Disruption of CerS6-mediated sphingolipid metabolism by FTO deficiency aggravates ulcerative colitis

Conclusions FTO downregulation promoted UC by decreasing CerS6 expression, leading to increased S1P accumulation in IECs and aggravating colitis via m6A-dependent mechanisms. Lower FTO expression in UC patients may enhance their response to vedolizumab treatment.

http://gut.bmj.com/cgi/content/short/73/2/268?rss=1

Source: Gut - January 5, 2024 Category: Gastroenterology Authors: Ma, Y., Zhang, X., Xuan, B., Li, D., Yin, N., Ning, L., Zhou, Y.-L., Yan, Y., Tong, T., Zhu, X., Huang, X., Hu, M., Wang, Z., Cui, Z., Li, H., Wang, J., Fang, J.-Y., Liu, R., Chen, H., Hong, J. Tags: Gut Inflammatory bowel disease Source Type: research