Correction: Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies
Bankwitz D, Bahai A, Labuhn M, et al. Hepatitis C reference viruses highlight potent antibody responses and diverse viral functional interactions with neutralising antibodies. Gut 2021;70:1745. doi:10.1136/gutjnl-2020-321190
Figure 1B: This schematic drawing depicts chimeric, JFH1-based HCVcc reporter constructs. The colour of the chimeric reporter construct GT2b (J8) was erroneously light blue for Core, p7 and the N-terminus of NS2. This colouring would indicate that the chimeric reporter construct GT2b (J8) encodes Core/p7/N-termNS2 genes of GT2a J6 isolate. In fact, the correct colour of Core/p7/N-termNS2 is dark blue i...
Source: Gut - January 5, 2024 Category: Gastroenterology Tags: Gut Correction Source Type: research
Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination
This study demonstrated a statistically significant reduction in alpha diversity and a shift in gut microbiota composition following BNT162b2 vaccination, characterised by reductions in Actinobacteriota, Blautia, Dorea, Adlercreutzia, Asacchaobacter, Coprococcus, Streptococcus, Collinsella and Ruminococcus spp and an increase in Bacteroides cacaae and Alistipes shahii. Our prospective observational study (n=52; figure 1A, ) similarly showed a shift in gut microbiota after the first BNT162b2 vaccine dose (p=0.016; ), including a reduction in Actinobacteria, Blautia spp (p<0.01; figure 1B), and alpha diversity (p=0.078; )...
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Lunken, G. R., Golding, L., Schick, A., Majdoubi, A., Lavoie, P. M., Vallance, B. A. Tags: Open access, Gut, COVID-19 PostScript Source Type: research
Atrophic autoimmune gastritis: 'a muddled or misguided core concept compromises our overall comprehension of the problem
We thank Lahner et al for their interest in our study: considering their extensive experience in the field of gastric autoimmunity, their contribution is particularly welcome.1 Overall, most of the authors’ comments are in keeping with the established knowledge of autoimmune gastritis and, therefore, not debatable. We also agree with the interesting citation from Jan Aart Scholte’s work on global governance, which can be applied to any field of science: ‘Definition is not everything, but everything involves definition... A muddled or misguided core concept compromises our overall comprehension of the prob...
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Rugge, M., Genta, R. M., Malfertheiner, P., Graham, D. Y. Tags: Gut PostScript Source Type: research
Right tool for the right bleeder
We read with great interest the study by Chan et al1 and would like to commend the group’s findings that use of over-the-scope clip (OTSC) as primary haemostasis in large peptic ulcers, compared with standard therapy, was not associated with a significant decrease in 30-day rebleeding. Currently, minimising rebleeding risk of peptic ulcers remains a challenge for endoscopists. Factors predicting the risk of rebleeding include underlying patient comorbidities, active bleeding, ulcer size, ulcer location,2 operator experience and capability of different devices.3 The study was well conducted, however, there are certain...
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Toh, D. E., Lo, S. W., Tsoi, A., Segal, J. P., Butt, J. Tags: Gut PostScript Source Type: research
Crohns-associated invariant T cells (CAITs) recognise small sulfonate molecules on CD1d
Main In the recent study by Rosati et al, we described a novel unconventional T cell population enriched in the peripheral blood of patients with Crohn’s disease (CD) and characterised by a semi-invariant T cell receptor (TCR) repertoire.1 However, the specificity of these Crohn’s-associated invariant T (CAIT) cells was not defined. Identifying the specificity of CAIT cells is essential to understand the origin of the antigen triggering their enrichment in CD. In our previous study, we observed that CAIT cells have TCRs similar to those reported for some natural killer T (NKT) type II cells.2 3 Here, we perform...
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Minervina, A. A., Pogorelyy, M. V., Paysen, S., Luening, U., Degenhardt, F., Franke, A., Thomas, P. G., Rosati, E. Tags: Open access, Gut PostScript Source Type: research
GI highlights from the literature
In this study, Harrold et al quantified cancer risk after ICB in patients with Lynch syndrome at a tertiary centre in New York. One hundred and seventy-two patients with Lynch-related tumours who underwent ICB over a 9-year period were identified retrospectively. Median... (Source: Gut)
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Smith, P. J. Tags: Gut JournalScan Source Type: research
Smart capsules for sensing and sampling the gut: status, challenges and prospects
Smart capsules are developing at a tremendous pace with a promise to become effective clinical tools for the diagnosis and monitoring of gut health. This field emerged in the early 2000s with a successful translation of an endoscopic capsule from laboratory prototype to a commercially viable clinical device. Recently, this field has accelerated and expanded into various domains beyond imaging, including the measurement of gut physiological parameters such as temperature, pH, pressure and gas sensing, and the development of sampling devices for better insight into gut health. In this review, the status of smart capsules for...
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Rehan, M., Al-Bahadly, I., Thomas, D. G., Young, W., Cheng, L. K., Avci, E. Tags: GUT Recent advances in clinical practice, Open access, Gut Source Type: research
Getting off tract: contributions of intraorgan microbiota to cancer in extraintestinal organs
The gastrointestinal ecosystem has received the most attention when examining the contributions of the human microbiome to health and disease. This concentration of effort is logical due to the overwhelming abundance of microbes in the gut coupled with the relative ease of sampling compared with other organs. However, the intestines are intimately connected to multiple extraintestinal organs, providing an opportunity for homeostatic microbial colonisation and pathogenesis in organs traditionally thought to be sterile or only transiently harbouring microbiota. These habitats are challenging to sample, and their low microbia...
