Aptamer-Based Proteomics Measuring Preoperative Cerebrospinal Fluid Protein Alterations Associated with Postoperative Delirium
Biomolecules. 2023 Sep 15;13(9):1395. doi: 10.3390/biom13091395.ABSTRACTDelirium is a common postoperative complication among older patients with many adverse outcomes. Due to a lack of validated biomarkers, prediction and monitoring of delirium by biological testing is not currently feasible. Circulating proteins in cerebrospinal fluid (CSF) may reflect biological processes causing delirium. Our goal was to discover and investigate candidate protein biomarkers in preoperative CSF that were associated with the development of postoperative delirium in older surgical patients. We employed a nested case-control study design c...
Source: Genomics Proteomics ... - September 28, 2023 Category: Genetics & Stem Cells Authors: Simon T Dillon Sarinnapha M Vasunilashorn Hasan H Otu Long Ngo Tamara Fong Xuesong Gu Michele Cavallari Alexandra Touroutoglou Mouhsin Shafi Sharon K Inouye Zhongcong Xie Edward R Marcantonio Towia A Libermann Source Type: research
Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis
Microorganisms. 2023 Aug 28;11(9):2175. doi: 10.3390/microorganisms11092175.ABSTRACTAtopic dermatitis (AD) is a common chronic inflammatory skin disease with a significant association with various type-2 inflammation-related comorbidities. Ongoing research suggests the crucial involvement of gut microbiome, especially in childhood onset AD, and hence, probiotics have emerged as a potential non-steroid-based therapeutics option to complement existing AD management plans. In order to delineate the impact of probiotics in the gut microbiome of pediatric AD patients from southern China, targeted 16S rRNA sequencing and thoroug...
Source: Genomics Proteomics ... - September 28, 2023 Category: Genetics & Stem Cells Authors: Chi Tung Choy Pui Ling Kella Siu Junwei Zhou Chi Ho Wong Yuk Wai Lee Ho Wang Chan Joseph Chi Ching Tsui Claudia Jun Yi Lo Steven King Fan Loo Stephen Kwok Wing Tsui Source Type: research
Incongruence between transcriptional and vascular pathophysiological cell states
This study shows incongruence between single-cell transcriptional states, vascular phenotypes and related pathophysiology. Our findings also suggest that the vascular structure abnormalization, rather than neoplasms, causes the reported anti-Dll4 antibody toxicity.PMID:37745941 | PMC:PMC7615119 | DOI:10.1038/s44161-023-00272-4 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - September 25, 2023 Category: Genetics & Stem Cells Authors: Macarena Fern ández-Chacón Severin M ühleder Alvaro Regano Lourdes Garcia-Ortega Susana F Rocha Carlos Torroja Maria S Sanchez-Mu ñoz Mariya Lytvyn Ver ónica Casquero-Garcia Macarena De Andr és-Laguillo Lars Muhl Michael M Orlich Konstantin Gaengel Source Type: research
Incongruence between transcriptional and vascular pathophysiological cell states
This study shows incongruence between single-cell transcriptional states, vascular phenotypes and related pathophysiology. Our findings also suggest that the vascular structure abnormalization, rather than neoplasms, causes the reported anti-Dll4 antibody toxicity.PMID:37745941 | PMC:PMC7615119 | DOI:10.1038/s44161-023-00272-4 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - September 25, 2023 Category: Genetics & Stem Cells Authors: Macarena Fern ández-Chacón Severin M ühleder Alvaro Regano Lourdes Garcia-Ortega Susana F Rocha Carlos Torroja Maria S Sanchez-Mu ñoz Mariya Lytvyn Ver ónica Casquero-Garcia Macarena De Andr és-Laguillo Lars Muhl Michael M Orlich Konstantin Gaengel Source Type: research
Incongruence between transcriptional and vascular pathophysiological cell states
This study shows incongruence between single-cell transcriptional states, vascular phenotypes and related pathophysiology. Our findings also suggest that the vascular structure abnormalization, rather than neoplasms, causes the reported anti-Dll4 antibody toxicity.PMID:37745941 | PMC:PMC7615119 | DOI:10.1038/s44161-023-00272-4 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - September 25, 2023 Category: Genetics & Stem Cells Authors: Macarena Fern ández-Chacón Severin M ühleder Alvaro Regano Lourdes Garcia-Ortega Susana F Rocha Carlos Torroja Maria S Sanchez-Mu ñoz Mariya Lytvyn Ver ónica Casquero-Garcia Macarena De Andr és-Laguillo Lars Muhl Michael M Orlich Konstantin Gaengel Source Type: research
