CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma
CONCLUSION: Our findings implicate CUL4A, CDT1, CDC6 and MCM7 in PDAC progression and identify CUL4A as an independent prognostic factor for this disease.PMID:38423594 | PMC:PMC10905276 | DOI:10.21873/cgp.20438 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Panagiotis Tavlas Sofia Nikou Christina Geramoutsou Pinelopi Bosgana Spyridon Champeris Tsaniras Maria Melachrinou Ioannis Maroulis Vasiliki Bravou Source Type: research
Impact of Tumor Grade Distribution on Genetic Alterations in Clear Cell Renal Cell Carcinoma and Prostate Cancer
CONCLUSION: Our results suggest the importance of selecting the maximum distribution of higher tumor grade areas to obtain results on the precise gene alterations for genomics-focused treatments.PMID:38423595 | PMC:PMC10905277 | DOI:10.21873/cgp.20441 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Kosuke Mizutani Seiji Sugiyama Koji Kameyama Shingo Kamei Shigeaki Yokoi Akemi Morikawa Makoto Takeuchi Kensaku Seike Toru Yamada Hidetoshi Ehara Seiya Sawada Kouseki Hirade Hirohito Furuta Kengo Matsunaga Tetsuya Yamada Ippei Sakamoto Yasutaka Kato Hiros Source Type: research
Non-homologous End-joining Genotype, mRNA Expression, and DNA Repair Capacity in Childhood Acute Lymphocytic Leukemia
CONCLUSION: Our study identified significant associations between XRCC4 rs3734091, rs28360071, XRCC5 rs828907, and XRCC6 rs5751129 genotypes and childhood ALL. Notably, lower transcriptional expression and reduced precise NHEJ repair capacity were observed in patients carrying the C allele of XRCC6 rs5751129. Further investigations are required to gain deeper insights into childhood ALL development.PMID:38423600 | PMC:PMC10905275 | DOI:10.21873/cgp.20436 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Chao-Chun Chen Wen-Shin Chang Jen-Sheng Pei Chien-Chung Kuo Chung-Hsing Wang Yun-Chi Wang Pei-Chen Hsu Jie-Long He Jian Gu DA-Tian Bau Chia-Wen Tsai Source Type: research
CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma
CONCLUSION: Our findings implicate CUL4A, CDT1, CDC6 and MCM7 in PDAC progression and identify CUL4A as an independent prognostic factor for this disease.PMID:38423594 | DOI:10.21873/cgp.20438 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Panagiotis Tavlas Sofia Nikou Christina Geramoutsou Pinelopi Bosgana Spyridon Champeris Tsaniras Maria Melachrinou Ioannis Maroulis Vasiliki Bravou Source Type: research
Impact of Tumor Grade Distribution on Genetic Alterations in Clear Cell Renal Cell Carcinoma and Prostate Cancer
CONCLUSION: Our results suggest the importance of selecting the maximum distribution of higher tumor grade areas to obtain results on the precise gene alterations for genomics-focused treatments.PMID:38423595 | DOI:10.21873/cgp.20441 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Kosuke Mizutani Seiji Sugiyama Koji Kameyama Shingo Kamei Shigeaki Yokoi Akemi Morikawa Makoto Takeuchi Kensaku Seike Toru Yamada Hidetoshi Ehara Seiya Sawada Kouseki Hirade Hirohito Furuta Kengo Matsunaga Tetsuya Yamada Ippei Sakamoto Yasutaka Kato Hiros Source Type: research
Non-homologous End-joining Genotype, mRNA Expression, and DNA Repair Capacity in Childhood Acute Lymphocytic Leukemia
CONCLUSION: Our study identified significant associations between XRCC4 rs3734091, rs28360071, XRCC5 rs828907, and XRCC6 rs5751129 genotypes and childhood ALL. Notably, lower transcriptional expression and reduced precise NHEJ repair capacity were observed in patients carrying the C allele of XRCC6 rs5751129. Further investigations are required to gain deeper insights into childhood ALL development.PMID:38423600 | DOI:10.21873/cgp.20436 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Chao-Chun Chen Wen-Shin Chang Jen-Sheng Pei Chien-Chung Kuo Chung-Hsing Wang Yun-Chi Wang Pei-Chen Hsu Jie-Long He Jian Gu DA-Tian Bau Chia-Wen Tsai Source Type: research
CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma
CONCLUSION: Our findings implicate CUL4A, CDT1, CDC6 and MCM7 in PDAC progression and identify CUL4A as an independent prognostic factor for this disease.PMID:38423594 | DOI:10.21873/cgp.20438 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Panagiotis Tavlas Sofia Nikou Christina Geramoutsou Pinelopi Bosgana Spyridon Champeris Tsaniras Maria Melachrinou Ioannis Maroulis Vasiliki Bravou Source Type: research
Impact of Tumor Grade Distribution on Genetic Alterations in Clear Cell Renal Cell Carcinoma and Prostate Cancer
CONCLUSION: Our results suggest the importance of selecting the maximum distribution of higher tumor grade areas to obtain results on the precise gene alterations for genomics-focused treatments.PMID:38423595 | DOI:10.21873/cgp.20441 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Kosuke Mizutani Seiji Sugiyama Koji Kameyama Shingo Kamei Shigeaki Yokoi Akemi Morikawa Makoto Takeuchi Kensaku Seike Toru Yamada Hidetoshi Ehara Seiya Sawada Kouseki Hirade Hirohito Furuta Kengo Matsunaga Tetsuya Yamada Ippei Sakamoto Yasutaka Kato Hiros Source Type: research
Non-homologous End-joining Genotype, mRNA Expression, and DNA Repair Capacity in Childhood Acute Lymphocytic Leukemia
CONCLUSION: Our study identified significant associations between XRCC4 rs3734091, rs28360071, XRCC5 rs828907, and XRCC6 rs5751129 genotypes and childhood ALL. Notably, lower transcriptional expression and reduced precise NHEJ repair capacity were observed in patients carrying the C allele of XRCC6 rs5751129. Further investigations are required to gain deeper insights into childhood ALL development.PMID:38423600 | DOI:10.21873/cgp.20436 (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - February 29, 2024 Category: Genetics & Stem Cells Authors: Chao-Chun Chen Wen-Shin Chang Jen-Sheng Pei Chien-Chung Kuo Chung-Hsing Wang Yun-Chi Wang Pei-Chen Hsu Jie-Long He Jian Gu DA-Tian Bau Chia-Wen Tsai Source Type: research
Circulating Proteome Analysis Identifies Reduced Inflammation After Initiation of Hemodynamic Support with Either Veno-Arterial Extracorporeal Membrane Oxygenation or Impella in Patients with Cardiogenic Shock
J Cardiovasc Transl Res. 2024 Feb 26. doi: 10.1007/s12265-024-10501-1. Online ahead of print.ABSTRACTIn-hospital mortality associated with cardiogenic shock (CS) remains high despite the use of percutaneous assist devices. We sought to determine whether support with VA-ECMO or Impella in patients with CS alters specific components of the plasma proteome. Plasma samples were collected before device implantation and 72 h after initiation of support in 11 CS patients receiving ECMO or Impella. SOMAscan was used to detect 1305 circulating proteins. Sixty-seven proteins were changed after ECMO (18 upregulated and 49 downregulat...
Source: Genomics Proteomics ... - February 27, 2024 Category: Genetics & Stem Cells Authors: Nikolaos A Diakos Lija Swain Shreyas Bhave Xiaoying Qiao Towia Libermann Jillian Haywood Siya Goel Shiva Annamalai Michele Esposito Haval Chweich Anthony Faugno Navin K Kapur Source Type: research
Circulating Proteome Analysis Identifies Reduced Inflammation After Initiation of Hemodynamic Support with Either Veno-Arterial Extracorporeal Membrane Oxygenation or Impella in Patients with Cardiogenic Shock
J Cardiovasc Transl Res. 2024 Feb 26. doi: 10.1007/s12265-024-10501-1. Online ahead of print.ABSTRACTIn-hospital mortality associated with cardiogenic shock (CS) remains high despite the use of percutaneous assist devices. We sought to determine whether support with VA-ECMO or Impella in patients with CS alters specific components of the plasma proteome. Plasma samples were collected before device implantation and 72 h after initiation of support in 11 CS patients receiving ECMO or Impella. SOMAscan was used to detect 1305 circulating proteins. Sixty-seven proteins were changed after ECMO (18 upregulated and 49 downregulat...
