IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling

Conclusion
IL-20 controls colitis and mucosal healing by interfering with the IFN/STAT2 death signalling pathway in IECs. These results indicate new directions for suppressing gut inflammation by modulating IL-20-controlled STAT2 signals.

Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Chiriac, M. T., Hracsko, Z., Günther, C., Gonzalez-Acera, M., Atreya, R., Stolzer, I., Wittner, L., Dressel, A., Schickedanz, L., Gamez-Belmonte, R., Erkert, L., Hundorfean, G., Zundler, S., Rath, T., Vetrano, S., Danese, S., Sturm, G., Trajanoski Tags: Open access, Gut Inflammatory bowel disease Source Type: research