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Thomas, S. C., Miller, G., Li, X., Saxena, D. Tags: GUT Recent advances in basic science, Gut Source Type: research
Three double-dose reinforced hepatitis B revaccination scheme for patients with cirrhosis unresponsive to the standard regimen: an open-label randomised clinical trial
Conclusion
For cirrhotic patients, the revaccination of non-responders to the first three dose cycle, with three additional 40 µg doses, achieved significantly better response rates to those obtained with an isolated 40 µg booster dose.
Trial registration number
NCT01884415. (Source: Gut)
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Giraldez-Gallego, A., Rodriguez-Seguel, E. d. P., Valencia-Martin, R., Morillo-Garcia, A., Salamanca-Rivera, C., Ruiz-Perez, R., Cuaresma-Duque, M., Rosso-Fernandez, C., Ferrer-Rios, M. T., Sousa-Martin, J. M., Praena-Fernandez, J. M., Desongles-Corrales, Tags: Gut Hepatology Source Type: research
Novel prognostic biomarkers in decompensated cirrhosis: a systematic review and meta-analysis
Conclusion
Novel biomarkers, including IL-6, uNGAL and copeptin, can probably improve prognostication of patients with decompensated cirrhosis compared with MELD alone. (Source: Gut)
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Juanola, A., Ma, A. T., de Wit, K., Gananandan, K., Roux, O., Zaccherini, G., Jimenez, C., Tonon, M., Sole, C., Villaseca, C., Uschner, F. E., Graupera, I., Pose, E., Moreta, M. J., Campion, D., Beuers, U., Mookerjee, R. P., Francoz, C., Durand, F., Varga Tags: Gut Hepatology Source Type: research
FAK suppresses antigen processing and presentation to promote immune evasion in pancreatic cancer
Conclusion
Therapies aimed at FAK degradation may unlock additional therapeutic benefit for the treatment of PDAC through increasing antigen diversity and promoting antigen presentation. (Source: Gut)
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Canel, M., Sławinska, A. D., Lonergan, D. W., Kallor, A. A., Upstill-Goddard, R., Davidson, C., von Kriegsheim, A., Biankin, A. V., Byron, A., Alfaro, J., Serrels, A. Tags: Open access, Gut Pancreas Source Type: research
UK and Ireland Joint Advisory Group (JAG) consensus statements for training and certification in diagnostic endoscopic ultrasound (EUS)
Conclusions
An evidence-based certification pathway has been commissioned by JAG to support and quality assure EUS training. This will form the basis to improve quality of training and safety standards in EUS in the UK and Ireland. (Source: Gut)
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: El Menabawey, T., McCrudden, R., Shetty, D., Hopper, A. D., Huggett, M. T., Bekkali, N., Carroll, N. R., Henry, E., Johnson, G. J., Keane, M. G., Love, M., McKay, C. J., Norton, S., Oppong, K., Penman, I., Ramesh, J., Ryan, B., Siau, K., Nayar, M. Tags: Open access, Gut Endoscopy Source Type: research
Predicting residual neoplasia after a non-curative gastric ESD: validation and modification of the eCura system in the Western setting: the W-eCura score
Conclusion
The eCura scoring system may be applied in Western countries to stratify the risk of LNM after a gastric HRR. A new score is proposed that may further decrease the number of unnecessary surgeries. (Source: Gut)
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Morais, R., Libanio, D., Dinis Ribeiro, M., Ferreira, A., Barreiro, P., Bourke, M. J., Gupta, S., Amaro, P., Küttner Magalhaes, R., Cecinato, P., Boal Carvalho, P., Pinho, R., Rodriguez de Santiago, E., Sferrazza, S., Lemmers, A., Figueiredo, M., Tags: Gut Endoscopy Source Type: research
Dietary wheat amylase trypsin inhibitors exacerbate CNS inflammation in experimental multiple sclerosis
Conclusions
Dietary wheat ATI activate murine and human myeloid cells. The amount of ATI present in an average human wheat-based diet caused mild intestinal inflammation, which was propagated to extraintestinal sites, leading to exacerbation of CNS inflammation and worsening of clinical symptoms in EAE. These results support the importance of the gut-brain axis in inflammatory CNS disease. (Source: Gut)
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Zevallos, V. F., Yogev, N., Hauptmann, J., Nikolaev, A., Pickert, G., Heib, V., Fittler, N., Steven, S., Luessi, F., Neerukonda, M., Janoschka, C., Tobinski, A.-M., Klotz, L., Waisman, A., Schuppan, D. Tags: Open access, Gut Gut immunity Source Type: research
Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis
Conclusion
We revealed that a novel tripeptide, RKH, derived from live AKK, may act as a novel endogenous antagonist for TLR4. RKH may serve as a novel potential therapeutic approach to combat lethal sepsis after successfully translating its efficacy into clinical practice. (Source: Gut)
Source: Gut - December 7, 2023 Category: Gastroenterology Authors: Xie, S., Li, J., Lyu, F., Xiong, Q., Gu, P., Chen, Y., Chen, M., Bao, J., Zhang, X., Wei, R., Deng, Y., Wang, H., Zeng, Z., Chen, Z., Deng, Y., Lian, Z., Zhao, J., Gong, W., Chen, Y., Liu, K.-X., Duan, Y., Jiang, Y., Zhou, H.-W., Chen, P. Tags: Editor's choice, Gut Gut microbiota Source Type: research