Source: Genomics Proteomics ... - February 27, 2024 Category: Genetics & Stem Cells Authors: Nikolaos A Diakos Lija Swain Shreyas Bhave Xiaoying Qiao Towia Libermann Jillian Haywood Siya Goel Shiva Annamalai Michele Esposito Haval Chweich Anthony Faugno Navin K Kapur Source Type: research
Circulating Proteome Analysis Identifies Reduced Inflammation After Initiation of Hemodynamic Support with Either Veno-Arterial Extracorporeal Membrane Oxygenation or Impella in Patients with Cardiogenic Shock
J Cardiovasc Transl Res. 2024 Feb 26. doi: 10.1007/s12265-024-10501-1. Online ahead of print.ABSTRACTIn-hospital mortality associated with cardiogenic shock (CS) remains high despite the use of percutaneous assist devices. We sought to determine whether support with VA-ECMO or Impella in patients with CS alters specific components of the plasma proteome. Plasma samples were collected before device implantation and 72 h after initiation of support in 11 CS patients receiving ECMO or Impella. SOMAscan was used to detect 1305 circulating proteins. Sixty-seven proteins were changed after ECMO (18 upregulated and 49 downregulat...
Source: Genomics Proteomics ... - February 27, 2024 Category: Genetics & Stem Cells Authors: Nikolaos A Diakos Lija Swain Shreyas Bhave Xiaoying Qiao Towia Libermann Jillian Haywood Siya Goel Shiva Annamalai Michele Esposito Haval Chweich Anthony Faugno Navin K Kapur Source Type: research
Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis
J Clin Invest. 2024 Feb 22:e170559. doi: 10.1172/JCI170559. Online ahead of print.ABSTRACTTranslocation Renal Cell Carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3 fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we show that human ASPSCR1-TFE3 driven by Pax8-Cre (a credentialed ccRCC driver) disrupted nephrogenesis and glomerular development causing neonatal death, whilst the ccRCC failed driver, Sglt2-Cre, induced aggressive tRCC (as well as ASPS) with complete penetrance and short latency. However, in both contexts, ASPSCR1-TFE3 led to characteristic morphological cellular chan...
Source: Genomics Proteomics ... - February 22, 2024 Category: Genetics & Stem Cells Authors: Gopinath Prakasam Akhilesh Mishra Alana Christie Jeffrey Miyata Deyssy Carrillo Vanina T Tcheuyap Hui Ye Quyen N Do Yunguan Wang Oscar Reig Torras Ramesh Butti Hua Zhong Jeffrey Gagan Kevin B Jones Thomas J Carroll Zora Modrusan Steffen Durinck Mai-Carmen Source Type: research
Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis
J Clin Invest. 2024 Feb 22:e170559. doi: 10.1172/JCI170559. Online ahead of print.ABSTRACTTranslocation Renal Cell Carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3 fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we show that human ASPSCR1-TFE3 driven by Pax8-Cre (a credentialed ccRCC driver) disrupted nephrogenesis and glomerular development causing neonatal death, whilst the ccRCC failed driver, Sglt2-Cre, induced aggressive tRCC (as well as ASPS) with complete penetrance and short latency. However, in both contexts, ASPSCR1-TFE3 led to characteristic morphological cellular chan...
Source: Genomics Proteomics ... - February 22, 2024 Category: Genetics & Stem Cells Authors: Gopinath Prakasam Akhilesh Mishra Alana Christie Jeffrey Miyata Deyssy Carrillo Vanina T Tcheuyap Hui Ye Quyen N Do Yunguan Wang Oscar Reig Torras Ramesh Butti Hua Zhong Jeffrey Gagan Kevin B Jones Thomas J Carroll Zora Modrusan Steffen Durinck Mai-Carmen Source Type: research
Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis
J Clin Invest. 2024 Feb 22:e170559. doi: 10.1172/JCI170559. Online ahead of print.ABSTRACTTranslocation Renal Cell Carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3 fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we show that human ASPSCR1-TFE3 driven by Pax8-Cre (a credentialed ccRCC driver) disrupted nephrogenesis and glomerular development causing neonatal death, whilst the ccRCC failed driver, Sglt2-Cre, induced aggressive tRCC (as well as ASPS) with complete penetrance and short latency. However, in both contexts, ASPSCR1-TFE3 led to characteristic morphological cellular chan...
Source: Genomics Proteomics ... - February 22, 2024 Category: Genetics & Stem Cells Authors: Gopinath Prakasam Akhilesh Mishra Alana Christie Jeffrey Miyata Deyssy Carrillo Vanina T Tcheuyap Hui Ye Quyen N Do Yunguan Wang Oscar Reig Torras Ramesh Butti Hua Zhong Jeffrey Gagan Kevin B Jones Thomas J Carroll Zora Modrusan Steffen Durinck Mai-Carmen Source Type: research
