-depth analyses of antibody and T cell responses in patients with inflammatory bowel disease (IBD) to COVID-19 vaccination. We prospectively recruited 100 SARS-CoV-2-uninfected patients with IBD on varying treatments at the Royal Melbourne Hospital (HREC/74403/MH-2021). Healthcare workers who did not have IBD and were not on immunosuppressive medication were enrolled as controls with approvals from Melbourne Health (HREC/68355/MH-2020) and University of Melbourne (HREC 22268, 21626). Participant characteristics are outlined in table 1. IBD medication regim...
Source: Gut - March 7, 2024 Category: Gastroenterology Authors: Zhang, E., Nguyen, T. H. O., Allen, L. F., Kedzierski, L., Rowntree, L. C., Chang, S. Y., Zhang, W., Habel, J. R., Foo, I. J., Menon, T., Mitchell, J., Leong, R. W., Bond, K., Williamson, D. A., Kedzierska, K., Christensen, B. Tags: Gut, COVID-19 PostScript Source Type: research
'Family-based strategy for Helicobacter pylori infection screening: an efficient alternative to 'test and treat strategy
We read with utmost interest the study by Zhou et al,1 which was the first family-based investigation of Helicobacter pylori (Hp) infection in China. The authors provided valuable insights into the occurrence of familial cluster effect on Hp infection and the superiority of the ‘family-based strategy’. However, their work failed to compare the screening efficiency of various established Hp management methods, leaving us curious about whether the ‘family-based strategy’ could identify more Hp-infected participants with equal number of tests conducted as compared with the widely used ‘test and t...
Source: Gut - March 7, 2024 Category: Gastroenterology Authors: Zhang, J., Deng, Y., Liu, C., Wang, H., Ren, H., Chen, S., Chen, L., Shi, B., Zhou, L. Tags: Open access, Gut PostScript Source Type: research
